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E3EQ73

- E3EQ73_BIFBS

UniProt

E3EQ73 - E3EQ73_BIFBS

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Protein
Isocitrate dehydrogenase [NADP]
Gene
icdA, BBIF_1018
Organism
Bifidobacterium bifidum (strain S17)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Binds 1 magnesium or manganese ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei77 – 771Substrate By similarityUniRule annotation
Binding sitei82 – 821NADP By similarity
Binding sitei109 – 1091Substrate By similarityUniRule annotation
Binding sitei132 – 1321Substrate By similarityUniRule annotation
Sitei139 – 1391Critical for catalysis By similarityUniRule annotation
Sitei212 – 2121Critical for catalysis By similarityUniRule annotation
Metal bindingi252 – 2521Magnesium or manganese By similarityUniRule annotation
Binding sitei260 – 2601NADP By similarity
Metal bindingi275 – 2751Magnesium or manganese By similarityUniRule annotation
Binding sitei328 – 3281NADP; via amide nitrogen and carbonyl oxygen By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi75 – 773NADP By similarity
Nucleotide bindingi310 – 3156NADP By similarity

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  3. magnesium ion binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. isocitrate metabolic process Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciBBIF883062:GH1R-1048-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Name:icdAImported
Ordered Locus Names:BBIF_1018Imported
OrganismiBifidobacterium bifidum (strain S17)Imported
Taxonomic identifieri883062 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeBifidobacterialesBifidobacteriaceaeBifidobacterium
ProteomesiUP000006869: Chromosome

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni94 – 1007Substrate binding By similarityUniRule annotation

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000019858.
KOiK00031.
OMAiKNTIMKV.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E3EQ73-1 [UniParc]FASTAAdd to Basket

« Hide

MAKIKVEGKV VELDGDEMTR VIWKDIKDRL ILPYLDVDLD YYDLGIENRD    50
ATDDQVTIDA AKAIQREHVG VKCATITPDE ARVKEFGLKK MWKSPNGTIR 100
NILGGTIFRE PIVMSNVPRL VPGWTKPIVV ARHAFGDQYK ATDFKVPGAG 150
RLTVTFTPED GSEPIEHVVY DYGQDGGVAQ VQYNVNDSIR GFARACFNYG 200
LMRHYPVYLS TKNTILKAYD GQFKDIFAEV FETDYKDKFA EAGLTYEHRL 250
IDDMVASSLK WHGGYIWACK NYDGDVQSDS VAQGFGSLGL MTSVLMTPDG 300
QTVEAEAAHG TVTRHYRRWL KGEKTSTNPI ASIFAWTGGL KHRADLDGTP 350
EVRHFAETLE KVIVDTVEGG QMTKDLAMLV GPDQAWLDTE GFMNALDENL 400
SKALTA 406
Length:406
Mass (Da):45,277
Last modified:January 11, 2011 - v1
Checksum:i2898830CA778C635
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002220 Genomic DNA. Translation: ADO53223.1.
RefSeqiYP_003938797.1. NC_014616.1.

Genome annotation databases

EnsemblBacteriaiADO53223; ADO53223; BBIF_1018.
GeneIDi9847237.
KEGGibbi:BBIF_1018.
PATRICi42479522. VBIBifBif172477_1052.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002220 Genomic DNA. Translation: ADO53223.1 .
RefSeqi YP_003938797.1. NC_014616.1.

3D structure databases

ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADO53223 ; ADO53223 ; BBIF_1018 .
GeneIDi 9847237.
KEGGi bbi:BBIF_1018.
PATRICi 42479522. VBIBifBif172477_1052.

Phylogenomic databases

HOGENOMi HOG000019858.
KOi K00031.
OMAi KNTIMKV.

Enzyme and pathway databases

BioCyci BBIF883062:GH1R-1048-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11822. PTHR11822. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: S17Imported.

Entry informationi

Entry nameiE3EQ73_BIFBS
AccessioniPrimary (citable) accession number: E3EQ73
Entry historyi
Integrated into UniProtKB/TrEMBL: January 11, 2011
Last sequence update: January 11, 2011
Last modified: July 9, 2014
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

Similar proteinsi