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E3H5M4

- E3H5M4_ROTDC

UniProt

E3H5M4 - E3H5M4_ROTDC

Protein

Alanine racemase

Gene

alr

Organism
Rothia dentocariosa (strain ATCC 17931 / CDC X599 / XDIA)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 30 (01 Oct 2014)
      Sequence version 1 (11 Jan 2011)
      Previous versions | rss
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    Functioni

    Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

    Catalytic activityi

    L-alanine = D-alanine.UniRule annotationSAAS annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei50 – 501Proton acceptor; specific for D-alanineUniRule annotation
    Binding sitei147 – 1471SubstrateUniRule annotation
    Active sitei288 – 2881Proton acceptor; specific for L-alanineUniRule annotation
    Binding sitei345 – 3451Substrate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. alanine racemase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. D-alanine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    IsomeraseUniRule annotationSAAS annotationImported

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciRDEN762948:GHPW-259-MONOMER.
    UniPathwayiUPA00042; UER00497.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
    Gene namesi
    Name:alrImported
    Ordered Locus Names:HMPREF0733_10256Imported
    OrganismiRothia dentocariosa (strain ATCC 17931 / CDC X599 / XDIA)Imported
    Taxonomic identifieri762948 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeMicrococcaceaeRothia
    ProteomesiUP000000387: Chromosome

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei50 – 501N6-(pyridoxal phosphate)lysineUniRule annotation

    Structurei

    3D structure databases

    ProteinModelPortaliE3H5M4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the alanine racemase family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000031444.
    KOiK01775.
    OMAiWELERVA.

    Family and domain databases

    Gene3Di2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPiMF_01201. Ala_racemase.
    InterProiIPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view]
    PfamiPF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view]
    PRINTSiPR00992. ALARACEMASE.
    SMARTiSM01005. Ala_racemase_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsiTIGR00492. alr. 1 hit.
    PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    E3H5M4-1 [UniParc]FASTAAdd to Basket

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    MTVPTRPLYT PNLQPGEAER TAIIDLNALE HNTRVLKDMI GERKLIAVVK    50
    ADAYGHGAYP VARSVLEAGA DILGVVHVTE ALELRSEGIT APIIAWLHTP 100
    QTDFDEALEA DIILGASGWD LEAIAEAANR TKKRARVHLK VDTGLGRNGS 150
    TFEDWPALVA RALELEAAGL VRIEGIFSHL AVADEPERPE TARQITRLNE 200
    FVTVARSAGL TPELVHLANS PGTITGASPL YNTNEAVLAD AVRCGIALYG 250
    LSPLAGVSSK DLNLRPVMTL GTHVCNVKEV PAGQGVSYGL RYSTDKPTTL 300
    ALIPLGYADG VPRIAEGAPV RIYPRADAAN PVEPRTYRVV GRIAMDQLVV 350
    DLEEPGLADP ARGILGGSAV LFGSGDNPPV EEWAAAAQTI NYEIVTRISP 400
    RVIRIYRGGA WVEREVDGLH ALGSLFGLDD EQTPETV 437
    Length:437
    Mass (Da):46,730
    Last modified:January 11, 2011 - v1
    Checksum:iEB3E27B86A9A5F81
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002280 Genomic DNA. Translation: ADP39714.1.
    RefSeqiWP_013397592.1. NC_014643.1.
    YP_003983148.1. NC_014643.1.

    Genome annotation databases

    EnsemblBacteriaiADP39714; ADP39714; HMPREF0733_10256.
    GeneIDi9901508.
    KEGGirdn:HMPREF0733_10256.
    PATRICi42675380. VBIRotDen160907_0254.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002280 Genomic DNA. Translation: ADP39714.1 .
    RefSeqi WP_013397592.1. NC_014643.1.
    YP_003983148.1. NC_014643.1.

    3D structure databases

    ProteinModelPortali E3H5M4.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADP39714 ; ADP39714 ; HMPREF0733_10256 .
    GeneIDi 9901508.
    KEGGi rdn:HMPREF0733_10256.
    PATRICi 42675380. VBIRotDen160907_0254.

    Phylogenomic databases

    HOGENOMi HOG000031444.
    KOi K01775.
    OMAi WELERVA.

    Enzyme and pathway databases

    UniPathwayi UPA00042 ; UER00497 .
    BioCyci RDEN762948:GHPW-259-MONOMER.

    Family and domain databases

    Gene3Di 2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPi MF_01201. Ala_racemase.
    InterProi IPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view ]
    Pfami PF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00992. ALARACEMASE.
    SMARTi SM01005. Ala_racemase_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsi TIGR00492. alr. 1 hit.
    PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The complete genome of Rothia dentocariosa ATCC 17931."
      Muzny D., Qin X., Buhay C., Dugan-Rocha S., Ding Y., Chen G., Hawes A., Holder M., Jhangiani S., Johnson A., Khan Z., Li Z., Liu W., Liu X., Perez L., Shen H., Wang Q., Watt J.
      , Xi L., Xin Y., Zhou J., Deng J., Jiang H., Liu Y., Qu J., Song X.-Z., Zhang L., Villasana D., Johnson A., Liu J., Liyanage D., Lorensuhewa L., Robinson T., Song A., Song B.-B., Dinh H., Thornton R., Coyle M., Francisco L., Jackson L., Javaid M., Korchina V., Kovar C., Mata R., Mathew T., Ngo R., Nguyen L., Nguyen N., Okwuonu G., Ongeri F., Pham C., Simmons D., Wilczek-Boney K., Hale W., Jakkamsetti A., Pham P., Ruth R., San Lucas F., Warren J., Zhang J., Zhao Z., Zhou C., Zhu D., Lee S., Bess C., Blankenburg K., Forbes L., Fu Q., Gubbala S., Hirani K., Jayaseelan J.C., Lara F., Munidasa M., Palculict T., Patil S., Pu L.-L., Saada N., Tang L., Weissenberger G., Zhu Y., Hemphill L., Shang Y., Youmans B., Ayvaz T., Ross M., Santibanez J., Aqrawi P., Gross S., Joshi V., Fowler G., Nazareth L., Reid J., Worley K., Petrosino J., Highlander S., Gibbs R.
      Submitted (OCT-2010) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 17931 / CDC X599 / XDIAImported.

    Entry informationi

    Entry nameiE3H5M4_ROTDC
    AccessioniPrimary (citable) accession number: E3H5M4
    Entry historyi
    Integrated into UniProtKB/TrEMBL: January 11, 2011
    Last sequence update: January 11, 2011
    Last modified: October 1, 2014
    This is version 30 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3