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E2RSF2

- E2RSF2_CANFA

UniProt

E2RSF2 - E2RSF2_CANFA

Protein

Superoxide dismutase

Gene

SOD2

Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Unreviewed - Annotation score: 5 out of 5- Protein inferred from homologyi
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    • History
      Entry version 34 (01 Oct 2014)
      Sequence version 1 (30 Nov 2010)
      Previous versions | rss
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    Functioni

    Destroys radicals which are normally produced within the cells and which are toxic to biological systems.UniRule annotation
    Destroys radicals which are normally produced within the cells and which are toxic to biological systems By similarity.

    Catalytic activityi

    2 superoxide + 2 H+ = O2 + H2O2.UniRule annotation

    GO - Molecular functioni

    1. metal ion binding Source: InterPro
    2. superoxide dismutase activity Source: UniProtKB-EC

    GO - Biological processi

    1. age-dependent response to reactive oxygen species Source: Ensembl
    2. detection of oxygen Source: Ensembl
    3. erythrophore differentiation Source: Ensembl
    4. glutathione metabolic process Source: Ensembl
    5. heart development Source: Ensembl
    6. hemopoiesis Source: Ensembl
    7. intrinsic apoptotic signaling pathway in response to DNA damage Source: Ensembl
    8. intrinsic apoptotic signaling pathway in response to oxidative stress Source: Ensembl
    9. iron ion homeostasis Source: Ensembl
    10. liver development Source: Ensembl
    11. locomotory behavior Source: Ensembl
    12. negative regulation of fat cell differentiation Source: Ensembl
    13. negative regulation of fibroblast proliferation Source: Ensembl
    14. negative regulation of neuron apoptotic process Source: Ensembl
    15. negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway Source: Ensembl
    16. neuron development Source: Ensembl
    17. oxygen homeostasis Source: Ensembl
    18. positive regulation of nitric oxide biosynthetic process Source: Ensembl
    19. post-embryonic development Source: Ensembl
    20. protein homotetramerization Source: Ensembl
    21. regulation of catalytic activity Source: Ensembl
    22. regulation of mitochondrial membrane potential Source: Ensembl
    23. regulation of transcription from RNA polymerase II promoter Source: Ensembl
    24. release of cytochrome c from mitochondria Source: Ensembl
    25. respiratory electron transport chain Source: Ensembl
    26. response to activity Source: Ensembl
    27. response to axon injury Source: Ensembl
    28. response to gamma radiation Source: Ensembl
    29. response to hydrogen peroxide Source: Ensembl
    30. response to hyperoxia Source: Ensembl
    31. superoxide anion generation Source: Ensembl
    32. vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure Source: Ensembl

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotation

    Enzyme and pathway databases

    ReactomeiREACT_174045. Detoxification of Reactive Oxygen Species.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Superoxide dismutaseUniRule annotation (EC:1.15.1.1UniRule annotation)
    Gene namesi
    Name:SOD2Imported
    OrganismiCanis familiaris (Dog) (Canis lupus familiaris)Imported
    Taxonomic identifieri9615 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
    ProteomesiUP000002254: Chromosome 1

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrial inner membrane Source: Ensembl

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the iron/manganese superoxide dismutase family.UniRule annotation

    Phylogenomic databases

    GeneTreeiENSGT00390000011877.
    KOiK04564.
    OMAiVENLINW.
    OrthoDBiEOG7FV3R5.
    TreeFamiTF105132.

    Family and domain databases

    InterProiIPR001189. Mn/Fe_SOD.
    IPR019833. Mn/Fe_SOD_BS.
    IPR019832. Mn/Fe_SOD_C.
    IPR019831. Mn/Fe_SOD_N.
    [Graphical view]
    PANTHERiPTHR11404. PTHR11404. 1 hit.
    PfamiPF02777. Sod_Fe_C. 1 hit.
    PF00081. Sod_Fe_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000349. SODismutase. 1 hit.
    PRINTSiPR01703. MNSODISMTASE.
    SUPFAMiSSF46609. SSF46609. 1 hit.
    SSF54719. SSF54719. 1 hit.
    PROSITEiPS00088. SOD_MN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    E2RSF2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLSRAALSTS RTLVPALGCL GSRQKHSLPD LPYDYGALEP HINAQIMQLH    50
    HSKHHAAYVN NLNTIEEKYL EALEKGDITA QIALQPGLKF NGGGHINHSI 100
    FWTNLSPKGG GEPKGELLEA IKRDFGSFDK FKEKLTTVSV GVQGSGWGWL 150
    GFNKEQGRLQ IAACFNQDPL QGTTGLIPLL GIDVWEHAYY LQYKNVRPDY 200
    LKAIWNVINW ENVTERYMAC KK 222
    Length:222
    Mass (Da):24,845
    Last modified:November 30, 2010 - v1
    Checksum:iF57E4BD7B8365999
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAEX03000317 Genomic DNA. No translation available.
    RefSeqiXP_533463.3. XM_533463.4.

    Genome annotation databases

    EnsembliENSCAFT00000001037; ENSCAFP00000000951; ENSCAFG00000000671.
    GeneIDi476258.
    KEGGicfa:476258.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAEX03000317 Genomic DNA. No translation available.
    RefSeqi XP_533463.3. XM_533463.4.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSCAFT00000001037 ; ENSCAFP00000000951 ; ENSCAFG00000000671 .
    GeneIDi 476258.
    KEGGi cfa:476258.

    Organism-specific databases

    CTDi 6648.

    Phylogenomic databases

    GeneTreei ENSGT00390000011877.
    KOi K04564.
    OMAi VENLINW.
    OrthoDBi EOG7FV3R5.
    TreeFami TF105132.

    Enzyme and pathway databases

    Reactomei REACT_174045. Detoxification of Reactive Oxygen Species.

    Miscellaneous databases

    NextBioi 20851956.

    Family and domain databases

    InterProi IPR001189. Mn/Fe_SOD.
    IPR019833. Mn/Fe_SOD_BS.
    IPR019832. Mn/Fe_SOD_C.
    IPR019831. Mn/Fe_SOD_N.
    [Graphical view ]
    PANTHERi PTHR11404. PTHR11404. 1 hit.
    Pfami PF02777. Sod_Fe_C. 1 hit.
    PF00081. Sod_Fe_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000349. SODismutase. 1 hit.
    PRINTSi PR01703. MNSODISMTASE.
    SUPFAMi SSF46609. SSF46609. 1 hit.
    SSF54719. SSF54719. 1 hit.
    PROSITEi PS00088. SOD_MN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence, comparative analysis and haplotype structure of the domestic dog."
      Broad Sequencing Platform
      Lindblad-Toh K., Wade C.M., Mikkelsen T.S., Karlsson E.K., Jaffe D.B., Kamal M., Clamp M., Chang J.L., Kulbokas E.J. III, Zody M.C., Mauceli E., Xie X., Breen M., Wayne R.K., Ostrander E.A., Ponting C.P., Galibert F., Smith D.R.
      , deJong P.J., Kirkness E.F., Alvarez P., Biagi T., Brockman W., Butler J., Chin C.-W., Cook A., Cuff J., Daly M.J., DeCaprio D., Gnerre S., Grabherr M., Kellis M., Kleber M., Bardeleben C., Goodstadt L., Heger A., Hitte C., Kim L., Koepfli K.-P., Parker H.G., Pollinger J.P., Searle S.M.J., Sutter N.B., Thomas R., Webber C., Baldwin J., Abebe A., Abouelleil A., Aftuck L., Ait-Zahra M., Aldredge T., Allen N., An P., Anderson S., Antoine C., Arachchi H., Aslam A., Ayotte L., Bachantsang P., Barry A., Bayul T., Benamara M., Berlin A., Bessette D., Blitshteyn B., Bloom T., Blye J., Boguslavskiy L., Bonnet C., Boukhgalter B., Brown A., Cahill P., Calixte N., Camarata J., Cheshatsang Y., Chu J., Citroen M., Collymore A., Cooke P., Dawoe T., Daza R., Decktor K., DeGray S., Dhargay N., Dooley K., Dooley K., Dorje P., Dorjee K., Dorris L., Duffey N., Dupes A., Egbiremolen O., Elong R., Falk J., Farina A., Faro S., Ferguson D., Ferreira P., Fisher S., FitzGerald M., Foley K., Foley C., Franke A., Friedrich D., Gage D., Garber M., Gearin G., Giannoukos G., Goode T., Goyette A., Graham J., Grandbois E., Gyaltsen K., Hafez N., Hagopian D., Hagos B., Hall J., Healy C., Hegarty R., Honan T., Horn A., Houde N., Hughes L., Hunnicutt L., Husby M., Jester B., Jones C., Kamat A., Kanga B., Kells C., Khazanovich D., Kieu A.C., Kisner P., Kumar M., Lance K., Landers T., Lara M., Lee W., Leger J.-P., Lennon N., Leuper L., LeVine S., Liu J., Liu X., Lokyitsang Y., Lokyitsang T., Lui A., Macdonald J., Major J., Marabella R., Maru K., Matthews C., McDonough S., Mehta T., Meldrim J., Melnikov A., Meneus L., Mihalev A., Mihova T., Miller K., Mittelman R., Mlenga V., Mulrain L., Munson G., Navidi A., Naylor J., Nguyen T., Nguyen N., Nguyen C., Nguyen T., Nicol R., Norbu N., Norbu C., Novod N., Nyima T., Olandt P., O'Neill B., O'Neill K., Osman S., Oyono L., Patti C., Perrin D., Phunkhang P., Pierre F., Priest M., Rachupka A., Raghuraman S., Rameau R., Ray V., Raymond C., Rege F., Rise C., Rogers J., Rogov P., Sahalie J., Settipalli S., Sharpe T., Shea T., Sheehan M., Sherpa N., Shi J., Shih D., Sloan J., Smith C., Sparrow T., Stalker J., Stange-Thomann N., Stavropoulos S., Stone C., Stone S., Sykes S., Tchuinga P., Tenzing P., Tesfaye S., Thoulutsang D., Thoulutsang Y., Topham K., Topping I., Tsamla T., Vassiliev H., Venkataraman V., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J., Wilson A., Yadav S., Yang S., Yang X., Young G., Yu Q., Zainoun J., Zembek L., Zimmer A., Lander E.S.
      Nature 438:803-819(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BoxerImported.
    2. Ensembl
      Submitted (JUL-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: BoxerImported.

    Entry informationi

    Entry nameiE2RSF2_CANFA
    AccessioniPrimary (citable) accession number: E2RSF2
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 30, 2010
    Last sequence update: November 30, 2010
    Last modified: October 1, 2014
    This is version 34 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3