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Protein

N5-carboxyaminoimidazole ribonucleotide mutase

Gene

purE

Organism
Paenibacillus polymyxa (strain SC2) (Bacillus polymyxa)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).UniRule annotation

Catalytic activityi

5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole = 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate.UniRule annotation

Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route).UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. N5-carboxyaminoimidazole ribonucleotide synthase (purK)
  2. N5-carboxyaminoimidazole ribonucleotide mutase (purE)
This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route), the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei11SubstrateUniRule annotation1
Binding sitei14SubstrateUniRule annotation1
Binding sitei41SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomeraseUniRule annotation
Biological processPurine biosynthesisUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00074; UER00943.

Names & Taxonomyi

Protein namesi
Recommended name:
N5-carboxyaminoimidazole ribonucleotide mutaseUniRule annotation (EC:5.4.99.18UniRule annotation)
Short name:
N5-CAIR mutaseUniRule annotation
Alternative name(s):
5-(carboxyamino)imidazole ribonucleotide mutaseUniRule annotation
Gene namesi
Name:purEUniRule annotationImported
ORF Names:PPSC2_04205Imported
OrganismiPaenibacillus polymyxa (strain SC2) (Bacillus polymyxa)Imported
Taxonomic identifieri886882 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesPaenibacillaceaePaenibacillus
Proteomesi
  • UP000006868 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi886882.PPSC2_c0849.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 154AIRCInterPro annotationAdd BLAST152

Sequence similaritiesi

Belongs to the AIR carboxylase family. Class I subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108UM6. Bacteria.
COG0041. LUCA.
HOGENOMiHOG000034141.
KOiK01588.
OMAiSIDGWDS.
OrthoDBiPOG091H01UJ.

Family and domain databases

Gene3Di3.40.50.7700. 1 hit.
HAMAPiMF_01929. PurE_classI. 1 hit.
InterProiView protein in InterPro
IPR033747. PurE_ClassI.
IPR000031. PurE_dom.
IPR024694. PurE_prokaryotes.
PfamiView protein in Pfam
PF00731. AIRC. 1 hit.
PIRSFiPIRSF001338. AIR_carboxylase. 1 hit.
SMARTiView protein in SMART
SM01001. AIRC. 1 hit.
SUPFAMiSSF52255. SSF52255. 1 hit.
TIGRFAMsiTIGR01162. purE. 1 hit.

Sequencei

Sequence statusi: Complete.

E3ECW3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVQVAVIMG STSDWDTMQH ACAVLDELEI GYEKKVVSAH RTPDLMFRFA
60 70 80 90 100
EEAAGRGLKV IIAGAGGAAH LPGMVAAKTS LPVIGVPVQS KALNGLDSLL
110 120 130 140 150
SIVQMPGGIP VATVAIGKAG STNAGLLAAQ ILGAFDEKIS QRVVARRDRI
160
RDEVLEGSDS L
Length:161
Mass (Da):16,718
Last modified:January 11, 2011 - v1
Checksum:i4967E58A7864DCEC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002213 Genomic DNA. Translation: ADO54832.1.
RefSeqiWP_013369467.1. NC_014622.2.

Genome annotation databases

EnsemblBacteriaiADO54832; ADO54832; PPSC2_04205.
GeneIDi25385507.
KEGGippm:PPSC2_04205.
PATRICifig|886882.15.peg.837.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiE3ECW3_PAEPS
AccessioniPrimary (citable) accession number: E3ECW3
Entry historyiIntegrated into UniProtKB/TrEMBL: January 11, 2011
Last sequence update: January 11, 2011
Last modified: June 7, 2017
This is version 49 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported