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Protein

Alanine racemase

Gene

EIO_1396

Organism
Ketogulonicigenium vulgare (strain Y25)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei33 – 331Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei128 – 1281SubstrateUniRule annotation
Active sitei242 – 2421Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei290 – 2901Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciKVUL880591:GHQW-1396-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:EIO_1396Imported
OrganismiKetogulonicigenium vulgare (strain Y25)Imported
Taxonomic identifieri880591 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeKetogulonicigenium
ProteomesiUP000006871 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei33 – 331N6-(pyridoxal phosphate)lysineUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliE3F1J5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000031445.
KOiK01775.
OMAiDAGTISY.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.

Sequencei

Sequence statusi: Complete.

E3F1J5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTGILTIDL DAIIGNWRKL AAMSRAEAGA VLKADAYGTG AARVGAALAE
60 70 80 90 100
AGVRKFFVAV AEEGVALREA VGPAPEIFVL SGHGTTDTAL IRQLNLTPVL
110 120 130 140 150
NSPQQLRRQF DALPGRPFAI QLDTGMNRLG FEWEDWAAVT DEVLGAGPRL
160 170 180 190 200
IMSHLACADE PDHPMNAYQL DLFKQMTEGM RVSRSLAATG GILLGPDYHF
210 220 230 240 250
DLVRPGIGLH GAAPYAQGAQ ALQLDLPVIQ TRDLIEGEVV GYGNTWQARR
260 270 280 290 300
PTRVATLAAG YADGVLRVLG AGTNVYSGDI ACPIIGRISM DLITVDITDL
310 320 330 340
DADPEVLTLI GPQQSVDDLA VTAKTIGYEI LTSLSPRYSR QYIGG
Length:345
Mass (Da):36,720
Last modified:January 11, 2011 - v1
Checksum:iA29BFE5D60E750B1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002224 Genomic DNA. Translation: ADO42529.1.
RefSeqiWP_013384180.1. NC_014625.1.
YP_003963829.1. NC_014625.1.

Genome annotation databases

EnsemblBacteriaiADO42529; ADO42529; EIO_1396.
KEGGikvu:EIO_1396.
PATRICi43495087. VBIKetVul170732_1633.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002224 Genomic DNA. Translation: ADO42529.1.
RefSeqiWP_013384180.1. NC_014625.1.
YP_003963829.1. NC_014625.1.

3D structure databases

ProteinModelPortaliE3F1J5.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADO42529; ADO42529; EIO_1396.
KEGGikvu:EIO_1396.
PATRICi43495087. VBIKetVul170732_1633.

Phylogenomic databases

HOGENOMiHOG000031445.
KOiK01775.
OMAiDAGTISY.

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.
BioCyciKVUL880591:GHQW-1396-MONOMER.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Y25Imported.

Entry informationi

Entry nameiE3F1J5_KETVY
AccessioniPrimary (citable) accession number: E3F1J5
Entry historyi
Integrated into UniProtKB/TrEMBL: January 11, 2011
Last sequence update: January 11, 2011
Last modified: May 27, 2015
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.