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Protein

Threonine--tRNA ligase

Gene

thrS

Organism
Achromobacter xylosoxidans (strain A8)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr).UniRule annotationSAAS annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi338 – 3381Zinc; catalyticUniRule annotation
Metal bindingi389 – 3891Zinc; catalyticUniRule annotation
Metal bindingi515 – 5151Zinc; catalyticUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetaseUniRule annotationSAAS annotation, Ligase

Keywords - Biological processi

Protein biosynthesisUniRule annotationSAAS annotation

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding, ZincUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciAXYL762376:GJUB-2262-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Threonine--tRNA ligaseUniRule annotationSAAS annotation (EC:6.1.1.3UniRule annotationSAAS annotation)
Alternative name(s):
Threonyl-tRNA synthetaseUniRule annotation
Gene namesi
Name:thrSUniRule annotationImported
Ordered Locus Names:AXYL_02262Imported
OrganismiAchromobacter xylosoxidans (strain A8)Imported
Taxonomic identifieri762376 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeAchromobacter
ProteomesiUP000006876 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi762376.AXYL_02262.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni247 – 538292CatalyticUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the class-II aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000003880.
KOiK01868.
OMAiKSGHWDK.

Family and domain databases

Gene3Di3.10.20.30. 1 hit.
3.40.50.800. 1 hit.
HAMAPiMF_00184. Thr_tRNA_synth.
InterProiIPR002314. aa-tRNA-synt_IIb_cons-dom.
IPR006195. aa-tRNA-synth_II.
IPR004154. Anticodon-bd.
IPR012675. Beta-grasp_dom.
IPR004095. TGS.
IPR012676. TGS-like.
IPR002320. Thr-tRNA-ligase_IIa.
IPR018163. Thr/Ala-tRNA-synth_IIc_edit.
IPR012947. tRNA_SAD.
[Graphical view]
PfamiPF03129. HGTP_anticodon. 1 hit.
PF02824. TGS. 1 hit.
PF00587. tRNA-synt_2b. 1 hit.
PF07973. tRNA_SAD. 1 hit.
[Graphical view]
PRINTSiPR01047. TRNASYNTHTHR.
SMARTiSM00863. tRNA_SAD. 1 hit.
[Graphical view]
SUPFAMiSSF52954. SSF52954. 1 hit.
SSF55186. SSF55186. 1 hit.
SSF81271. SSF81271. 1 hit.
TIGRFAMsiTIGR00418. thrS. 1 hit.
PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E3HJW2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVQITLPDGS QRQYPGPVTV AEVAQSIGTG LAKAALGGRV TFEGSDSKLV
60 70 80 90 100
DTSFRIEGDA RLAIVTAKDA DGLDLIRHST AHLLAYAVKE LFPDAQVTIG
110 120 130 140 150
PVIDNGFYYD FSYKRPFTPE DLAAIEKKMA ELAKKDEVVT REEWSRDDAV
160 170 180 190 200
EFFKGIGEKY KAEIIASIPS NEPLSLYREG DFIDLCRGPH VPSTGKLKVF
210 220 230 240 250
KLMKVAGAYW RGDSKNEMLQ RIYGTAWATK EEQEAYLHML EEAERRDHRK
260 270 280 290 300
IGRELELFHF QDEAPGLIFW HPKGWALWQQ VEQYMRSVYR DNGYQEVKAP
310 320 330 340 350
QILDISLWKK TGHWDNYREN MFTTESENRV YGLKPMNCPG HVQIFNAGLH
360 370 380 390 400
SYRELPLRYG EFGQCHRNEP SGSLHGMMRV RGFTQDDGHI FCTEEQLQDE
410 420 430 440 450
CADFTALLQK VYRDFGFTEV LYKVATRPEK RIGSDEVWDT AEAALMESLR
460 470 480 490 500
RTGCEFEVSP GEGAFYGPKV EYTLKDAIGR HWQCGTIQVD FSMPVRLGAE
510 520 530 540 550
YVDQNDQRRP PVMLHRAILG SLERFIGMLI ENHAGAMPPW LAPVQAVVCC
560 570 580 590 600
ISEPSADYAA EITQSLKKQG FRVESDLRGE KITRKIREHS LQKVPYILVV
610 620 630 640 650
GDKEKQNGTV AVRGLGGLDL GAIAYDEFVA RLSEDVSTRR DVNQPGSSAA
Length:650
Mass (Da):73,415
Last modified:January 11, 2011 - v1
Checksum:i7AB89A90CE298D7E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002287 Genomic DNA. Translation: ADP15584.1.
RefSeqiWP_013392910.1. NC_014640.1.
YP_003978299.1. NC_014640.1.

Genome annotation databases

EnsemblBacteriaiADP15584; ADP15584; AXYL_02262.
GeneIDi9896594.
KEGGiaxy:AXYL_02262.
PATRICi42557550. VBIAchXyl160325_2255.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002287 Genomic DNA. Translation: ADP15584.1.
RefSeqiWP_013392910.1. NC_014640.1.
YP_003978299.1. NC_014640.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi762376.AXYL_02262.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADP15584; ADP15584; AXYL_02262.
GeneIDi9896594.
KEGGiaxy:AXYL_02262.
PATRICi42557550. VBIAchXyl160325_2255.

Phylogenomic databases

HOGENOMiHOG000003880.
KOiK01868.
OMAiKSGHWDK.

Enzyme and pathway databases

BioCyciAXYL762376:GJUB-2262-MONOMER.

Family and domain databases

Gene3Di3.10.20.30. 1 hit.
3.40.50.800. 1 hit.
HAMAPiMF_00184. Thr_tRNA_synth.
InterProiIPR002314. aa-tRNA-synt_IIb_cons-dom.
IPR006195. aa-tRNA-synth_II.
IPR004154. Anticodon-bd.
IPR012675. Beta-grasp_dom.
IPR004095. TGS.
IPR012676. TGS-like.
IPR002320. Thr-tRNA-ligase_IIa.
IPR018163. Thr/Ala-tRNA-synth_IIc_edit.
IPR012947. tRNA_SAD.
[Graphical view]
PfamiPF03129. HGTP_anticodon. 1 hit.
PF02824. TGS. 1 hit.
PF00587. tRNA-synt_2b. 1 hit.
PF07973. tRNA_SAD. 1 hit.
[Graphical view]
PRINTSiPR01047. TRNASYNTHTHR.
SMARTiSM00863. tRNA_SAD. 1 hit.
[Graphical view]
SUPFAMiSSF52954. SSF52954. 1 hit.
SSF55186. SSF55186. 1 hit.
SSF81271. SSF81271. 1 hit.
TIGRFAMsiTIGR00418. thrS. 1 hit.
PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete genome sequence of the haloaromatic acids-degrading bacterium Achromobacter xylosoxidans A8."
    Strnad H., Ridl J., Paces J., Kolar M., Vlcek C., Paces V.
    J. Bacteriol. 193:791-792(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: A8Imported.

Entry informationi

Entry nameiE3HJW2_ACHXA
AccessioniPrimary (citable) accession number: E3HJW2
Entry historyi
Integrated into UniProtKB/TrEMBL: January 11, 2011
Last sequence update: January 11, 2011
Last modified: June 24, 2015
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.