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E3ECX2

- E3ECX2_PAEPS

UniProt

E3ECX2 - E3ECX2_PAEPS

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Protein
Amidophosphoribosyltransferase
Gene
PPSC2_c0858
Organism
Paenibacillus polymyxa (strain SC2) (Bacillus polymyxa)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate = L-glutamine + 5-phospho-alpha-D-ribose 1-diphosphate + H2O.UniRule annotation

Cofactori

Binds 1 4Fe-4S cluster per subunit By similarity.UniRule annotation
Binds 1 magnesium ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei33 – 331For GATase activity By similarityUniRule annotation
Metal bindingi267 – 2671Iron-sulfur (4Fe-4S) By similarityUniRule annotation
Metal bindingi413 – 4131Iron-sulfur (4Fe-4S) By similarityUniRule annotation
Metal bindingi469 – 4691Iron-sulfur (4Fe-4S) By similarityUniRule annotation
Metal bindingi472 – 4721Iron-sulfur (4Fe-4S) By similarityUniRule annotation

GO - Molecular functioni

  1. amidophosphoribosyltransferase activity Source: UniProtKB-EC
  2. iron-sulfur cluster binding Source: UniProtKB-KW
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
  2. nucleoside metabolic process Source: InterPro
  3. purine nucleobase biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

GlycosyltransferaseUniRule annotationImported, Transferase

Keywords - Biological processi

Purine biosynthesisUniRule annotation

Keywords - Ligandi

Iron, Iron-sulfurUniRule annotation, MagnesiumUniRule annotation, Metal-binding

Enzyme and pathway databases

BioCyciPPOL886882:GBY1-933-MONOMER.
UniPathwayiUPA00074; UER00124.

Protein family/group databases

MEROPSiC44.001.

Names & Taxonomyi

Protein namesi
Recommended name:
AmidophosphoribosyltransferaseUniRule annotation (EC:2.4.2.14UniRule annotation)
Short name:
ATaseUniRule annotation
Alternative name(s):
Glutamine phosphoribosylpyrophosphate amidotransferase
Gene namesi
Ordered Locus Names:PPSC2_c0858Imported
OrganismiPaenibacillus polymyxa (strain SC2) (Bacillus polymyxa)Imported
Taxonomic identifieri886882 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesPaenibacillaceaePaenibacillus
ProteomesiUP000006868: Chromosome

Structurei

3D structure databases

ProteinModelPortaliE3ECX2.

Family & Domainsi

Sequence similaritiesi

In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000033688.
KOiK00764.
OMAiSGIPYEM.

Family and domain databases

Gene3Di3.40.50.2020. 1 hit.
3.60.20.10. 1 hit.
InterProiIPR005854. Amd_phspho_trans.
IPR017932. GATase_2_dom.
IPR000583. GATase_dom.
IPR029055. Ntn_hydrolases_N.
IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
[Graphical view]
PfamiPF13537. GATase_7. 1 hit.
PF00156. Pribosyltran. 1 hit.
[Graphical view]
PIRSFiPIRSF000485. Amd_phspho_trans. 1 hit.
SUPFAMiSSF53271. SSF53271. 1 hit.
SSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR01134. purF. 1 hit.
PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E3ECX2-1 [UniParc]FASTAAdd to Basket

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MSDEITARTL WTGDYYNEGS GKEGLFDKLK EECGVFGVYR HSDAASLAYY    50
GLHALQHRGE ESAGICVSSG DEFHYHRGMG LVKEVFNKDL MASLTGDIAI 100
GHVRYSTSGD SKLTNAQPLV FKYRDGDLAV ATNGNIVNAL QIRHELEQGG 150
SIFQTTSDTE VVAHLIARSS KDLVEAAKDA LKRIVGGFAF LIMTNDKLLV 200
ASDPNGLRPL TMGRLGDAYL FASESCALET IGAELLRDIE PGELLILDKN 250
GLHEDRYTED KQRKALCAME YIYFARPDSD LNGANLHAAR KRMGSQLALE 300
AFVDADLVTG VPDSSISAAI GYAEQTGIPY ELGMIKNKYT GRTFIQPSQE 350
LREQGVKMKL SAVRRVVEGK RVIMIDDSIV RGTTSRRIVN MLRDAGALEV 400
HVRITSPPFK NPCFYGIDTP DRRELIASSK TVEEIRQEIN ADSLFFMSAE 450
GLIAAVGGHN EQDYKGGLCL ACFDNDYPTQ VDFKGEEKFG CSC 493
Length:493
Mass (Da):54,175
Last modified:January 11, 2011 - v1
Checksum:iB0E2327A471F1ACA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002213 Genomic DNA. Translation: ADO54841.1.
RefSeqiWP_013369475.1. NC_014622.1.
YP_003945082.1. NC_014622.1.

Genome annotation databases

EnsemblBacteriaiADO54841; ADO54841; PPSC2_c0858.
GeneIDi9849180.
KEGGippm:PPSC2_c0858.
PATRICi42505074. VBIPaePol172748_0828.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002213 Genomic DNA. Translation: ADO54841.1 .
RefSeqi WP_013369475.1. NC_014622.1.
YP_003945082.1. NC_014622.1.

3D structure databases

ProteinModelPortali E3ECX2.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi C44.001.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADO54841 ; ADO54841 ; PPSC2_c0858 .
GeneIDi 9849180.
KEGGi ppm:PPSC2_c0858.
PATRICi 42505074. VBIPaePol172748_0828.

Phylogenomic databases

HOGENOMi HOG000033688.
KOi K00764.
OMAi SGIPYEM.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00124 .
BioCyci PPOL886882:GBY1-933-MONOMER.

Family and domain databases

Gene3Di 3.40.50.2020. 1 hit.
3.60.20.10. 1 hit.
InterProi IPR005854. Amd_phspho_trans.
IPR017932. GATase_2_dom.
IPR000583. GATase_dom.
IPR029055. Ntn_hydrolases_N.
IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
[Graphical view ]
Pfami PF13537. GATase_7. 1 hit.
PF00156. Pribosyltran. 1 hit.
[Graphical view ]
PIRSFi PIRSF000485. Amd_phspho_trans. 1 hit.
SUPFAMi SSF53271. SSF53271. 1 hit.
SSF56235. SSF56235. 1 hit.
TIGRFAMsi TIGR01134. purF. 1 hit.
PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of Paenibacillus polymyxa SC2, a strain of plant growth-promoting Rhizobacterium with broad-spectrum antimicrobial activity."
    Ma M., Wang C., Ding Y., Li L., Shen D., Jiang X., Guan D., Cao F., Chen H., Feng R., Wang X., Ge Y., Yao L., Bing X., Yang X., Li J., Du B.
    J. Bacteriol. 193:311-312(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC2Imported.

Entry informationi

Entry nameiE3ECX2_PAEPS
AccessioniPrimary (citable) accession number: E3ECX2
Entry historyi
Integrated into UniProtKB/TrEMBL: January 11, 2011
Last sequence update: January 11, 2011
Last modified: September 3, 2014
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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