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Protein

3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA

Gene

cpdA

Organism
Enterobacter lignolyticus (strain SCF1)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes.UniRule annotation

Catalytic activityi

Adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate.UniRule annotation

Cofactori

a metal cationUniRule annotationNote: Binds 2 metal cations per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi8 – 81Metal cation 1UniRule annotation
Metal bindingi10 – 101Metal cation 1UniRule annotation
Binding sitei10 – 101cAMPUniRule annotation
Metal bindingi50 – 501Metal cation 1UniRule annotation
Metal bindingi50 – 501Metal cation 2UniRule annotation
Binding sitei50 – 501cAMPUniRule annotation
Metal bindingi80 – 801Metal cation 2UniRule annotation
Metal bindingi156 – 1561Metal cation 2UniRule annotation
Metal bindingi195 – 1951Metal cation 2UniRule annotation
Metal bindingi197 – 1971Metal cation 1UniRule annotation
Binding sitei197 – 1971cAMPUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi80 – 812cAMPUniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

cAMP, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciECLO701347:GH9V-3960-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
3',5'-cyclic adenosine monophosphate phosphodiesterase CpdAUniRule annotation (EC:3.1.4.17UniRule annotation)
Short name:
3',5'-cyclic AMP phosphodiesteraseUniRule annotation
Short name:
cAMP phosphodiesteraseUniRule annotation
Gene namesi
Name:cpdAUniRule annotation
Ordered Locus Names:Entcl_3882
OrganismiEnterobacter lignolyticus (strain SCF1)
Taxonomic identifieri701347 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEnterobacterEnterobacter cloacae complex
ProteomesiUP000006872 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2782783',5'-cyclic adenosine monophosphate phosphodiesterase CpdAPRO_0000413367Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi701347.Entcl_3882.

Family & Domainsi

Sequence similaritiesi

Belongs to the cAMP phosphodiesterase class-III family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000238352.
OMAiTAVFMHH.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
HAMAPiMF_00905. cAMP_phophodiest_CpdA.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR026575. cAMP_Pdiest_CpdA.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.

Sequencei

Sequence statusi: Complete.

E3GCF1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLAHISDTH FRSQNHKLYG FIDVNAGNAD VVSQLNGLRE RPDAVVVSGD
60 70 80 90 100
IVNCGRPEEY QVARQVLGAL RYPLLLIPGN HDDKACFLEY LRPLCPQLGS
110 120 130 140 150
DPQNMRYAID DFATRLLFID SSLAGHAKGW LTDNTVAWLE AQLSDAGDKP
160 170 180 190 200
TAVFMHHPPL PLGNAQMDPI ACENGHRLLA LVERFPSLVR IFCGHNHNLT
210 220 230 240 250
MTQYRQATIA TLPATVHQVP YCHEDTRPYY DMSPPSCLMH RQVGEQWVSY
260 270
QHSLAHYAGP WLYDEHISCP TDERRSPC
Length:278
Mass (Da):31,308
Last modified:January 11, 2011 - v1
Checksum:iCFF0D7D4DDB3AF10
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002272 Genomic DNA. Translation: ADO50122.1.
RefSeqiWP_013367845.1. NC_014618.1.
YP_003943406.1. NC_014618.1.

Genome annotation databases

EnsemblBacteriaiADO50122; ADO50122; Entcl_3882.
KEGGiesc:Entcl_3882.
PATRICi42602022. VBIEntClo171306_3959.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002272 Genomic DNA. Translation: ADO50122.1.
RefSeqiWP_013367845.1. NC_014618.1.
YP_003943406.1. NC_014618.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi701347.Entcl_3882.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADO50122; ADO50122; Entcl_3882.
KEGGiesc:Entcl_3882.
PATRICi42602022. VBIEntClo171306_3959.

Phylogenomic databases

HOGENOMiHOG000238352.
OMAiTAVFMHH.

Enzyme and pathway databases

BioCyciECLO701347:GH9V-3960-MONOMER.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
HAMAPiMF_00905. cAMP_phophodiest_CpdA.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR026575. cAMP_Pdiest_CpdA.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SCF1.

Entry informationi

Entry nameiCPDA_ENTLS
AccessioniPrimary (citable) accession number: E3GCF1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2011
Last sequence update: January 11, 2011
Last modified: June 24, 2015
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.