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E3HSW2

- E3HSW2_ACHXA

UniProt

E3HSW2 - E3HSW2_ACHXA

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Protein

Kynureninase

Gene

kynU

Organism
Achromobacter xylosoxidans (strain A8)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.UniRule annotation

Catalytic activityi

L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine.UniRule annotation
L-kynurenine + H2O = anthranilate + L-alanine.UniRule annotation

Cofactori

Pyridoxal phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei97 – 971Pyridoxal phosphate; via amide nitrogenUniRule annotation
Binding sitei98 – 981Pyridoxal phosphateUniRule annotation
Binding sitei201 – 2011Pyridoxal phosphateUniRule annotation
Binding sitei204 – 2041Pyridoxal phosphateUniRule annotation
Binding sitei226 – 2261Pyridoxal phosphateUniRule annotation
Binding sitei256 – 2561Pyridoxal phosphateUniRule annotation
Binding sitei282 – 2821Pyridoxal phosphateUniRule annotation

GO - Molecular functioni

  1. kynureninase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' NAD biosynthetic process from tryptophan Source: UniProtKB-HAMAP
  2. anthranilate metabolic process Source: UniProtKB-HAMAP
  3. L-kynurenine catabolic process Source: UniProtKB-UniPathway
  4. quinolinate biosynthetic process Source: UniProtKB-HAMAP
  5. tryptophan catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotation

Keywords - Biological processi

Pyridine nucleotide biosynthesisUniRule annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotation

Enzyme and pathway databases

BioCyciAXYL762376:GJUB-5263-MONOMER.
UniPathwayiUPA00253; UER00329.
UPA00334; UER00455.

Names & Taxonomyi

Protein namesi
Recommended name:
KynureninaseUniRule annotation (EC:3.7.1.3UniRule annotation)
Alternative name(s):
L-kynurenine hydrolaseUniRule annotation
Gene namesi
Name:kynUUniRule annotationImported
Ordered Locus Names:AXYL_05263Imported
OrganismiAchromobacter xylosoxidans (strain A8)Imported
Taxonomic identifieri762376 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeAchromobacter
ProteomesiUP000006876: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: InterPro
Complete GO annotation...

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei227 – 2271N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni129 – 1324Pyridoxal phosphate bindingUniRule annotation

Sequence similaritiesi

Belongs to the kynureninase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000242437.
KOiK01556.
OMAiVWDLAHS.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_01970. Kynureninase.
InterProiIPR000192. Aminotrans_V_dom.
IPR010111. Kynureninase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR14084. PTHR14084. 1 hit.
PfamiPF00266. Aminotran_5. 1 hit.
[Graphical view]
PIRSFiPIRSF038800. KYNU. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01814. kynureninase. 1 hit.

Sequencei

Sequence statusi: Complete.

E3HSW2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNTRDACVNA DRQDPLAPLK DRFDLPPGVL YMDGNSLGVL PKDAAARAAA
60 70 80 90 100
VIGQEWGTGL IRSWNTAGWF ELPARLGDKL GRLLGAREGE LVVTDTTSLN
110 120 130 140 150
IFKALAAALR IQQHQHPQRR VILSERDNFP TDLYMIQGMI DLLQQGYEMR
160 170 180 190 200
LIDDELPLEK ALDESVAVML LSHVNYRSGQ MHDMAAVTAL AHERGALAIW
210 220 230 240 250
DLAHAAGAVP VDLNGANADF AVGCTYKYLN GGPGSPAFIW VAPRHTKDFW
260 270 280 290 300
QPLSGWWGHT RPFDMAVAYE PAGGVRRYLC GTQPIVSLSL VECGLDVAHA
310 320 330 340 350
ADMAEVRKKS LALGDLFIAL VEERCAEHPL TLVTPRKHAD RGSHVSFRHP
360 370 380 390 400
NGFEVMQALI ARGVIGDYRE PEVLRFGLTP LYFGYADVWD AVDILKDVLD
410
TRSWDKPEFK HRAAVT
Length:416
Mass (Da):45,951
Last modified:January 11, 2011 - v1
Checksum:iAE2B2EED914FF224
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002287 Genomic DNA. Translation: ADP18563.1.
RefSeqiYP_003981278.1. NC_014640.1.

Genome annotation databases

EnsemblBacteriaiADP18563; ADP18563; AXYL_05263.
GeneIDi9899595.
KEGGiaxy:AXYL_05263.
PATRICi42563608. VBIAchXyl160325_5263.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002287 Genomic DNA. Translation: ADP18563.1 .
RefSeqi YP_003981278.1. NC_014640.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADP18563 ; ADP18563 ; AXYL_05263 .
GeneIDi 9899595.
KEGGi axy:AXYL_05263.
PATRICi 42563608. VBIAchXyl160325_5263.

Phylogenomic databases

HOGENOMi HOG000242437.
KOi K01556.
OMAi VWDLAHS.

Enzyme and pathway databases

UniPathwayi UPA00253 ; UER00329 .
UPA00334 ; UER00455 .
BioCyci AXYL762376:GJUB-5263-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPi MF_01970. Kynureninase.
InterProi IPR000192. Aminotrans_V_dom.
IPR010111. Kynureninase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
PANTHERi PTHR14084. PTHR14084. 1 hit.
Pfami PF00266. Aminotran_5. 1 hit.
[Graphical view ]
PIRSFi PIRSF038800. KYNU. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR01814. kynureninase. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of the haloaromatic acids-degrading bacterium Achromobacter xylosoxidans A8."
    Strnad H., Ridl J., Paces J., Kolar M., Vlcek C., Paces V.
    J. Bacteriol. 193:791-792(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: A8Imported.

Entry informationi

Entry nameiE3HSW2_ACHXA
AccessioniPrimary (citable) accession number: E3HSW2
Entry historyi
Integrated into UniProtKB/TrEMBL: January 11, 2011
Last sequence update: January 11, 2011
Last modified: October 29, 2014
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3