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E3IC15 (E3IC15_GEOS0) Unreviewed, UniProtKB/TrEMBL

Last modified February 19, 2014. Version 24. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
UDP-N-acetylenolpyruvoylglucosamine reductase HAMAP-Rule MF_00037

EC=1.3.1.98 HAMAP-Rule MF_00037
Alternative name(s):
UDP-N-acetylmuramate dehydrogenase HAMAP-Rule MF_00037
Gene names
Name:murB HAMAP-Rule MF_00037
Ordered Locus Names:GY4MC1_2947 EMBL ADP75637.1
OrganismGeobacillus sp. (strain Y4.1MC1) [Complete proteome] [HAMAP] EMBL ADP75637.1
Taxonomic identifier581103 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillus

Protein attributes

Sequence length308 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00037 SAAS SAAS016167

Catalytic activity

UDP-N-acetyl-alpha-D-muramate + NADP+ = UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine + NADPH. HAMAP-Rule MF_00037 SAAS SAAS016167

Cofactor

FAD By similarity. HAMAP-Rule MF_00037 SAAS SAAS016167

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00037 SAAS SAAS016167

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00037 SAAS SAAS016167.

Sequence similarities

Belongs to the MurB family. HAMAP-Rule MF_00037

Contains 1 FAD-binding PCMH-type domain. HAMAP-Rule MF_00037

Contains FAD-binding PCMH-type domain. SAAS SAAS016167

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain35 – 199165FAD-binding PCMH-type By similarity HAMAP-Rule MF_00037

Sites

Active site1781 By similarity HAMAP-Rule MF_00037
Active site2281Proton donor By similarity HAMAP-Rule MF_00037
Active site2981 By similarity HAMAP-Rule MF_00037

Sequences

Sequence LengthMass (Da)Tools
E3IC15 [UniParc].

Last modified January 11, 2011. Version 1.
Checksum: A5B5F3538EACE429

FASTA30834,070
        10         20         30         40         50         60 
MMYENNVIYQ ELVRICGEKN VLRDEPLKYH TLVKIGGKAD FLVWPETYEQ VVEVIRLKEK 

        70         80         90        100        110        120 
HHLPFTLLGN GSNVIVRDGG IRGIVVQLKH LTEIKVEGEK IIAQSGADIK AVSRVALEHS 

       130        140        150        160        170        180 
LTGLEFACGI PGSVGGAIMM NAGAYDGEIK DVIDHVKVVT QTGEQKILRK DDLQLGYRTS 

       190        200        210        220        230        240 
IISKTNDIVL EAVFQLKKGD PQKIKEKMDD LTFRRESKQP LEYPSVGSVF KRPPGYFAGK 

       250        260        270        280        290        300 
LIQDSGLQGK GVGGAEVSTK HAGFIINKNN ATASDYIATI ELVRKTVKEK FGVDLELEVK 


IIGEDIKQ 

« Hide

References

[1]"Complete sequence of chromosome of Geobacillus sp. Y4.1MC1."
US DOE Joint Genome Institute
Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L., Pitluck S., Chertkov O., Zhang X., Detter J.C., Han C., Tapia R., Land M., Hauser L., Jeffries C., Kyrpides N., Ivanova N., Ovchinnikova G. expand/collapse author list , Brumm P., Mead D., Woyke T.
Submitted (OCT-2010) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Y4.1MC1 EMBL ADP75637.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP002293 Genomic DNA. Translation: ADP75637.1.
RefSeqYP_003990248.1. NC_014650.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADP75637; ADP75637; GY4MC1_2947.
GeneID9929829.
KEGGgmc:GY4MC1_2947.
PATRIC42636224. VBIGeoSp111282_3234.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000284355.
KOK00075.
OMADIDLHTE.

Enzyme and pathway databases

BioCycGSP581103:GHT2-3024-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.43.10. 1 hit.
3.30.465.10. 1 hit.
3.90.78.10. 1 hit.
HAMAPMF_00037. MurB.
InterProIPR016169. CO_DH_flavot_FAD-bd_sub2.
IPR016166. FAD-bd_2.
IPR016167. FAD-bd_2_sub1.
IPR003170. MurB.
IPR011601. MurB_C.
IPR006094. Oxid_FAD_bind_N.
[Graphical view]
PANTHERPTHR21071. PTHR21071. 1 hit.
PfamPF01565. FAD_binding_4. 1 hit.
PF02873. MurB_C. 1 hit.
[Graphical view]
SUPFAMSSF56176. SSF56176. 1 hit.
SSF56194. SSF56194. 1 hit.
TIGRFAMsTIGR00179. murB. 1 hit.
PROSITEPS51387. FAD_PCMH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameE3IC15_GEOS0
AccessionPrimary (citable) accession number: E3IC15
Entry history
Integrated into UniProtKB/TrEMBL: January 11, 2011
Last sequence update: January 11, 2011
Last modified: February 19, 2014
This is version 24 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)