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E3GCF1 (CPDA_ENTLS) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 24. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA

Short name=3',5'-cyclic AMP phosphodiesterase
Short name=cAMP phosphodiesterase
EC=3.1.4.17
Gene names
Name:cpdA
Ordered Locus Names:Entcl_3882
OrganismEnterobacter lignolyticus (strain SCF1) [Complete proteome] [HAMAP]
Taxonomic identifier701347 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEnterobacterEnterobacter cloacae complex

Protein attributes

Sequence length278 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes By similarity. HAMAP-Rule MF_00905

Catalytic activity

Adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate. HAMAP-Rule MF_00905

Cofactor

Binds 2 metal cations per subunit By similarity. HAMAP-Rule MF_00905

Sequence similarities

Belongs to the cAMP phosphodiesterase class-III family.

Ontologies

Keywords
   LigandcAMP
Metal-binding
Nucleotide-binding
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular_function3',5'-cyclic-AMP phosphodiesterase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

nucleotide binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 2782783',5'-cyclic adenosine monophosphate phosphodiesterase CpdA HAMAP-Rule MF_00905
PRO_0000413367

Regions

Nucleotide binding80 – 812cAMP By similarity

Sites

Metal binding81Metal cation 1 By similarity
Metal binding101Metal cation 1 By similarity
Metal binding501Metal cation 1 By similarity
Metal binding501Metal cation 2 By similarity
Metal binding801Metal cation 2 By similarity
Metal binding1561Metal cation 2 By similarity
Metal binding1951Metal cation 2 By similarity
Metal binding1971Metal cation 1 By similarity
Binding site101cAMP By similarity
Binding site501cAMP By similarity
Binding site1971cAMP By similarity

Sequences

Sequence LengthMass (Da)Tools
E3GCF1 [UniParc].

Last modified January 11, 2011. Version 1.
Checksum: CFF0D7D4DDB3AF10

FASTA27831,308
        10         20         30         40         50         60 
MLLAHISDTH FRSQNHKLYG FIDVNAGNAD VVSQLNGLRE RPDAVVVSGD IVNCGRPEEY 

        70         80         90        100        110        120 
QVARQVLGAL RYPLLLIPGN HDDKACFLEY LRPLCPQLGS DPQNMRYAID DFATRLLFID 

       130        140        150        160        170        180 
SSLAGHAKGW LTDNTVAWLE AQLSDAGDKP TAVFMHHPPL PLGNAQMDPI ACENGHRLLA 

       190        200        210        220        230        240 
LVERFPSLVR IFCGHNHNLT MTQYRQATIA TLPATVHQVP YCHEDTRPYY DMSPPSCLMH 

       250        260        270 
RQVGEQWVSY QHSLAHYAGP WLYDEHISCP TDERRSPC 

« Hide

References

[1]"Complete sequence of Enterobacter cloacae SCF1."
US DOE Joint Genome Institute
Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L., Pitluck S., Davenport K., Detter J.C., Han C., Tapia R., Land M., Hauser L., Chang Y.-J., Jeffries C., Kyrpides N., Ivanova N., Mikhailova N. expand/collapse author list , DeAngelis K., Arkin A.P., Chivian D., Edwards B., Woo H., Hazen T.C., Woyke T.
Submitted (OCT-2010) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SCF1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP002272 Genomic DNA. Translation: ADO50122.1.
RefSeqYP_003943406.1. NC_014618.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADO50122; ADO50122; Entcl_3882.
GeneID9908964.
KEGGesc:Entcl_3882.
PATRIC42602022. VBIEntClo171306_3959.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000238352.
OMAGDIVNCG.

Enzyme and pathway databases

BioCycECLO701347:GH9V-3960-MONOMER.

Family and domain databases

HAMAPMF_00905. cAMP_phophodiest_CpdA.
InterProIPR004843. Calcineurin-like_PHP_apaH.
IPR026575. cAMP_Pdiest_CpdA.
[Graphical view]
PfamPF00149. Metallophos. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCPDA_ENTLS
AccessionPrimary (citable) accession number: E3GCF1
Entry history
Integrated into UniProtKB/Swiss-Prot: October 19, 2011
Last sequence update: January 11, 2011
Last modified: April 16, 2014
This is version 24 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families