Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

N5-carboxyaminoimidazole ribonucleotide mutase

Gene

purE

Organism
Paenibacillus polymyxa (strain SC2) (Bacillus polymyxa)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).UniRule annotation

Catalytic activityi

5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole = 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate.UniRule annotation

Pathway: IMP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route).UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. N5-carboxyaminoimidazole ribonucleotide synthase (purK)
  2. N5-carboxyaminoimidazole ribonucleotide mutase (purE)
This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route), the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei11 – 111SubstrateUniRule annotation
Binding sitei14 – 141SubstrateUniRule annotation
Binding sitei41 – 411SubstrateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotation

Keywords - Biological processi

Purine biosynthesisUniRule annotation

Enzyme and pathway databases

BioCyciPPOL886882:GBY1-924-MONOMER.
UniPathwayiUPA00074; UER00943.

Names & Taxonomyi

Protein namesi
Recommended name:
N5-carboxyaminoimidazole ribonucleotide mutaseUniRule annotation (EC:5.4.99.18UniRule annotation)
Short name:
N5-CAIR mutaseUniRule annotation
Alternative name(s):
5-(carboxyamino)imidazole ribonucleotide mutaseUniRule annotation
Gene namesi
Name:purEUniRule annotationImported
ORF Names:PPSC2_04205Imported
OrganismiPaenibacillus polymyxa (strain SC2) (Bacillus polymyxa)Imported
Taxonomic identifieri886882 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesPaenibacillaceaePaenibacillus
ProteomesiUP000006868 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi886882.PPSC2_c0849.

Family & Domainsi

Sequence similaritiesi

Belongs to the AIR carboxylase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000034141.
KOiK01588.
OMAiGLKQKVI.

Family and domain databases

Gene3Di3.40.50.7700. 1 hit.
HAMAPiMF_01929. PurE.
InterProiIPR024694. N5-CAIR_mutase_PurE.
IPR000031. PurE_dom.
[Graphical view]
PfamiPF00731. AIRC. 1 hit.
[Graphical view]
PIRSFiPIRSF001338. AIR_carboxylase. 1 hit.
SMARTiSM01001. AIRC. 1 hit.
[Graphical view]
SUPFAMiSSF52255. SSF52255. 1 hit.
TIGRFAMsiTIGR01162. purE. 1 hit.

Sequencei

Sequence statusi: Complete.

E3ECW3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVQVAVIMG STSDWDTMQH ACAVLDELEI GYEKKVVSAH RTPDLMFRFA
60 70 80 90 100
EEAAGRGLKV IIAGAGGAAH LPGMVAAKTS LPVIGVPVQS KALNGLDSLL
110 120 130 140 150
SIVQMPGGIP VATVAIGKAG STNAGLLAAQ ILGAFDEKIS QRVVARRDRI
160
RDEVLEGSDS L
Length:161
Mass (Da):16,718
Last modified:January 11, 2011 - v1
Checksum:i4967E58A7864DCEC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002213 Genomic DNA. Translation: ADO54832.1.
RefSeqiWP_013369467.1. NC_014622.1.
YP_003945073.1. NC_014622.1.

Genome annotation databases

EnsemblBacteriaiADO54832; ADO54832; PPSC2_c0849.
GeneIDi9849171.
KEGGippm:PPSC2_c0849.
PATRICi42505058. VBIPaePol172748_0820.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002213 Genomic DNA. Translation: ADO54832.1.
RefSeqiWP_013369467.1. NC_014622.1.
YP_003945073.1. NC_014622.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi886882.PPSC2_c0849.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADO54832; ADO54832; PPSC2_c0849.
GeneIDi9849171.
KEGGippm:PPSC2_c0849.
PATRICi42505058. VBIPaePol172748_0820.

Phylogenomic databases

HOGENOMiHOG000034141.
KOiK01588.
OMAiGLKQKVI.

Enzyme and pathway databases

UniPathwayiUPA00074; UER00943.
BioCyciPPOL886882:GBY1-924-MONOMER.

Family and domain databases

Gene3Di3.40.50.7700. 1 hit.
HAMAPiMF_01929. PurE.
InterProiIPR024694. N5-CAIR_mutase_PurE.
IPR000031. PurE_dom.
[Graphical view]
PfamiPF00731. AIRC. 1 hit.
[Graphical view]
PIRSFiPIRSF001338. AIR_carboxylase. 1 hit.
SMARTiSM01001. AIRC. 1 hit.
[Graphical view]
SUPFAMiSSF52255. SSF52255. 1 hit.
TIGRFAMsiTIGR01162. purE. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete genome sequence of Paenibacillus polymyxa SC2, a strain of plant growth-promoting Rhizobacterium with broad-spectrum antimicrobial activity."
    Ma M., Wang C., Ding Y., Li L., Shen D., Jiang X., Guan D., Cao F., Chen H., Feng R., Wang X., Ge Y., Yao L., Bing X., Yang X., Li J., Du B.
    J. Bacteriol. 193:311-312(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC2Imported.

Entry informationi

Entry nameiE3ECW3_PAEPS
AccessioniPrimary (citable) accession number: E3ECW3
Entry historyi
Integrated into UniProtKB/TrEMBL: January 11, 2011
Last sequence update: January 11, 2011
Last modified: June 24, 2015
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.