Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

E3H4U1

- E3H4U1_ROTDC

UniProt

E3H4U1 - E3H4U1_ROTDC

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Glutamate-1-semialdehyde 2,1-aminomutase

Gene

hemL

Organism
Rothia dentocariosa (strain ATCC 17931 / CDC X599 / XDIA)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-4-amino-5-oxopentanoate = 5-aminolevulinate.UniRule annotationSAAS annotation

Cofactori

Pyridoxal phosphate.UniRule annotationSAAS annotation

Pathwayi

GO - Molecular functioni

  1. glutamate-1-semialdehyde 2,1-aminomutase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: InterPro
  3. transaminase activity Source: InterPro

GO - Biological processi

  1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Biological processi

Porphyrin biosynthesisUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciRDEN762948:GHPW-105-MONOMER.
UniPathwayiUPA00251; UER00317.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate-1-semialdehyde 2,1-aminomutaseUniRule annotation (EC:5.4.3.8UniRule annotation)
Short name:
GSAUniRule annotation
Alternative name(s):
Glutamate-1-semialdehyde aminotransferaseUniRule annotation
Gene namesi
Name:hemLUniRule annotationImported
Ordered Locus Names:HMPREF0733_10102Imported
OrganismiRothia dentocariosa (strain ATCC 17931 / CDC X599 / XDIA)Imported
Taxonomic identifieri762948 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeMicrococcaceaeRothia
ProteomesiUP000000387: Chromosome

Subcellular locationi

Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei285 – 2851N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliE3H4U1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000020210.
KOiK01845.
OMAiRFMVSGN.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPiMF_00375. HemL_aminotrans_3.
InterProiIPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11986. PTHR11986. 1 hit.
PfamiPF00202. Aminotran_3. 1 hit.
[Graphical view]
PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR00713. hemL. 1 hit.

Sequencei

Sequence statusi: Complete.

E3H4U1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSLSAEHHLA HQHSEELFER SRSVIPGGVN SPVRAFNSVG GTPAFVDRAS
60 70 80 90 100
GPYIYDADGN EYVDLVCSWG PAILGHAHPQ VVAAVQEAAS RGLSFGAASA
110 120 130 140 150
PEAELAELVV DRINTAIPGA IEQVRMVSTG TEATMTAIRL ARGITGRDKI
160 170 180 190 200
IKFSGCYHGH VDALLSEAGS GVATLALPGS AGVTAATASE TIVLPYNDLD
210 220 230 240 250
AVREAFAAHP GEIAAVITEA APCNMGVVTP EPGFNRGLRE ITQSNNALLI
260 270 280 290 300
FDEVLTGFRV SSAGYWGKFA PEDNGWVPDI FTFGKVIGGG MPIAALAGKR
310 320 330 340 350
EVMEYLAPTG PVYQAGTLSG NPLSVASGIT TLKLADDALY RTLDTRSEQL
360 370 380 390 400
QAALTQALTD AGVDHSIQTA GNLFSVAFGT GEHGVHNYAD IKGSATAKYT
410 420 430 440
AFFHAMLDAG VYLPPSAFEA WFLSGAHDDA AMERIIEALP GAARAAAKA
Length:449
Mass (Da):46,763
Last modified:January 11, 2011 - v1
Checksum:iF9E10EC284532521
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002280 Genomic DNA. Translation: ADP39560.1.
RefSeqiYP_003982994.1. NC_014643.1.

Genome annotation databases

EnsemblBacteriaiADP39560; ADP39560; HMPREF0733_10102.
GeneIDi9901354.
KEGGirdn:HMPREF0733_10102.
PATRICi42675082. VBIRotDen160907_0105.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002280 Genomic DNA. Translation: ADP39560.1 .
RefSeqi YP_003982994.1. NC_014643.1.

3D structure databases

ProteinModelPortali E3H4U1.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADP39560 ; ADP39560 ; HMPREF0733_10102 .
GeneIDi 9901354.
KEGGi rdn:HMPREF0733_10102.
PATRICi 42675082. VBIRotDen160907_0105.

Phylogenomic databases

HOGENOMi HOG000020210.
KOi K01845.
OMAi RFMVSGN.

Enzyme and pathway databases

UniPathwayi UPA00251 ; UER00317 .
BioCyci RDEN762948:GHPW-105-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPi MF_00375. HemL_aminotrans_3.
InterProi IPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
PANTHERi PTHR11986. PTHR11986. 1 hit.
Pfami PF00202. Aminotran_3. 1 hit.
[Graphical view ]
PIRSFi PIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR00713. hemL. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The complete genome of Rothia dentocariosa ATCC 17931."
    Muzny D., Qin X., Buhay C., Dugan-Rocha S., Ding Y., Chen G., Hawes A., Holder M., Jhangiani S., Johnson A., Khan Z., Li Z., Liu W., Liu X., Perez L., Shen H., Wang Q., Watt J.
    , Xi L., Xin Y., Zhou J., Deng J., Jiang H., Liu Y., Qu J., Song X.-Z., Zhang L., Villasana D., Johnson A., Liu J., Liyanage D., Lorensuhewa L., Robinson T., Song A., Song B.-B., Dinh H., Thornton R., Coyle M., Francisco L., Jackson L., Javaid M., Korchina V., Kovar C., Mata R., Mathew T., Ngo R., Nguyen L., Nguyen N., Okwuonu G., Ongeri F., Pham C., Simmons D., Wilczek-Boney K., Hale W., Jakkamsetti A., Pham P., Ruth R., San Lucas F., Warren J., Zhang J., Zhao Z., Zhou C., Zhu D., Lee S., Bess C., Blankenburg K., Forbes L., Fu Q., Gubbala S., Hirani K., Jayaseelan J.C., Lara F., Munidasa M., Palculict T., Patil S., Pu L.-L., Saada N., Tang L., Weissenberger G., Zhu Y., Hemphill L., Shang Y., Youmans B., Ayvaz T., Ross M., Santibanez J., Aqrawi P., Gross S., Joshi V., Fowler G., Nazareth L., Reid J., Worley K., Petrosino J., Highlander S., Gibbs R.
    Submitted (OCT-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 17931 / CDC X599 / XDIAImported.

Entry informationi

Entry nameiE3H4U1_ROTDC
AccessioniPrimary (citable) accession number: E3H4U1
Entry historyi
Integrated into UniProtKB/TrEMBL: January 11, 2011
Last sequence update: January 11, 2011
Last modified: October 29, 2014
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3