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Protein

Alanine racemase

Gene

alr

Organism
Haemophilus influenzae (strain R2846 / 12)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei36 – 361Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei132 – 1321SubstrateUniRule annotation
Active sitei256 – 2561Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei304 – 3041Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciHINF262727:GLDQ-1051-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alrImported
Ordered Locus Names:R2846_1051Imported
OrganismiHaemophilus influenzae (strain R2846 / 12)Imported
Taxonomic identifieri262727 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000006874: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei36 – 361N6-(pyridoxal phosphate)lysineUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliE3GV15.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

KOiK01775.
OMAiPSDWVRP.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E3GV15-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNVKPATSKI SSHALKQNLE IIKQKALNSK IIAVVKANAY GHGVVFVAST
60 70 80 90 100
LEQNVDCFGV ARLEEALALR SNGITKPILL LEGFFNEQDL PILAVNNIET
110 120 130 140 150
VVHNHEQLEA LKRSNLPSPI KVWLKIDTGM HRLGVALDEV DYFYQELKKL
160 170 180 190 200
PQIQPHLGFV SHFSRADELE SDYTQLQINR FLSATKDKQG ERTIAASGGI
210 220 230 240 250
LFWPKSHLEC IRPGIIMYGI SPTDTIGKEF GLTPVMNLTS SLIAVRHHKQ
260 270 280 290 300
GDPVGYGGIW TSPRDTKIGV VAMGYGDGYP RDVPEGTPVY LNGRLVPIVG
310 320 330 340 350
RVSMDMLTVD LGADSQDLVG DEVILWGKEL PIETVAKFTG ILSYELITKL
360
TPRVITEYVD
Length:360
Mass (Da):39,739
Last modified:January 11, 2011 - v1
Checksum:i7CA65E21D4419B9A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002276 Genomic DNA. Translation: ADO96449.1.
RefSeqiWP_014550843.1. NC_017452.1.
YP_005829504.1. NC_017452.1.

Genome annotation databases

EnsemblBacteriaiADO96449; ADO96449; R2846_1051.
GeneIDi12597729.
KEGGihie:R2846_1051.
PATRICi43043567. VBIHaeInf30952_1054.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002276 Genomic DNA. Translation: ADO96449.1.
RefSeqiWP_014550843.1. NC_017452.1.
YP_005829504.1. NC_017452.1.

3D structure databases

ProteinModelPortaliE3GV15.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADO96449; ADO96449; R2846_1051.
GeneIDi12597729.
KEGGihie:R2846_1051.
PATRICi43043567. VBIHaeInf30952_1054.

Phylogenomic databases

KOiK01775.
OMAiPSDWVRP.

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.
BioCyciHINF262727:GLDQ-1051-MONOMER.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the middle ear isolate Haemophilus influenzae R2846."
    VanWagoner T.M., Erwin A.L., Kaul R., Mahaffey M., Zhou Y., Aggarwal G., Chang J., Deng H., Gillett W., Haugen E., Kibukawa M., Phelps K., Saenphimma C., Sivam D., Worthy E.A., Olson M.V., Stull T.L., Smith A.L.
    Submitted (OCT-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: R2846 / 12Imported.

Entry informationi

Entry nameiE3GV15_HAEI2
AccessioniPrimary (citable) accession number: E3GV15
Entry historyi
Integrated into UniProtKB/TrEMBL: January 11, 2011
Last sequence update: January 11, 2011
Last modified: March 4, 2015
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.