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Protein

2,3-bisphosphoglycerate-dependent phosphoglycerate mutase

Gene

gpm5

Organism
Bifidobacterium bifidum (strain S17)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.UniRule annotation

Catalytic activityi

2-phospho-D-glycerate = 3-phospho-D-glycerate.UniRule annotationSAAS annotation

Pathwayi: glycolysis

This protein is involved in step 3 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Phosphoglycerate kinase (pgk)
  3. 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase (gpm5)
  4. Enolase (eno)
  5. Pyruvate kinase (pyk)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei10Tele-phosphohistidine intermediateUniRule annotation1
Binding sitei61SubstrateUniRule annotation1
Active sitei88Proton donor/acceptorUniRule annotation1
Binding sitei99SubstrateUniRule annotation1
Sitei180Transition state stabilizerUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Biological processi

GluconeogenesisUniRule annotation, GlycolysisUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00109; UER00186.

Names & Taxonomyi

Protein namesi
Recommended name:
2,3-bisphosphoglycerate-dependent phosphoglycerate mutaseUniRule annotation (EC:5.4.2.11UniRule annotation)
Short name:
BPG-dependent PGAMUniRule annotation
Short name:
PGAMUniRule annotation
Short name:
PhosphoglyceromutaseUniRule annotation
Short name:
dPGMUniRule annotation
Gene namesi
Name:gpm5Imported
Synonyms:gpmAUniRule annotation
Ordered Locus Names:BBIF_1433Imported
OrganismiBifidobacterium bifidum (strain S17)Imported
Taxonomic identifieri883062 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaBifidobacterialesBifidobacteriaceaeBifidobacterium
Proteomesi
  • UP000006869 Componenti: Chromosome

Structurei

3D structure databases

ProteinModelPortaliE3ER63.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni9 – 16Substrate bindingUniRule annotation8
Regioni22 – 23Substrate bindingUniRule annotation2
Regioni88 – 91Substrate bindingUniRule annotation4
Regioni115 – 116Substrate bindingUniRule annotation2
Regioni181 – 182Substrate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.UniRule annotationSAAS annotation

Phylogenomic databases

HOGENOMiHOG000221682.
KOiK01834.
OMAiVKNQGKK.

Family and domain databases

CDDicd07067. HP_PGM_like. 1 hit.
Gene3Di3.40.50.1240. 1 hit.
HAMAPiMF_01039. PGAM_GpmA. 1 hit.
InterProiIPR013078. His_Pase_superF_clade-1.
IPR029033. His_PPase_superfam.
IPR001345. PG/BPGM_mutase_AS.
IPR005952. Phosphogly_mut1.
[Graphical view]
PANTHERiPTHR11931. PTHR11931. 1 hit.
PfamiPF00300. His_Phos_1. 2 hits.
[Graphical view]
SMARTiSM00855. PGAM. 1 hit.
[Graphical view]
SUPFAMiSSF53254. SSF53254. 1 hit.
TIGRFAMsiTIGR01258. pgm_1. 1 hit.
PROSITEiPS00175. PG_MUTASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E3ER63-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTYKLVLLRH GQSAWNKTNQ FTGWVDVPLT EQGEAEAKRG GELLKEKNVL
60 70 80 90 100
PDIVFTSLLR RAINTANIAL DAADRLWIPV QRDWRLNERH YGALQGKNKT
110 120 130 140 150
EIRQEYGDEK FMLWRRSYAT PPPEIDPNDQ YAQNHDPRYA GDPVPEAECL
160 170 180 190 200
ANVVERVKPY FESAIEPELR AGKTVLIAAH GNSLRAIVKM LDNLSEDEIA
210 220 230 240
KVNIPTAIPL LYELDENFKP VKPRGEYLDP EAAAAGAAAV AAQGQK
Length:246
Mass (Da):27,627
Last modified:January 11, 2011 - v1
Checksum:i55D75151C543DBA1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002220 Genomic DNA. Translation: ADO53638.1.
RefSeqiWP_003814666.1. NC_014616.1.

Genome annotation databases

EnsemblBacteriaiADO53638; ADO53638; BBIF_1433.
KEGGibbi:BBIF_1433.
PATRICi42480424. VBIBifBif172477_1488.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002220 Genomic DNA. Translation: ADO53638.1.
RefSeqiWP_003814666.1. NC_014616.1.

3D structure databases

ProteinModelPortaliE3ER63.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADO53638; ADO53638; BBIF_1433.
KEGGibbi:BBIF_1433.
PATRICi42480424. VBIBifBif172477_1488.

Phylogenomic databases

HOGENOMiHOG000221682.
KOiK01834.
OMAiVKNQGKK.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00186.

Family and domain databases

CDDicd07067. HP_PGM_like. 1 hit.
Gene3Di3.40.50.1240. 1 hit.
HAMAPiMF_01039. PGAM_GpmA. 1 hit.
InterProiIPR013078. His_Pase_superF_clade-1.
IPR029033. His_PPase_superfam.
IPR001345. PG/BPGM_mutase_AS.
IPR005952. Phosphogly_mut1.
[Graphical view]
PANTHERiPTHR11931. PTHR11931. 1 hit.
PfamiPF00300. His_Phos_1. 2 hits.
[Graphical view]
SMARTiSM00855. PGAM. 1 hit.
[Graphical view]
SUPFAMiSSF53254. SSF53254. 1 hit.
TIGRFAMsiTIGR01258. pgm_1. 1 hit.
PROSITEiPS00175. PG_MUTASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiE3ER63_BIFBS
AccessioniPrimary (citable) accession number: E3ER63
Entry historyi
Integrated into UniProtKB/TrEMBL: January 11, 2011
Last sequence update: January 11, 2011
Last modified: November 30, 2016
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.