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E3H9U4 (E3H9U4_ILYPC) Unreviewed, UniProtKB/TrEMBL

Last modified February 19, 2014. Version 26. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase HAMAP-Rule MF_00047

EC=6.3.2.4 HAMAP-Rule MF_00047
Alternative name(s):
D-Ala-D-Ala ligase HAMAP-Rule MF_00047
D-alanylalanine synthetase HAMAP-Rule MF_00047
Gene names
Name:ddl HAMAP-Rule MF_00047
Ordered Locus Names:Ilyop_1852 EMBL ADO83623.1
OrganismIlyobacter polytropus (strain DSM 2926 / CuHBu1) [Complete proteome] [HAMAP] EMBL ADO83623.1
Taxonomic identifier572544 [NCBI]
Taxonomic lineageBacteriaFusobacteriaFusobacterialesFusobacteriaceaeIlyobacter

Protein attributes

Sequence length284 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047 SAAS SAAS005905

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047 SAAS SAAS005905

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. HAMAP-Rule MF_00047 SAAS SAAS005905

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047 SAAS SAAS005905

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047 SAAS SAAS005905.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00047

Contains ATP-grasp domain. SAAS SAAS005905

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain79 – 284206ATP-grasp By similarity HAMAP-Rule MF_00047
Nucleotide binding118 – 17154ATP By similarity HAMAP-Rule MF_00047

Sites

Metal binding2391Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding2511Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding2511Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047
Metal binding2531Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
E3H9U4 [UniParc].

Last modified January 11, 2011. Version 1.
Checksum: 07658898C40BE169

FASTA28431,372
        10         20         30         40         50         60 
MKIAVFMGGV SSEREISLRT GKAILESLIR QGYDAYGVDL KEDNLLTAFT ENEYDLAYLA 

        70         80         90        100        110        120 
LHGEFGEDGR IQAVLDIIKK PYTGSGVTPS AIAMDKNMTK IIAEKAGIRI PKSYRDKSEI 

       130        140        150        160        170        180 
ISFPVVVKPT TEGSSVGLYI CNSIEEVEKA EKNLMGKSLL IEEFVSGEEL TVGVLNGEPL 

       190        200        210        220        230        240 
GVLKISPKSG LYDFQSKYTV GMTEYEYPAK VSPKVYEEAM IFSKKIHQEL GLSGVSRSDF 

       250        260        270        280 
ILKDDKIYFL EVNTCPGMTE TSLVPKLATL KGYTFDDLVK KIIQ 

« Hide

References

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP002281 Genomic DNA. Translation: ADO83623.1.
RefSeqYP_003967971.1. NC_014632.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADO83623; ADO83623; Ilyop_1852.
GeneID9869375.
KEGGipo:Ilyop_1852.
PATRIC42647487. VBIIlyPol34265_1913.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000011592.
KOK01921.
OMATPDWVAL.

Enzyme and pathway databases

BioCycIPOL572544:GJ9I-1893-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 2 hits.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameE3H9U4_ILYPC
AccessionPrimary (citable) accession number: E3H9U4
Entry history
Integrated into UniProtKB/TrEMBL: January 11, 2011
Last sequence update: January 11, 2011
Last modified: February 19, 2014
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)