ID   E3DNV5_HALPG            Unreviewed;       404 AA.
AC   E3DNV5;
DT   11-JAN-2011, integrated into UniProtKB/TrEMBL.
DT   11-JAN-2011, sequence version 1.
DT   27-MAR-2024, entry version 50.
DE   RecName: Full=alanine transaminase {ECO:0000256|ARBA:ARBA00026106};
DE            EC=2.6.1.2 {ECO:0000256|ARBA:ARBA00026106};
GN   OrderedLocusNames=Hprae_0425 {ECO:0000313|EMBL:ADO76579.1};
OS   Halanaerobium praevalens (strain ATCC 33744 / DSM 2228 / GSL).
OC   Bacteria; Bacillota; Clostridia; Halanaerobiales; Halanaerobiaceae;
OC   Halanaerobium.
OX   NCBI_TaxID=572479 {ECO:0000313|EMBL:ADO76579.1, ECO:0000313|Proteomes:UP000006866};
RN   [1] {ECO:0000313|Proteomes:UP000006866}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 33744 / DSM 2228 / GSL
RC   {ECO:0000313|Proteomes:UP000006866};
RG   US DOE Joint Genome Institute (JGI-PGF);
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA   Bruce D., Goodwin L., Pitluck S., Kyrpides N., Mavromatis K., Ivanova N.,
RA   Ovchinnikova G., Chertkov O., Detter J.C., Han C., Larimer F., Land M.,
RA   Hauser L., Markowitz V., Cheng J.-F., Hugenholtz P., Woyke T., Wu D.,
RA   Tindall B., Pomrenke H.G., Brambilla E., Klenk H.-P., Eisen J.A.;
RT   "The complete genome of Halanaerobium praevalens DSM 2228.";
RL   Submitted (OCT-2010) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ADO76579.1, ECO:0000313|Proteomes:UP000006866}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 33744 / DSM 2228 / GSL
RC   {ECO:0000313|Proteomes:UP000006866};
RX   PubMed=21886858;
RA   Ivanova N., Sikorski J., Chertkov O., Nolan M., Lucas S., Hammon N.,
RA   Deshpande S., Cheng J.F., Tapia R., Han C., Goodwin L., Pitluck S.,
RA   Huntemann M., Liolios K., Pagani I., Mavromatis K., Ovchinikova G.,
RA   Pati A., Chen A., Palaniappan K., Land M., Hauser L., Brambilla E.M.,
RA   Kannan K.P., Rohde M., Tindall B.J., Goker M., Detter J.C., Woyke T.,
RA   Bristow J., Eisen J.A., Markowitz V., Hugenholtz P., Kyrpides N.C.,
RA   Klenk H.P., Lapidus A.;
RT   "Complete genome sequence of the extremely halophilic Halanaerobium
RT   praevalens type strain (GSL).";
RL   Stand. Genomic Sci. 4:312-321(2011).
CC   -!- COFACTOR:
CC       Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC         Evidence={ECO:0000256|ARBA:ARBA00001933};
CC   -!- SIMILARITY: Belongs to the class-I pyridoxal-phosphate-dependent
CC       aminotransferase family. {ECO:0000256|ARBA:ARBA00007441}.
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DR   EMBL; CP002175; ADO76579.1; -; Genomic_DNA.
DR   RefSeq; WP_014552612.1; NC_017455.1.
DR   AlphaFoldDB; E3DNV5; -.
DR   STRING; 572479.Hprae_0425; -.
DR   KEGG; hpk:Hprae_0425; -.
DR   PATRIC; fig|572479.3.peg.431; -.
DR   eggNOG; COG0436; Bacteria.
DR   HOGENOM; CLU_017584_4_2_9; -.
DR   OrthoDB; 9802328at2; -.
DR   Proteomes; UP000006866; Chromosome.
DR   GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR   GO; GO:0008483; F:transaminase activity; IEA:UniProtKB-KW.
DR   GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR   CDD; cd00609; AAT_like; 1.
DR   Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR   Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR   InterPro; IPR004839; Aminotransferase_I/II.
DR   InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR   InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR   InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR   PANTHER; PTHR43488; GLUTAMATE-PYRUVATE AMINOTRANSFERASE ALAA; 1.
DR   PANTHER; PTHR43488:SF2; GLUTAMATE-PYRUVATE AMINOTRANSFERASE ALAA; 1.
DR   Pfam; PF00155; Aminotran_1_2; 1.
DR   SUPFAM; SSF53383; PLP-dependent transferases; 1.
PE   3: Inferred from homology;
KW   Aminotransferase {ECO:0000313|EMBL:ADO76579.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006866};
KW   Transferase {ECO:0000313|EMBL:ADO76579.1}.
FT   DOMAIN          62..395
FT                   /note="Aminotransferase class I/classII"
FT                   /evidence="ECO:0000259|Pfam:PF00155"
SQ   SEQUENCE   404 AA;  45539 MW;  4EDC512BBFE99E38 CRC64;
     MDYIKKSLKL DNVCYDIRGP VLEEATRLEE EGYNIYKLNI GNTAPFGFNA PDEIIHDVMY
     NLKNAQGYCD SKGIFSARKA VMQYYQKKGI MDVEINDIYI GNGVSELITL AMQGLLDSGD
     EVLIPMPDYP LWTASVNLAG GKAVHYLCDE ESNWYPDLVD IRAKINQNTK AIVIINPNNP
     TGANYPQEIL EGIIKIAKEN QLIIYSDEIY EKITYNKQKH CSIATLTDDV LVVTFSGLSK
     SHRIPGFRAG WMMISGKKYH AQGYIEGLNI LSSMRLCSNV PSQYAIQTSL GGYQSIDELV
     LPGGRLKEQR DLAHKLLTDI PGISCVKPDA GLYLFPKIDT DLYNIKNDEQ FILDLLIQEK
     VLLVQGSGFN WPKPNHFRVV FLPGEEDLKI ALGRLHKFLN NYKQ
//