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E3IC15

- E3IC15_GEOS0

UniProt

E3IC15 - E3IC15_GEOS0

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Protein

UDP-N-acetylenolpyruvoylglucosamine reductase

Gene
murB, GY4MC1_2947
Organism
Geobacillus sp. (strain Y4.1MC1)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Cell wall formation By similarity.UniRule annotationSAAS annotations

Catalytic activityi

UDP-N-acetyl-alpha-D-muramate + NADP+ = UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine + NADPH.UniRule annotationSAAS annotations

Cofactori

FAD By similarity.UniRule annotationSAAS annotations

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei178 – 1781 By similarityUniRule annotation
Active sitei228 – 2281Proton donor By similarityUniRule annotation
Active sitei298 – 2981 By similarityUniRule annotation

GO - Molecular functioni

  1. flavin adenine dinucleotide binding Source: InterPro
  2. UDP-N-acetylmuramate dehydrogenase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. peptidoglycan biosynthetic process Source: UniProtKB-HAMAP
  4. regulation of cell shape Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationSAAS annotationsImported

Keywords - Biological processi

Cell cycle, Cell divisionUniRule annotationSAAS annotations, Cell shape, Cell wall biogenesis/degradationUniRule annotationSAAS annotations, Peptidoglycan synthesisUniRule annotationSAAS annotations

Keywords - Ligandi

FADUniRule annotationSAAS annotations, Flavoprotein, NADPUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciGSP581103:GHT2-3024-MONOMER.
UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-N-acetylenolpyruvoylglucosamine reductaseUniRule annotation (EC:1.3.1.98UniRule annotation)
Alternative name(s):
UDP-N-acetylmuramate dehydrogenase
Gene namesi
Name:murBUniRule annotation
Ordered Locus Names:GY4MC1_2947Imported
OrganismiGeobacillus sp. (strain Y4.1MC1)Imported
Taxonomic identifieri581103 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillus
ProteomesiUP000002034: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotationSAAS annotations

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotations

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini35 – 199165FAD-binding PCMH-type By similarityUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the MurB family.UniRule annotation
Contains FAD-binding PCMH-type domain.SAAS annotations

Phylogenomic databases

HOGENOMiHOG000284355.
KOiK00075.
OMAiWMNAGTR.

Family and domain databases

Gene3Di3.30.43.10. 1 hit.
3.30.465.10. 1 hit.
3.90.78.10. 1 hit.
HAMAPiMF_00037. MurB.
InterProiIPR016169. CO_DH_flavot_FAD-bd_sub2.
IPR016166. FAD-bd_2.
IPR016167. FAD-bd_2_sub1.
IPR003170. MurB.
IPR011601. MurB_C.
IPR006094. Oxid_FAD_bind_N.
[Graphical view]
PANTHERiPTHR21071. PTHR21071. 1 hit.
PfamiPF01565. FAD_binding_4. 1 hit.
PF02873. MurB_C. 1 hit.
[Graphical view]
SUPFAMiSSF56176. SSF56176. 1 hit.
SSF56194. SSF56194. 1 hit.
TIGRFAMsiTIGR00179. murB. 1 hit.
PROSITEiPS51387. FAD_PCMH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E3IC15-1 [UniParc]FASTAAdd to Basket

« Hide

MMYENNVIYQ ELVRICGEKN VLRDEPLKYH TLVKIGGKAD FLVWPETYEQ    50
VVEVIRLKEK HHLPFTLLGN GSNVIVRDGG IRGIVVQLKH LTEIKVEGEK 100
IIAQSGADIK AVSRVALEHS LTGLEFACGI PGSVGGAIMM NAGAYDGEIK 150
DVIDHVKVVT QTGEQKILRK DDLQLGYRTS IISKTNDIVL EAVFQLKKGD 200
PQKIKEKMDD LTFRRESKQP LEYPSVGSVF KRPPGYFAGK LIQDSGLQGK 250
GVGGAEVSTK HAGFIINKNN ATASDYIATI ELVRKTVKEK FGVDLELEVK 300
IIGEDIKQ 308
Length:308
Mass (Da):34,070
Last modified:January 11, 2011 - v1
Checksum:iA5B5F3538EACE429
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002293 Genomic DNA. Translation: ADP75637.1.
RefSeqiWP_013401396.1. NC_014650.1.
YP_003990248.1. NC_014650.1.

Genome annotation databases

EnsemblBacteriaiADP75637; ADP75637; GY4MC1_2947.
GeneIDi9929829.
KEGGigmc:GY4MC1_2947.
PATRICi42636224. VBIGeoSp111282_3234.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002293 Genomic DNA. Translation: ADP75637.1 .
RefSeqi WP_013401396.1. NC_014650.1.
YP_003990248.1. NC_014650.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADP75637 ; ADP75637 ; GY4MC1_2947 .
GeneIDi 9929829.
KEGGi gmc:GY4MC1_2947.
PATRICi 42636224. VBIGeoSp111282_3234.

Phylogenomic databases

HOGENOMi HOG000284355.
KOi K00075.
OMAi WMNAGTR.

Enzyme and pathway databases

UniPathwayi UPA00219 .
BioCyci GSP581103:GHT2-3024-MONOMER.

Family and domain databases

Gene3Di 3.30.43.10. 1 hit.
3.30.465.10. 1 hit.
3.90.78.10. 1 hit.
HAMAPi MF_00037. MurB.
InterProi IPR016169. CO_DH_flavot_FAD-bd_sub2.
IPR016166. FAD-bd_2.
IPR016167. FAD-bd_2_sub1.
IPR003170. MurB.
IPR011601. MurB_C.
IPR006094. Oxid_FAD_bind_N.
[Graphical view ]
PANTHERi PTHR21071. PTHR21071. 1 hit.
Pfami PF01565. FAD_binding_4. 1 hit.
PF02873. MurB_C. 1 hit.
[Graphical view ]
SUPFAMi SSF56176. SSF56176. 1 hit.
SSF56194. SSF56194. 1 hit.
TIGRFAMsi TIGR00179. murB. 1 hit.
PROSITEi PS51387. FAD_PCMH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome of Geobacillus sp. Y4.1MC1."
    US DOE Joint Genome Institute
    Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L., Pitluck S., Chertkov O., Zhang X., Detter J.C., Han C., Tapia R., Land M., Hauser L., Jeffries C., Kyrpides N., Ivanova N., Ovchinnikova G.
    , Brumm P., Mead D., Woyke T.
    Submitted (OCT-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Y4.1MC1Imported.

Entry informationi

Entry nameiE3IC15_GEOS0
AccessioniPrimary (citable) accession number: E3IC15
Entry historyi
Integrated into UniProtKB/TrEMBL: January 11, 2011
Last sequence update: January 11, 2011
Last modified: September 3, 2014
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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