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E3H8R7

- E3H8R7_ILYPC

UniProt

E3H8R7 - E3H8R7_ILYPC

Protein
Submitted name:

Dethiobiotin synthase

Gene

Ilyop_1552

Organism
Ilyobacter polytropus (strain DSM 2926 / CuHBu1)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 27 (01 Oct 2014)
      Sequence version 1 (11 Jan 2011)
      Previous versions | rss
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    Functioni

    Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring.SAAS annotation

    Catalytic activityi

    ATP + 7,8-diaminononanoate + CO2 = ADP + phosphate + dethiobiotin.SAAS annotation

    Cofactori

    Magnesium.SAAS annotation

    Pathwayi

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. dethiobiotin synthase activity Source: UniProtKB-EC
    3. magnesium ion binding Source: InterPro
    4. thymidine kinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. biotin biosynthetic process Source: UniProtKB-UniPathway
    2. DNA metabolic process Source: InterPro

    Keywords - Molecular functioni

    LigaseSAAS annotationImported, TransferaseImported

    Keywords - Biological processi

    Biotin biosynthesisSAAS annotation

    Keywords - Ligandi

    ATP-bindingSAAS annotation, MagnesiumSAAS annotation, Metal-bindingSAAS annotation, Nucleotide-binding, ZincSAAS annotation

    Enzyme and pathway databases

    BioCyciIPOL572544:GJ9I-1583-MONOMER.
    UniPathwayiUPA00078; UER00161.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Dethiobiotin synthaseImported (EC:2.7.1.21Imported, EC:6.3.3.3Imported)
    Gene namesi
    Ordered Locus Names:Ilyop_1552Imported
    OrganismiIlyobacter polytropus (strain DSM 2926 / CuHBu1)Imported
    Taxonomic identifieri572544 [NCBI]
    Taxonomic lineageiBacteriaFusobacteriaFusobacterialesFusobacteriaceaeIlyobacter
    ProteomesiUP000006875: Chromosome

    Subcellular locationi

    Cytoplasm SAAS annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmSAAS annotation

    Interactioni

    Subunit structurei

    Homotetramer.SAAS annotation

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the thymidine kinase family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000109206.
    KOiK00857.
    OMAiNGEPAYY.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    HAMAPiMF_00124. Thymidine_kinase.
    MF_00336. BioD.
    InterProiIPR004472. DTB_synth_BioD.
    IPR027417. P-loop_NTPase.
    IPR001267. Thymidine_kinase.
    IPR020633. Thymidine_kinase_CS.
    IPR020634. Thymidine_kinase_subgr.
    [Graphical view]
    PANTHERiPTHR11441. PTHR11441. 1 hit.
    PfamiPF00265. TK. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 2 hits.
    TIGRFAMsiTIGR00347. bioD. 1 hit.
    PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    E3H8R7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MHFLLTEGMG WIEVITGGMF SGKSEELIRR LIRSKYASQK VVAFKHSIDK    50
    RYDESNVVSH SSIFIEGVPA ASVKEMEKIF YEKYSDAEVI GIDEVQFFGE 100
    PVVEFCEKLS DMGKRVIVAG LDQDFRGEPF EPIDSLLAKA EYVDKLSAIC 150
    AVCGNPASRT QRLVNGEPAY YNDPVVLVGA SESYEARCRK CHVVKREDNK 200
    EGKLYFIVGT DTDIGKTYAG LKLVKQEMDK GLKVTAIKPV ETGSETFPEN 250
    LEGSDSYAYA RLLGKNVEDV NIFFYKKPMS PDAAAEADET SVDIKTIKEK 300
    IDKELLENDV VFVEGAGGLL VPFVENYMYL DLLVDYRKKS EVILISGNVL 350
    GTINHTLLTI DVLKRNDIKI KGVVFNNKEN IEDKKFLKNN VETVKRIGKV 400
    EILAENEYGE 410
    Length:410
    Mass (Da):45,957
    Last modified:January 11, 2011 - v1
    Checksum:iC26462E2FC69FFDF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002281 Genomic DNA. Translation: ADO83331.1.
    RefSeqiWP_013387998.1. NC_014632.1.
    YP_003967679.1. NC_014632.1.

    Genome annotation databases

    EnsemblBacteriaiADO83331; ADO83331; Ilyop_1552.
    GeneIDi9869065.
    KEGGiipo:Ilyop_1552.
    PATRICi42646847. VBIIlyPol34265_1600.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002281 Genomic DNA. Translation: ADO83331.1 .
    RefSeqi WP_013387998.1. NC_014632.1.
    YP_003967679.1. NC_014632.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADO83331 ; ADO83331 ; Ilyop_1552 .
    GeneIDi 9869065.
    KEGGi ipo:Ilyop_1552.
    PATRICi 42646847. VBIIlyPol34265_1600.

    Phylogenomic databases

    HOGENOMi HOG000109206.
    KOi K00857.
    OMAi NGEPAYY.

    Enzyme and pathway databases

    UniPathwayi UPA00078 ; UER00161 .
    BioCyci IPOL572544:GJ9I-1583-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    HAMAPi MF_00124. Thymidine_kinase.
    MF_00336. BioD.
    InterProi IPR004472. DTB_synth_BioD.
    IPR027417. P-loop_NTPase.
    IPR001267. Thymidine_kinase.
    IPR020633. Thymidine_kinase_CS.
    IPR020634. Thymidine_kinase_subgr.
    [Graphical view ]
    PANTHERi PTHR11441. PTHR11441. 1 hit.
    Pfami PF00265. TK. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 2 hits.
    TIGRFAMsi TIGR00347. bioD. 1 hit.
    PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 2926 / CuHBu1Imported.

    Entry informationi

    Entry nameiE3H8R7_ILYPC
    AccessioniPrimary (citable) accession number: E3H8R7
    Entry historyi
    Integrated into UniProtKB/TrEMBL: January 11, 2011
    Last sequence update: January 11, 2011
    Last modified: October 1, 2014
    This is version 27 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3