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E3GBE3

- E3GBE3_ENTLS

UniProt

E3GBE3 - E3GBE3_ENTLS

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Protein

Isocitrate dehydrogenase [NADP]

Gene

Entcl_2658

Organism
Enterobacter lignolyticus (strain SCF1)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Note: Binds 1 magnesium or manganese ion per subunit.

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Biological processi

Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciECLO701347:GH9V-2707-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Ordered Locus Names:Entcl_2658Imported
OrganismiEnterobacter lignolyticus (strain SCF1)Imported
Taxonomic identifieri701347 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEnterobacterEnterobacter cloacae complex
ProteomesiUP000006872: Chromosome

Family & Domainsi

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000021113.
KOiK00031.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E3GBE3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MESKVVVPAE GQKITLQNGK LNVPHNPIIP FIEGDGIGVD VTPPMIKVVN
60 70 80 90 100
AAVEKAYKGE RKISWMEIYT GEKSTHVYGQ DVWLPAETLD LIREYRVAIK
110 120 130 140 150
GPLTTPVGGG IRSLNVALRQ ELDLYVCLRP VRYYQGTPSP VKHPELTDMV
160 170 180 190 200
IFRENAEDIY AGIEWKADSA DAEKVIKFLR EEMGVKKIRF PEHCGIGIKP
210 220 230 240 250
CSEEGTKRLV RAAIEYAIAN DRDSVTLVHK GNIMKFTEGA FKDWGYQLAR
260 270 280 290 300
EEFGGELIDG GPWQKIKNPR TGKEIIIKDV IADAFLQQIL LRPAEYDVIA
310 320 330 340 350
CMNLNGDYIS DALAAQVGGI GIAPGANIGD ECALFEATHG TAPKYAGQDK
360 370 380 390 400
VNPGSVILSA EMMLRHMEWF EAADLIVKGM EGAIAAKTVT YDFERLMDGA
410
KLLKCSEFGD AIIANM
Length:416
Mass (Da):45,842
Last modified:January 11, 2011 - v1
Checksum:i532FBD2754CBD125
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002272 Genomic DNA. Translation: ADO48906.1.
RefSeqiYP_003942190.1. NC_014618.1.

Genome annotation databases

EnsemblBacteriaiADO48906; ADO48906; Entcl_2658.
GeneIDi9907711.
KEGGiesc:Entcl_2658.
PATRICi42599467. VBIEntClo171306_2700.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002272 Genomic DNA. Translation: ADO48906.1 .
RefSeqi YP_003942190.1. NC_014618.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADO48906 ; ADO48906 ; Entcl_2658 .
GeneIDi 9907711.
KEGGi esc:Entcl_2658.
PATRICi 42599467. VBIEntClo171306_2700.

Phylogenomic databases

HOGENOMi HOG000021113.
KOi K00031.

Enzyme and pathway databases

BioCyci ECLO701347:GH9V-2707-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11835. PTHR11835. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00183. prok_nadp_idh. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SCF1Imported.

Entry informationi

Entry nameiE3GBE3_ENTLS
AccessioniPrimary (citable) accession number: E3GBE3
Entry historyi
Integrated into UniProtKB/TrEMBL: January 11, 2011
Last sequence update: January 11, 2011
Last modified: November 26, 2014
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3