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E3GW42 (HPRT_METFV) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 24. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hypoxanthine/guanine phosphoribosyltransferase

Short name=HGPRTase
EC=2.4.2.8
Gene names
Name:hpt
Ordered Locus Names:Mfer_1012
OrganismMethanothermus fervidus (strain ATCC 43054 / DSM 2088 / JCM 10308 / V24 S) [Complete proteome] [HAMAP]
Taxonomic identifier523846 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanothermaceaeMethanothermus

Protein attributes

Sequence length189 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis By similarity. HAMAP-Rule MF_01467

Catalytic activity

IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP-Rule MF_01467

GMP + diphosphate = guanine + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP-Rule MF_01467

Pathway

Purine metabolism; IMP biosynthesis via salvage pathway; IMP from hypoxanthine: step 1/1. HAMAP-Rule MF_01467

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_01467

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_01467.

Sequence similarities

Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily.

Ontologies

Keywords
   Biological processPurine salvage
   Cellular componentCytoplasm
   Molecular functionGlycosyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processIMP salvage

Inferred from electronic annotation. Source: UniProtKB-UniPathway

purine ribonucleoside salvage

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionguanine phosphoribosyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

hypoxanthine phosphoribosyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 189189Hypoxanthine/guanine phosphoribosyltransferase HAMAP-Rule MF_01467
PRO_0000415486

Sequences

Sequence LengthMass (Da)Tools
E3GW42 [UniParc].

Last modified January 11, 2011. Version 1.
Checksum: AB7727B9E1A94047

FASTA18920,682
        10         20         30         40         50         60 
MLEKLKSTLE KSPVIKKGEY HYFVSPVTDG IPLTEPNLLM EIVDAIEKKF DLEDIDKIVC 

        70         80         90        100        110        120 
IEAMGIHLAT ALSIKTGIPF VVIRKKKYGL PGEVEIRQVT GYGESNLYVN GVNSGDKILV 

       130        140        150        160        170        180 
IDDVVSTGGT LISVINALKK ISADIKYVIA VVEKGEGRKK VEKETGTKVN TLVKVDVIDG 


EVKIINNEV 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP002278 Genomic DNA. Translation: ADP77807.1.
RefSeqYP_004004569.1. NC_014658.1.

3D structure databases

ProteinModelPortalE3GW42.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADP77807; ADP77807; Mfer_1012.
GeneID9962750.
KEGGmfv:Mfer_1012.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000228520.
KOK00759.
OMAIATDIPY.

Enzyme and pathway databases

BioCycMFER523846:GC24-1049-MONOMER.
UniPathwayUPA00591; UER00648.

Family and domain databases

Gene3D3.40.50.2020. 1 hit.
HAMAPMF_01467. Hypx_phosphoribosyltr.
InterProIPR026597. HGPRTase-like.
IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
[Graphical view]
PfamPF00156. Pribosyltran. 1 hit.
[Graphical view]
SUPFAMSSF53271. SSF53271. 1 hit.
PROSITEPS00103. PUR_PYR_PR_TRANSFER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHPRT_METFV
AccessionPrimary (citable) accession number: E3GW42
Entry history
Integrated into UniProtKB/Swiss-Prot: February 22, 2012
Last sequence update: January 11, 2011
Last modified: July 9, 2014
This is version 24 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways