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E3I8H6

- E3I8H6_RHOVT

UniProt

E3I8H6 - E3I8H6_RHOVT

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Protein

Glutathione synthetase

Gene

gshB

Organism
Rhodomicrobium vannielii (strain ATCC 17100 / ATH 3.1.1 / DSM 162 / LMG 4299)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione.UniRule annotation

Cofactori

Note: Binds 1 magnesium or manganese ion per subunit.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi280 – 2801Magnesium or manganeseUniRule annotation
Metal bindingi282 – 2821Magnesium or manganeseUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi151 – 20757ATPUniRule annotationAdd
BLAST

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. glutathione synthase activity Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP
  4. manganese ion binding Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported

Keywords - Biological processi

Glutathione biosynthesisUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciRVAN648757:GHZT-1660-MONOMER.
UniPathwayiUPA00142; UER00210.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione synthetaseUniRule annotation (EC:6.3.2.3UniRule annotation)
Alternative name(s):
GSH synthetaseUniRule annotation
Glutathione synthaseUniRule annotation
Gene namesi
Name:gshBUniRule annotation
Ordered Locus Names:Rvan_1634Imported
OrganismiRhodomicrobium vannielii (strain ATCC 17100 / ATH 3.1.1 / DSM 162 / LMG 4299)Imported
Taxonomic identifieri648757 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesHyphomicrobiaceaeRhodomicrobium
ProteomesiUP000001399: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: InterPro
Complete GO annotation...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini125 – 309185ATP-graspUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the prokaryotic GSH synthase family.UniRule annotation
Contains 1 ATP-grasp domain.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000265022.
KOiK01920.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
HAMAPiMF_00162. GSH_S.
InterProiIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR006284. Glut_synth_pro.
IPR004218. GSHS_ATP-bd.
IPR004215. GSHS_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PfamiPF02955. GSH-S_ATP. 1 hit.
PF02951. GSH-S_N. 1 hit.
[Graphical view]
SUPFAMiSSF52440. SSF52440. 1 hit.
TIGRFAMsiTIGR01380. glut_syn. 1 hit.
PROSITEiPS50975. ATP_GRASP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E3I8H6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRLKTGVQMD PIEKINIWGD STFALLLEAQ KRQHSIFYYT PDKLILRGGR
60 70 80 90 100
AFAEGHELRV HDIEGAHFEL GARQKLALDE LDVIHLRQDP PFDMAYITTT
110 120 130 140 150
HILDSVHPKT LVVNDPTSVR NAPEKLFVTQ FPDLMPPTLI ARTLGDVTAF
160 170 180 190 200
REEFGDIIVK PLYGNGGAAV FRIKPDDTNT GSLVELFQTV FREPFVVQRY
210 220 230 240 250
LPDVRAGDKR IILVDGEPVG AINRVPAANE TRSNMHVGGR PEATELTPRE
260 270 280 290 300
REICAAIGPE LKKRGLIFVG IDVIGDYLTE INVTSPTGIR EVKRFGGADI
310
AALVWDVVEE KVRSAKVP
Length:318
Mass (Da):35,409
Last modified:January 11, 2011 - v1
Checksum:iD0198D80603D3C03
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002292 Genomic DNA. Translation: ADP70885.1.
RefSeqiWP_013419281.1. NC_014664.1.
YP_004011984.1. NC_014664.1.

Genome annotation databases

EnsemblBacteriaiADP70885; ADP70885; Rvan_1634.
GeneIDi9932424.
KEGGirva:Rvan_1634.
PATRICi42670475. VBIRhoVan113057_1718.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002292 Genomic DNA. Translation: ADP70885.1 .
RefSeqi WP_013419281.1. NC_014664.1.
YP_004011984.1. NC_014664.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADP70885 ; ADP70885 ; Rvan_1634 .
GeneIDi 9932424.
KEGGi rva:Rvan_1634.
PATRICi 42670475. VBIRhoVan113057_1718.

Phylogenomic databases

HOGENOMi HOG000265022.
KOi K01920.

Enzyme and pathway databases

UniPathwayi UPA00142 ; UER00210 .
BioCyci RVAN648757:GHZT-1660-MONOMER.

Family and domain databases

Gene3Di 3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
HAMAPi MF_00162. GSH_S.
InterProi IPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR006284. Glut_synth_pro.
IPR004218. GSHS_ATP-bd.
IPR004215. GSHS_N.
IPR016185. PreATP-grasp_dom.
[Graphical view ]
Pfami PF02955. GSH-S_ATP. 1 hit.
PF02951. GSH-S_N. 1 hit.
[Graphical view ]
SUPFAMi SSF52440. SSF52440. 1 hit.
TIGRFAMsi TIGR01380. glut_syn. 1 hit.
PROSITEi PS50975. ATP_GRASP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 17100 / ATH 3.1.1 / DSM 162 / LMG 4299Imported.

Entry informationi

Entry nameiE3I8H6_RHOVT
AccessioniPrimary (citable) accession number: E3I8H6
Entry historyi
Integrated into UniProtKB/TrEMBL: January 11, 2011
Last sequence update: January 11, 2011
Last modified: November 26, 2014
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3