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E3E8Y4 (E3E8Y4_PAEPS) Unreviewed, UniProtKB/TrEMBL

Last modified May 29, 2013. Version 21. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Homoserine kinase HAMAP-Rule MF_00384
Short name=HK HAMAP-Rule MF_00384
Short name=HSK HAMAP-Rule MF_00384
EC=2.7.1.39 HAMAP-Rule MF_00384
Gene names
Name:thrB HAMAP-Rule MF_00384
Ordered Locus Names:PPSC2_c4132 EMBL ADO58082.1
OrganismPaenibacillus polymyxa (strain SC2) (Bacillus polymyxa) [Complete proteome] [HAMAP]
Taxonomic identifier886882 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacilli › Bacillales › Paenibacillaceae › Paenibacillus ›

Protein attributes

Sequence length322 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate By similarity. HAMAP-Rule MF_00384 SAAS SAAS006203

Catalytic activity

ATP + L-homoserine = ADP + O-phospho-L-homoserine. HAMAP-Rule MF_00384 SAAS SAAS006203

Pathway

Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5. HAMAP-Rule MF_00384 SAAS SAAS006203

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00384 SAAS SAAS006203.

Sequence similarities

Belongs to the GHMP kinase family. Homoserine kinase subfamily. HAMAP-Rule MF_00384

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding90 – 10011ATP By similarity HAMAP-Rule MF_00384

Sequences

Sequence LengthMass (Da)Tools
E3E8Y4 [UniParc].

Last modified January 11, 2011. Version 1.
Checksum: 679775A4E035FBA1

FASTA32234,732
        10         20         30         40         50         60 
MTVLKTARVR VPASTANLGP GFDTLGMALS LYAWIELKEA EQTAFHLYGD QMNGVPQDKT 

        70         80         90        100        110        120 
NLIYKVAQMV FREAGVSVPE LEISMYSDIP LTRGLGSSAS AIVGALVAAN TLIGSPLSDS 

       130        140        150        160        170        180 
KLFDMASAIE KHPDNVGASL FGGIITAVWD GKHAKHLRIE PDANLEVMVV IPDFQLSTSK 

       190        200        210        220        230        240 
AREVLPTHVS LKDAVYNISH ASMLVAALAS GRTDLIAEAM RDQLHQPYRA ALVPGMTEIL 

       250        260        270        280        290        300 
QNAYHYGALG VALSGAGPTL LALTDQRENR KAELEQYLTE TMNKEGITAS VLNLRPEIEG 

       310        320 
AKVYTEGNTH PFMDMIKGEL TI

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References

[1]"Complete genome sequence of Paenibacillus polymyxa SC2, a strain of plant growth-promoting Rhizobacterium with broad-spectrum antimicrobial activity."
Ma M., Wang C., Ding Y., Li L., Shen D., Jiang X., Guan D., Cao F., Chen H., Feng R., Wang X., Ge Y., Yao L., Bing X., Yang X., Li J., Du B.
J. Bacteriol. 193:311-312(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SC2.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP002213 Genomic DNA. Translation: ADO58082.1.
RefSeqYP_003948323.1. NC_014622.1.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADO58082; ADO58082; PPSC2_c4132.
GeneID9852421.
KEGGppm:PPSC2_c4132.
PATRIC42511370. VBIPaePol172748_3944.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000247199.
KOK00872.
OMALHEPYRW.

Enzyme and pathway databases

BioCycPPOL886882:GBY1-4243-MONOMER.
UniPathwayUPA00050; UER00064.

Family and domain databases

Gene3D3.30.230.10. 1 hit.
HAMAPMF_00384. Homoser_kinase.
InterProIPR013750. GHMP_kinase_C_dom.
IPR006204. GHMP_kinase_N_dom.
IPR006203. GHMP_knse_ATP-bd_CS.
IPR000870. Homoserine_kinase.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
PfamPF08544. GHMP_kinases_C. 1 hit.
PF00288. GHMP_kinases_N. 1 hit.
[Graphical view]
PIRSFPIRSF000676. Homoser_kin. 1 hit.
PRINTSPR00958. HOMSERKINASE.
SUPFAMSSF54211. Ribosomal_S5_D2-typ_fold. 1 hit.
TIGRFAMsTIGR00191. thrB. 1 hit.
PROSITEPS00627. GHMP_KINASES_ATP. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameE3E8Y4_PAEPS
AccessionPrimary (citable) accession number: E3E8Y4
Entry history
Integrated into UniProtKB/TrEMBL: January 11, 2011
Last sequence update: January 11, 2011
Last modified: May 29, 2013
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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