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E3GW42

- HPRT_METFV

UniProt

E3GW42 - HPRT_METFV

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Protein

Hypoxanthine/guanine phosphoribosyltransferase

Gene

hpt

Organism
Methanothermus fervidus (strain ATCC 43054 / DSM 2088 / JCM 10308 / V24 S)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis.UniRule annotation

Catalytic activityi

IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation
GMP + diphosphate = guanine + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. guanine phosphoribosyltransferase activity Source: UniProtKB-EC
  2. hypoxanthine phosphoribosyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. IMP salvage Source: UniProtKB-UniPathway
  2. purine ribonucleoside salvage Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Purine salvage

Enzyme and pathway databases

BioCyciMFER523846:GC24-1049-MONOMER.
UniPathwayiUPA00591; UER00648.

Names & Taxonomyi

Protein namesi
Recommended name:
Hypoxanthine/guanine phosphoribosyltransferaseUniRule annotation (EC:2.4.2.8UniRule annotation)
Short name:
HGPRTaseUniRule annotation
Gene namesi
Name:hptUniRule annotation
Ordered Locus Names:Mfer_1012
OrganismiMethanothermus fervidus (strain ATCC 43054 / DSM 2088 / JCM 10308 / V24 S)
Taxonomic identifieri523846 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanothermaceaeMethanothermus
ProteomesiUP000002315: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 189189Hypoxanthine/guanine phosphoribosyltransferasePRO_0000415486Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliE3GW42.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000228520.
KOiK00759.
OMAiIATDIPY.

Family and domain databases

Gene3Di3.40.50.2020. 1 hit.
HAMAPiMF_01467. Hypx_phosphoribosyltr.
InterProiIPR026597. HGPRTase-like.
IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
[Graphical view]
PfamiPF00156. Pribosyltran. 1 hit.
[Graphical view]
SUPFAMiSSF53271. SSF53271. 1 hit.
PROSITEiPS00103. PUR_PYR_PR_TRANSFER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E3GW42-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLEKLKSTLE KSPVIKKGEY HYFVSPVTDG IPLTEPNLLM EIVDAIEKKF
60 70 80 90 100
DLEDIDKIVC IEAMGIHLAT ALSIKTGIPF VVIRKKKYGL PGEVEIRQVT
110 120 130 140 150
GYGESNLYVN GVNSGDKILV IDDVVSTGGT LISVINALKK ISADIKYVIA
160 170 180
VVEKGEGRKK VEKETGTKVN TLVKVDVIDG EVKIINNEV
Length:189
Mass (Da):20,682
Last modified:January 11, 2011 - v1
Checksum:iAB7727B9E1A94047
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002278 Genomic DNA. Translation: ADP77807.1.
RefSeqiYP_004004569.1. NC_014658.1.

Genome annotation databases

EnsemblBacteriaiADP77807; ADP77807; Mfer_1012.
GeneIDi9962750.
KEGGimfv:Mfer_1012.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002278 Genomic DNA. Translation: ADP77807.1 .
RefSeqi YP_004004569.1. NC_014658.1.

3D structure databases

ProteinModelPortali E3GW42.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADP77807 ; ADP77807 ; Mfer_1012 .
GeneIDi 9962750.
KEGGi mfv:Mfer_1012.

Phylogenomic databases

HOGENOMi HOG000228520.
KOi K00759.
OMAi IATDIPY.

Enzyme and pathway databases

UniPathwayi UPA00591 ; UER00648 .
BioCyci MFER523846:GC24-1049-MONOMER.

Family and domain databases

Gene3Di 3.40.50.2020. 1 hit.
HAMAPi MF_01467. Hypx_phosphoribosyltr.
InterProi IPR026597. HGPRTase-like.
IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
[Graphical view ]
Pfami PF00156. Pribosyltran. 1 hit.
[Graphical view ]
SUPFAMi SSF53271. SSF53271. 1 hit.
PROSITEi PS00103. PUR_PYR_PR_TRANSFER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43054 / DSM 2088 / JCM 10308 / V24 S.

Entry informationi

Entry nameiHPRT_METFV
AccessioniPrimary (citable) accession number: E3GW42
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 22, 2012
Last sequence update: January 11, 2011
Last modified: October 29, 2014
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3