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Protein

UDP-N-acetylenolpyruvoylglucosamine reductase

Gene

murB

Organism
Geobacillus sp. (strain Y4.1MC1)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Cell wall formation.UniRule annotationSAAS annotation

Catalytic activityi

UDP-N-acetyl-alpha-D-muramate + NADP+ = UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine + NADPH.UniRule annotationSAAS annotation

Cofactori

FADUniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei178 – 1781UniRule annotation
Active sitei228 – 2281Proton donorUniRule annotation
Active sitei298 – 2981UniRule annotation

GO - Molecular functioni

  1. flavin adenine dinucleotide binding Source: InterPro
  2. UDP-N-acetylmuramate dehydrogenase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. cell wall organization Source: UniProtKB-KW
  4. peptidoglycan biosynthetic process Source: UniProtKB-HAMAP
  5. regulation of cell shape Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationSAAS annotation

Keywords - Biological processi

Cell cycle, Cell divisionUniRule annotationSAAS annotation, Cell shape, Cell wall biogenesis/degradationUniRule annotationSAAS annotation, Peptidoglycan synthesisUniRule annotationSAAS annotation

Keywords - Ligandi

FADUniRule annotationSAAS annotation, Flavoprotein, NADPUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciGSP581103:GHT2-3024-MONOMER.
UniPathwayiUPA00219.
UPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-N-acetylenolpyruvoylglucosamine reductaseUniRule annotationSAAS annotation (EC:1.3.1.98UniRule annotationSAAS annotation)
Alternative name(s):
UDP-N-acetylmuramate dehydrogenaseUniRule annotation
Gene namesi
Name:murBUniRule annotation
Ordered Locus Names:GY4MC1_2947Imported
OrganismiGeobacillus sp. (strain Y4.1MC1)Imported
Taxonomic identifieri581103 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillus
ProteomesiUP000002034: Chromosome

Subcellular locationi

Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini35 – 199165FAD-binding PCMH-typeUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the MurB family.UniRule annotation
Contains 1 FAD-binding PCMH-type domain.UniRule annotation
Contains FAD-binding PCMH-type domain.SAAS annotation

Phylogenomic databases

HOGENOMiHOG000284355.
KOiK00075.
OMAiVKVTREN.

Family and domain databases

Gene3Di3.30.43.10. 1 hit.
3.30.465.10. 1 hit.
3.90.78.10. 1 hit.
HAMAPiMF_00037. MurB.
InterProiIPR016169. CO_DH_flavot_FAD-bd_sub2.
IPR016166. FAD-bd_2.
IPR016167. FAD-bd_2_sub1.
IPR003170. MurB.
IPR011601. MurB_C.
IPR006094. Oxid_FAD_bind_N.
[Graphical view]
PANTHERiPTHR21071. PTHR21071. 1 hit.
PfamiPF01565. FAD_binding_4. 1 hit.
PF02873. MurB_C. 1 hit.
[Graphical view]
SUPFAMiSSF56176. SSF56176. 1 hit.
SSF56194. SSF56194. 1 hit.
TIGRFAMsiTIGR00179. murB. 1 hit.
PROSITEiPS51387. FAD_PCMH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E3IC15-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MMYENNVIYQ ELVRICGEKN VLRDEPLKYH TLVKIGGKAD FLVWPETYEQ
60 70 80 90 100
VVEVIRLKEK HHLPFTLLGN GSNVIVRDGG IRGIVVQLKH LTEIKVEGEK
110 120 130 140 150
IIAQSGADIK AVSRVALEHS LTGLEFACGI PGSVGGAIMM NAGAYDGEIK
160 170 180 190 200
DVIDHVKVVT QTGEQKILRK DDLQLGYRTS IISKTNDIVL EAVFQLKKGD
210 220 230 240 250
PQKIKEKMDD LTFRRESKQP LEYPSVGSVF KRPPGYFAGK LIQDSGLQGK
260 270 280 290 300
GVGGAEVSTK HAGFIINKNN ATASDYIATI ELVRKTVKEK FGVDLELEVK

IIGEDIKQ
Length:308
Mass (Da):34,070
Last modified:January 11, 2011 - v1
Checksum:iA5B5F3538EACE429
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002293 Genomic DNA. Translation: ADP75637.1.
RefSeqiWP_013401396.1. NC_014650.1.
YP_003990248.1. NC_014650.1.

Genome annotation databases

EnsemblBacteriaiADP75637; ADP75637; GY4MC1_2947.
GeneIDi9929829.
KEGGigmc:GY4MC1_2947.
PATRICi42636224. VBIGeoSp111282_3234.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002293 Genomic DNA. Translation: ADP75637.1.
RefSeqiWP_013401396.1. NC_014650.1.
YP_003990248.1. NC_014650.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADP75637; ADP75637; GY4MC1_2947.
GeneIDi9929829.
KEGGigmc:GY4MC1_2947.
PATRICi42636224. VBIGeoSp111282_3234.

Phylogenomic databases

HOGENOMiHOG000284355.
KOiK00075.
OMAiVKVTREN.

Enzyme and pathway databases

UniPathwayiUPA00219.
UPA00219.
BioCyciGSP581103:GHT2-3024-MONOMER.

Family and domain databases

Gene3Di3.30.43.10. 1 hit.
3.30.465.10. 1 hit.
3.90.78.10. 1 hit.
HAMAPiMF_00037. MurB.
InterProiIPR016169. CO_DH_flavot_FAD-bd_sub2.
IPR016166. FAD-bd_2.
IPR016167. FAD-bd_2_sub1.
IPR003170. MurB.
IPR011601. MurB_C.
IPR006094. Oxid_FAD_bind_N.
[Graphical view]
PANTHERiPTHR21071. PTHR21071. 1 hit.
PfamiPF01565. FAD_binding_4. 1 hit.
PF02873. MurB_C. 1 hit.
[Graphical view]
SUPFAMiSSF56176. SSF56176. 1 hit.
SSF56194. SSF56194. 1 hit.
TIGRFAMsiTIGR00179. murB. 1 hit.
PROSITEiPS51387. FAD_PCMH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequence of chromosome of Geobacillus sp. Y4.1MC1."
    US DOE Joint Genome Institute
    Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L., Pitluck S., Chertkov O., Zhang X., Detter J.C., Han C., Tapia R., Land M., Hauser L., Jeffries C., Kyrpides N., Ivanova N., Ovchinnikova G.
    , Brumm P., Mead D., Woyke T.
    Submitted (OCT-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Y4.1MC1Imported.

Entry informationi

Entry nameiE3IC15_GEOS0
AccessioniPrimary (citable) accession number: E3IC15
Entry historyi
Integrated into UniProtKB/TrEMBL: January 11, 2011
Last sequence update: January 11, 2011
Last modified: February 4, 2015
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.