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Protein

Thymidine kinase

Gene

Ilyop_1552

Organism
Ilyobacter polytropus (strain DSM 2926 / CuHBu1)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring.SAAS annotation

Catalytic activityi

ATP + 7,8-diaminononanoate + CO2 = ADP + phosphate + dethiobiotin.SAAS annotation

Cofactori

Mg2+SAAS annotation

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. dethiobiotin synthase activity Source: UniProtKB-EC
  3. magnesium ion binding Source: InterPro
  4. thymidine kinase activity Source: InterPro

GO - Biological processi

  1. biotin biosynthetic process Source: UniProtKB-UniPathway
  2. DNA metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

LigaseSAAS annotationImported, TransferaseImported

Keywords - Biological processi

Biotin biosynthesisSAAS annotation

Keywords - Ligandi

ATP-bindingSAAS annotation, MagnesiumSAAS annotation, Metal-bindingSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciIPOL572544:GJ9I-1583-MONOMER.
UniPathwayiUPA00078; UER00161.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseSAAS annotation (EC:6.3.3.3SAAS annotation)
Gene namesi
Ordered Locus Names:Ilyop_1552Imported
OrganismiIlyobacter polytropus (strain DSM 2926 / CuHBu1)Imported
Taxonomic identifieri572544 [NCBI]
Taxonomic lineageiBacteriaFusobacteriaFusobacterialesFusobacteriaceaeIlyobacter
ProteomesiUP000006875 Componenti: Chromosome

Subcellular locationi

Cytoplasm SAAS annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmSAAS annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000109206.
KOiK00857.
OMAiNGEPAYY.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00124. Thymidine_kinase.
MF_00336. BioD.
InterProiIPR004472. DTB_synth_BioD.
IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
TIGRFAMsiTIGR00347. bioD. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E3H8R7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHFLLTEGMG WIEVITGGMF SGKSEELIRR LIRSKYASQK VVAFKHSIDK
60 70 80 90 100
RYDESNVVSH SSIFIEGVPA ASVKEMEKIF YEKYSDAEVI GIDEVQFFGE
110 120 130 140 150
PVVEFCEKLS DMGKRVIVAG LDQDFRGEPF EPIDSLLAKA EYVDKLSAIC
160 170 180 190 200
AVCGNPASRT QRLVNGEPAY YNDPVVLVGA SESYEARCRK CHVVKREDNK
210 220 230 240 250
EGKLYFIVGT DTDIGKTYAG LKLVKQEMDK GLKVTAIKPV ETGSETFPEN
260 270 280 290 300
LEGSDSYAYA RLLGKNVEDV NIFFYKKPMS PDAAAEADET SVDIKTIKEK
310 320 330 340 350
IDKELLENDV VFVEGAGGLL VPFVENYMYL DLLVDYRKKS EVILISGNVL
360 370 380 390 400
GTINHTLLTI DVLKRNDIKI KGVVFNNKEN IEDKKFLKNN VETVKRIGKV
410
EILAENEYGE
Length:410
Mass (Da):45,957
Last modified:January 11, 2011 - v1
Checksum:iC26462E2FC69FFDF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002281 Genomic DNA. Translation: ADO83331.1.
RefSeqiWP_013387998.1. NC_014632.1.
YP_003967679.1. NC_014632.1.

Genome annotation databases

EnsemblBacteriaiADO83331; ADO83331; Ilyop_1552.
KEGGiipo:Ilyop_1552.
PATRICi42646847. VBIIlyPol34265_1600.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002281 Genomic DNA. Translation: ADO83331.1.
RefSeqiWP_013387998.1. NC_014632.1.
YP_003967679.1. NC_014632.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADO83331; ADO83331; Ilyop_1552.
KEGGiipo:Ilyop_1552.
PATRICi42646847. VBIIlyPol34265_1600.

Phylogenomic databases

HOGENOMiHOG000109206.
KOiK00857.
OMAiNGEPAYY.

Enzyme and pathway databases

UniPathwayiUPA00078; UER00161.
BioCyciIPOL572544:GJ9I-1583-MONOMER.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00124. Thymidine_kinase.
MF_00336. BioD.
InterProiIPR004472. DTB_synth_BioD.
IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
TIGRFAMsiTIGR00347. bioD. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 2926 / CuHBu1Imported.

Entry informationi

Entry nameiE3H8R7_ILYPC
AccessioniPrimary (citable) accession number: E3H8R7
Entry historyi
Integrated into UniProtKB/TrEMBL: January 11, 2011
Last sequence update: January 11, 2011
Last modified: April 1, 2015
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.