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E3IC15

- E3IC15_GEOS0

UniProt

E3IC15 - E3IC15_GEOS0

Protein

UDP-N-acetylenolpyruvoylglucosamine reductase

Gene

murB

Organism
Geobacillus sp. (strain Y4.1MC1)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 28 (01 Oct 2014)
      Sequence version 1 (11 Jan 2011)
      Previous versions | rss
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    Functioni

    Cell wall formation.UniRule annotationSAAS annotation

    Catalytic activityi

    UDP-N-acetyl-alpha-D-muramate + NADP+ = UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine + NADPH.UniRule annotationSAAS annotation

    Cofactori

    FAD.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei178 – 1781UniRule annotation
    Active sitei228 – 2281Proton donorUniRule annotation
    Active sitei298 – 2981UniRule annotation

    GO - Molecular functioni

    1. flavin adenine dinucleotide binding Source: InterPro
    2. UDP-N-acetylmuramate dehydrogenase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. peptidoglycan biosynthetic process Source: UniProtKB-HAMAP
    4. regulation of cell shape Source: UniProtKB-KW

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotationSAAS annotationImported

    Keywords - Biological processi

    Cell cycle, Cell divisionUniRule annotationSAAS annotation, Cell shape, Cell wall biogenesis/degradationUniRule annotationSAAS annotation, Peptidoglycan synthesisUniRule annotationSAAS annotation

    Keywords - Ligandi

    FADUniRule annotationSAAS annotation, Flavoprotein, NADPUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciGSP581103:GHT2-3024-MONOMER.
    UniPathwayiUPA00219.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UDP-N-acetylenolpyruvoylglucosamine reductaseUniRule annotation (EC:1.3.1.98UniRule annotation)
    Alternative name(s):
    UDP-N-acetylmuramate dehydrogenaseUniRule annotation
    Gene namesi
    Name:murBUniRule annotation
    Ordered Locus Names:GY4MC1_2947Imported
    OrganismiGeobacillus sp. (strain Y4.1MC1)Imported
    Taxonomic identifieri581103 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillus
    ProteomesiUP000002034: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotationSAAS annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotationSAAS annotation

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini35 – 199165FAD-binding PCMH-typeUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the MurB family.UniRule annotation
    Contains 1 FAD-binding PCMH-type domain.UniRule annotation
    Contains FAD-binding PCMH-type domain.SAAS annotation

    Phylogenomic databases

    HOGENOMiHOG000284355.
    KOiK00075.
    OMAiWMNAGTR.

    Family and domain databases

    Gene3Di3.30.43.10. 1 hit.
    3.30.465.10. 1 hit.
    3.90.78.10. 1 hit.
    HAMAPiMF_00037. MurB.
    InterProiIPR016169. CO_DH_flavot_FAD-bd_sub2.
    IPR016166. FAD-bd_2.
    IPR016167. FAD-bd_2_sub1.
    IPR003170. MurB.
    IPR011601. MurB_C.
    IPR006094. Oxid_FAD_bind_N.
    [Graphical view]
    PANTHERiPTHR21071. PTHR21071. 1 hit.
    PfamiPF01565. FAD_binding_4. 1 hit.
    PF02873. MurB_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF56176. SSF56176. 1 hit.
    SSF56194. SSF56194. 1 hit.
    TIGRFAMsiTIGR00179. murB. 1 hit.
    PROSITEiPS51387. FAD_PCMH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    E3IC15-1 [UniParc]FASTAAdd to Basket

    « Hide

    MMYENNVIYQ ELVRICGEKN VLRDEPLKYH TLVKIGGKAD FLVWPETYEQ    50
    VVEVIRLKEK HHLPFTLLGN GSNVIVRDGG IRGIVVQLKH LTEIKVEGEK 100
    IIAQSGADIK AVSRVALEHS LTGLEFACGI PGSVGGAIMM NAGAYDGEIK 150
    DVIDHVKVVT QTGEQKILRK DDLQLGYRTS IISKTNDIVL EAVFQLKKGD 200
    PQKIKEKMDD LTFRRESKQP LEYPSVGSVF KRPPGYFAGK LIQDSGLQGK 250
    GVGGAEVSTK HAGFIINKNN ATASDYIATI ELVRKTVKEK FGVDLELEVK 300
    IIGEDIKQ 308
    Length:308
    Mass (Da):34,070
    Last modified:January 11, 2011 - v1
    Checksum:iA5B5F3538EACE429
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002293 Genomic DNA. Translation: ADP75637.1.
    RefSeqiWP_013401396.1. NC_014650.1.
    YP_003990248.1. NC_014650.1.

    Genome annotation databases

    EnsemblBacteriaiADP75637; ADP75637; GY4MC1_2947.
    GeneIDi9929829.
    KEGGigmc:GY4MC1_2947.
    PATRICi42636224. VBIGeoSp111282_3234.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002293 Genomic DNA. Translation: ADP75637.1 .
    RefSeqi WP_013401396.1. NC_014650.1.
    YP_003990248.1. NC_014650.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADP75637 ; ADP75637 ; GY4MC1_2947 .
    GeneIDi 9929829.
    KEGGi gmc:GY4MC1_2947.
    PATRICi 42636224. VBIGeoSp111282_3234.

    Phylogenomic databases

    HOGENOMi HOG000284355.
    KOi K00075.
    OMAi WMNAGTR.

    Enzyme and pathway databases

    UniPathwayi UPA00219 .
    BioCyci GSP581103:GHT2-3024-MONOMER.

    Family and domain databases

    Gene3Di 3.30.43.10. 1 hit.
    3.30.465.10. 1 hit.
    3.90.78.10. 1 hit.
    HAMAPi MF_00037. MurB.
    InterProi IPR016169. CO_DH_flavot_FAD-bd_sub2.
    IPR016166. FAD-bd_2.
    IPR016167. FAD-bd_2_sub1.
    IPR003170. MurB.
    IPR011601. MurB_C.
    IPR006094. Oxid_FAD_bind_N.
    [Graphical view ]
    PANTHERi PTHR21071. PTHR21071. 1 hit.
    Pfami PF01565. FAD_binding_4. 1 hit.
    PF02873. MurB_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56176. SSF56176. 1 hit.
    SSF56194. SSF56194. 1 hit.
    TIGRFAMsi TIGR00179. murB. 1 hit.
    PROSITEi PS51387. FAD_PCMH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome of Geobacillus sp. Y4.1MC1."
      US DOE Joint Genome Institute
      Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L., Pitluck S., Chertkov O., Zhang X., Detter J.C., Han C., Tapia R., Land M., Hauser L., Jeffries C., Kyrpides N., Ivanova N., Ovchinnikova G.
      , Brumm P., Mead D., Woyke T.
      Submitted (OCT-2010) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Y4.1MC1Imported.

    Entry informationi

    Entry nameiE3IC15_GEOS0
    AccessioniPrimary (citable) accession number: E3IC15
    Entry historyi
    Integrated into UniProtKB/TrEMBL: January 11, 2011
    Last sequence update: January 11, 2011
    Last modified: October 1, 2014
    This is version 28 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3