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E3DRG9

- E3DRG9_HALPG

UniProt

E3DRG9 - E3DRG9_HALPG

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Protein

Thymidine kinase

Gene
tdk, Hprae_1976
Organism
Halanaerobium praevalens (strain ATCC 33744 / DSM 2228 / GSL)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotationSAAS annotations

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei89 – 891Proton acceptor By similarityUniRule annotation
Metal bindingi145 – 1451Zinc By similarityUniRule annotation
Metal bindingi148 – 1481Zinc By similarityUniRule annotation
Metal bindingi183 – 1831Zinc By similarityUniRule annotation
Metal bindingi186 – 1861Zinc By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi15 – 228ATP By similarityUniRule annotation
Nucleotide bindingi88 – 914ATP By similarityUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. thymidine kinase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationSAAS annotationsImported, Transferase

Keywords - Biological processi

DNA synthesisUniRule annotationSAAS annotations

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotations, Metal-bindingUniRule annotationSAAS annotations, Nucleotide-binding, ZincUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciHPRA572479:GLDS-2043-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotation
Ordered Locus Names:Hprae_1976Imported
OrganismiHalanaerobium praevalens (strain ATCC 33744 / DSM 2228 / GSL)Imported
Taxonomic identifieri572479 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaHalanaerobialesHalanaerobiaceaeHalanaerobium
ProteomesiUP000006866: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotationSAAS annotations

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotations

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotationSAAS annotations

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

KOiK00857.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E3DRG9-1 [UniParc]FASTAAdd to Basket

« Hide

MYKITKSGWL EIITGPMYCG KSEELIRRLN RVKIAKQKVR VFKPVLDDRY    50
SKKDVVSHSG NSIEAVPVDH PEEILKRIDK TVDVVGIDEA QFFHSDLVAI 100
CEELADEGIR VILAGLDRDF RNQPFGPMPE LMARAEYVDK LHAICIQCGE 150
PASRTQRLIN GQPARADDPV ILVGAAEVYE ARCRSCHSLR TD 192
Length:192
Mass (Da):21,632
Last modified:January 11, 2011 - v1
Checksum:i14E0DA779ECD278F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002175 Genomic DNA. Translation: ADO78101.1.
RefSeqiWP_014554117.1. NC_017455.1.
YP_005837261.1. NC_017455.1.

Genome annotation databases

EnsemblBacteriaiADO78101; ADO78101; Hprae_1976.
GeneIDi12443978.
KEGGihpk:Hprae_1976.
PATRICi43057326. VBIHalPra106773_2011.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002175 Genomic DNA. Translation: ADO78101.1 .
RefSeqi WP_014554117.1. NC_017455.1.
YP_005837261.1. NC_017455.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADO78101 ; ADO78101 ; Hprae_1976 .
GeneIDi 12443978.
KEGGi hpk:Hprae_1976.
PATRICi 43057326. VBIHalPra106773_2011.

Phylogenomic databases

KOi K00857.

Enzyme and pathway databases

BioCyci HPRA572479:GLDS-2043-MONOMER.

Family and domain databases

HAMAPi MF_00124. Thymidine_kinase.
InterProi IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view ]
PANTHERi PTHR11441. PTHR11441. 1 hit.
Pfami PF00265. TK. 1 hit.
[Graphical view ]
PIRSFi PIRSF035805. TK_cell. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33744 / DSM 2228 / GSL.

Entry informationi

Entry nameiE3DRG9_HALPG
AccessioniPrimary (citable) accession number: E3DRG9
Entry historyi
Integrated into UniProtKB/TrEMBL: January 11, 2011
Last sequence update: January 11, 2011
Last modified: September 3, 2014
This is version 18 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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