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Protein

UDP-N-acetylglucosamine 1-carboxyvinyltransferase

Gene

murA

Organism
Paenibacillus polymyxa (strain SC2) (Bacillus polymyxa)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.UniRule annotationSAAS annotation

Catalytic activityi

Phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine.UniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei117 – 1171Proton donorUniRule annotation

GO - Molecular functioni

  1. UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. cell wall organization Source: UniProtKB-KW
  4. peptidoglycan biosynthetic process Source: UniProtKB-HAMAP
  5. regulation of cell shape Source: UniProtKB-KW
  6. UDP-N-acetylgalactosamine biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

TransferaseUniRule annotationSAAS annotation

Keywords - Biological processi

Cell cycle, Cell divisionUniRule annotationSAAS annotation, Cell shape, Cell wall biogenesis/degradationUniRule annotationSAAS annotation, Peptidoglycan synthesisUniRule annotationSAAS annotation

Keywords - Ligandi

PyruvateUniRule annotation

Enzyme and pathway databases

BioCyciPPOL886882:GBY1-5103-MONOMER.
UniPathwayiUPA00219.
UPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-N-acetylglucosamine 1-carboxyvinyltransferaseUniRule annotationSAAS annotation (EC:2.5.1.7UniRule annotationSAAS annotation)
Alternative name(s):
Enoylpyruvate transferaseUniRule annotation
UDP-N-acetylglucosamine enolpyruvyl transferaseUniRule annotation
Gene namesi
Name:murAUniRule annotation
Ordered Locus Names:PPSC2_c4953Imported
OrganismiPaenibacillus polymyxa (strain SC2) (Bacillus polymyxa)Imported
Taxonomic identifieri886882 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesPaenibacillaceaePaenibacillus
ProteomesiUP000006868: Chromosome

Subcellular locationi

Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei117 – 11712-(S-cysteinyl)pyruvic acid O-phosphothioketalUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliE3EBS4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the EPSP synthase family. MurA subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000075602.
KOiK00790.
OMAiIRTAPHP.

Family and domain databases

Gene3Di3.65.10.10. 2 hits.
HAMAPiMF_00111. MurA.
InterProiIPR001986. Enolpyruvate_Tfrase_dom.
IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b.
IPR005750. UDP_GlcNAc_COvinyl_MurA.
[Graphical view]
PANTHERiPTHR21090:SF4. PTHR21090:SF4. 1 hit.
PfamiPF00275. EPSP_synthase. 1 hit.
[Graphical view]
SUPFAMiSSF55205. SSF55205. 1 hit.
TIGRFAMsiTIGR01072. murA. 1 hit.

Sequencei

Sequence statusi: Complete.

E3EBS4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKFIVRGGN RLTGSVKVSG AKNSVLPIIA ASLLGEEGES VIMDAPPLDD
60 70 80 90 100
VMTINKVLES LGAGVTYQDE VIRVDARKII SCEAPYEWVR KMRASFLVMG
110 120 130 140 150
PLLTRLGRTR ISLPGGCAIG TRPIDQHLKG FEALGAEISL GQGFIEAKSN
160 170 180 190 200
GRLRGAKVYL DVASVGATEN IMMAATLAEG VTTIENAAKE PEIVDLANFL
210 220 230 240 250
NGMGAKVRGA GTGVIRIEGV EKLHGVKHTV IPDRVEAGTY MVAAAITGGN
260 270 280 290 300
VYVEGAISDH LGPVISKMEE MGVTIQPDEN GIRVIADKPL KAVDVKTLPY
310 320 330 340 350
PGFPTDMQSQ MMALQLAAEG TSIITETVFE NRFMHVDEFH LMNAEIKVEG
360 370 380 390 400
RSAIVTGNAK LTGAKVTSTD LRAGAALILT GLIAEGTTEV SGVHHIDRGY
410 420 430 440 450
VHLAEKLTGL GADIYRVTVD ESKLDHSAST ERVGQKKRRG ICSRRFSLPS

PNL
Length:453
Mass (Da):48,266
Last modified:January 11, 2011 - v1
Checksum:i3A65A50C495D5AF2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002213 Genomic DNA. Translation: ADO58892.1.
RefSeqiWP_013373429.1. NC_014622.1.
YP_003949133.1. NC_014622.1.

Genome annotation databases

EnsemblBacteriaiADO58892; ADO58892; PPSC2_c4953.
GeneIDi9853230.
KEGGippm:PPSC2_c4953.
PATRICi42513032. VBIPaePol172748_4739.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002213 Genomic DNA. Translation: ADO58892.1.
RefSeqiWP_013373429.1. NC_014622.1.
YP_003949133.1. NC_014622.1.

3D structure databases

ProteinModelPortaliE3EBS4.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADO58892; ADO58892; PPSC2_c4953.
GeneIDi9853230.
KEGGippm:PPSC2_c4953.
PATRICi42513032. VBIPaePol172748_4739.

Phylogenomic databases

HOGENOMiHOG000075602.
KOiK00790.
OMAiIRTAPHP.

Enzyme and pathway databases

UniPathwayiUPA00219.
UPA00219.
BioCyciPPOL886882:GBY1-5103-MONOMER.

Family and domain databases

Gene3Di3.65.10.10. 2 hits.
HAMAPiMF_00111. MurA.
InterProiIPR001986. Enolpyruvate_Tfrase_dom.
IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b.
IPR005750. UDP_GlcNAc_COvinyl_MurA.
[Graphical view]
PANTHERiPTHR21090:SF4. PTHR21090:SF4. 1 hit.
PfamiPF00275. EPSP_synthase. 1 hit.
[Graphical view]
SUPFAMiSSF55205. SSF55205. 1 hit.
TIGRFAMsiTIGR01072. murA. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete genome sequence of Paenibacillus polymyxa SC2, a strain of plant growth-promoting Rhizobacterium with broad-spectrum antimicrobial activity."
    Ma M., Wang C., Ding Y., Li L., Shen D., Jiang X., Guan D., Cao F., Chen H., Feng R., Wang X., Ge Y., Yao L., Bing X., Yang X., Li J., Du B.
    J. Bacteriol. 193:311-312(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC2Imported.

Entry informationi

Entry nameiE3EBS4_PAEPS
AccessioniPrimary (citable) accession number: E3EBS4
Entry historyi
Integrated into UniProtKB/TrEMBL: January 11, 2011
Last sequence update: January 11, 2011
Last modified: February 4, 2015
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.