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E3GBE3

- E3GBE3_ENTLS

UniProt

E3GBE3 - E3GBE3_ENTLS

Protein

Isocitrate dehydrogenase [NADP]

Gene

Entcl_2658

Organism
Enterobacter lignolyticus (strain SCF1)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 26 (01 Oct 2014)
      Sequence version 1 (11 Jan 2011)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. magnesium ion binding Source: InterPro
    3. NAD binding Source: InterPro

    GO - Biological processi

    1. glyoxylate cycle Source: UniProtKB-KW
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotationImported

    Keywords - Biological processi

    Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

    Keywords - Ligandi

    ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

    Enzyme and pathway databases

    BioCyciECLO701347:GH9V-2707-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
    Gene namesi
    Ordered Locus Names:Entcl_2658Imported
    OrganismiEnterobacter lignolyticus (strain SCF1)Imported
    Taxonomic identifieri701347 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEnterobacterEnterobacter cloacae complex
    ProteomesiUP000006872: Chromosome

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000021113.
    KOiK00031.

    Family and domain databases

    Gene3Di3.40.718.10. 1 hit.
    InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR001804. Isocitrate/isopropylmalate_DH.
    IPR004439. Isocitrate_DH_NADP_dimer_prok.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PANTHERiPTHR11835. PTHR11835. 1 hit.
    PfamiPF00180. Iso_dh. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
    PROSITEiPS00470. IDH_IMDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    E3GBE3-1 [UniParc]FASTAAdd to Basket

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    MESKVVVPAE GQKITLQNGK LNVPHNPIIP FIEGDGIGVD VTPPMIKVVN    50
    AAVEKAYKGE RKISWMEIYT GEKSTHVYGQ DVWLPAETLD LIREYRVAIK 100
    GPLTTPVGGG IRSLNVALRQ ELDLYVCLRP VRYYQGTPSP VKHPELTDMV 150
    IFRENAEDIY AGIEWKADSA DAEKVIKFLR EEMGVKKIRF PEHCGIGIKP 200
    CSEEGTKRLV RAAIEYAIAN DRDSVTLVHK GNIMKFTEGA FKDWGYQLAR 250
    EEFGGELIDG GPWQKIKNPR TGKEIIIKDV IADAFLQQIL LRPAEYDVIA 300
    CMNLNGDYIS DALAAQVGGI GIAPGANIGD ECALFEATHG TAPKYAGQDK 350
    VNPGSVILSA EMMLRHMEWF EAADLIVKGM EGAIAAKTVT YDFERLMDGA 400
    KLLKCSEFGD AIIANM 416
    Length:416
    Mass (Da):45,842
    Last modified:January 11, 2011 - v1
    Checksum:i532FBD2754CBD125
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002272 Genomic DNA. Translation: ADO48906.1.
    RefSeqiYP_003942190.1. NC_014618.1.

    Genome annotation databases

    EnsemblBacteriaiADO48906; ADO48906; Entcl_2658.
    GeneIDi9907711.
    KEGGiesc:Entcl_2658.
    PATRICi42599467. VBIEntClo171306_2700.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002272 Genomic DNA. Translation: ADO48906.1 .
    RefSeqi YP_003942190.1. NC_014618.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADO48906 ; ADO48906 ; Entcl_2658 .
    GeneIDi 9907711.
    KEGGi esc:Entcl_2658.
    PATRICi 42599467. VBIEntClo171306_2700.

    Phylogenomic databases

    HOGENOMi HOG000021113.
    KOi K00031.

    Enzyme and pathway databases

    BioCyci ECLO701347:GH9V-2707-MONOMER.

    Family and domain databases

    Gene3Di 3.40.718.10. 1 hit.
    InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR001804. Isocitrate/isopropylmalate_DH.
    IPR004439. Isocitrate_DH_NADP_dimer_prok.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    PANTHERi PTHR11835. PTHR11835. 1 hit.
    Pfami PF00180. Iso_dh. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00183. prok_nadp_idh. 1 hit.
    PROSITEi PS00470. IDH_IMDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SCF1Imported.

    Entry informationi

    Entry nameiE3GBE3_ENTLS
    AccessioniPrimary (citable) accession number: E3GBE3
    Entry historyi
    Integrated into UniProtKB/TrEMBL: January 11, 2011
    Last sequence update: January 11, 2011
    Last modified: October 1, 2014
    This is version 26 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3