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Protein

Alanine racemase

Gene

Rvan_0945

Organism
Rhodomicrobium vannielii (strain ATCC 17100 / ATH 3.1.1 / DSM 162 / LMG 4299)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei52 – 521Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei150 – 1501SubstrateUniRule annotation
Active sitei272 – 2721Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei325 – 3251Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciRVAN648757:GHZT-959-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:Rvan_0945Imported
OrganismiRhodomicrobium vannielii (strain ATCC 17100 / ATH 3.1.1 / DSM 162 / LMG 4299)Imported
Taxonomic identifieri648757 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesHyphomicrobiaceaeRhodomicrobium
ProteomesiUP000001399 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei52 – 521N6-(pyridoxal phosphate)lysineUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliE3I2D7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000031445.
KOiK01775.
OMAiTLMAHFA.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E3I2D7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTGFSEAVE RALAAAPASA NGVLVIRLPA LRRNYRRAAE ASLKAETAAV
60 70 80 90 100
VKANAYGLGI QPVLTALQKE TARTFFVATL DEALALRTFA NDATIYTLNG
110 120 130 140 150
LMPGTSAVYR DARLRPVLNS LAEVEEWSAY CREHEARLPA AIQFDTGMCR
160 170 180 190 200
VGLEPEAADA LAEKPELLQP FRPAVLMSHL VRADEPMHPL NEVQFKRFEA
210 220 230 240 250
VTSLFPGIAK SLVNSAGCLL RRKYHLDLAR PGIAIYGGNP QKVEPSQFEP
260 270 280 290 300
VVWLFGRIVQ VRHGEKGFTV GYGGTETLRR DSRIATVGVG YADGYFRGVS
310 320 330 340 350
SSDAKPGAVG HIGEHALPLI GRVSMDLTTF DATDVPEALV HRGGFVELLG
360 370 380
EKTTVDDLAR HAGTIGYEVL TSLGRRYHRV YVDE
Length:384
Mass (Da):41,772
Last modified:January 10, 2011 - v1
Checksum:i421D2C1868280A01
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002292 Genomic DNA. Translation: ADP70221.1.
RefSeqiWP_013418625.1. NC_014664.1.
YP_004011320.1. NC_014664.1.

Genome annotation databases

EnsemblBacteriaiADP70221; ADP70221; Rvan_0945.
KEGGirva:Rvan_0945.
PATRICi42669016. VBIRhoVan113057_1001.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002292 Genomic DNA. Translation: ADP70221.1.
RefSeqiWP_013418625.1. NC_014664.1.
YP_004011320.1. NC_014664.1.

3D structure databases

ProteinModelPortaliE3I2D7.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADP70221; ADP70221; Rvan_0945.
KEGGirva:Rvan_0945.
PATRICi42669016. VBIRhoVan113057_1001.

Phylogenomic databases

HOGENOMiHOG000031445.
KOiK01775.
OMAiTLMAHFA.

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.
BioCyciRVAN648757:GHZT-959-MONOMER.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 17100 / ATH 3.1.1 / DSM 162 / LMG 4299Imported.

Entry informationi

Entry nameiE3I2D7_RHOVT
AccessioniPrimary (citable) accession number: E3I2D7
Entry historyi
Integrated into UniProtKB/TrEMBL: January 10, 2011
Last sequence update: January 10, 2011
Last modified: March 31, 2015
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.