Skip Header

Contribute Send feedback
Read comments (?) or add your own

E3DW75 (E3DW75_BACA1) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 20. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase RuleBase RU004136
EC=6.3.2.10 RuleBase RU004136
Gene names
Ordered Locus Names:BATR1942_21020 EMBL ADP35119.1
OrganismBacillus atrophaeus (strain 1942) [Complete proteome] [HAMAP] EMBL ADP35119.1
Taxonomic identifier720555 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Bacillus ›

Protein attributes

Sequence length455 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein By similarity. RuleBase RU004136

Catalytic activity

ATP + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-L-lysine + D-alanyl-D-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine. RuleBase RU004136

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. RuleBase RU004136

Subcellular location

Cytoplasm By similarity RuleBase RU004136.

Sequence similarities

Belongs to the MurCDEF family.

Sequences

Sequence LengthMass (Da)Tools
E3DW75 [UniParc].

Last modified January 11, 2011. Version 1.
Checksum: 76379305C998AD04

FASTA45549,512
        10         20         30         40         50         60 
MIKRTAKKIA EMVKGTLTDP TYENIVIQGV ATDTRKLEKN QLFIPLTGEN FNGHTFVGQA 

        70         80         90        100        110        120 
FENGVSAVLW NKSEPNPPQD QAVILVDDTL GALQELSKAY LQELGTRVIG VTGSNGKTTT 

       130        140        150        160        170        180 
KDMLHAVLQT QFRVHKTEGN FNNHIGLPLT VLSMPEDTEV AVLEMGMSGK GEIDLLTRLA 

       190        200        210        220        230        240 
NPEAAVITNI GESHMQDLGS REGIAEAKLE ITNGLKKDGI LIYIGDEPLL NKRSYSCRTK 

       250        260        270        280        290        300 
TFGADEGNDY QLEDVKQTED GTHFSIKGID KTFFIPVLGK HNVLNAIAAF AAGIHFGITV 

       310        320        330        340        350        360 
ENAAKGLSGL KVTGMRLELL KSESGVSIIN DAYNASPTSM KAAIELIESM EGYGKKMLVL 

       370        380        390        400        410        420 
GDMLELGDLE QEFHTECGAV INPAAIDYVF TYGKLGAFIA AGAHRHFDQE RVSHFNDKAE 

       430        440        450 
LLQAVAEKAE KGDLILFKAS RGMKLEEIVK DLMKG

« Hide

References

[1]"Genomic signatures of strain selection and enhancement in Bacillus atrophaeus subsp. Globigii, a historical biowarfare simulant."
Gibbons H.S., Broomall S., McNew L.A., Daligault H., Chapman C., Bruce D., Karavis M., McGregor P., Hong C., Park K.H., Akmal A., Feldman A., Lin J.S., Chang W.E., Higgs B.W., Demirev P., Lindquist J., Liem A. expand/collapse author list , Fochler E., Tapia R., Bishop-Lilly K., Detter C., Han C., Sozhamannan S., Rosenzweig C.N., Skowronski E.
Submitted (SEP-2010) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 1942.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP002207 Genomic DNA. Translation: ADP35119.1.
RefSeqYP_003976050.1. NC_014639.1.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADP35119; ADP35119; BATR1942_21020.
GeneID9894215.
KEGGbae:BATR1942_21020.
PATRIC42575485. VBIBacAtr152324_4312.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000268119.
KOK01929.

Enzyme and pathway databases

BioCycBATR720555:GHTA-4247-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.40.1190.10. 1 hit.
3.90.190.20. 1 hit.
InterProIPR004101. Mur_ligase_C.
IPR013221. Mur_ligase_cen.
IPR000713. Mur_ligase_N.
IPR005863. UDP-N-AcMur-pentapeptide_synth.
[Graphical view]
PANTHERPTHR23135:SF3. PTHR23135:SF3. 1 hit.
PfamPF01225. Mur_ligase. 1 hit.
PF02875. Mur_ligase_C. 1 hit.
PF08245. Mur_ligase_M. 1 hit.
[Graphical view]
SUPFAMSSF53244. Mur_ligase_C. 1 hit.
SSF53623. Mur_ligase_cen. 1 hit.
TIGRFAMsTIGR01143. murF. 1 hit.
ProtoNetSearch...

Entry information

Entry nameE3DW75_BACA1
AccessionPrimary (citable) accession number: E3DW75
Entry history
Integrated into UniProtKB/TrEMBL: January 11, 2011
Last sequence update: January 11, 2011
Last modified: May 1, 2013
This is version 20 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info