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E3HJW2

- E3HJW2_ACHXA

UniProt

E3HJW2 - E3HJW2_ACHXA

Protein

Threonine--tRNA ligase

Gene

thrS

Organism
Achromobacter xylosoxidans (strain A8)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 30 (01 Oct 2014)
      Sequence version 1 (11 Jan 2011)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr).UniRule annotationSAAS annotation

    Cofactori

    Binds 1 zinc ion per subunit.UniRule annotationSAAS annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi338 – 3381Zinc; catalyticUniRule annotation
    Metal bindingi389 – 3891Zinc; catalyticUniRule annotation
    Metal bindingi515 – 5151Zinc; catalyticUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. metal ion binding Source: UniProtKB-KW
    3. threonine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. threonyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetaseUniRule annotationSAAS annotationImported, Ligase

    Keywords - Biological processi

    Protein biosynthesisUniRule annotationSAAS annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding, ZincUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciAXYL762376:GJUB-2262-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Threonine--tRNA ligaseUniRule annotation (EC:6.1.1.3UniRule annotation)
    Alternative name(s):
    Threonyl-tRNA synthetaseUniRule annotation
    Gene namesi
    Name:thrSUniRule annotationImported
    Ordered Locus Names:AXYL_02262Imported
    OrganismiAchromobacter xylosoxidans (strain A8)Imported
    Taxonomic identifieri762376 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeAchromobacter
    ProteomesiUP000006876: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotationSAAS annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotationSAAS annotation

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni247 – 538292CatalyticUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the class-II aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000003880.
    KOiK01868.
    OMAiHFKLQKI.

    Family and domain databases

    Gene3Di3.10.20.30. 1 hit.
    3.40.50.800. 1 hit.
    HAMAPiMF_00184. Thr_tRNA_synth.
    InterProiIPR002314. aa-tRNA-synt_IIb_cons-dom.
    IPR006195. aa-tRNA-synth_II.
    IPR004154. Anticodon-bd.
    IPR012675. Beta-grasp_dom.
    IPR004095. TGS.
    IPR012676. TGS-like.
    IPR002320. Thr-tRNA-ligase_IIa.
    IPR018163. Thr/Ala-tRNA-synth_IIc_edit.
    IPR012947. tRNA_SAD.
    [Graphical view]
    PfamiPF03129. HGTP_anticodon. 1 hit.
    PF02824. TGS. 1 hit.
    PF00587. tRNA-synt_2b. 1 hit.
    PF07973. tRNA_SAD. 1 hit.
    [Graphical view]
    PRINTSiPR01047. TRNASYNTHTHR.
    SMARTiSM00863. tRNA_SAD. 1 hit.
    [Graphical view]
    SUPFAMiSSF52954. SSF52954. 1 hit.
    SSF55186. SSF55186. 1 hit.
    SSF81271. SSF81271. 1 hit.
    TIGRFAMsiTIGR00418. thrS. 1 hit.
    PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    E3HJW2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVQITLPDGS QRQYPGPVTV AEVAQSIGTG LAKAALGGRV TFEGSDSKLV    50
    DTSFRIEGDA RLAIVTAKDA DGLDLIRHST AHLLAYAVKE LFPDAQVTIG 100
    PVIDNGFYYD FSYKRPFTPE DLAAIEKKMA ELAKKDEVVT REEWSRDDAV 150
    EFFKGIGEKY KAEIIASIPS NEPLSLYREG DFIDLCRGPH VPSTGKLKVF 200
    KLMKVAGAYW RGDSKNEMLQ RIYGTAWATK EEQEAYLHML EEAERRDHRK 250
    IGRELELFHF QDEAPGLIFW HPKGWALWQQ VEQYMRSVYR DNGYQEVKAP 300
    QILDISLWKK TGHWDNYREN MFTTESENRV YGLKPMNCPG HVQIFNAGLH 350
    SYRELPLRYG EFGQCHRNEP SGSLHGMMRV RGFTQDDGHI FCTEEQLQDE 400
    CADFTALLQK VYRDFGFTEV LYKVATRPEK RIGSDEVWDT AEAALMESLR 450
    RTGCEFEVSP GEGAFYGPKV EYTLKDAIGR HWQCGTIQVD FSMPVRLGAE 500
    YVDQNDQRRP PVMLHRAILG SLERFIGMLI ENHAGAMPPW LAPVQAVVCC 550
    ISEPSADYAA EITQSLKKQG FRVESDLRGE KITRKIREHS LQKVPYILVV 600
    GDKEKQNGTV AVRGLGGLDL GAIAYDEFVA RLSEDVSTRR DVNQPGSSAA 650
    Length:650
    Mass (Da):73,415
    Last modified:January 11, 2011 - v1
    Checksum:i7AB89A90CE298D7E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002287 Genomic DNA. Translation: ADP15584.1.
    RefSeqiWP_013392910.1. NC_014640.1.
    YP_003978299.1. NC_014640.1.

    Genome annotation databases

    EnsemblBacteriaiADP15584; ADP15584; AXYL_02262.
    GeneIDi9896594.
    KEGGiaxy:AXYL_02262.
    PATRICi42557550. VBIAchXyl160325_2255.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002287 Genomic DNA. Translation: ADP15584.1 .
    RefSeqi WP_013392910.1. NC_014640.1.
    YP_003978299.1. NC_014640.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADP15584 ; ADP15584 ; AXYL_02262 .
    GeneIDi 9896594.
    KEGGi axy:AXYL_02262.
    PATRICi 42557550. VBIAchXyl160325_2255.

    Phylogenomic databases

    HOGENOMi HOG000003880.
    KOi K01868.
    OMAi HFKLQKI.

    Enzyme and pathway databases

    BioCyci AXYL762376:GJUB-2262-MONOMER.

    Family and domain databases

    Gene3Di 3.10.20.30. 1 hit.
    3.40.50.800. 1 hit.
    HAMAPi MF_00184. Thr_tRNA_synth.
    InterProi IPR002314. aa-tRNA-synt_IIb_cons-dom.
    IPR006195. aa-tRNA-synth_II.
    IPR004154. Anticodon-bd.
    IPR012675. Beta-grasp_dom.
    IPR004095. TGS.
    IPR012676. TGS-like.
    IPR002320. Thr-tRNA-ligase_IIa.
    IPR018163. Thr/Ala-tRNA-synth_IIc_edit.
    IPR012947. tRNA_SAD.
    [Graphical view ]
    Pfami PF03129. HGTP_anticodon. 1 hit.
    PF02824. TGS. 1 hit.
    PF00587. tRNA-synt_2b. 1 hit.
    PF07973. tRNA_SAD. 1 hit.
    [Graphical view ]
    PRINTSi PR01047. TRNASYNTHTHR.
    SMARTi SM00863. tRNA_SAD. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52954. SSF52954. 1 hit.
    SSF55186. SSF55186. 1 hit.
    SSF81271. SSF81271. 1 hit.
    TIGRFAMsi TIGR00418. thrS. 1 hit.
    PROSITEi PS50862. AA_TRNA_LIGASE_II. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of the haloaromatic acids-degrading bacterium Achromobacter xylosoxidans A8."
      Strnad H., Ridl J., Paces J., Kolar M., Vlcek C., Paces V.
      J. Bacteriol. 193:791-792(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: A8Imported.

    Entry informationi

    Entry nameiE3HJW2_ACHXA
    AccessioniPrimary (citable) accession number: E3HJW2
    Entry historyi
    Integrated into UniProtKB/TrEMBL: January 11, 2011
    Last sequence update: January 11, 2011
    Last modified: October 1, 2014
    This is version 30 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3