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E3ECX2

- E3ECX2_PAEPS

UniProt

E3ECX2 - E3ECX2_PAEPS

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Protein

Amidophosphoribosyltransferase

Gene

PPSC2_c0858

Organism
Paenibacillus polymyxa (strain SC2) (Bacillus polymyxa)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate = L-glutamine + 5-phospho-alpha-D-ribose 1-diphosphate + H2O.UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • Note: Binds 1 4Fe-4S cluster per subunit.UniRule annotation
  • Note: Binds 1 magnesium ion per subunit.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei33 – 331For GATase activityUniRule annotation

GO - Molecular functioni

  1. amidophosphoribosyltransferase activity Source: UniProtKB-EC
  2. iron-sulfur cluster binding Source: UniProtKB-KW
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
  2. nucleoside metabolic process Source: InterPro
  3. purine nucleobase biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

GlycosyltransferaseUniRule annotationImported, Transferase

Keywords - Biological processi

Purine biosynthesisUniRule annotation

Keywords - Ligandi

Iron, Iron-sulfurUniRule annotation, MagnesiumUniRule annotation, Metal-binding

Enzyme and pathway databases

BioCyciPPOL886882:GBY1-933-MONOMER.
UniPathwayiUPA00074; UER00124.

Protein family/group databases

MEROPSiC44.A03.

Names & Taxonomyi

Protein namesi
Recommended name:
AmidophosphoribosyltransferaseUniRule annotation (EC:2.4.2.14UniRule annotation)
Short name:
ATaseUniRule annotation
Alternative name(s):
Glutamine phosphoribosylpyrophosphate amidotransferaseUniRule annotation
Gene namesi
Ordered Locus Names:PPSC2_c0858Imported
OrganismiPaenibacillus polymyxa (strain SC2) (Bacillus polymyxa)Imported
Taxonomic identifieri886882 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesPaenibacillaceaePaenibacillus
ProteomesiUP000006868: Chromosome

Structurei

3D structure databases

ProteinModelPortaliE3ECX2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000033688.
KOiK00764.
OMAiSGIPYEM.

Family and domain databases

Gene3Di3.40.50.2020. 1 hit.
3.60.20.10. 1 hit.
InterProiIPR005854. Amd_phspho_trans.
IPR017932. GATase_2_dom.
IPR000583. GATase_dom.
IPR029055. Ntn_hydrolases_N.
IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
[Graphical view]
PfamiPF13537. GATase_7. 1 hit.
PF00156. Pribosyltran. 1 hit.
[Graphical view]
PIRSFiPIRSF000485. Amd_phspho_trans. 1 hit.
SUPFAMiSSF53271. SSF53271. 1 hit.
SSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR01134. purF. 1 hit.
PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E3ECX2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSDEITARTL WTGDYYNEGS GKEGLFDKLK EECGVFGVYR HSDAASLAYY
60 70 80 90 100
GLHALQHRGE ESAGICVSSG DEFHYHRGMG LVKEVFNKDL MASLTGDIAI
110 120 130 140 150
GHVRYSTSGD SKLTNAQPLV FKYRDGDLAV ATNGNIVNAL QIRHELEQGG
160 170 180 190 200
SIFQTTSDTE VVAHLIARSS KDLVEAAKDA LKRIVGGFAF LIMTNDKLLV
210 220 230 240 250
ASDPNGLRPL TMGRLGDAYL FASESCALET IGAELLRDIE PGELLILDKN
260 270 280 290 300
GLHEDRYTED KQRKALCAME YIYFARPDSD LNGANLHAAR KRMGSQLALE
310 320 330 340 350
AFVDADLVTG VPDSSISAAI GYAEQTGIPY ELGMIKNKYT GRTFIQPSQE
360 370 380 390 400
LREQGVKMKL SAVRRVVEGK RVIMIDDSIV RGTTSRRIVN MLRDAGALEV
410 420 430 440 450
HVRITSPPFK NPCFYGIDTP DRRELIASSK TVEEIRQEIN ADSLFFMSAE
460 470 480 490
GLIAAVGGHN EQDYKGGLCL ACFDNDYPTQ VDFKGEEKFG CSC
Length:493
Mass (Da):54,175
Last modified:January 11, 2011 - v1
Checksum:iB0E2327A471F1ACA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002213 Genomic DNA. Translation: ADO54841.1.
RefSeqiYP_003945082.1. NC_014622.1.

Genome annotation databases

EnsemblBacteriaiADO54841; ADO54841; PPSC2_c0858.
GeneIDi9849180.
KEGGippm:PPSC2_c0858.
PATRICi42505074. VBIPaePol172748_0828.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002213 Genomic DNA. Translation: ADO54841.1 .
RefSeqi YP_003945082.1. NC_014622.1.

3D structure databases

ProteinModelPortali E3ECX2.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi C44.A03.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADO54841 ; ADO54841 ; PPSC2_c0858 .
GeneIDi 9849180.
KEGGi ppm:PPSC2_c0858.
PATRICi 42505074. VBIPaePol172748_0828.

Phylogenomic databases

HOGENOMi HOG000033688.
KOi K00764.
OMAi SGIPYEM.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00124 .
BioCyci PPOL886882:GBY1-933-MONOMER.

Family and domain databases

Gene3Di 3.40.50.2020. 1 hit.
3.60.20.10. 1 hit.
InterProi IPR005854. Amd_phspho_trans.
IPR017932. GATase_2_dom.
IPR000583. GATase_dom.
IPR029055. Ntn_hydrolases_N.
IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
[Graphical view ]
Pfami PF13537. GATase_7. 1 hit.
PF00156. Pribosyltran. 1 hit.
[Graphical view ]
PIRSFi PIRSF000485. Amd_phspho_trans. 1 hit.
SUPFAMi SSF53271. SSF53271. 1 hit.
SSF56235. SSF56235. 1 hit.
TIGRFAMsi TIGR01134. purF. 1 hit.
PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of Paenibacillus polymyxa SC2, a strain of plant growth-promoting Rhizobacterium with broad-spectrum antimicrobial activity."
    Ma M., Wang C., Ding Y., Li L., Shen D., Jiang X., Guan D., Cao F., Chen H., Feng R., Wang X., Ge Y., Yao L., Bing X., Yang X., Li J., Du B.
    J. Bacteriol. 193:311-312(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC2Imported.

Entry informationi

Entry nameiE3ECX2_PAEPS
AccessioniPrimary (citable) accession number: E3ECX2
Entry historyi
Integrated into UniProtKB/TrEMBL: January 11, 2011
Last sequence update: January 11, 2011
Last modified: November 26, 2014
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3