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Protein

Thymidine kinase

Gene

tdk

Organism
Halanaerobium praevalens (strain ATCC 33744 / DSM 2228 / GSL)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei89Proton acceptorUniRule annotation1
Metal bindingi145ZincUniRule annotation1
Metal bindingi148ZincUniRule annotation1
Metal bindingi183ZincUniRule annotation1
Metal bindingi186ZincUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi15 – 22ATPUniRule annotation8
Nucleotide bindingi88 – 91ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseUniRule annotationImported, Transferase
Biological processDNA synthesisUniRule annotation
LigandATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding, ZincUniRule annotation

Enzyme and pathway databases

BioCyciHPRA572479:G1GOF-2024-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotation
Ordered Locus Names:Hprae_1976Imported
OrganismiHalanaerobium praevalens (strain ATCC 33744 / DSM 2228 / GSL)Imported
Taxonomic identifieri572479 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaHalanaerobialesHalanaerobiaceaeHalanaerobium
Proteomesi
  • UP000006866 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi572479.Hprae_1976

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107104 Bacteria
COG1435 LUCA
KOiK00857
OMAiCAGLDQD
OrthoDBiPOG091H0659

Family and domain databases

HAMAPiMF_00124 Thymidine_kinase, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR001267 Thymidine_kinase
IPR020633 Thymidine_kinase_CS
PANTHERiPTHR11441 PTHR11441, 1 hit
PfamiView protein in Pfam
PF00265 TK, 1 hit
PIRSFiPIRSF035805 TK_cell, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00603 TK_CELLULAR_TYPE, 1 hit

Sequencei

Sequence statusi: Complete.

E3DRG9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYKITKSGWL EIITGPMYCG KSEELIRRLN RVKIAKQKVR VFKPVLDDRY
60 70 80 90 100
SKKDVVSHSG NSIEAVPVDH PEEILKRIDK TVDVVGIDEA QFFHSDLVAI
110 120 130 140 150
CEELADEGIR VILAGLDRDF RNQPFGPMPE LMARAEYVDK LHAICIQCGE
160 170 180 190
PASRTQRLIN GQPARADDPV ILVGAAEVYE ARCRSCHSLR TD
Length:192
Mass (Da):21,632
Last modified:January 11, 2011 - v1
Checksum:i14E0DA779ECD278F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002175 Genomic DNA Translation: ADO78101.1
RefSeqiWP_014554117.1, NC_017455.1

Genome annotation databases

EnsemblBacteriaiADO78101; ADO78101; Hprae_1976
KEGGihpk:Hprae_1976
PATRICifig|572479.3.peg.2011

Similar proteinsi

Entry informationi

Entry nameiE3DRG9_HALPG
AccessioniPrimary (citable) accession number: E3DRG9
Entry historyiIntegrated into UniProtKB/TrEMBL: January 11, 2011
Last sequence update: January 11, 2011
Last modified: March 28, 2018
This is version 39 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health