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Protein

Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex

Gene

PDHX

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cofactori

(R)-lipoateUniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionAcyltransferaseUniRule annotation, Transferase

Enzyme and pathway databases

ReactomeiR-CFA-204174 Regulation of pyruvate dehydrogenase (PDH) complex
R-CFA-389661 Glyoxylate metabolism and glycine degradation
R-CFA-5362517 Signaling by Retinoic Acid
R-CFA-70268 Pyruvate metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complexUniRule annotation (EC:2.3.1.-UniRule annotation)
Gene namesi
Name:PDHXImported
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)Imported
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Chromosome 18

Organism-specific databases

VGNCiVGNC:44375 PDHX

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

PaxDbiE2RM20

Expressioni

Gene expression databases

BgeeiENSCAFG00000006898

Interactioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000010269

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini56 – 132Lipoyl-bindingInterPro annotationAdd BLAST77
Domaini183 – 220Peripheral subunit-binding (PSBD)InterPro annotationAdd BLAST38

Sequence similaritiesi

Belongs to the 2-oxoacid dehydrogenase family.UniRule annotation

Keywords - Domaini

LipoylUniRule annotation

Phylogenomic databases

eggNOGiKOG0557 Eukaryota
COG0508 LUCA
GeneTreeiENSGT00890000139393
InParanoidiE2RM20
OMAiSWRLGCD
OrthoDBiEOG091G0CAV
TreeFamiTF332256

Family and domain databases

Gene3Di3.30.559.101 hit
4.10.320.101 hit
InterProiView protein in InterPro
IPR003016 2-oxoA_DH_lipoyl-BS
IPR001078 2-oxoacid_DH_actylTfrase
IPR000089 Biotin_lipoyl
IPR023213 CAT-like_dom_sf
IPR036625 E3-bd_dom_sf
IPR004167 PSBD
IPR011053 Single_hybrid_motif
PfamiView protein in Pfam
PF00198 2-oxoacid_dh, 1 hit
PF00364 Biotin_lipoyl, 1 hit
PF02817 E3_binding, 1 hit
SUPFAMiSSF47005 SSF47005, 1 hit
SSF51230 SSF51230, 1 hit
PROSITEiView protein in PROSITE
PS50968 BIOTINYL_LIPOYL, 1 hit
PS00189 LIPOYL, 1 hit
PS51826 PSBD, 1 hit

Sequencei

Sequence statusi: Complete.

E2RM20-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAASWRLGCD PRGLRYLLGF GGCRRLALAR GASGWPLGRG ASWRWLHSTQ
60 70 80 90 100
RLRADPIKIL MPSLSPTMEE GNIVKWLKKE GEAVSTGDAL CEIETDKAVV
110 120 130 140 150
TLDASDDGIL AKIVVEEGSK NIRLGSLIGL LVEEGEDWKH VEIPKDEGPP
160 170 180 190 200
SPASKPSVPS PSPEPQISTP VKKEHILGKL QFRLSPAARN ILEKHALDAS
210 220 230 240 250
QGTATGPRGI FTKEDALKLV QLKETGKITE SRPTPAPPAT PTVPLPPQAT
260 270 280 290 300
ATPPYSRPMI PPVSTPGQPN VPGTFTEIPA SNIRRVIAKR LTESKSTVPH
310 320 330 340 350
AYATADCDLG AVLKARQSLV KDDIKVSVND FIIKAAAVTL KQMPDVNVSW
360 370 380 390 400
DGEGPKQLPF IDISVAVATD KGLITPIIKD AAAKGIQEIA DSVKALSKKA
410 420 430 440 450
RDGKLLPEEY QGGSFSISNL GMFGIDEFTA VINPPQACIL AVGRFRPVLK
460 470 480 490 500
LEQDEEGNDR LQQRQLITVT MSSDSRVVDD ELATRFLENF KANLENPIRL

A
Length:501
Mass (Da):54,093
Last modified:November 30, 2010 - v1
Checksum:i85A02817397E75F5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAEX03011388 Genomic DNA No translation available.
RefSeqiXP_533153.2, XM_533153.5

Genome annotation databases

EnsembliENSCAFT00000011083; ENSCAFP00000010269; ENSCAFG00000006898
GeneIDi475942

Similar proteinsi

Entry informationi

Entry nameiE2RM20_CANLF
AccessioniPrimary (citable) accession number: E2RM20
Entry historyiIntegrated into UniProtKB/TrEMBL: November 30, 2010
Last sequence update: November 30, 2010
Last modified: March 28, 2018
This is version 51 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported