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E3DYS6

- E3DYS6_BACA1

UniProt

E3DYS6 - E3DYS6_BACA1

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Protein

Thymidine kinase

Gene

tdk

Organism
Bacillus atrophaeus (strain 1942)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei89 – 891Proton acceptorUniRule annotation
Metal bindingi145 – 1451ZincUniRule annotation
Metal bindingi148 – 1481ZincUniRule annotation
Metal bindingi183 – 1831ZincUniRule annotation
Metal bindingi186 – 1861ZincUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi15 – 228ATPUniRule annotation
Nucleotide bindingi88 – 914ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. thymidine kinase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotation, Transferase

Keywords - Biological processi

DNA synthesisUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding, ZincUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciBATR720555:GHTA-3315-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotation
Ordered Locus Names:BATR1942_16490Imported
OrganismiBacillus atrophaeus (strain 1942)Imported
Taxonomic identifieri720555 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
ProteomesiUP000006867: Chromosome

Subcellular locationi

Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotationSAAS annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000076390.
KOiK00857.
OMAiDATHTQV.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E3DYS6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MYIMKQSGWL ELICGSMFSG KSEELIRRVK RATYAKQEVR VFKPAIDNRY
60 70 80 90 100
SEEAVVSHNG TSMTSHVIAA PAEIWNHISE TTDVIAVDEV QFFDRMIIEV
110 120 130 140 150
LSSLADKGYR VIAAGLDMDF RGEPFGVVPD LMAMAETVTK LQAVCSVCGS
160 170 180 190
PASRTQRLIN GKPASYDDPI ILVGASESYE ARCRHHHEVP EKAGNAGN
Length:198
Mass (Da):21,837
Last modified:January 11, 2011 - v1
Checksum:i7583753BA29519B2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002207 Genomic DNA. Translation: ADP34217.1.
RefSeqiWP_003326531.1. NC_014639.1.
YP_003975148.1. NC_014639.1.

Genome annotation databases

EnsemblBacteriaiADP34217; ADP34217; BATR1942_16490.
GeneIDi9893283.
KEGGibae:BATR1942_16490.
PATRICi42573526. VBIBacAtr152324_3352.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002207 Genomic DNA. Translation: ADP34217.1 .
RefSeqi WP_003326531.1. NC_014639.1.
YP_003975148.1. NC_014639.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADP34217 ; ADP34217 ; BATR1942_16490 .
GeneIDi 9893283.
KEGGi bae:BATR1942_16490.
PATRICi 42573526. VBIBacAtr152324_3352.

Phylogenomic databases

HOGENOMi HOG000076390.
KOi K00857.
OMAi DATHTQV.

Enzyme and pathway databases

BioCyci BATR720555:GHTA-3315-MONOMER.

Family and domain databases

HAMAPi MF_00124. Thymidine_kinase.
InterProi IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view ]
PANTHERi PTHR11441. PTHR11441. 1 hit.
Pfami PF00265. TK. 1 hit.
[Graphical view ]
PIRSFi PIRSF035805. TK_cell. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genomic signatures of strain selection and enhancement in Bacillus atrophaeus subsp. Globigii, a historical biowarfare simulant."
    Gibbons H.S., Broomall S., McNew L.A., Daligault H., Chapman C., Bruce D., Karavis M., McGregor P., Hong C., Park K.H., Akmal A., Feldman A., Lin J.S., Chang W.E., Higgs B.W., Demirev P., Lindquist J., Liem A.
    , Fochler E., Tapia R., Bishop-Lilly K., Detter C., Han C., Sozhamannan S., Rosenzweig C.N., Skowronski E.
    Submitted (SEP-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1942Imported.

Entry informationi

Entry nameiE3DYS6_BACA1
AccessioniPrimary (citable) accession number: E3DYS6
Entry historyi
Integrated into UniProtKB/TrEMBL: January 11, 2011
Last sequence update: January 11, 2011
Last modified: November 26, 2014
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3