E3DWT0 (E3DWT0_BACA1) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
UvrABC system protein A HAMAP-Rule MF_00205
Short name=UvrA protein HAMAP-Rule MF_00205

Alternative name(s):
Excinuclease ABC subunit A HAMAP-Rule MF_00205

Gene names

Name:	uvrA HAMAP-Rule MF_00205 EMBL ADP34010.1
Ordered Locus Names:	BATR1942_15455 EMBL ADP34010.1

Organism

Bacillus atrophaeus (strain 1942) [Complete proteome] [HAMAP] EMBL ADP34010.1

Taxonomic identifier

720555 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Bacillus › Bacillus subtilis group › Bacillus atrophaeus

Protein attributes

Sequence length	957 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate By similarity. SAAS SAAS004602 HAMAP-Rule MF_00205
Subunit structure	Forms a heterotetramer with UvrB during the search for lesions By similarity. HAMAP-Rule MF_00205 SAAS SAAS004602
Subcellular location	Cytoplasm By similarity SAAS SAAS004602 HAMAP-Rule MF_00205.
Sequence similarities	Belongs to the ABC transporter superfamily. UvrA family. HAMAP-Rule MF_00205 Contains 1 ABC transporter domain. HAMAP-Rule MF_00205 Contains 2 ABC transporter domains. HAMAP-Rule MF_00205

Ontologies

Keywords
Biological process	DNA damage DNA excision SAAS SAAS004602 HAMAP-Rule MF_00205 DNA repair SOS response SAAS SAAS004602 HAMAP-Rule MF_00205 Transport HAMAP-Rule MF_00205
Cellular component	Cytoplasm SAAS SAAS004602 HAMAP-Rule MF_00205 Membrane HAMAP-Rule MF_00205
Domain	Repeat SAAS SAAS004602 HAMAP-Rule MF_00205 Zinc-finger SAAS SAAS004602 HAMAP-Rule MF_00205
Ligand	ATP-binding SAAS SAAS004602 HAMAP-Rule MF_00205 DNA-binding SAAS SAAS004602 HAMAP-Rule MF_00205 Metal-binding Nucleotide-binding Zinc
Molecular function	Excision nuclease SAAS SAAS004602 HAMAP-Rule MF_00205
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	ATP catabolic process Inferred from electronic annotation. Source: GOC SOS response Inferred from electronic annotation. Source: HAMAP nucleic acid phosphodiester bond hydrolysis Inferred from electronic annotation. Source: GOC nucleotide-excision repair Inferred from electronic annotation. Source: HAMAP transport Inferred from electronic annotation. Source: HAMAP
Cellular_component	ATP-binding cassette (ABC) transporter complex Inferred from electronic annotation. Source: HAMAP cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell excinuclease repair complex Inferred from electronic annotation. Source: InterPro
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP ATPase activity Inferred from electronic annotation. Source: InterPro DNA binding Inferred from electronic annotation. Source: HAMAP excinuclease ABC activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Domain	604 – 935	332	ABC transporter By similarity HAMAP-Rule MF_00205
	Nucleotide binding	33 – 40	8	ATP By similarity HAMAP-Rule MF_00205
	Zinc finger	252 – 279	28	C4-type By similarity HAMAP-Rule MF_00205
	Nucleotide binding	639 – 646	8	ATP By similarity HAMAP-Rule MF_00205
	Zinc finger	738 – 764	27	C4-type By similarity HAMAP-Rule MF_00205

Sequences

	Sequence		Length	Mass (Da)
	E3DWT0 [UniParc]. Last modified January 11, 2011. Version 1. Checksum: 235799A3837AEECD	FASTA	957	106,220
	10 20 30 40 50 60 MAMDRIEVKG ARAHNLKNID VTIPRDQLVV VTGLSGSGKS SLAFDTIYAE GQRRYVESLS 70 80 90 100 110 120 AYARQFLGQM DKPDVDAIEG LSPAISIDQK TTSRNPRSTV GTVTEIYDYL RLLYARVGKP 130 140 150 160 170 180 HCPEHGIEIT SQTIEQMVDR ILEYPERTKL QVLAPIVSGR KGAHVKVLEQ IRKQGYVRVR 190 200 210 220 230 240 IDGEMAELSE EIELEKNKKH SIEVVIDRIV VKEGVAPRLS DSLETALRLG EGRVMIDVMG 250 260 270 280 290 300 QEELMFSEHH ACPHCGFSIG ELEPRLFSFN SPFGACPTCD GLGMKLEVDS DLVIPNKDLS 310 320 330 340 350 360 LKENAIAPWT PISSQYYPQL LQAVCSHYGI DMEVPVKELP DHLLDKVLYG SGNEQIYFKY 370 380 390 400 410 420 ENDFGQVREN HIEFEGVLRN IERRYKETSS DYIREQMEQY MSQKPCPTCK GYRLKKEALA 430 440 450 460 470 480 VLVDGRHIGK ITELSIADAL QFFKGLSLSE KDMQIADLIL REIVERLSFL DKVGLDYLTL 490 500 510 520 530 540 SRAAGTLSGG EAQRIRLATQ IGSRLSGVLY ILDEPSIGLH QRDNDRLISA LKNMRDLGNT 550 560 570 580 590 600 LIVVEHDEDT MMAADYLIDI GPGAGVHGGQ VISAGTPKEV MADKDSLTGS YLSGEKFIPL 610 620 630 640 650 660 PPERRKPDGR FIEIKGASEN NLKKANAKFP LGTFTAVTGV SGSGKSTLVN EILHKALAQK 670 680 690 700 710 720 LHKAKAKPGS HKEIKGLDHL DKVIDIDQAP IGRTPRSNPA TYTGVFDDIR DVFAQTNEAK 730 740 750 760 770 780 VRGYKKGRFS FNVKGGRCEA CRGDGIIKIE MHFLPDVYVP CEVCHGKRYN RETLEVTYKG 790 800 810 820 830 840 KSISDVLDMT VEYALSFFEN IPKIKRKLQT LFDVGLGYIT LGQPATTLSG GEAQRVKLAS 850 860 870 880 890 900 ELHKRSTGRT LYILDEPTTG LHVDDIARLL IVLQRLVDNG DTVLVIEHNL DIIKTADYIV 910 920 930 940 950 DLGPEGGAGG GTIVASGTPE DVMEVKESYT GHYLKPVVER DRKRMKALIK AKETVTP

References

[1]

"Genomic signatures of strain selection and enhancement in Bacillus atrophaeus subsp. Globigii, a historical biowarfare simulant." Gibbons H.S., Broomall S., McNew L.A., Daligault H., Chapman C., Bruce D., Karavis M., McGregor P., Hong C., Park K.H., Akmal A., Feldman A., Lin J.S., Chang W.E., Higgs B.W., Demirev P., Lindquist J., Liem A. , Fochler E., Tapia R., Bishop-Lilly K., Detter C., Han C., Sozhamannan S., Rosenzweig C.N., Skowronski E. Submitted (SEP-2010) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 1942.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP002207 Genomic DNA. Translation: ADP34010.1.
RefSeq	YP_003974941.1. NC_014639.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ADP34010; ADP34010; BATR1942_15455.
GeneID	9893076.
KEGG	bae:BATR1942_15455.
PATRIC	42573108. VBIBacAtr152324_3142.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HOG000050449.
KO	K03701.
Enzyme and pathway databases
BioCyc	BATR720555:GHTA-3108-MONOMER.
Family and domain databases
Gene3D	3.30.1490.20. 2 hits.
HAMAP	MF_00205. UvrA.
InterPro	IPR003593. AAA+_ATPase. IPR003439. ABC_transporter-like. IPR017871. ABC_transporter_CS. IPR013815. ATP_grasp_subdomain_1. IPR004602. UvrA. [Graphical view]
Pfam	PF00005. ABC_tran. 2 hits. [Graphical view]
SMART	SM00382. AAA. 1 hit. [Graphical view]
TIGRFAMs	TIGR00630. uvra. 1 hit.
PROSITE	PS00211. ABC_TRANSPORTER_1. 2 hits. PS50893. ABC_TRANSPORTER_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

E3DWT0_BACA1

Accession

Primary (citable) accession number: E3DWT0

Entry history

Integrated into UniProtKB/TrEMBL:	January 11, 2011
Last sequence update:	January 11, 2011
Last modified:	May 1, 2013
This is version 24 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)