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Protein

Coenzyme A biosynthesis bifunctional protein CoaBC

Gene

ELI_2256

Organism
Eubacterium limosum (strain KIST612)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.UniRule annotation

Catalytic activityi

CTP + (R)-4'-phosphopantothenate + L-cysteine = CMP + diphosphate + N-((R)-4'-phosphopantothenoyl)-L-cysteine.UniRule annotation
N-((R)-4'-phosphopantothenoyl)-L-cysteine = pantotheine 4'-phosphate + CO2.UniRule annotation

Cofactori

FMNUniRule annotation

Pathwayi: coenzyme A biosynthesis

This protein is involved in step 2 and 3 of the subpathway that synthesizes CoA from (R)-pantothenate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Type III pantothenate kinase (coaX)
  2. Coenzyme A biosynthesis bifunctional protein CoaBC (ELI_2256)
  3. Coenzyme A biosynthesis bifunctional protein CoaBC (ELI_2256)
  4. Phosphopantetheine adenylyltransferase (coaD)
  5. Dephospho-CoA kinase (coaE)
This subpathway is part of the pathway coenzyme A biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CoA from (R)-pantothenate, the pathway coenzyme A biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDecarboxylaseUniRule annotation, LigaseUniRule annotationImported, Lyase
LigandFlavoprotein, FMNUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00241; UER00353.
UPA00241; UER00354.

Names & Taxonomyi

Protein namesi
Recommended name:
Coenzyme A biosynthesis bifunctional protein CoaBCUniRule annotation (EC:4.1.1.36UniRule annotation, EC:6.3.2.5UniRule annotation)
Alternative name(s):
DNA/pantothenate metabolism flavoproteinUniRule annotation
Gene namesi
Ordered Locus Names:ELI_2256Imported
OrganismiEubacterium limosum (strain KIST612)Imported
Taxonomic identifieri903814 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesEubacteriaceaeEubacterium
Proteomesi
  • UP000006873 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi903814.ELI_2256.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 178FlavoproteinInterPro annotationAdd BLAST173
Domaini186 – 369DFPInterPro annotationAdd BLAST184

Sequence similaritiesi

In the C-terminal section; belongs to the PPC synthetase family.UniRule annotation
In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CJS. Bacteria.
COG0452. LUCA.
HOGENOMiHOG000037525.
KOiK13038.
OMAiVRFIGNH.
OrthoDBiPOG091H021V.

Family and domain databases

Gene3Di3.40.50.10300. 1 hit.
3.40.50.1950. 1 hit.
InterProiView protein in InterPro
IPR005252. CoaBC.
IPR007085. DNA/pantothenate-metab_flavo_C.
IPR003382. Flavoprotein.
PfamiView protein in Pfam
PF04127. DFP. 1 hit.
PF02441. Flavoprotein. 1 hit.
SUPFAMiSSF102645. SSF102645. 1 hit.
SSF52507. SSF52507. 1 hit.
TIGRFAMsiTIGR00521. coaBC_dfp. 1 hit.

Sequencei

Sequence statusi: Complete.

E3GMW7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLKNKTVIL GVSGSIAAYK MANVASTLAK WGCDVHVIMT PNATEIIAPM
60 70 80 90 100
TFSTLTGNNC IVDTFDKNIN YNVAHVSLAK RADLLMIAPA TANVLAKLAH
110 120 130 140 150
GLADDMLTTT ALACTCKKIV SPAMNTNMFH NPVVQDNLDI LRKYNFEIVQ
160 170 180 190 200
PDSGVLACKD IGDGKLPKEE VLIDHILKEI AFEKDLAGKK VLITAGPTCE
210 220 230 240 250
AIDPVRYITN HSSGKMGYAL ARNAMLRGAE VTLVSGPTAL PPVPFVNMVD
260 270 280 290 300
IVSAKDMFEA VTSRSEQQDI IIKAAAVADY TPSDYSDEKV KKKEGAMNIA
310 320 330 340 350
LNRTQDILAW LGANRRPGQF LCGFSMETQN LLENSQAKLI RKNVDMMIAN
360 370 380 390
NLKVEGAGFS GDTNVVTVIT KDRATELPKQ TKENVAGQIL DTILECLP
Length:398
Mass (Da):43,053
Last modified:January 11, 2011 - v1
Checksum:i6A9F036DE4CD8AF9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002273 Genomic DNA. Translation: ADO37239.1.
RefSeqiWP_013380560.1. NC_014624.2.

Genome annotation databases

EnsemblBacteriaiADO37239; ADO37239; ELI_2256.
KEGGielm:ELI_2256.

Similar proteinsi

Entry informationi

Entry nameiE3GMW7_EUBLK
AccessioniPrimary (citable) accession number: E3GMW7
Entry historyiIntegrated into UniProtKB/TrEMBL: January 11, 2011
Last sequence update: January 11, 2011
Last modified: September 27, 2017
This is version 36 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported