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Protein

Glutamate-1-semialdehyde 2,1-aminomutase

Gene

hemL

Organism
Rothia dentocariosa (strain ATCC 17931 / CDC X599 / XDIA)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-4-amino-5-oxopentanoate = 5-aminolevulinate.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi

GO - Molecular functioni

  1. glutamate-1-semialdehyde 2,1-aminomutase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: InterPro
  3. transaminase activity Source: InterPro

GO - Biological processi

  1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Biological processi

Porphyrin biosynthesisUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciRDEN762948:GHPW-105-MONOMER.
UniPathwayiUPA00251; UER00317.
UPA00251; UER00317.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate-1-semialdehyde 2,1-aminomutaseUniRule annotationSAAS annotation (EC:5.4.3.8UniRule annotationSAAS annotation)
Short name:
GSAUniRule annotation
Alternative name(s):
Glutamate-1-semialdehyde aminotransferaseUniRule annotation
Gene namesi
Name:hemLUniRule annotationImported
Ordered Locus Names:HMPREF0733_10102Imported
OrganismiRothia dentocariosa (strain ATCC 17931 / CDC X599 / XDIA)Imported
Taxonomic identifieri762948 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeMicrococcaceaeRothia
ProteomesiUP000000387 Componenti: Chromosome

Subcellular locationi

Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei285 – 2851N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000020210.
KOiK01845.
OMAiCGHAHPE.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPiMF_00375. HemL_aminotrans_3.
InterProiIPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11986. PTHR11986. 1 hit.
PfamiPF00202. Aminotran_3. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR00713. hemL. 1 hit.

Sequencei

Sequence statusi: Complete.

E3H4U1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLSAEHHLA HQHSEELFER SRSVIPGGVN SPVRAFNSVG GTPAFVDRAS
60 70 80 90 100
GPYIYDADGN EYVDLVCSWG PAILGHAHPQ VVAAVQEAAS RGLSFGAASA
110 120 130 140 150
PEAELAELVV DRINTAIPGA IEQVRMVSTG TEATMTAIRL ARGITGRDKI
160 170 180 190 200
IKFSGCYHGH VDALLSEAGS GVATLALPGS AGVTAATASE TIVLPYNDLD
210 220 230 240 250
AVREAFAAHP GEIAAVITEA APCNMGVVTP EPGFNRGLRE ITQSNNALLI
260 270 280 290 300
FDEVLTGFRV SSAGYWGKFA PEDNGWVPDI FTFGKVIGGG MPIAALAGKR
310 320 330 340 350
EVMEYLAPTG PVYQAGTLSG NPLSVASGIT TLKLADDALY RTLDTRSEQL
360 370 380 390 400
QAALTQALTD AGVDHSIQTA GNLFSVAFGT GEHGVHNYAD IKGSATAKYT
410 420 430 440
AFFHAMLDAG VYLPPSAFEA WFLSGAHDDA AMERIIEALP GAARAAAKA
Length:449
Mass (Da):46,763
Last modified:January 10, 2011 - v1
Checksum:iF9E10EC284532521
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002280 Genomic DNA. Translation: ADP39560.1.
RefSeqiYP_003982994.1. NC_014643.1.

Genome annotation databases

EnsemblBacteriaiADP39560; ADP39560; HMPREF0733_10102.
KEGGirdn:HMPREF0733_10102.
PATRICi42675082. VBIRotDen160907_0105.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002280 Genomic DNA. Translation: ADP39560.1.
RefSeqiYP_003982994.1. NC_014643.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADP39560; ADP39560; HMPREF0733_10102.
KEGGirdn:HMPREF0733_10102.
PATRICi42675082. VBIRotDen160907_0105.

Phylogenomic databases

HOGENOMiHOG000020210.
KOiK01845.
OMAiCGHAHPE.

Enzyme and pathway databases

UniPathwayiUPA00251; UER00317.
UPA00251; UER00317.
BioCyciRDEN762948:GHPW-105-MONOMER.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPiMF_00375. HemL_aminotrans_3.
InterProiIPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11986. PTHR11986. 1 hit.
PfamiPF00202. Aminotran_3. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR00713. hemL. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The complete genome of Rothia dentocariosa ATCC 17931."
    Muzny D., Qin X., Buhay C., Dugan-Rocha S., Ding Y., Chen G., Hawes A., Holder M., Jhangiani S., Johnson A., Khan Z., Li Z., Liu W., Liu X., Perez L., Shen H., Wang Q., Watt J.
    , Xi L., Xin Y., Zhou J., Deng J., Jiang H., Liu Y., Qu J., Song X.-Z., Zhang L., Villasana D., Johnson A., Liu J., Liyanage D., Lorensuhewa L., Robinson T., Song A., Song B.-B., Dinh H., Thornton R., Coyle M., Francisco L., Jackson L., Javaid M., Korchina V., Kovar C., Mata R., Mathew T., Ngo R., Nguyen L., Nguyen N., Okwuonu G., Ongeri F., Pham C., Simmons D., Wilczek-Boney K., Hale W., Jakkamsetti A., Pham P., Ruth R., San Lucas F., Warren J., Zhang J., Zhao Z., Zhou C., Zhu D., Lee S., Bess C., Blankenburg K., Forbes L., Fu Q., Gubbala S., Hirani K., Jayaseelan J.C., Lara F., Munidasa M., Palculict T., Patil S., Pu L.-L., Saada N., Tang L., Weissenberger G., Zhu Y., Hemphill L., Shang Y., Youmans B., Ayvaz T., Ross M., Santibanez J., Aqrawi P., Gross S., Joshi V., Fowler G., Nazareth L., Reid J., Worley K., Petrosino J., Highlander S., Gibbs R.
    Submitted (SEP-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 17931 / CDC X599 / XDIAImported.

Entry informationi

Entry nameiE3H4U1_ROTDC
AccessioniPrimary (citable) accession number: E3H4U1
Entry historyi
Integrated into UniProtKB/TrEMBL: January 10, 2011
Last sequence update: January 10, 2011
Last modified: March 31, 2015
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.