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E3GBE3

- E3GBE3_ENTLS

UniProt

E3GBE3 - E3GBE3_ENTLS

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Protein

Isocitrate dehydrogenase [NADP]

Gene
Entcl_2658
Organism
Enterobacter lignolyticus (strain SCF1)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Binds 1 magnesium or manganese ion per subunit By similarity.UniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Biological processi

Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciECLO701347:GH9V-2707-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Ordered Locus Names:Entcl_2658Imported
OrganismiEnterobacter lignolyticus (strain SCF1)Imported
Taxonomic identifieri701347 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEnterobacterEnterobacter cloacae complex
ProteomesiUP000006872: Chromosome

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000021113.
KOiK00031.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E3GBE3-1 [UniParc]FASTAAdd to Basket

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MESKVVVPAE GQKITLQNGK LNVPHNPIIP FIEGDGIGVD VTPPMIKVVN    50
AAVEKAYKGE RKISWMEIYT GEKSTHVYGQ DVWLPAETLD LIREYRVAIK 100
GPLTTPVGGG IRSLNVALRQ ELDLYVCLRP VRYYQGTPSP VKHPELTDMV 150
IFRENAEDIY AGIEWKADSA DAEKVIKFLR EEMGVKKIRF PEHCGIGIKP 200
CSEEGTKRLV RAAIEYAIAN DRDSVTLVHK GNIMKFTEGA FKDWGYQLAR 250
EEFGGELIDG GPWQKIKNPR TGKEIIIKDV IADAFLQQIL LRPAEYDVIA 300
CMNLNGDYIS DALAAQVGGI GIAPGANIGD ECALFEATHG TAPKYAGQDK 350
VNPGSVILSA EMMLRHMEWF EAADLIVKGM EGAIAAKTVT YDFERLMDGA 400
KLLKCSEFGD AIIANM 416
Length:416
Mass (Da):45,842
Last modified:January 11, 2011 - v1
Checksum:i532FBD2754CBD125
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002272 Genomic DNA. Translation: ADO48906.1.
RefSeqiYP_003942190.1. NC_014618.1.

Genome annotation databases

EnsemblBacteriaiADO48906; ADO48906; Entcl_2658.
GeneIDi9907711.
KEGGiesc:Entcl_2658.
PATRICi42599467. VBIEntClo171306_2700.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002272 Genomic DNA. Translation: ADO48906.1 .
RefSeqi YP_003942190.1. NC_014618.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADO48906 ; ADO48906 ; Entcl_2658 .
GeneIDi 9907711.
KEGGi esc:Entcl_2658.
PATRICi 42599467. VBIEntClo171306_2700.

Phylogenomic databases

HOGENOMi HOG000021113.
KOi K00031.

Enzyme and pathway databases

BioCyci ECLO701347:GH9V-2707-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11835. PTHR11835. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00183. prok_nadp_idh. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SCF1.

Entry informationi

Entry nameiE3GBE3_ENTLS
AccessioniPrimary (citable) accession number: E3GBE3
Entry historyi
Integrated into UniProtKB/TrEMBL: January 11, 2011
Last sequence update: January 11, 2011
Last modified: May 14, 2014
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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