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E3GCF1

- CPDA_ENTLS

UniProt

E3GCF1 - CPDA_ENTLS

Protein

3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA

Gene

cpdA

Organism
Enterobacter lignolyticus (strain SCF1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 27 (01 Oct 2014)
      Sequence version 1 (11 Jan 2011)
      Previous versions | rss
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    Functioni

    Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes.UniRule annotation

    Catalytic activityi

    Adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate.UniRule annotation

    Cofactori

    Binds 2 metal cations per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi8 – 81Metal cation 1UniRule annotation
    Metal bindingi10 – 101Metal cation 1UniRule annotation
    Binding sitei10 – 101cAMPUniRule annotation
    Metal bindingi50 – 501Metal cation 1UniRule annotation
    Metal bindingi50 – 501Metal cation 2UniRule annotation
    Binding sitei50 – 501cAMPUniRule annotation
    Metal bindingi80 – 801Metal cation 2UniRule annotation
    Metal bindingi156 – 1561Metal cation 2UniRule annotation
    Metal bindingi195 – 1951Metal cation 2UniRule annotation
    Metal bindingi197 – 1971Metal cation 1UniRule annotation
    Binding sitei197 – 1971cAMPUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi80 – 812cAMPUniRule annotation

    GO - Molecular functioni

    1. 3',5'-cyclic-AMP phosphodiesterase activity Source: UniProtKB-HAMAP
    2. metal ion binding Source: UniProtKB-HAMAP
    3. nucleotide binding Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    cAMP, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciECLO701347:GH9V-3960-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    3',5'-cyclic adenosine monophosphate phosphodiesterase CpdAUniRule annotation (EC:3.1.4.17UniRule annotation)
    Short name:
    3',5'-cyclic AMP phosphodiesteraseUniRule annotation
    Short name:
    cAMP phosphodiesteraseUniRule annotation
    Gene namesi
    Name:cpdAUniRule annotation
    Ordered Locus Names:Entcl_3882
    OrganismiEnterobacter lignolyticus (strain SCF1)
    Taxonomic identifieri701347 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEnterobacterEnterobacter cloacae complex
    ProteomesiUP000006872: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 2782783',5'-cyclic adenosine monophosphate phosphodiesterase CpdAPRO_0000413367Add
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cAMP phosphodiesterase class-III family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000238352.

    Family and domain databases

    Gene3Di3.60.21.10. 1 hit.
    HAMAPiMF_00905. cAMP_phophodiest_CpdA.
    InterProiIPR004843. Calcineurin-like_PHP_apaH.
    IPR026575. cAMP_Pdiest_CpdA.
    IPR029052. Metallo-depent_PP-like.
    [Graphical view]
    PfamiPF00149. Metallophos. 1 hit.
    [Graphical view]
    SUPFAMiSSF56300. SSF56300. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    E3GCF1-1 [UniParc]FASTAAdd to Basket

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    MLLAHISDTH FRSQNHKLYG FIDVNAGNAD VVSQLNGLRE RPDAVVVSGD    50
    IVNCGRPEEY QVARQVLGAL RYPLLLIPGN HDDKACFLEY LRPLCPQLGS 100
    DPQNMRYAID DFATRLLFID SSLAGHAKGW LTDNTVAWLE AQLSDAGDKP 150
    TAVFMHHPPL PLGNAQMDPI ACENGHRLLA LVERFPSLVR IFCGHNHNLT 200
    MTQYRQATIA TLPATVHQVP YCHEDTRPYY DMSPPSCLMH RQVGEQWVSY 250
    QHSLAHYAGP WLYDEHISCP TDERRSPC 278
    Length:278
    Mass (Da):31,308
    Last modified:January 11, 2011 - v1
    Checksum:iCFF0D7D4DDB3AF10
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002272 Genomic DNA. Translation: ADO50122.1.
    RefSeqiYP_003943406.1. NC_014618.1.

    Genome annotation databases

    EnsemblBacteriaiADO50122; ADO50122; Entcl_3882.
    GeneIDi9908964.
    KEGGiesc:Entcl_3882.
    PATRICi42602022. VBIEntClo171306_3959.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002272 Genomic DNA. Translation: ADO50122.1 .
    RefSeqi YP_003943406.1. NC_014618.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADO50122 ; ADO50122 ; Entcl_3882 .
    GeneIDi 9908964.
    KEGGi esc:Entcl_3882.
    PATRICi 42602022. VBIEntClo171306_3959.

    Phylogenomic databases

    HOGENOMi HOG000238352.

    Enzyme and pathway databases

    BioCyci ECLO701347:GH9V-3960-MONOMER.

    Family and domain databases

    Gene3Di 3.60.21.10. 1 hit.
    HAMAPi MF_00905. cAMP_phophodiest_CpdA.
    InterProi IPR004843. Calcineurin-like_PHP_apaH.
    IPR026575. cAMP_Pdiest_CpdA.
    IPR029052. Metallo-depent_PP-like.
    [Graphical view ]
    Pfami PF00149. Metallophos. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56300. SSF56300. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SCF1.

    Entry informationi

    Entry nameiCPDA_ENTLS
    AccessioniPrimary (citable) accession number: E3GCF1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 19, 2011
    Last sequence update: January 11, 2011
    Last modified: October 1, 2014
    This is version 27 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3