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E3K7C3

- MTAP1_PUCGT

UniProt

E3K7C3 - MTAP1_PUCGT

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Protein
S-methyl-5'-thioadenosine phosphorylase 1
Gene
PGTG_06409
Organism
Puccinia graminis f. sp. tritici (strain CRL 75-36-700-3 / race SCCL) (Black stem rust fungus)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates By similarity.UniRule annotation

Catalytic activityi

S-methyl-5'-thioadenosine + phosphate = adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei14 – 141Phosphate By similarity
Sitei180 – 1801Important for substrate specificity By similarity
Binding sitei198 – 1981Substrate; via amide nitrogen By similarity
Binding sitei199 – 1991Phosphate By similarity
Sitei235 – 2351Important for substrate specificity By similarity

GO - Molecular functioni

  1. S-methyl-5-thioadenosine phosphorylase activity Source: UniProtKB-HAMAP
  2. mRNA binding Source: EnsemblFungi
  3. phosphorylase activity Source: InterPro

GO - Biological processi

  1. L-methionine salvage from methylthioadenosine Source: UniProtKB-HAMAP
  2. glutamate biosynthetic process Source: EnsemblFungi
  3. purine ribonucleoside salvage Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Purine salvage

Enzyme and pathway databases

UniPathwayiUPA00904; UER00873.

Names & Taxonomyi

Protein namesi
Recommended name:
S-methyl-5'-thioadenosine phosphorylase 1 (EC:2.4.2.28)
Alternative name(s):
5'-methylthioadenosine phosphorylase 1
Short name:
MTA phosphorylase 1
Short name:
MTAP 1
Short name:
MTAPase 1
Gene namesi
ORF Names:PGTG_06409
OrganismiPuccinia graminis f. sp. tritici (strain CRL 75-36-700-3 / race SCCL) (Black stem rust fungus)
Taxonomic identifieri418459 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaPucciniomycotinaPucciniomycetesPuccinialesPucciniaceaePuccinia
ProteomesiUP000008783: Unassembled WGS sequence

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 303303S-methyl-5'-thioadenosine phosphorylase 1UniRule annotation
PRO_0000415133Add
BLAST

Interactioni

Subunit structurei

Homotrimer By similarity.UniRule annotation

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni57 – 582Phosphate binding By similarity
Regioni90 – 912Phosphate binding By similarity
Regioni222 – 2243Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

KOiK00772.
OMAiHVVGMTA.
OrthoDBiEOG77DJGM.

Family and domain databases

Gene3Di3.40.50.1580. 1 hit.
HAMAPiMF_01963. MTAP.
InterProiIPR010044. MTAP.
IPR000845. Nucleoside_phosphorylase_d.
IPR001369. PNP/MTAP.
IPR018099. Purine_phosphorylase-2_CS.
[Graphical view]
PANTHERiPTHR11904. PTHR11904. 1 hit.
PfamiPF01048. PNP_UDP_1. 1 hit.
[Graphical view]
SUPFAMiSSF53167. SSF53167. 1 hit.
TIGRFAMsiTIGR01694. MTAP. 1 hit.
PROSITEiPS01240. PNP_MTAP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E3K7C3-1 [UniParc]FASTAAdd to Basket

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MTGHAPLVGV IGGSGLYKLE GIEPVESLNI DTPWGRPSSP ITLFKLPSGP    50
VVAFLARHGV SHQFTPSEVP SRANIAALKK IGCQVIIAFS AVGSLREEIK 100
PRDIVVPSQI IDRTKSVRPC TFFEGLGVVG HAMFGEPFDT ELTGLVTKSI 150
KEAVTGFEMN DRIGVHAEKV AICMEGPAFS TRAESNMYRM FGGDIINMSV 200
LPEAKLAREA ELSYALIAQI TDYDAWRESE EPVTVAEVMA TIAANVSVSN 250
RLTLTILDEV HNAVAKGQLK TCKGTMEYSV MTKKEMISEE SKKTLSFILP 300
YFS 303
Length:303
Mass (Da):32,896
Last modified:January 11, 2011 - v1
Checksum:iADA699B2E9CF9AE0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS178275 Genomic DNA. Translation: EFP80453.1.
RefSeqiXP_003324872.1. XM_003324824.2.

Genome annotation databases

EnsemblFungiiEFP80453; EFP80453; PGTG_06409.
GeneIDi10539462.
KEGGipgr:PGTG_06409.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS178275 Genomic DNA. Translation: EFP80453.1 .
RefSeqi XP_003324872.1. XM_003324824.2.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii EFP80453 ; EFP80453 ; PGTG_06409 .
GeneIDi 10539462.
KEGGi pgr:PGTG_06409.

Phylogenomic databases

KOi K00772.
OMAi HVVGMTA.
OrthoDBi EOG77DJGM.

Enzyme and pathway databases

UniPathwayi UPA00904 ; UER00873 .

Family and domain databases

Gene3Di 3.40.50.1580. 1 hit.
HAMAPi MF_01963. MTAP.
InterProi IPR010044. MTAP.
IPR000845. Nucleoside_phosphorylase_d.
IPR001369. PNP/MTAP.
IPR018099. Purine_phosphorylase-2_CS.
[Graphical view ]
PANTHERi PTHR11904. PTHR11904. 1 hit.
Pfami PF01048. PNP_UDP_1. 1 hit.
[Graphical view ]
SUPFAMi SSF53167. SSF53167. 1 hit.
TIGRFAMsi TIGR01694. MTAP. 1 hit.
PROSITEi PS01240. PNP_MTAP_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CRL 75-36-700-3 / race SCCL.

Entry informationi

Entry nameiMTAP1_PUCGT
AccessioniPrimary (citable) accession number: E3K7C3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 25, 2012
Last sequence update: January 11, 2011
Last modified: June 11, 2014
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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