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E3D3X1

- E3D3X1_NEIM7

UniProt

E3D3X1 - E3D3X1_NEIM7

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Protein

Phosphoenolpyruvate carboxylase

Gene

ppc

Organism
Neisseria meningitidis serogroup B (strain alpha710)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.UniRule annotationSAAS annotation

Catalytic activityi

Phosphate + oxaloacetate = H2O + phosphoenolpyruvate + HCO3-.UniRule annotationSAAS annotation

Cofactori

Note: Magnesium.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei157 – 1571UniRule annotation
Active sitei585 – 5851UniRule annotation

GO - Molecular functioni

  1. magnesium ion binding Source: UniProtKB-HAMAP
  2. phosphoenolpyruvate carboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbon fixation Source: UniProtKB-HAMAP
  2. oxaloacetate metabolic process Source: UniProtKB-HAMAP
  3. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotationSAAS annotation

Keywords - Biological processi

Carbon dioxide fixationUniRule annotationSAAS annotation

Keywords - Ligandi

MagnesiumUniRule annotationSAAS annotation, PyruvateImported

Enzyme and pathway databases

BioCyciNMEN630588:GLHP-2046-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxylaseUniRule annotation (EC:4.1.1.31UniRule annotation)
Short name:
PEPCUniRule annotation
Short name:
PEPCaseUniRule annotation
Gene namesi
Name:ppcUniRule annotation
Ordered Locus Names:NMBB_2367Imported
OrganismiNeisseria meningitidis serogroup B (strain alpha710)Imported
Taxonomic identifieri630588 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria
ProteomesiUP000006929: Chromosome

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the PEPCase type 1 family.UniRule annotation

Phylogenomic databases

KOiK01595.

Family and domain databases

HAMAPiMF_00595. PEPcase_type1.
InterProiIPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF00311. PEPcase. 1 hit.
[Graphical view]
PRINTSiPR00150. PEPCARBXLASE.
SUPFAMiSSF51621. SSF51621. 1 hit.
PROSITEiPS00781. PEPCASE_1. 1 hit.
PS00393. PEPCASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E3D3X1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRHLRYIYSI YGNERKIMQL HILNNPKDAA LAADAEFLKQ SLFNLLHEEA
60 70 80 90 100
SPLVVETVKL LSTSDDSAAL IEKVLPQLDE QQTHDLTLAC GLFAQILNIA
110 120 130 140 150
EDVHHERRRQ IHEEAGRGGA EGSLTETVRR LKAGKADGKS VQRQLDNTSV
160 170 180 190 200
TAVLTAHPTE VQRQTVLSFN RRIRALLPQR ERCTNADALA RLRREIDTIL
210 220 230 240 250
LGLWQTSETR RHKLSVNDEI NNGVSIFPMS FFEALPKLYR KMEHDFQTAY
260 270 280 290 300
PDVRVPNILK IGGWIGGDRD GNPFVSAETL RFAFRRHADA VFRFYRGELD
310 320 330 340 350
KLYRELPLSI RRVKVNDDVM ALAALSPDEE LARTEEPYRR AIAYIMARAM
360 370 380 390 400
GKARALGLGM GCKFGFLEPY ASAQEFLDDL KKLQRSLIDN GSRLLAEGRL
410 420 430 440 450
ADLIRSVSVF GFHMMPLDLR QHAGKHADVV TELFQHAGLE DYNSLNEEQK
460 470 480 490 500
QAVLLRELSH QRPLYSPFIT YSDHTRHELA IFNEARKIKD EFGEDAVTQS
510 520 530 540 550
IISNCEQPSD LLALALLLKE SGLLAVENGK PHSRINIVPL FETIEALENA
560 570 580 590 600
CPVMETMFRL DWYDALLESR GNIQEIMLGY SDSNKDGGYV TSSWCLYQAE
610 620 630 640 650
LGLVELFKKY DVRMRLFHGR GGSVGRGGGP SYQAILAQPA GSVAGQIRIT
660 670 680 690 700
EQGEVITAKY ADPGNAQRNL ETLVAATLEA SILPDKKDPD AKLMQALSDV
710 720 730 740 750
SFKYYRELIT HPDFIDYFLQ TSPIQEIATL NLGSRPASRK TLARIQDLRA
760 770 780 790 800
IPWVFSWMQN RLMLPAWYGF GSAVETLCEG SPETLAALRE HAQSNPFFQA
810 820 830 840 850
MLSNMEQVMA KTDITLAENY AGLSESPEKA AVIFGMIKEE YQRSRKALLD
860 870 880 890 900
LLQTEELLRD NRSLARSLAL RIPYLNALNG LQVAMLKRLR KEPDNPHALL
910
MVHLTINGVA QGLRNTG
Length:917
Mass (Da):103,265
Last modified:January 11, 2011 - v1
Checksum:i209AFEB38A242C9D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001561 Genomic DNA. Translation: ADO32481.1.
RefSeqiWP_014575612.1. NC_017505.1.
YP_005883612.1. NC_017505.1.

Genome annotation databases

EnsemblBacteriaiADO32481; ADO32481; NMBB_2367.
GeneIDi12399994.
KEGGinmp:NMBB_2367.
PATRICi43138228. VBINeiMen23504_2762.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001561 Genomic DNA. Translation: ADO32481.1 .
RefSeqi WP_014575612.1. NC_017505.1.
YP_005883612.1. NC_017505.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADO32481 ; ADO32481 ; NMBB_2367 .
GeneIDi 12399994.
KEGGi nmp:NMBB_2367.
PATRICi 43138228. VBINeiMen23504_2762.

Phylogenomic databases

KOi K01595.

Enzyme and pathway databases

BioCyci NMEN630588:GLHP-2046-MONOMER.

Family and domain databases

HAMAPi MF_00595. PEPcase_type1.
InterProi IPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view ]
Pfami PF00311. PEPcase. 1 hit.
[Graphical view ]
PRINTSi PR00150. PEPCARBXLASE.
SUPFAMi SSF51621. SSF51621. 1 hit.
PROSITEi PS00781. PEPCASE_1. 1 hit.
PS00393. PEPCASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Comparative genome biology of a serogroup B carriage and disease strain supports a polygenic nature of meningococcal virulence."
    Joseph B., Schneiker-Bekel S., Schramm-Gluck A., Blom J., Claus H., Linke B., Schwarz R.F., Becker A., Goesmann A., Frosch M., Schoen C.
    J. Bacteriol. 192:5363-5377(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: alpha710Imported.

Entry informationi

Entry nameiE3D3X1_NEIM7
AccessioniPrimary (citable) accession number: E3D3X1
Entry historyi
Integrated into UniProtKB/TrEMBL: January 11, 2011
Last sequence update: January 11, 2011
Last modified: November 26, 2014
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3