ftsZ

Functionⁱ

Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.UniRule annotation

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	158	GTPUniRule annotation	1
Binding siteⁱ	162	GTPUniRule annotation	1
Binding siteⁱ	206	GTPUniRule annotation	1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	40 – 44	GTPUniRule annotation		5
Nucleotide bindingⁱ	127 – 129	GTPUniRule annotation		3

GO - Molecular functionⁱ

GTPase activity Source: UniProtKB-UniRule
GTP binding Source: UniProtKB-UniRule

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell septum assembly Source: UniProtKB-UniRule
FtsZ-dependent cytokinesis Source: UniProtKB-UniRule
protein polymerization Source: UniProtKB-UniRule

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Cell cycle, Cell division, SeptationUniRule annotation
Ligand	GTP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Cell division protein FtsZUniRule annotation
Gene namesⁱ	Name:ftsZUniRule annotation ORF Names:Apau_2363Imported
Organismⁱ	Aminomonas paucivorans DSM 12260Imported
Taxonomic identifierⁱ	584708 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Synergistetes › Synergistia › Synergistales › Synergistaceae › Aminomonas › Aminomonas paucivorans
Proteomesⁱ	UP000005096 Componentⁱ: Chromosome

Subcellular locationⁱ

Cytoplasm
UniRule annotation
Automatic assertion according to rulesⁱ
- HAMAP-Rule:MF_00909

Note:

Assembles at midcell at the inner surface of the cytoplasmic membrane.UniRule annotation

GO - Cellular componentⁱ

cell division site Source: UniProtKB-UniRule
cytoplasm Source: UniProtKB-SubCell

View the complete GO annotation on QuickGO ...

Keywords - Cellular componentⁱ

CytoplasmUniRule annotation

Interactionⁱ

Subunit structureⁱ

Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.UniRule annotation

Protein-protein interaction databases

STRINGⁱ	584708.Apau_2363

STRINGⁱ

584708.Apau_2363

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	32 – 224	TubulinInterPro annotationAdd BLAST		193
Domainⁱ	226 – 343	Tubulin_CInterPro annotationAdd BLAST		118

Sequence similaritiesⁱ

Belongs to the FtsZ family.UniRule annotation

Phylogenomic databases

eggNOGⁱ	ENOG4105CDK Bacteria COG0206 LUCA
Database of Orthologous Groups More...OrthoDBⁱ	POG091H02KK

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd02201 FtsZ_type1, 1 hit
Gene3Dⁱ	3.40.50.14401 hit
HAMAPⁱ	MF_00909 FtsZ, 1 hit
InterProⁱ	View protein in InterPro IPR000158 Cell_div_FtsZ IPR024757 FtsZ_C IPR008280 Tub_FtsZ_C IPR018316 Tubulin/FtsZ_2-layer-sand-dom IPR036525 Tubulin/FtsZ_GTPase_sf IPR003008 Tubulin_FtsZ_GTPase
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF12327 FtsZ_C, 1 hit PF00091 Tubulin, 1 hit
PRINTSⁱ	PR00423 CELLDVISFTSZ
SMARTⁱ	View protein in SMART SM00864 Tubulin, 1 hit SM00865 Tubulin_C, 1 hit
SUPFAMⁱ	SSF52490 SSF52490, 1 hit SSF55307 SSF55307, 1 hit
TIGRFAMsⁱ	TIGR00065 ftsZ, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

E3D097-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MPNHLLSVIP GDERVQDQGT IRLERDECRR EVIKVIGVGG GGNNALNHII 
        60         70         80         90        100
RSGVQGVDYI AANTDLGSLD QSSSDWKVVL GAKLTRGLGA GACPEVGRDA 
       110        120        130        140        150
ALESREEIRQ ALKGSDMVYL TAGMGGGTGT GALPVIAQMA KEMGILSVAV 
       160        170        180        190        200
VTRPFGFEGK KRCRQAQEGI DQLRESVDAL IVVPNDKLLE MADRNMPLQD 
       210        220        230        240        250
SFRLADDVLR QAVQGVTDLV VRPGLVNVDF ADLRTVMSNA GAAVMGIGVG 
       260        270        280        290        300
KGENRAKEAV QKALESPLME TPMRRAKGVL LNVTGGMDLG IHEVYEAAEL 
       310        320        330        340        350
LREHLDEDAN FVWGYVPDAA MEGSVQMVVI ATGFEPGTSP ARRERETPGL 
       360        370        380        390 
HLQSASARGP KAPERPEAEA PREGAEEDGL FLQTPTTGLD TPSVWRRRE

Length:399

Mass (Da):42,762

Last modified:January 11, 2011 - v1

Checksum:ⁱ30B35E78AE8190D0

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CM001022 Genomic DNA Translation: EFQ24770.1
NCBI Reference Sequences More...RefSeqⁱ	WP_006302018.1, NZ_CM001022.1

Genome annotation databases

EnsemblBacteriaⁱ	EFQ24770; EFQ24770; Apau_2363

EnsemblBacteriaⁱ

EFQ24770; EFQ24770; Apau_2363

Similar proteinsⁱ

50% Identity

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
E3D097	A0A1M5NX88 UPI000478618C UPI000411E90E UPI0003FB8C2F UPI000B989871 A0A1I2QTG8 UPI0003FC62CB A0A117LIB7 A0A1F8MRC3 A0A2D6L9K2 +65	Thermosyntropha lipolytica DSM 11003 Aminiphilus circumscriptus Solirubrobacter sp. URHD0082 Solirubrobacter soli Clostridiales bacterium SK-Y3 Desulfotomaculum arcticum Desulfotomaculum alcoholivorax Actinobacteria bacterium 66_15 Chloroflexi bacterium RBG_13_52_12 bacterium And more	399	UniRef50_E3D097	Cluster: Cell division protein FtsZ	76

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CM001022 Genomic DNA Translation: EFQ24770.1
NCBI Reference Sequences More...RefSeqⁱ	WP_006302018.1, NZ_CM001022.1

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	584708.Apau_2363

STRINGⁱ

584708.Apau_2363

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	EFQ24770; EFQ24770; Apau_2363

EnsemblBacteriaⁱ

EFQ24770; EFQ24770; Apau_2363

Phylogenomic databases

eggNOGⁱ	ENOG4105CDK Bacteria COG0206 LUCA
Database of Orthologous Groups More...OrthoDBⁱ	POG091H02KK

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd02201 FtsZ_type1, 1 hit
Gene3Dⁱ	3.40.50.14401 hit
HAMAPⁱ	MF_00909 FtsZ, 1 hit
InterProⁱ	View protein in InterPro IPR000158 Cell_div_FtsZ IPR024757 FtsZ_C IPR008280 Tub_FtsZ_C IPR018316 Tubulin/FtsZ_2-layer-sand-dom IPR036525 Tubulin/FtsZ_GTPase_sf IPR003008 Tubulin_FtsZ_GTPase
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF12327 FtsZ_C, 1 hit PF00091 Tubulin, 1 hit
PRINTSⁱ	PR00423 CELLDVISFTSZ
SMARTⁱ	View protein in SMART SM00864 Tubulin, 1 hit SM00865 Tubulin_C, 1 hit
SUPFAMⁱ	SSF52490 SSF52490, 1 hit SSF55307 SSF55307, 1 hit
TIGRFAMsⁱ	TIGR00065 ftsZ, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	E3D097_9BACT
Accessionⁱ	E3D097Primary (citable) accession number: E3D097
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	January 11, 2011
	Last sequence update:	January 11, 2011
	Last modified:	February 28, 2018
	This is version 48 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteomeImported

UniProtKB - E3D097 (E3D097_9BACT)

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Cell division protein FtsZ

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Functionⁱ

Sites

Regions

GO - Molecular functionⁱ

GO - Biological processⁱ

Keywordsⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Keywords - Cellular componentⁱ

Interactionⁱ

Subunit structureⁱ

Protein-protein interaction databases

Family & Domainsⁱ

Domains and Repeats

Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

Sequenceⁱ

Sequence databases

Genome annotation databases

Similar proteinsⁱ

Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Family and domain databases

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - E3D097 (E3D097_9BACT)

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Cell division protein FtsZ

ftsZ

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Interactionⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ