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Protein

Alanine racemase

Gene

alr

Organism
Corynebacterium pseudotuberculosis (strain I19)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei36 – 361Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei135 – 1351SubstrateUniRule annotation
Active sitei262 – 2621Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei310 – 3101Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciCPSE889513:GLBZ-432-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alrImported
Ordered Locus Names:CpI19_0413Imported
OrganismiCorynebacterium pseudotuberculosis (strain I19)Imported
Taxonomic identifieri889513 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium
ProteomesiUP000008202: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei36 – 361N6-(pyridoxal phosphate)lysineUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliE3F6Y8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

KOiK01775.
OMAiPSDWVRP.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.

Sequencei

Sequence statusi: Complete.

E3F6Y8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNLLEARIDL AAIAHNTRLI KDKAAAQGAQ LMCVVKADGY NHGAVEVATV
60 70 80 90 100
MEENGADQFG VATIGEGLAL REGGIESSIL SWIWSPEQDL GAAITAEIDL
110 120 130 140 150
AAISLEHVKA LVRASESYGK KPVRVTVKVD TGLHRSGVDK QDWRESFCML
160 170 180 190 200
RDAENIQVTG VFSHFSSADE SDSTETEQQE RAFLNAIELG RSLGLELPVN
210 220 230 240 250
HIANSPATLN RPDLYFDMVR PGLALYGHEP IPGESHGLRE AMSWVGRVTV
260 270 280 290 300
VKPIARGEGT SYGLTWRAEQ DGYLCVVPVG YADGLPRSAQ GHLEITIGGR
310 320 330 340 350
RYPQVGRVCM DQIVVALGEN PYGVAQGDEA VILGPTGMTA TELATAMGTI
360 370
NYELVCRPCG RTVRVFEHSD
Length:370
Mass (Da):39,912
Last modified:January 11, 2011 - v1
Checksum:i8F524C63B7CA7940
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002251 Genomic DNA. Translation: ADO25697.1.
RefSeqiYP_005684860.1. NC_017303.1.

Genome annotation databases

EnsemblBacteriaiADO25697; ADO25697; CpI19_0413.
GeneIDi12296959.
KEGGicpx:CpI19_0413.
PATRICi42903660. VBICorPse169742_0434.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002251 Genomic DNA. Translation: ADO25697.1.
RefSeqiYP_005684860.1. NC_017303.1.

3D structure databases

ProteinModelPortaliE3F6Y8.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADO25697; ADO25697; CpI19_0413.
GeneIDi12296959.
KEGGicpx:CpI19_0413.
PATRICi42903660. VBICorPse169742_0434.

Phylogenomic databases

KOiK01775.
OMAiPSDWVRP.

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.
BioCyciCPSE889513:GLBZ-432-MONOMER.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: I19.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: I19Imported.

Entry informationi

Entry nameiE3F6Y8_CORP9
AccessioniPrimary (citable) accession number: E3F6Y8
Entry historyi
Integrated into UniProtKB/TrEMBL: January 11, 2011
Last sequence update: January 11, 2011
Last modified: February 4, 2015
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.