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E3D3X1

- E3D3X1_NEIM7

UniProt

E3D3X1 - E3D3X1_NEIM7

Protein

Phosphoenolpyruvate carboxylase

Gene

ppc

Organism
Neisseria meningitidis serogroup B (strain alpha710)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 20 (01 Oct 2014)
      Sequence version 1 (11 Jan 2011)
      Previous versions | rss
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    Functioni

    Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.UniRule annotationSAAS annotation

    Catalytic activityi

    Phosphate + oxaloacetate = H2O + phosphoenolpyruvate + HCO3-.UniRule annotationSAAS annotation

    Cofactori

    Magnesium.UniRule annotationSAAS annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei157 – 1571UniRule annotation
    Active sitei585 – 5851UniRule annotation

    GO - Molecular functioni

    1. magnesium ion binding Source: UniProtKB-HAMAP
    2. phosphoenolpyruvate carboxylase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. carbon fixation Source: UniProtKB-HAMAP
    2. oxaloacetate metabolic process Source: UniProtKB-HAMAP
    3. tricarboxylic acid cycle Source: InterPro

    Keywords - Molecular functioni

    LyaseUniRule annotationSAAS annotationImported

    Keywords - Biological processi

    Carbon dioxide fixationUniRule annotationSAAS annotation

    Keywords - Ligandi

    MagnesiumUniRule annotationSAAS annotation, PyruvateImported

    Enzyme and pathway databases

    BioCyciNMEN630588:GLHP-2046-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoenolpyruvate carboxylaseUniRule annotation (EC:4.1.1.31UniRule annotation)
    Short name:
    PEPCUniRule annotation
    Short name:
    PEPCaseUniRule annotation
    Gene namesi
    Name:ppcUniRule annotation
    Ordered Locus Names:NMBB_2367Imported
    OrganismiNeisseria meningitidis serogroup B (strain alpha710)Imported
    Taxonomic identifieri630588 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria
    ProteomesiUP000006929: Chromosome

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PEPCase type 1 family.UniRule annotation

    Phylogenomic databases

    KOiK01595.

    Family and domain databases

    HAMAPiMF_00595. PEPcase_type1.
    InterProiIPR021135. PEP_COase.
    IPR018129. PEP_COase_AS.
    IPR022805. PEP_COase_bac/pln-type.
    IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
    [Graphical view]
    PfamiPF00311. PEPcase. 1 hit.
    [Graphical view]
    PRINTSiPR00150. PEPCARBXLASE.
    SUPFAMiSSF51621. SSF51621. 1 hit.
    PROSITEiPS00781. PEPCASE_1. 1 hit.
    PS00393. PEPCASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    E3D3X1-1 [UniParc]FASTAAdd to Basket

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    MRHLRYIYSI YGNERKIMQL HILNNPKDAA LAADAEFLKQ SLFNLLHEEA    50
    SPLVVETVKL LSTSDDSAAL IEKVLPQLDE QQTHDLTLAC GLFAQILNIA 100
    EDVHHERRRQ IHEEAGRGGA EGSLTETVRR LKAGKADGKS VQRQLDNTSV 150
    TAVLTAHPTE VQRQTVLSFN RRIRALLPQR ERCTNADALA RLRREIDTIL 200
    LGLWQTSETR RHKLSVNDEI NNGVSIFPMS FFEALPKLYR KMEHDFQTAY 250
    PDVRVPNILK IGGWIGGDRD GNPFVSAETL RFAFRRHADA VFRFYRGELD 300
    KLYRELPLSI RRVKVNDDVM ALAALSPDEE LARTEEPYRR AIAYIMARAM 350
    GKARALGLGM GCKFGFLEPY ASAQEFLDDL KKLQRSLIDN GSRLLAEGRL 400
    ADLIRSVSVF GFHMMPLDLR QHAGKHADVV TELFQHAGLE DYNSLNEEQK 450
    QAVLLRELSH QRPLYSPFIT YSDHTRHELA IFNEARKIKD EFGEDAVTQS 500
    IISNCEQPSD LLALALLLKE SGLLAVENGK PHSRINIVPL FETIEALENA 550
    CPVMETMFRL DWYDALLESR GNIQEIMLGY SDSNKDGGYV TSSWCLYQAE 600
    LGLVELFKKY DVRMRLFHGR GGSVGRGGGP SYQAILAQPA GSVAGQIRIT 650
    EQGEVITAKY ADPGNAQRNL ETLVAATLEA SILPDKKDPD AKLMQALSDV 700
    SFKYYRELIT HPDFIDYFLQ TSPIQEIATL NLGSRPASRK TLARIQDLRA 750
    IPWVFSWMQN RLMLPAWYGF GSAVETLCEG SPETLAALRE HAQSNPFFQA 800
    MLSNMEQVMA KTDITLAENY AGLSESPEKA AVIFGMIKEE YQRSRKALLD 850
    LLQTEELLRD NRSLARSLAL RIPYLNALNG LQVAMLKRLR KEPDNPHALL 900
    MVHLTINGVA QGLRNTG 917
    Length:917
    Mass (Da):103,265
    Last modified:January 11, 2011 - v1
    Checksum:i209AFEB38A242C9D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001561 Genomic DNA. Translation: ADO32481.1.
    RefSeqiYP_005883612.1. NC_017505.1.

    Genome annotation databases

    EnsemblBacteriaiADO32481; ADO32481; NMBB_2367.
    GeneIDi12399994.
    KEGGinmp:NMBB_2367.
    PATRICi43138228. VBINeiMen23504_2762.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001561 Genomic DNA. Translation: ADO32481.1 .
    RefSeqi YP_005883612.1. NC_017505.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADO32481 ; ADO32481 ; NMBB_2367 .
    GeneIDi 12399994.
    KEGGi nmp:NMBB_2367.
    PATRICi 43138228. VBINeiMen23504_2762.

    Phylogenomic databases

    KOi K01595.

    Enzyme and pathway databases

    BioCyci NMEN630588:GLHP-2046-MONOMER.

    Family and domain databases

    HAMAPi MF_00595. PEPcase_type1.
    InterProi IPR021135. PEP_COase.
    IPR018129. PEP_COase_AS.
    IPR022805. PEP_COase_bac/pln-type.
    IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
    [Graphical view ]
    Pfami PF00311. PEPcase. 1 hit.
    [Graphical view ]
    PRINTSi PR00150. PEPCARBXLASE.
    SUPFAMi SSF51621. SSF51621. 1 hit.
    PROSITEi PS00781. PEPCASE_1. 1 hit.
    PS00393. PEPCASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Comparative genome biology of a serogroup B carriage and disease strain supports a polygenic nature of meningococcal virulence."
      Joseph B., Schneiker-Bekel S., Schramm-Gluck A., Blom J., Claus H., Linke B., Schwarz R.F., Becker A., Goesmann A., Frosch M., Schoen C.
      J. Bacteriol. 192:5363-5377(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: alpha710Imported.

    Entry informationi

    Entry nameiE3D3X1_NEIM7
    AccessioniPrimary (citable) accession number: E3D3X1
    Entry historyi
    Integrated into UniProtKB/TrEMBL: January 11, 2011
    Last sequence update: January 11, 2011
    Last modified: October 1, 2014
    This is version 20 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3