phnN

Functionⁱ

Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP).UniRule annotation

Catalytic activityⁱ

ATP + alpha-D-ribose 1,5-bisphosphate = ADP + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

Pathwayⁱ: 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route II).UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:

Phosphopentomutase (deoB)
no protein annotated in this organism
Ribose 1,5-bisphosphate phosphokinase PhnN (phnN)

This subpathway is part of the pathway 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route II), the pathway 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis and in Metabolic intermediate biosynthesis.

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	10 – 17	ATPUniRule annotation		8

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
ribose 1,5-bisphosphate phosphokinase activity Source: UniProtKB-EC

Complete GO annotation...

GO - Biological processⁱ

5-phosphoribose 1-diphosphate biosynthetic process Source: UniProtKB-UniPathway

Complete GO annotation...

Keywordsⁱ

Molecular function	Transferase
Ligand	ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayⁱ	UPA00087; UER00175.

UniPathwayⁱ

UPA00087; UER00175.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Ribose 1,5-bisphosphate phosphokinase PhnNUniRule annotation (EC:2.7.4.23UniRule annotation) Alternative name(s): Ribose 1,5-bisphosphokinaseUniRule annotation
Gene namesⁱ	Name:phnNUniRule annotation Ordered Locus Names:Entcl_4075
Organismⁱ	Enterobacter lignolyticus (strain SCF1)
Taxonomic identifierⁱ	701347 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Enterobacter › Enterobacter cloacae complex › Enterobacter lignolyticus
Proteomesⁱ	UP000006872 Componentⁱ: Chromosome

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000412782	1 – 189	Ribose 1,5-bisphosphate phosphokinase PhnNAdd BLAST		189

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	701347.Entcl_4075.

STRINGⁱ

701347.Entcl_4075.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	E3G1M3.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the ribose 1,5-bisphosphokinase family.UniRule annotation

Phylogenomic databases

eggNOGⁱ	ENOG4105MFQ. Bacteria. COG3709. LUCA.
HOGENOMⁱ	HOG000037637.
KEGG Orthology (KO) More...KOⁱ	K05774.
OMAⁱ	MARLIWL.
Database of Orthologous Groups More...OrthoDBⁱ	POG091H0H09.

Family and domain databases

HAMAPⁱ	MF_00836. PhnN. 1 hit.
InterProⁱ	View protein in InterPro IPR008145. GK/Ca_channel_bsu. IPR027417. P-loop_NTPase. IPR012699. PhnN.
SMARTⁱ	View protein in SMART SM00072. GuKc. 1 hit.
SUPFAMⁱ	SSF52540. SSF52540. 1 hit.
TIGRFAMsⁱ	TIGR02322. phosphon_PhnN. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

E3G1M3-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MTGKLIWLVG PSGSGKDSLL EALRKQEHPQ MLVAHRYITR PAGAGCENHV 
        60         70         80         90        100
ALSEHEFFTR AAQHLFALSW HANNLYYGVG MEIDLWLHAG LDVVVNGSRA 
       110        120        130        140        150
HLPQAKARYG ESLLPVCLQV SPDILRQRLE QRGRENALEI AQRLERAARY 
       160        170        180 
TPQQCVMLNN DGSLLQSVEM FLHLIRTHGN HKESQHACL

Length:189

Mass (Da):21,273

Last modified:January 11, 2011 - v1

Checksum:ⁱE6AA6879E6244D85

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CP002272 Genomic DNA. Translation: ADO50308.1.
NCBI Reference Sequences More...RefSeqⁱ	WP_013368024.1. NC_014618.1.

Genome annotation databases

EnsemblBacteriaⁱ	ADO50308; ADO50308; Entcl_4075.
KEGGⁱ	esc:Entcl_4075.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CP002272 Genomic DNA. Translation: ADO50308.1.
NCBI Reference Sequences More...RefSeqⁱ	WP_013368024.1. NC_014618.1.

3D structure databases

ProteinModelPortalⁱ	E3G1M3.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	701347.Entcl_4075.

STRINGⁱ

701347.Entcl_4075.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	ADO50308; ADO50308; Entcl_4075.
KEGGⁱ	esc:Entcl_4075.

Phylogenomic databases

eggNOGⁱ	ENOG4105MFQ. Bacteria. COG3709. LUCA.
HOGENOMⁱ	HOG000037637.
KEGG Orthology (KO) More...KOⁱ	K05774.
OMAⁱ	MARLIWL.
Database of Orthologous Groups More...OrthoDBⁱ	POG091H0H09.

Enzyme and pathway databases

UniPathwayⁱ	UPA00087; UER00175.

UniPathwayⁱ

UPA00087; UER00175.

Family and domain databases

HAMAPⁱ	MF_00836. PhnN. 1 hit.
InterProⁱ	View protein in InterPro IPR008145. GK/Ca_channel_bsu. IPR027417. P-loop_NTPase. IPR012699. PhnN.
SMARTⁱ	View protein in SMART SM00072. GuKc. 1 hit.
SUPFAMⁱ	SSF52540. SSF52540. 1 hit.
TIGRFAMsⁱ	TIGR02322. phosphon_PhnN. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PHNN_ENTLS
Accessionⁱ	E3G1M3Primary (citable) accession number: E3G1M3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	September 21, 2011
	Last sequence update:	January 11, 2011
	Last modified:	June 7, 2017
	This is version 51 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Prokaryotic Protein Annotation Program

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - E3G1M3 (PHNN_ENTLS)

Your basket is currently empty.

Ribose 1,5-bisphosphate phosphokinase PhnN

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">‘Function’</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

Pathwayⁱ: 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ