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E3EQ73 (E3EQ73_BIFBS) Unreviewed, UniProtKB/TrEMBL

Last modified October 16, 2013. Version 22. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Isocitrate dehydrogenase [NADP] PIRNR PIRNR000108

EC=1.1.1.42 PIRNR PIRNR000108
Gene names
Name:icdA EMBL ADO53223.1
Ordered Locus Names:BBIF_1018 EMBL ADO53223.1
OrganismBifidobacterium bifidum (strain S17) [Complete proteome] [HAMAP] EMBL ADO53223.1
Taxonomic identifier883062 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeBifidobacterialesBifidobacteriaceaeBifidobacterium

Protein attributes

Sequence length406 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH. PIRNR PIRNR000108

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity. PIRNR PIRNR000108 PIRSR PIRSR000108-3

Sequence similarities

Belongs to the isocitrate and isopropylmalate dehydrogenases family. PIRNR PIRNR000108 RuleBase RU004443

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding75 – 773NADP By similarity PIRSR PIRSR000108-4
Nucleotide binding310 – 3156NADP By similarity PIRSR PIRSR000108-4
Region94 – 1007Substrate binding By similarity PIRSR PIRSR000108-2

Sites

Metal binding2521Magnesium or manganese By similarity
Metal binding2751Magnesium or manganese By similarity
Binding site771Substrate By similarity PIRSR PIRSR000108-2
Binding site821NADP By similarity PIRSR PIRSR000108-4
Binding site1091Substrate By similarity PIRSR PIRSR000108-2
Binding site1321Substrate By similarity PIRSR PIRSR000108-2
Binding site2601NADP By similarity PIRSR PIRSR000108-4
Binding site3281NADP; via amide nitrogen and carbonyl oxygen By similarity PIRSR PIRSR000108-4
Site1391Critical for catalysis By similarity PIRSR PIRSR000108-1
Site2121Critical for catalysis By similarity PIRSR PIRSR000108-1

Sequences

Sequence LengthMass (Da)Tools
E3EQ73 [UniParc].

Last modified January 11, 2011. Version 1.
Checksum: 2898830CA778C635

FASTA40645,277
        10         20         30         40         50         60 
MAKIKVEGKV VELDGDEMTR VIWKDIKDRL ILPYLDVDLD YYDLGIENRD ATDDQVTIDA 

        70         80         90        100        110        120 
AKAIQREHVG VKCATITPDE ARVKEFGLKK MWKSPNGTIR NILGGTIFRE PIVMSNVPRL 

       130        140        150        160        170        180 
VPGWTKPIVV ARHAFGDQYK ATDFKVPGAG RLTVTFTPED GSEPIEHVVY DYGQDGGVAQ 

       190        200        210        220        230        240 
VQYNVNDSIR GFARACFNYG LMRHYPVYLS TKNTILKAYD GQFKDIFAEV FETDYKDKFA 

       250        260        270        280        290        300 
EAGLTYEHRL IDDMVASSLK WHGGYIWACK NYDGDVQSDS VAQGFGSLGL MTSVLMTPDG 

       310        320        330        340        350        360 
QTVEAEAAHG TVTRHYRRWL KGEKTSTNPI ASIFAWTGGL KHRADLDGTP EVRHFAETLE 

       370        380        390        400 
KVIVDTVEGG QMTKDLAMLV GPDQAWLDTE GFMNALDENL SKALTA 

« Hide

References

[1]"Complete genome sequence of Bifidobacterium bifidum S17."
Zhurina D., Zomer A., Gleinser M., Brancaccio V.F., Auchter M., Waidmann M.S., Westermann C., van Sinderen D., Riedel C.U.
J. Bacteriol. 193:301-302(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: S17 EMBL ADO53223.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP002220 Genomic DNA. Translation: ADO53223.1.
RefSeqYP_003938797.1. NC_014616.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADO53223; ADO53223; BBIF_1018.
GeneID9847237.
KEGGbbi:BBIF_1018.
PATRIC42479522. VBIBifBif172477_1052.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000019858.
KOK00031.
OMAQHQQGKP.

Enzyme and pathway databases

BioCycBBIF883062:GH1R-1048-MONOMER.

Family and domain databases

Gene3D3.40.718.10. 1 hit.
InterProIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERPTHR11822. PTHR11822. 1 hit.
PfamPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsTIGR00127. nadp_idh_euk. 1 hit.
PROSITEPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameE3EQ73_BIFBS
AccessionPrimary (citable) accession number: E3EQ73
Entry history
Integrated into UniProtKB/TrEMBL: January 11, 2011
Last sequence update: January 11, 2011
Last modified: October 16, 2013
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)