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E3H4U1

- E3H4U1_ROTDC

UniProt

E3H4U1 - E3H4U1_ROTDC

Protein

Glutamate-1-semialdehyde 2,1-aminomutase

Gene

hemL

Organism
Rothia dentocariosa (strain ATCC 17931 / CDC X599 / XDIA)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 31 (01 Oct 2014)
      Sequence version 1 (11 Jan 2011)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    (S)-4-amino-5-oxopentanoate = 5-aminolevulinate.UniRule annotationSAAS annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotationSAAS annotation

    Pathwayi

    GO - Molecular functioni

    1. glutamate-1-semialdehyde 2,1-aminomutase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: InterPro
    3. transaminase activity Source: InterPro

    GO - Biological processi

    1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    IsomeraseUniRule annotationSAAS annotationImported

    Keywords - Biological processi

    Porphyrin biosynthesisUniRule annotationSAAS annotation

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciRDEN762948:GHPW-105-MONOMER.
    UniPathwayiUPA00251; UER00317.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamate-1-semialdehyde 2,1-aminomutaseUniRule annotation (EC:5.4.3.8UniRule annotation)
    Short name:
    GSAUniRule annotation
    Alternative name(s):
    Glutamate-1-semialdehyde aminotransferaseUniRule annotation
    Gene namesi
    Name:hemLUniRule annotationImported
    Ordered Locus Names:HMPREF0733_10102Imported
    OrganismiRothia dentocariosa (strain ATCC 17931 / CDC X599 / XDIA)Imported
    Taxonomic identifieri762948 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeMicrococcaceaeRothia
    ProteomesiUP000000387: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotationSAAS annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotationSAAS annotation

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei285 – 2851N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Structurei

    3D structure databases

    ProteinModelPortaliE3H4U1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000020210.
    KOiK01845.
    OMAiRFMVSGN.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 2 hits.
    HAMAPiMF_00375. HemL_aminotrans_3.
    InterProiIPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
    IPR005814. Aminotrans_3.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PANTHERiPTHR11986. PTHR11986. 1 hit.
    PfamiPF00202. Aminotran_3. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
    SUPFAMiSSF53383. SSF53383. 1 hit.
    TIGRFAMsiTIGR00713. hemL. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    E3H4U1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSLSAEHHLA HQHSEELFER SRSVIPGGVN SPVRAFNSVG GTPAFVDRAS    50
    GPYIYDADGN EYVDLVCSWG PAILGHAHPQ VVAAVQEAAS RGLSFGAASA 100
    PEAELAELVV DRINTAIPGA IEQVRMVSTG TEATMTAIRL ARGITGRDKI 150
    IKFSGCYHGH VDALLSEAGS GVATLALPGS AGVTAATASE TIVLPYNDLD 200
    AVREAFAAHP GEIAAVITEA APCNMGVVTP EPGFNRGLRE ITQSNNALLI 250
    FDEVLTGFRV SSAGYWGKFA PEDNGWVPDI FTFGKVIGGG MPIAALAGKR 300
    EVMEYLAPTG PVYQAGTLSG NPLSVASGIT TLKLADDALY RTLDTRSEQL 350
    QAALTQALTD AGVDHSIQTA GNLFSVAFGT GEHGVHNYAD IKGSATAKYT 400
    AFFHAMLDAG VYLPPSAFEA WFLSGAHDDA AMERIIEALP GAARAAAKA 449
    Length:449
    Mass (Da):46,763
    Last modified:January 11, 2011 - v1
    Checksum:iF9E10EC284532521
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002280 Genomic DNA. Translation: ADP39560.1.
    RefSeqiYP_003982994.1. NC_014643.1.

    Genome annotation databases

    EnsemblBacteriaiADP39560; ADP39560; HMPREF0733_10102.
    GeneIDi9901354.
    KEGGirdn:HMPREF0733_10102.
    PATRICi42675082. VBIRotDen160907_0105.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002280 Genomic DNA. Translation: ADP39560.1 .
    RefSeqi YP_003982994.1. NC_014643.1.

    3D structure databases

    ProteinModelPortali E3H4U1.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADP39560 ; ADP39560 ; HMPREF0733_10102 .
    GeneIDi 9901354.
    KEGGi rdn:HMPREF0733_10102.
    PATRICi 42675082. VBIRotDen160907_0105.

    Phylogenomic databases

    HOGENOMi HOG000020210.
    KOi K01845.
    OMAi RFMVSGN.

    Enzyme and pathway databases

    UniPathwayi UPA00251 ; UER00317 .
    BioCyci RDEN762948:GHPW-105-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 2 hits.
    HAMAPi MF_00375. HemL_aminotrans_3.
    InterProi IPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
    IPR005814. Aminotrans_3.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    PANTHERi PTHR11986. PTHR11986. 1 hit.
    Pfami PF00202. Aminotran_3. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
    SUPFAMi SSF53383. SSF53383. 1 hit.
    TIGRFAMsi TIGR00713. hemL. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The complete genome of Rothia dentocariosa ATCC 17931."
      Muzny D., Qin X., Buhay C., Dugan-Rocha S., Ding Y., Chen G., Hawes A., Holder M., Jhangiani S., Johnson A., Khan Z., Li Z., Liu W., Liu X., Perez L., Shen H., Wang Q., Watt J.
      , Xi L., Xin Y., Zhou J., Deng J., Jiang H., Liu Y., Qu J., Song X.-Z., Zhang L., Villasana D., Johnson A., Liu J., Liyanage D., Lorensuhewa L., Robinson T., Song A., Song B.-B., Dinh H., Thornton R., Coyle M., Francisco L., Jackson L., Javaid M., Korchina V., Kovar C., Mata R., Mathew T., Ngo R., Nguyen L., Nguyen N., Okwuonu G., Ongeri F., Pham C., Simmons D., Wilczek-Boney K., Hale W., Jakkamsetti A., Pham P., Ruth R., San Lucas F., Warren J., Zhang J., Zhao Z., Zhou C., Zhu D., Lee S., Bess C., Blankenburg K., Forbes L., Fu Q., Gubbala S., Hirani K., Jayaseelan J.C., Lara F., Munidasa M., Palculict T., Patil S., Pu L.-L., Saada N., Tang L., Weissenberger G., Zhu Y., Hemphill L., Shang Y., Youmans B., Ayvaz T., Ross M., Santibanez J., Aqrawi P., Gross S., Joshi V., Fowler G., Nazareth L., Reid J., Worley K., Petrosino J., Highlander S., Gibbs R.
      Submitted (OCT-2010) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 17931 / CDC X599 / XDIAImported.

    Entry informationi

    Entry nameiE3H4U1_ROTDC
    AccessioniPrimary (citable) accession number: E3H4U1
    Entry historyi
    Integrated into UniProtKB/TrEMBL: January 11, 2011
    Last sequence update: January 11, 2011
    Last modified: October 1, 2014
    This is version 31 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3