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E3GCF1

- CPDA_ENTLS

UniProt

E3GCF1 - CPDA_ENTLS

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Protein

3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA

Gene
cpdA, Entcl_3882
Organism
Enterobacter lignolyticus (strain SCF1)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes By similarity.UniRule annotation

Catalytic activityi

Adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate.UniRule annotation

Cofactori

Binds 2 metal cations per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi8 – 81Metal cation 1 By similarity
Metal bindingi10 – 101Metal cation 1 By similarity
Binding sitei10 – 101cAMP By similarity
Metal bindingi50 – 501Metal cation 1 By similarity
Metal bindingi50 – 501Metal cation 2 By similarity
Binding sitei50 – 501cAMP By similarity
Metal bindingi80 – 801Metal cation 2 By similarity
Metal bindingi156 – 1561Metal cation 2 By similarity
Metal bindingi195 – 1951Metal cation 2 By similarity
Metal bindingi197 – 1971Metal cation 1 By similarity
Binding sitei197 – 1971cAMP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi80 – 812cAMP By similarity

GO - Molecular functioni

  1. 3',5'-cyclic-AMP phosphodiesterase activity Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-HAMAP
  3. nucleotide binding Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

cAMP, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciECLO701347:GH9V-3960-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA (EC:3.1.4.17)
Short name:
3',5'-cyclic AMP phosphodiesterase
Short name:
cAMP phosphodiesterase
Gene namesi
Name:cpdA
Ordered Locus Names:Entcl_3882
OrganismiEnterobacter lignolyticus (strain SCF1)
Taxonomic identifieri701347 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEnterobacterEnterobacter cloacae complex
ProteomesiUP000006872: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2782783',5'-cyclic adenosine monophosphate phosphodiesterase CpdAUniRule annotationPRO_0000413367Add
BLAST

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000238352.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
HAMAPiMF_00905. cAMP_phophodiest_CpdA.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR026575. cAMP_Pdiest_CpdA.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.

Sequencei

Sequence statusi: Complete.

E3GCF1-1 [UniParc]FASTAAdd to Basket

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MLLAHISDTH FRSQNHKLYG FIDVNAGNAD VVSQLNGLRE RPDAVVVSGD    50
IVNCGRPEEY QVARQVLGAL RYPLLLIPGN HDDKACFLEY LRPLCPQLGS 100
DPQNMRYAID DFATRLLFID SSLAGHAKGW LTDNTVAWLE AQLSDAGDKP 150
TAVFMHHPPL PLGNAQMDPI ACENGHRLLA LVERFPSLVR IFCGHNHNLT 200
MTQYRQATIA TLPATVHQVP YCHEDTRPYY DMSPPSCLMH RQVGEQWVSY 250
QHSLAHYAGP WLYDEHISCP TDERRSPC 278
Length:278
Mass (Da):31,308
Last modified:January 11, 2011 - v1
Checksum:iCFF0D7D4DDB3AF10
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002272 Genomic DNA. Translation: ADO50122.1.
RefSeqiYP_003943406.1. NC_014618.1.

Genome annotation databases

EnsemblBacteriaiADO50122; ADO50122; Entcl_3882.
GeneIDi9908964.
KEGGiesc:Entcl_3882.
PATRICi42602022. VBIEntClo171306_3959.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002272 Genomic DNA. Translation: ADO50122.1 .
RefSeqi YP_003943406.1. NC_014618.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADO50122 ; ADO50122 ; Entcl_3882 .
GeneIDi 9908964.
KEGGi esc:Entcl_3882.
PATRICi 42602022. VBIEntClo171306_3959.

Phylogenomic databases

HOGENOMi HOG000238352.

Enzyme and pathway databases

BioCyci ECLO701347:GH9V-3960-MONOMER.

Family and domain databases

Gene3Di 3.60.21.10. 1 hit.
HAMAPi MF_00905. cAMP_phophodiest_CpdA.
InterProi IPR004843. Calcineurin-like_PHP_apaH.
IPR026575. cAMP_Pdiest_CpdA.
IPR029052. Metallo-depent_PP-like.
[Graphical view ]
Pfami PF00149. Metallophos. 1 hit.
[Graphical view ]
SUPFAMi SSF56300. SSF56300. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SCF1.

Entry informationi

Entry nameiCPDA_ENTLS
AccessioniPrimary (citable) accession number: E3GCF1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2011
Last sequence update: January 11, 2011
Last modified: June 11, 2014
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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