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E3I8H6

- E3I8H6_RHOVT

UniProt

E3I8H6 - E3I8H6_RHOVT

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Protein
Glutathione synthetase
Gene
gshB, Rvan_1634
Organism
Rhodomicrobium vannielii (strain ATCC 17100 / ATH 3.1.1 / DSM 162 / LMG 4299)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione.UniRule annotation

Cofactori

Binds 1 magnesium or manganese ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi280 – 2801Magnesium or manganese By similarityUniRule annotation
Metal bindingi282 – 2821Magnesium or manganese By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi151 – 20757ATP By similarityUniRule annotation
Add
BLAST

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. glutathione synthase activity Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP
  4. manganese ion binding Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    LigaseUniRule annotationImported

    Keywords - Biological processi

    Glutathione biosynthesisUniRule annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotation, MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciRVAN648757:GHZT-1660-MONOMER.
    UniPathwayiUPA00142; UER00210.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutathione synthetaseUniRule annotation (EC:6.3.2.3UniRule annotation)
    Alternative name(s):
    GSH synthetase
    Glutathione synthase
    Gene namesi
    Name:gshBUniRule annotation
    Ordered Locus Names:Rvan_1634Imported
    OrganismiRhodomicrobium vannielii (strain ATCC 17100 / ATH 3.1.1 / DSM 162 / LMG 4299)Imported
    Taxonomic identifieri648757 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesHyphomicrobiaceaeRhodomicrobium
    ProteomesiUP000001399: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: InterPro
    Complete GO annotation...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini125 – 309185ATP-grasp By similarityUniRule annotation
    Add
    BLAST

    Sequence similaritiesi

    Belongs to the prokaryotic GSH synthase family.UniRule annotation
    Contains 1 ATP-grasp domain.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000265022.
    KOiK01920.

    Family and domain databases

    Gene3Di3.30.1490.20. 1 hit.
    3.30.470.20. 1 hit.
    3.40.50.20. 1 hit.
    HAMAPiMF_00162. GSH_S.
    InterProiIPR011761. ATP-grasp.
    IPR013815. ATP_grasp_subdomain_1.
    IPR013816. ATP_grasp_subdomain_2.
    IPR006284. Glut_synth_pro.
    IPR004218. GSHS_ATP-bd.
    IPR004215. GSHS_N.
    IPR016185. PreATP-grasp_dom.
    [Graphical view]
    PfamiPF02955. GSH-S_ATP. 1 hit.
    PF02951. GSH-S_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF52440. SSF52440. 1 hit.
    TIGRFAMsiTIGR01380. glut_syn. 1 hit.
    PROSITEiPS50975. ATP_GRASP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    E3I8H6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRLKTGVQMD PIEKINIWGD STFALLLEAQ KRQHSIFYYT PDKLILRGGR    50
    AFAEGHELRV HDIEGAHFEL GARQKLALDE LDVIHLRQDP PFDMAYITTT 100
    HILDSVHPKT LVVNDPTSVR NAPEKLFVTQ FPDLMPPTLI ARTLGDVTAF 150
    REEFGDIIVK PLYGNGGAAV FRIKPDDTNT GSLVELFQTV FREPFVVQRY 200
    LPDVRAGDKR IILVDGEPVG AINRVPAANE TRSNMHVGGR PEATELTPRE 250
    REICAAIGPE LKKRGLIFVG IDVIGDYLTE INVTSPTGIR EVKRFGGADI 300
    AALVWDVVEE KVRSAKVP 318
    Length:318
    Mass (Da):35,409
    Last modified:January 11, 2011 - v1
    Checksum:iD0198D80603D3C03
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002292 Genomic DNA. Translation: ADP70885.1.
    RefSeqiWP_013419281.1. NC_014664.1.
    YP_004011984.1. NC_014664.1.

    Genome annotation databases

    EnsemblBacteriaiADP70885; ADP70885; Rvan_1634.
    GeneIDi9932424.
    KEGGirva:Rvan_1634.
    PATRICi42670475. VBIRhoVan113057_1718.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002292 Genomic DNA. Translation: ADP70885.1 .
    RefSeqi WP_013419281.1. NC_014664.1.
    YP_004011984.1. NC_014664.1.

    3D structure databases

    ModBasei Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADP70885 ; ADP70885 ; Rvan_1634 .
    GeneIDi 9932424.
    KEGGi rva:Rvan_1634.
    PATRICi 42670475. VBIRhoVan113057_1718.

    Phylogenomic databases

    HOGENOMi HOG000265022.
    KOi K01920.

    Enzyme and pathway databases

    UniPathwayi UPA00142 ; UER00210 .
    BioCyci RVAN648757:GHZT-1660-MONOMER.

    Family and domain databases

    Gene3Di 3.30.1490.20. 1 hit.
    3.30.470.20. 1 hit.
    3.40.50.20. 1 hit.
    HAMAPi MF_00162. GSH_S.
    InterProi IPR011761. ATP-grasp.
    IPR013815. ATP_grasp_subdomain_1.
    IPR013816. ATP_grasp_subdomain_2.
    IPR006284. Glut_synth_pro.
    IPR004218. GSHS_ATP-bd.
    IPR004215. GSHS_N.
    IPR016185. PreATP-grasp_dom.
    [Graphical view ]
    Pfami PF02955. GSH-S_ATP. 1 hit.
    PF02951. GSH-S_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52440. SSF52440. 1 hit.
    TIGRFAMsi TIGR01380. glut_syn. 1 hit.
    PROSITEi PS50975. ATP_GRASP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 17100 / ATH 3.1.1 / DSM 162 / LMG 4299.

    Entry informationi

    Entry nameiE3I8H6_RHOVT
    AccessioniPrimary (citable) accession number: E3I8H6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: January 11, 2011
    Last sequence update: January 11, 2011
    Last modified: September 3, 2014
    This is version 24 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    External Data

    Dasty 3

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