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E3H8R7

- E3H8R7_ILYPC

UniProt

E3H8R7 - E3H8R7_ILYPC

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Protein
Submitted name:

Dethiobiotin synthase

Gene
Ilyop_1552
Organism
Ilyobacter polytropus (strain DSM 2926 / CuHBu1)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring By similarity.SAAS annotations

Catalytic activityi

ATP + 7,8-diaminononanoate + CO2 = ADP + phosphate + dethiobiotin.SAAS annotations

Cofactori

Magnesium By similarity.SAAS annotations

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. dethiobiotin synthase activity Source: UniProtKB-EC
  3. magnesium ion binding Source: InterPro
  4. thymidine kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. biotin biosynthetic process Source: UniProtKB-UniPathway
  2. DNA metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

LigaseSAAS annotationsImported, TransferaseImported

Keywords - Biological processi

Biotin biosynthesisSAAS annotations

Keywords - Ligandi

ATP-bindingSAAS annotations, MagnesiumSAAS annotations, Metal-bindingSAAS annotations, Nucleotide-binding, ZincSAAS annotations

Enzyme and pathway databases

BioCyciIPOL572544:GJ9I-1583-MONOMER.
UniPathwayiUPA00078; UER00161.

Names & Taxonomyi

Protein namesi
Submitted name:
Dethiobiotin synthaseImported (EC:2.7.1.21Imported, EC:6.3.3.3Imported)
Gene namesi
Ordered Locus Names:Ilyop_1552Imported
OrganismiIlyobacter polytropus (strain DSM 2926 / CuHBu1)Imported
Taxonomic identifieri572544 [NCBI]
Taxonomic lineageiBacteriaFusobacteriaFusobacterialesFusobacteriaceaeIlyobacter
ProteomesiUP000006875: Chromosome

Subcellular locationi

Cytoplasm By similarity SAAS annotations

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmSAAS annotations

Interactioni

Subunit structurei

Homotetramer By similarity.SAAS annotations

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000109206.
KOiK00857.
OMAiNGEPAYY.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00124. Thymidine_kinase.
MF_00336. BioD.
InterProiIPR004472. DTB_synth_BioD.
IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
TIGRFAMsiTIGR00347. bioD. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E3H8R7-1 [UniParc]FASTAAdd to Basket

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MHFLLTEGMG WIEVITGGMF SGKSEELIRR LIRSKYASQK VVAFKHSIDK    50
RYDESNVVSH SSIFIEGVPA ASVKEMEKIF YEKYSDAEVI GIDEVQFFGE 100
PVVEFCEKLS DMGKRVIVAG LDQDFRGEPF EPIDSLLAKA EYVDKLSAIC 150
AVCGNPASRT QRLVNGEPAY YNDPVVLVGA SESYEARCRK CHVVKREDNK 200
EGKLYFIVGT DTDIGKTYAG LKLVKQEMDK GLKVTAIKPV ETGSETFPEN 250
LEGSDSYAYA RLLGKNVEDV NIFFYKKPMS PDAAAEADET SVDIKTIKEK 300
IDKELLENDV VFVEGAGGLL VPFVENYMYL DLLVDYRKKS EVILISGNVL 350
GTINHTLLTI DVLKRNDIKI KGVVFNNKEN IEDKKFLKNN VETVKRIGKV 400
EILAENEYGE 410
Length:410
Mass (Da):45,957
Last modified:January 11, 2011 - v1
Checksum:iC26462E2FC69FFDF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002281 Genomic DNA. Translation: ADO83331.1.
RefSeqiWP_013387998.1. NC_014632.1.
YP_003967679.1. NC_014632.1.

Genome annotation databases

EnsemblBacteriaiADO83331; ADO83331; Ilyop_1552.
GeneIDi9869065.
KEGGiipo:Ilyop_1552.
PATRICi42646847. VBIIlyPol34265_1600.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002281 Genomic DNA. Translation: ADO83331.1 .
RefSeqi WP_013387998.1. NC_014632.1.
YP_003967679.1. NC_014632.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADO83331 ; ADO83331 ; Ilyop_1552 .
GeneIDi 9869065.
KEGGi ipo:Ilyop_1552.
PATRICi 42646847. VBIIlyPol34265_1600.

Phylogenomic databases

HOGENOMi HOG000109206.
KOi K00857.
OMAi NGEPAYY.

Enzyme and pathway databases

UniPathwayi UPA00078 ; UER00161 .
BioCyci IPOL572544:GJ9I-1583-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
HAMAPi MF_00124. Thymidine_kinase.
MF_00336. BioD.
InterProi IPR004472. DTB_synth_BioD.
IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view ]
PANTHERi PTHR11441. PTHR11441. 1 hit.
Pfami PF00265. TK. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 2 hits.
TIGRFAMsi TIGR00347. bioD. 1 hit.
PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 2926 / CuHBu1.

Entry informationi

Entry nameiE3H8R7_ILYPC
AccessioniPrimary (citable) accession number: E3H8R7
Entry historyi
Integrated into UniProtKB/TrEMBL: January 11, 2011
Last sequence update: January 11, 2011
Last modified: September 3, 2014
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3