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Protein

Glutamate decarboxylase

Gene

ELI_0972

Organism
Eubacterium limosum (strain KIST612)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

L-glutamate = 4-aminobutanoate + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

  1. glutamate decarboxylase activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glutamate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

DecarboxylaseUniRule annotation, Lyase

Keywords - Ligandi

Pyridoxal phosphateUniRule annotation

Enzyme and pathway databases

BioCyciELIM903814:GH0C-970-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate decarboxylaseUniRule annotation (EC:4.1.1.15UniRule annotation)
Gene namesi
Ordered Locus Names:ELI_0972Imported
OrganismiEubacterium limosum (strain KIST612)Imported
Taxonomic identifieri903814 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesEubacteriaceaeEubacterium
ProteomesiUP000006873 Componenti: Chromosome

Family & Domainsi

Sequence similaritiesi

Belongs to the group II decarboxylase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000070228.
KOiK01580.
OMAiDPDLVWD.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11999:SF1. PTHR11999:SF1. 1 hit.
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.

Sequencei

Sequence statusi: Complete.

E3GJR7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLYSKDDQDK LKDRYLTPIF GTEASDEPLP KYKLRKDPVE PEVAYRLIKD
60 70 80 90 100
DLLDEGSARL NLSTFCQTYM EPEATKIMAE TLEKNAIDKS EYPQTTELEN
110 120 130 140 150
RCVNMIADLW HAPDDEKFLG TSTVGSSEAC MLGGMAMKFR WRNNAIKQGL
160 170 180 190 200
DVKAKKPNLV ISSGYQVCWE KFCVYWDIEM RLVPLDEQHM SMNMDTVMDF
210 220 230 240 250
VDEYTIGIVG IMGITYTGKF DDIKALDTLV EDYNQKNPKF PIYIHVDGAS
260 270 280 290 300
GGMFAPFIEP DLEWDFRLKN VVSINTSGHK YGLVYPGIGW VLWRDEKWLP
310 320 330 340 350
KELIFSVSYL GGSLPTMAIN FSRSASQIIG QYYNFLRYGY EGYKKIHERT
360 370 380 390 400
RDVAMYISKE LEKTGLFEIY NDGSNLPIVC WKMKKDANKE WNLYDLADRI
410 420 430 440 450
RMKGWQVPAY PLPENLQDDI IQRVVVRADL SEQLGVLLME DMNRAIKELD
460 470
EAHILPHGGD QVNNKGVYGF TH
Length:472
Mass (Da):54,332
Last modified:January 10, 2011 - v1
Checksum:i9A32576151576E1E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002273 Genomic DNA. Translation: ADO35975.1.
RefSeqiYP_003958938.1. NC_014624.2.

Genome annotation databases

EnsemblBacteriaiADO35975; ADO35975; ELI_0972.
KEGGielm:ELI_0972.
PATRICi42605073. VBIEubLim172772_0910.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002273 Genomic DNA. Translation: ADO35975.1.
RefSeqiYP_003958938.1. NC_014624.2.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADO35975; ADO35975; ELI_0972.
KEGGielm:ELI_0972.
PATRICi42605073. VBIEubLim172772_0910.

Phylogenomic databases

HOGENOMiHOG000070228.
KOiK01580.
OMAiDPDLVWD.

Enzyme and pathway databases

BioCyciELIM903814:GH0C-970-MONOMER.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11999:SF1. PTHR11999:SF1. 1 hit.
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Eubacterium limosum (strain KIST612)."
    Roh H., Ko H.-J., Kim D., Choi D.G., Park S., Kim S., Kim K.H., Chang I.S., Choi I.-G.
    Submitted (AUG-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KIST612Imported.
  2. Roh H., Ko H.-J., Kim D., Choi D.G., Park S., Kim S., Kim K.H., Chang I.S., Choi I.-G.
    Submitted (AUG-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: KIST612.

Entry informationi

Entry nameiE3GJR7_EUBLK
AccessioniPrimary (citable) accession number: E3GJR7
Entry historyi
Integrated into UniProtKB/TrEMBL: January 10, 2011
Last sequence update: January 10, 2011
Last modified: March 31, 2015
This is version 24 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.