E3H4U1 (E3H4U1_ROTDC) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Glutamate-1-semialdehyde 2,1-aminomutase HAMAP-Rule MF_00375
Short name=GSA HAMAP-Rule MF_00375
EC=5.4.3.8 HAMAP-Rule MF_00375

Alternative name(s):
Glutamate-1-semialdehyde aminotransferase HAMAP-Rule MF_00375

Gene names

Name:	hemL HAMAP-Rule MF_00375 EMBL ADP39560.1
Ordered Locus Names:	HMPREF0733_10102 EMBL ADP39560.1

Organism

Rothia dentocariosa (strain ATCC 17931 / CDC X599 / XDIA) [Complete proteome] [HAMAP]

Taxonomic identifier

762948 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Actinobacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micrococcineae › Micrococcaceae › Rothia › Rothia dentocariosa

Protein attributes

Sequence length	449 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	(S)-4-amino-5-oxopentanoate = 5-aminolevulinate. HAMAP-Rule MF_00375 SAAS SAAS004639
Cofactor	Pyridoxal phosphate By similarity. HAMAP-Rule MF_00375 SAAS SAAS004639
Pathway	Porphyrin biosynthesis; chlorophyll biosynthesis. HAMAP-Rule MF_00375 Porphyrin metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from L-glutamyl-tRNA(Glu): step 2/2. HAMAP-Rule MF_00375 SAAS SAAS004639
Subunit structure	Homodimer By similarity. HAMAP-Rule MF_00375
Subcellular location	Cytoplasm By similarity HAMAP-Rule MF_00375 SAAS SAAS004639.
Sequence similarities	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily. HAMAP-Rule MF_00375

Ontologies

Keywords
Biological process	Chlorophyll biosynthesis HAMAP-Rule MF_00375 Porphyrin biosynthesis HAMAP-Rule MF_00375 SAAS SAAS004639
Cellular component	Cytoplasm HAMAP-Rule MF_00375 SAAS SAAS004639
Ligand	Pyridoxal phosphate SAAS SAAS004639 HAMAP-Rule MF_00375
Molecular function	Isomerase HAMAP-Rule MF_00375 SAAS SAAS004639 EMBL ADP39560.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	chlorophyll biosynthetic process Inferred from electronic annotation. Source: HAMAP protoporphyrinogen IX biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	glutamate-1-semialdehyde 2,1-aminomutase activity Inferred from electronic annotation. Source: HAMAP pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro transaminase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Amino acid modifications
	Modified residue	285	1	N6-(pyridoxal phosphate)lysine By similarity HAMAP-Rule MF_00375

Sequences

	Sequence		Length	Mass (Da)
	E3H4U1 [UniParc]. Last modified January 11, 2011. Version 1. Checksum: F9E10EC284532521	FASTA	449	46,763
	10 20 30 40 50 60 MSLSAEHHLA HQHSEELFER SRSVIPGGVN SPVRAFNSVG GTPAFVDRAS GPYIYDADGN 70 80 90 100 110 120 EYVDLVCSWG PAILGHAHPQ VVAAVQEAAS RGLSFGAASA PEAELAELVV DRINTAIPGA 130 140 150 160 170 180 IEQVRMVSTG TEATMTAIRL ARGITGRDKI IKFSGCYHGH VDALLSEAGS GVATLALPGS 190 200 210 220 230 240 AGVTAATASE TIVLPYNDLD AVREAFAAHP GEIAAVITEA APCNMGVVTP EPGFNRGLRE 250 260 270 280 290 300 ITQSNNALLI FDEVLTGFRV SSAGYWGKFA PEDNGWVPDI FTFGKVIGGG MPIAALAGKR 310 320 330 340 350 360 EVMEYLAPTG PVYQAGTLSG NPLSVASGIT TLKLADDALY RTLDTRSEQL QAALTQALTD 370 380 390 400 410 420 AGVDHSIQTA GNLFSVAFGT GEHGVHNYAD IKGSATAKYT AFFHAMLDAG VYLPPSAFEA 430 440 WFLSGAHDDA AMERIIEALP GAARAAAKA

References

[1]

"The complete genome of Rothia dentocariosa ATCC 17931." Muzny D., Qin X., Buhay C., Dugan-Rocha S., Ding Y., Chen G., Hawes A., Holder M., Jhangiani S., Johnson A., Khan Z., Li Z., Liu W., Liu X., Perez L., Shen H., Wang Q., Watt J. , Xi L., Xin Y., Zhou J., Deng J., Jiang H., Liu Y., Qu J., Song X.-Z., Zhang L., Villasana D., Johnson A., Liu J., Liyanage D., Lorensuhewa L., Robinson T., Song A., Song B.-B., Dinh H., Thornton R., Coyle M., Francisco L., Jackson L., Javaid M., Korchina V., Kovar C., Mata R., Mathew T., Ngo R., Nguyen L., Nguyen N., Okwuonu G., Ongeri F., Pham C., Simmons D., Wilczek-Boney K., Hale W., Jakkamsetti A., Pham P., Ruth R., San Lucas F., Warren J., Zhang J., Zhao Z., Zhou C., Zhu D., Lee S., Bess C., Blankenburg K., Forbes L., Fu Q., Gubbala S., Hirani K., Jayaseelan J.C., Lara F., Munidasa M., Palculict T., Patil S., Pu L.-L., Saada N., Tang L., Weissenberger G., Zhu Y., Hemphill L., Shang Y., Youmans B., Ayvaz T., Ross M., Santibanez J., Aqrawi P., Gross S., Joshi V., Fowler G., Nazareth L., Reid J., Worley K., Petrosino J., Highlander S., Gibbs R. Submitted (OCT-2010) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 17931 / CDC X599 / XDIA.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP002280 Genomic DNA. Translation: ADP39560.1.
RefSeq	YP_003982994.1. NC_014643.1.
3D structure databases
ProteinModelPortal	E3H4U1.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ADP39560; ADP39560; HMPREF0733_10102.
GeneID	9901354.
KEGG	rdn:HMPREF0733_10102.
PATRIC	42675082. VBIRotDen160907_0105.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HOG000020210.
KO	K01845.
OMA	SSAGYWG.
Enzyme and pathway databases
BioCyc	RDEN762948:GHPW-104-MONOMER.
UniPathway	UPA00251; UER00317. UPA00668.
Family and domain databases
Gene3D	3.40.640.10. 1 hit. 3.90.1150.10. 2 hits.
HAMAP	MF_00375. HemL_aminotrans_3.
InterPro	IPR004639. 4pyrrol_synth_GluAld_NH2Trfase. IPR005814. Aminotrans_3. IPR015424. PyrdxlP-dep_Trfase. IPR015421. PyrdxlP-dep_Trfase_major_sub1. IPR015422. PyrdxlP-dep_Trfase_major_sub2. [Graphical view]
PANTHER	PTHR11986. PTHR11986. 1 hit. PTHR11986:SF5. PTHR11986:SF5. 1 hit.
Pfam	PF00202. Aminotran_3. 1 hit. [Graphical view]
SUPFAM	SSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
TIGRFAMs	TIGR00713. hemL. 1 hit.
ProtoNet	Search...

Entry information

Entry name

E3H4U1_ROTDC

Accession

Primary (citable) accession number: E3H4U1

Entry history

Integrated into UniProtKB/TrEMBL:	January 11, 2011
Last sequence update:	January 11, 2011
Last modified:	May 1, 2013
This is version 22 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)