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E3HSW2

- E3HSW2_ACHXA

UniProt

E3HSW2 - E3HSW2_ACHXA

Protein

Kynureninase

Gene

kynU

Organism
Achromobacter xylosoxidans (strain A8)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 27 (01 Oct 2014)
      Sequence version 1 (11 Jan 2011)
      Previous versions | rss
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    Functioni

    Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.UniRule annotation

    Catalytic activityi

    L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine.UniRule annotation
    L-kynurenine + H2O = anthranilate + L-alanine.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei97 – 971Pyridoxal phosphate; via amide nitrogenUniRule annotation
    Binding sitei98 – 981Pyridoxal phosphateUniRule annotation
    Binding sitei201 – 2011Pyridoxal phosphateUniRule annotation
    Binding sitei204 – 2041Pyridoxal phosphateUniRule annotation
    Binding sitei226 – 2261Pyridoxal phosphateUniRule annotation
    Binding sitei256 – 2561Pyridoxal phosphateUniRule annotation
    Binding sitei282 – 2821Pyridoxal phosphateUniRule annotation

    GO - Molecular functioni

    1. kynureninase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' NAD biosynthetic process from tryptophan Source: UniProtKB-HAMAP
    2. anthranilate metabolic process Source: UniProtKB-HAMAP
    3. L-kynurenine catabolic process Source: UniProtKB-UniPathway
    4. quinolinate biosynthetic process Source: UniProtKB-HAMAP
    5. tryptophan catabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    HydrolaseUniRule annotationImported

    Keywords - Biological processi

    Pyridine nucleotide biosynthesisUniRule annotation

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotation

    Enzyme and pathway databases

    BioCyciAXYL762376:GJUB-5263-MONOMER.
    UniPathwayiUPA00253; UER00329.
    UPA00334; UER00455.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    KynureninaseUniRule annotation (EC:3.7.1.3UniRule annotation)
    Alternative name(s):
    L-kynurenine hydrolaseUniRule annotation
    Gene namesi
    Name:kynUUniRule annotationImported
    Ordered Locus Names:AXYL_05263Imported
    OrganismiAchromobacter xylosoxidans (strain A8)Imported
    Taxonomic identifieri762376 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeAchromobacter
    ProteomesiUP000006876: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: InterPro

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei227 – 2271N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni129 – 1324Pyridoxal phosphate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the kynureninase family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000242437.
    KOiK01556.
    OMAiVWDLAHS.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    HAMAPiMF_01970. Kynureninase.
    InterProiIPR000192. Aminotrans_V/Cys_dSase.
    IPR010111. Kynureninase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PANTHERiPTHR14084. PTHR14084. 1 hit.
    PfamiPF00266. Aminotran_5. 1 hit.
    [Graphical view]
    PIRSFiPIRSF038800. KYNU. 1 hit.
    SUPFAMiSSF53383. SSF53383. 1 hit.
    TIGRFAMsiTIGR01814. kynureninase. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    E3HSW2-1 [UniParc]FASTAAdd to Basket

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    MNTRDACVNA DRQDPLAPLK DRFDLPPGVL YMDGNSLGVL PKDAAARAAA    50
    VIGQEWGTGL IRSWNTAGWF ELPARLGDKL GRLLGAREGE LVVTDTTSLN 100
    IFKALAAALR IQQHQHPQRR VILSERDNFP TDLYMIQGMI DLLQQGYEMR 150
    LIDDELPLEK ALDESVAVML LSHVNYRSGQ MHDMAAVTAL AHERGALAIW 200
    DLAHAAGAVP VDLNGANADF AVGCTYKYLN GGPGSPAFIW VAPRHTKDFW 250
    QPLSGWWGHT RPFDMAVAYE PAGGVRRYLC GTQPIVSLSL VECGLDVAHA 300
    ADMAEVRKKS LALGDLFIAL VEERCAEHPL TLVTPRKHAD RGSHVSFRHP 350
    NGFEVMQALI ARGVIGDYRE PEVLRFGLTP LYFGYADVWD AVDILKDVLD 400
    TRSWDKPEFK HRAAVT 416
    Length:416
    Mass (Da):45,951
    Last modified:January 11, 2011 - v1
    Checksum:iAE2B2EED914FF224
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002287 Genomic DNA. Translation: ADP18563.1.
    RefSeqiYP_003981278.1. NC_014640.1.

    Genome annotation databases

    EnsemblBacteriaiADP18563; ADP18563; AXYL_05263.
    GeneIDi9899595.
    KEGGiaxy:AXYL_05263.
    PATRICi42563608. VBIAchXyl160325_5263.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002287 Genomic DNA. Translation: ADP18563.1 .
    RefSeqi YP_003981278.1. NC_014640.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADP18563 ; ADP18563 ; AXYL_05263 .
    GeneIDi 9899595.
    KEGGi axy:AXYL_05263.
    PATRICi 42563608. VBIAchXyl160325_5263.

    Phylogenomic databases

    HOGENOMi HOG000242437.
    KOi K01556.
    OMAi VWDLAHS.

    Enzyme and pathway databases

    UniPathwayi UPA00253 ; UER00329 .
    UPA00334 ; UER00455 .
    BioCyci AXYL762376:GJUB-5263-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    HAMAPi MF_01970. Kynureninase.
    InterProi IPR000192. Aminotrans_V/Cys_dSase.
    IPR010111. Kynureninase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    PANTHERi PTHR14084. PTHR14084. 1 hit.
    Pfami PF00266. Aminotran_5. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF038800. KYNU. 1 hit.
    SUPFAMi SSF53383. SSF53383. 1 hit.
    TIGRFAMsi TIGR01814. kynureninase. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of the haloaromatic acids-degrading bacterium Achromobacter xylosoxidans A8."
      Strnad H., Ridl J., Paces J., Kolar M., Vlcek C., Paces V.
      J. Bacteriol. 193:791-792(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: A8Imported.

    Entry informationi

    Entry nameiE3HSW2_ACHXA
    AccessioniPrimary (citable) accession number: E3HSW2
    Entry historyi
    Integrated into UniProtKB/TrEMBL: January 11, 2011
    Last sequence update: January 11, 2011
    Last modified: October 1, 2014
    This is version 27 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3