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E3HSW2

- E3HSW2_ACHXA

UniProt

E3HSW2 - E3HSW2_ACHXA

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Protein

Kynureninase

Gene
kynU, AXYL_05263
Organism
Achromobacter xylosoxidans (strain A8)
Status
Unreviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively By similarity.UniRule annotation

Catalytic activityi

L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine.UniRule annotation
L-kynurenine + H2O = anthranilate + L-alanine.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei97 – 971Pyridoxal phosphate; via amide nitrogen By similarityUniRule annotation
Binding sitei98 – 981Pyridoxal phosphate By similarityUniRule annotation
Binding sitei201 – 2011Pyridoxal phosphate By similarityUniRule annotation
Binding sitei204 – 2041Pyridoxal phosphate By similarityUniRule annotation
Binding sitei226 – 2261Pyridoxal phosphate By similarityUniRule annotation
Binding sitei256 – 2561Pyridoxal phosphate By similarityUniRule annotation
Binding sitei282 – 2821Pyridoxal phosphate By similarityUniRule annotation

GO - Molecular functioni

  1. kynureninase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' NAD biosynthetic process from tryptophan Source: UniProtKB-HAMAP
  2. anthranilate metabolic process Source: UniProtKB-HAMAP
  3. L-kynurenine catabolic process Source: UniProtKB-UniPathway
  4. quinolinate biosynthetic process Source: UniProtKB-HAMAP
  5. tryptophan catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotationImported

Keywords - Biological processi

Pyridine nucleotide biosynthesisUniRule annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotation

Enzyme and pathway databases

BioCyciAXYL762376:GJUB-5263-MONOMER.
UniPathwayiUPA00253; UER00329.
UPA00334; UER00455.

Names & Taxonomyi

Protein namesi
Recommended name:
KynureninaseUniRule annotation (EC:3.7.1.3UniRule annotation)
Alternative name(s):
L-kynurenine hydrolase
Gene namesi
Name:kynUUniRule annotationImported
Ordered Locus Names:AXYL_05263Imported
OrganismiAchromobacter xylosoxidans (strain A8)Imported
Taxonomic identifieri762376 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeAchromobacter
ProteomesiUP000006876: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: InterPro
Complete GO annotation...

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei227 – 2271N6-(pyridoxal phosphate)lysine By similarityUniRule annotation

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni129 – 1324Pyridoxal phosphate binding By similarityUniRule annotation

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000242437.
KOiK01556.
OMAiVWDLAHS.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_01970. Kynureninase.
InterProiIPR000192. Aminotrans_V/Cys_dSase.
IPR010111. Kynureninase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR14084. PTHR14084. 1 hit.
PfamiPF00266. Aminotran_5. 1 hit.
[Graphical view]
PIRSFiPIRSF038800. KYNU. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01814. kynureninase. 1 hit.

Sequencei

Sequence statusi: Complete.

E3HSW2-1 [UniParc]FASTAAdd to Basket

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MNTRDACVNA DRQDPLAPLK DRFDLPPGVL YMDGNSLGVL PKDAAARAAA    50
VIGQEWGTGL IRSWNTAGWF ELPARLGDKL GRLLGAREGE LVVTDTTSLN 100
IFKALAAALR IQQHQHPQRR VILSERDNFP TDLYMIQGMI DLLQQGYEMR 150
LIDDELPLEK ALDESVAVML LSHVNYRSGQ MHDMAAVTAL AHERGALAIW 200
DLAHAAGAVP VDLNGANADF AVGCTYKYLN GGPGSPAFIW VAPRHTKDFW 250
QPLSGWWGHT RPFDMAVAYE PAGGVRRYLC GTQPIVSLSL VECGLDVAHA 300
ADMAEVRKKS LALGDLFIAL VEERCAEHPL TLVTPRKHAD RGSHVSFRHP 350
NGFEVMQALI ARGVIGDYRE PEVLRFGLTP LYFGYADVWD AVDILKDVLD 400
TRSWDKPEFK HRAAVT 416
Length:416
Mass (Da):45,951
Last modified:January 11, 2011 - v1
Checksum:iAE2B2EED914FF224
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002287 Genomic DNA. Translation: ADP18563.1.
RefSeqiYP_003981278.1. NC_014640.1.

Genome annotation databases

EnsemblBacteriaiADP18563; ADP18563; AXYL_05263.
GeneIDi9899595.
KEGGiaxy:AXYL_05263.
PATRICi42563608. VBIAchXyl160325_5263.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002287 Genomic DNA. Translation: ADP18563.1 .
RefSeqi YP_003981278.1. NC_014640.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADP18563 ; ADP18563 ; AXYL_05263 .
GeneIDi 9899595.
KEGGi axy:AXYL_05263.
PATRICi 42563608. VBIAchXyl160325_5263.

Phylogenomic databases

HOGENOMi HOG000242437.
KOi K01556.
OMAi VWDLAHS.

Enzyme and pathway databases

UniPathwayi UPA00253 ; UER00329 .
UPA00334 ; UER00455 .
BioCyci AXYL762376:GJUB-5263-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPi MF_01970. Kynureninase.
InterProi IPR000192. Aminotrans_V/Cys_dSase.
IPR010111. Kynureninase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
PANTHERi PTHR14084. PTHR14084. 1 hit.
Pfami PF00266. Aminotran_5. 1 hit.
[Graphical view ]
PIRSFi PIRSF038800. KYNU. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR01814. kynureninase. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of the haloaromatic acid-degrading bacterium Achromobacter xylosoxidans A8."
    Strnad H., Ridl J., Paces J., Kolar M., Vlcek C., Paces V.
    J. Bacteriol. 193:791-792(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: A8Imported.

Entry informationi

Entry nameiE3HSW2_ACHXA
AccessioniPrimary (citable) accession number: E3HSW2
Entry historyi
Integrated into UniProtKB/TrEMBL: January 11, 2011
Last sequence update: January 11, 2011
Last modified: July 9, 2014
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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