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E3H4U1

- E3H4U1_ROTDC

UniProt

E3H4U1 - E3H4U1_ROTDC

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Protein
Glutamate-1-semialdehyde 2,1-aminomutase
Gene
hemL, HMPREF0733_10102
Organism
Rothia dentocariosa (strain ATCC 17931 / CDC X599 / XDIA)
Status
Unreviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

(S)-4-amino-5-oxopentanoate = 5-aminolevulinate.UniRule annotationSAAS annotations

Cofactori

Pyridoxal phosphate By similarity.UniRule annotationSAAS annotations

Pathwayi

GO - Molecular functioni

  1. glutamate-1-semialdehyde 2,1-aminomutase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: InterPro
  3. transaminase activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotationsImported

Keywords - Biological processi

Porphyrin biosynthesisUniRule annotationSAAS annotations

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciRDEN762948:GHPW-105-MONOMER.
UniPathwayiUPA00251; UER00317.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate-1-semialdehyde 2,1-aminomutaseUniRule annotation (EC:5.4.3.8UniRule annotation)
Short name:
GSAUniRule annotation
Alternative name(s):
Glutamate-1-semialdehyde aminotransferase
Gene namesi
Name:hemLUniRule annotationImported
Ordered Locus Names:HMPREF0733_10102Imported
OrganismiRothia dentocariosa (strain ATCC 17931 / CDC X599 / XDIA)Imported
Taxonomic identifieri762948 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeMicrococcaceaeRothia
ProteomesiUP000000387: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotationSAAS annotations

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotations

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei285 – 2851N6-(pyridoxal phosphate)lysine By similarityUniRule annotation

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliE3H4U1.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000020210.
KOiK01845.
OMAiRFMVSGN.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPiMF_00375. HemL_aminotrans_3.
InterProiIPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11986. PTHR11986. 1 hit.
PfamiPF00202. Aminotran_3. 1 hit.
[Graphical view]
PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR00713. hemL. 1 hit.

Sequencei

Sequence statusi: Complete.

E3H4U1-1 [UniParc]FASTAAdd to Basket

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MSLSAEHHLA HQHSEELFER SRSVIPGGVN SPVRAFNSVG GTPAFVDRAS    50
GPYIYDADGN EYVDLVCSWG PAILGHAHPQ VVAAVQEAAS RGLSFGAASA 100
PEAELAELVV DRINTAIPGA IEQVRMVSTG TEATMTAIRL ARGITGRDKI 150
IKFSGCYHGH VDALLSEAGS GVATLALPGS AGVTAATASE TIVLPYNDLD 200
AVREAFAAHP GEIAAVITEA APCNMGVVTP EPGFNRGLRE ITQSNNALLI 250
FDEVLTGFRV SSAGYWGKFA PEDNGWVPDI FTFGKVIGGG MPIAALAGKR 300
EVMEYLAPTG PVYQAGTLSG NPLSVASGIT TLKLADDALY RTLDTRSEQL 350
QAALTQALTD AGVDHSIQTA GNLFSVAFGT GEHGVHNYAD IKGSATAKYT 400
AFFHAMLDAG VYLPPSAFEA WFLSGAHDDA AMERIIEALP GAARAAAKA 449
Length:449
Mass (Da):46,763
Last modified:January 11, 2011 - v1
Checksum:iF9E10EC284532521
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002280 Genomic DNA. Translation: ADP39560.1.
RefSeqiYP_003982994.1. NC_014643.1.

Genome annotation databases

EnsemblBacteriaiADP39560; ADP39560; HMPREF0733_10102.
GeneIDi9901354.
KEGGirdn:HMPREF0733_10102.
PATRICi42675082. VBIRotDen160907_0105.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002280 Genomic DNA. Translation: ADP39560.1 .
RefSeqi YP_003982994.1. NC_014643.1.

3D structure databases

ProteinModelPortali E3H4U1.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADP39560 ; ADP39560 ; HMPREF0733_10102 .
GeneIDi 9901354.
KEGGi rdn:HMPREF0733_10102.
PATRICi 42675082. VBIRotDen160907_0105.

Phylogenomic databases

HOGENOMi HOG000020210.
KOi K01845.
OMAi RFMVSGN.

Enzyme and pathway databases

UniPathwayi UPA00251 ; UER00317 .
BioCyci RDEN762948:GHPW-105-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPi MF_00375. HemL_aminotrans_3.
InterProi IPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
PANTHERi PTHR11986. PTHR11986. 1 hit.
Pfami PF00202. Aminotran_3. 1 hit.
[Graphical view ]
PIRSFi PIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR00713. hemL. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The complete genome of Rothia dentocariosa ATCC 17931."
    Muzny D., Qin X., Buhay C., Dugan-Rocha S., Ding Y., Chen G., Hawes A., Holder M., Jhangiani S., Johnson A., Khan Z., Li Z., Liu W., Liu X., Perez L., Shen H., Wang Q., Watt J.
    , Xi L., Xin Y., Zhou J., Deng J., Jiang H., Liu Y., Qu J., Song X.-Z., Zhang L., Villasana D., Johnson A., Liu J., Liyanage D., Lorensuhewa L., Robinson T., Song A., Song B.-B., Dinh H., Thornton R., Coyle M., Francisco L., Jackson L., Javaid M., Korchina V., Kovar C., Mata R., Mathew T., Ngo R., Nguyen L., Nguyen N., Okwuonu G., Ongeri F., Pham C., Simmons D., Wilczek-Boney K., Hale W., Jakkamsetti A., Pham P., Ruth R., San Lucas F., Warren J., Zhang J., Zhao Z., Zhou C., Zhu D., Lee S., Bess C., Blankenburg K., Forbes L., Fu Q., Gubbala S., Hirani K., Jayaseelan J.C., Lara F., Munidasa M., Palculict T., Patil S., Pu L.-L., Saada N., Tang L., Weissenberger G., Zhu Y., Hemphill L., Shang Y., Youmans B., Ayvaz T., Ross M., Santibanez J., Aqrawi P., Gross S., Joshi V., Fowler G., Nazareth L., Reid J., Worley K., Petrosino J., Highlander S., Gibbs R.
    Submitted (OCT-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 17931 / CDC X599 / XDIA.

Entry informationi

Entry nameiE3H4U1_ROTDC
AccessioniPrimary (citable) accession number: E3H4U1
Entry historyi
Integrated into UniProtKB/TrEMBL: January 11, 2011
Last sequence update: January 11, 2011
Last modified: July 9, 2014
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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