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E3DRG9

- E3DRG9_HALPG

UniProt

E3DRG9 - E3DRG9_HALPG

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Protein

Thymidine kinase

Gene

tdk

Organism
Halanaerobium praevalens (strain ATCC 33744 / DSM 2228 / GSL)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei89 – 891Proton acceptorUniRule annotation
Metal bindingi145 – 1451ZincUniRule annotation
Metal bindingi148 – 1481ZincUniRule annotation
Metal bindingi183 – 1831ZincUniRule annotation
Metal bindingi186 – 1861ZincUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi15 – 228ATPUniRule annotation
Nucleotide bindingi88 – 914ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. thymidine kinase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotation, Transferase

Keywords - Biological processi

DNA synthesisUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding, ZincUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciHPRA572479:GLDS-2043-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotation
Ordered Locus Names:Hprae_1976Imported
OrganismiHalanaerobium praevalens (strain ATCC 33744 / DSM 2228 / GSL)Imported
Taxonomic identifieri572479 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaHalanaerobialesHalanaerobiaceaeHalanaerobium
ProteomesiUP000006866: Chromosome

Subcellular locationi

Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotationSAAS annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

KOiK00857.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E3DRG9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MYKITKSGWL EIITGPMYCG KSEELIRRLN RVKIAKQKVR VFKPVLDDRY
60 70 80 90 100
SKKDVVSHSG NSIEAVPVDH PEEILKRIDK TVDVVGIDEA QFFHSDLVAI
110 120 130 140 150
CEELADEGIR VILAGLDRDF RNQPFGPMPE LMARAEYVDK LHAICIQCGE
160 170 180 190
PASRTQRLIN GQPARADDPV ILVGAAEVYE ARCRSCHSLR TD
Length:192
Mass (Da):21,632
Last modified:January 11, 2011 - v1
Checksum:i14E0DA779ECD278F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002175 Genomic DNA. Translation: ADO78101.1.
RefSeqiWP_014554117.1. NC_017455.1.
YP_005837261.1. NC_017455.1.

Genome annotation databases

EnsemblBacteriaiADO78101; ADO78101; Hprae_1976.
GeneIDi12443978.
KEGGihpk:Hprae_1976.
PATRICi43057326. VBIHalPra106773_2011.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002175 Genomic DNA. Translation: ADO78101.1 .
RefSeqi WP_014554117.1. NC_017455.1.
YP_005837261.1. NC_017455.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADO78101 ; ADO78101 ; Hprae_1976 .
GeneIDi 12443978.
KEGGi hpk:Hprae_1976.
PATRICi 43057326. VBIHalPra106773_2011.

Phylogenomic databases

KOi K00857.

Enzyme and pathway databases

BioCyci HPRA572479:GLDS-2043-MONOMER.

Family and domain databases

HAMAPi MF_00124. Thymidine_kinase.
InterProi IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view ]
PANTHERi PTHR11441. PTHR11441. 1 hit.
Pfami PF00265. TK. 1 hit.
[Graphical view ]
PIRSFi PIRSF035805. TK_cell. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33744 / DSM 2228 / GSLImported.

Entry informationi

Entry nameiE3DRG9_HALPG
AccessioniPrimary (citable) accession number: E3DRG9
Entry historyi
Integrated into UniProtKB/TrEMBL: January 11, 2011
Last sequence update: January 11, 2011
Last modified: October 29, 2014
This is version 20 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3