Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

E2RHY7

- E2RHY7_CANFA

UniProt

E2RHY7 - E2RHY7_CANFA

Protein
Submitted name:

Uncharacterized protein

Gene

SERPINH1

Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 32 (01 Oct 2014)
      Sequence version 1 (30 Nov 2010)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei315 – 3151SuccinateImported

    GO - Biological processi

    1. collagen biosynthetic process Source: Ensembl
    2. collagen fibril organization Source: Ensembl
    3. protein maturation Source: Ensembl

    Enzyme and pathway databases

    ReactomeiREACT_182378. Collagen biosynthesis and modifying enzymes.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Uncharacterized proteinImported
    Gene namesi
    Name:SERPINH1Imported
    OrganismiCanis familiaris (Dog) (Canis lupus familiaris)Imported
    Taxonomic identifieri9615 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
    ProteomesiUP000002254: Chromosome 21

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum Source: Ensembl
    2. endoplasmic reticulum-Golgi intermediate compartment Source: Ensembl
    3. extracellular space Source: InterPro

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3ZHAX-ray2.55A/B/C/D/K/L/P/Q36-418[»]
    4AU3X-ray2.78A/B/C/D36-418[»]
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni63 – 664Succinate bindingImported

    Sequence similaritiesi

    Belongs to the serpin family.UniRule annotation

    Phylogenomic databases

    GeneTreeiENSGT00750000117718.
    KOiK09501.
    OMAiGVPMMHR.
    OrthoDBiEOG7GBFX4.
    TreeFamiTF343094.

    Family and domain databases

    InterProiIPR023795. Serpin_CS.
    IPR023796. Serpin_dom.
    IPR000215. Serpin_fam.
    [Graphical view]
    PANTHERiPTHR11461. PTHR11461. 1 hit.
    PfamiPF00079. Serpin. 1 hit.
    [Graphical view]
    SMARTiSM00093. SERPIN. 1 hit.
    [Graphical view]
    SUPFAMiSSF56574. SSF56574. 1 hit.
    PROSITEiPS00284. SERPIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    E2RHY7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRFLLLLNTC CLLAVVLAAE VKKPAAAAAP GSAEKLSPKA ATLAERSAGL    50
    AFSLYQAMAK DQAVENILLS PVVVASSLGL VSLGGKATTA SQAKAVLSAE 100
    QLRDEEVHAG LGELLRSLSN STARNVTWKL GSRLYGPSSV SFAEDFVRSS 150
    KQHYNCEHSK INFRDKRSAL QSINEWAAQT TDGKLPEVTK DVERTDGALL 200
    VNAMFFKPHW DEKFHHKMVD NRGFMVTRSY TVGVTMMHRT GLYNYYDDEK 250
    EKLQIVEMPL AHKLSSLIIL MPHHVEPLER LEKLLTKEQL KIWMGKMQKK 300
    AVAISLPKGV VEVTHDLQKH LAGLGLTEAI DKNKADLSRM SGKKDLYLAS 350
    VFHATAFEWD TEGNPFDQDI YGREELRSPK LFYADHPFIF LVRDTQSGSL 400
    LFIGRLVRPK GDKMRDEL 418
    Length:418
    Mass (Da):46,583
    Last modified:November 30, 2010 - v1
    Checksum:iC15CF571FF20D3A2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAEX03012798 Genomic DNA. No translation available.
    AAEX03012799 Genomic DNA. No translation available.
    RefSeqiNP_001159360.1. NM_001165888.1.
    XP_005633353.1. XM_005633296.1.
    UniGeneiCfa.6125.

    Genome annotation databases

    EnsembliENSCAFT00000008665; ENSCAFP00000008031; ENSCAFG00000005386.
    GeneIDi485187.
    KEGGicfa:485187.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAEX03012798 Genomic DNA. No translation available.
    AAEX03012799 Genomic DNA. No translation available.
    RefSeqi NP_001159360.1. NM_001165888.1.
    XP_005633353.1. XM_005633296.1.
    UniGenei Cfa.6125.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3ZHA X-ray 2.55 A/B/C/D/K/L/P/Q 36-418 [» ]
    4AU3 X-ray 2.78 A/B/C/D 36-418 [» ]
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSCAFT00000008665 ; ENSCAFP00000008031 ; ENSCAFG00000005386 .
    GeneIDi 485187.
    KEGGi cfa:485187.

    Organism-specific databases

    CTDi 871.

    Phylogenomic databases

    GeneTreei ENSGT00750000117718.
    KOi K09501.
    OMAi GVPMMHR.
    OrthoDBi EOG7GBFX4.
    TreeFami TF343094.

    Enzyme and pathway databases

    Reactomei REACT_182378. Collagen biosynthesis and modifying enzymes.

    Miscellaneous databases

    NextBioi 20859226.

    Family and domain databases

    InterProi IPR023795. Serpin_CS.
    IPR023796. Serpin_dom.
    IPR000215. Serpin_fam.
    [Graphical view ]
    PANTHERi PTHR11461. PTHR11461. 1 hit.
    Pfami PF00079. Serpin. 1 hit.
    [Graphical view ]
    SMARTi SM00093. SERPIN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56574. SSF56574. 1 hit.
    PROSITEi PS00284. SERPIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence, comparative analysis and haplotype structure of the domestic dog."
      Broad Sequencing Platform
      Lindblad-Toh K., Wade C.M., Mikkelsen T.S., Karlsson E.K., Jaffe D.B., Kamal M., Clamp M., Chang J.L., Kulbokas E.J. III, Zody M.C., Mauceli E., Xie X., Breen M., Wayne R.K., Ostrander E.A., Ponting C.P., Galibert F., Smith D.R.
      , deJong P.J., Kirkness E.F., Alvarez P., Biagi T., Brockman W., Butler J., Chin C.-W., Cook A., Cuff J., Daly M.J., DeCaprio D., Gnerre S., Grabherr M., Kellis M., Kleber M., Bardeleben C., Goodstadt L., Heger A., Hitte C., Kim L., Koepfli K.-P., Parker H.G., Pollinger J.P., Searle S.M.J., Sutter N.B., Thomas R., Webber C., Baldwin J., Abebe A., Abouelleil A., Aftuck L., Ait-Zahra M., Aldredge T., Allen N., An P., Anderson S., Antoine C., Arachchi H., Aslam A., Ayotte L., Bachantsang P., Barry A., Bayul T., Benamara M., Berlin A., Bessette D., Blitshteyn B., Bloom T., Blye J., Boguslavskiy L., Bonnet C., Boukhgalter B., Brown A., Cahill P., Calixte N., Camarata J., Cheshatsang Y., Chu J., Citroen M., Collymore A., Cooke P., Dawoe T., Daza R., Decktor K., DeGray S., Dhargay N., Dooley K., Dooley K., Dorje P., Dorjee K., Dorris L., Duffey N., Dupes A., Egbiremolen O., Elong R., Falk J., Farina A., Faro S., Ferguson D., Ferreira P., Fisher S., FitzGerald M., Foley K., Foley C., Franke A., Friedrich D., Gage D., Garber M., Gearin G., Giannoukos G., Goode T., Goyette A., Graham J., Grandbois E., Gyaltsen K., Hafez N., Hagopian D., Hagos B., Hall J., Healy C., Hegarty R., Honan T., Horn A., Houde N., Hughes L., Hunnicutt L., Husby M., Jester B., Jones C., Kamat A., Kanga B., Kells C., Khazanovich D., Kieu A.C., Kisner P., Kumar M., Lance K., Landers T., Lara M., Lee W., Leger J.-P., Lennon N., Leuper L., LeVine S., Liu J., Liu X., Lokyitsang Y., Lokyitsang T., Lui A., Macdonald J., Major J., Marabella R., Maru K., Matthews C., McDonough S., Mehta T., Meldrim J., Melnikov A., Meneus L., Mihalev A., Mihova T., Miller K., Mittelman R., Mlenga V., Mulrain L., Munson G., Navidi A., Naylor J., Nguyen T., Nguyen N., Nguyen C., Nguyen T., Nicol R., Norbu N., Norbu C., Novod N., Nyima T., Olandt P., O'Neill B., O'Neill K., Osman S., Oyono L., Patti C., Perrin D., Phunkhang P., Pierre F., Priest M., Rachupka A., Raghuraman S., Rameau R., Ray V., Raymond C., Rege F., Rise C., Rogers J., Rogov P., Sahalie J., Settipalli S., Sharpe T., Shea T., Sheehan M., Sherpa N., Shi J., Shih D., Sloan J., Smith C., Sparrow T., Stalker J., Stange-Thomann N., Stavropoulos S., Stone C., Stone S., Sykes S., Tchuinga P., Tenzing P., Tesfaye S., Thoulutsang D., Thoulutsang Y., Topham K., Topping I., Tsamla T., Vassiliev H., Venkataraman V., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J., Wilson A., Yadav S., Yang S., Yang X., Young G., Yu Q., Zainoun J., Zembek L., Zimmer A., Lander E.S.
      Nature 438:803-819(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BoxerImported.
    2. Ensembl
      Submitted (JUL-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: BoxerImported.
    3. "Molecular basis for the action of the collagen-specific chaperone Hsp47/SERPINH1 and its structure-specific client recognition."
      Widmer C., Gebauer J.M., Brunstein E., Rosenbaum S., Zaucke F., Drogemuller C., Leeb T., Baumann U.
      Proc. Natl. Acad. Sci. U.S.A. 109:13243-13247(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.55 ANGSTROMS) OF 36-418 IN COMPLEX WITH SUCCINATE.

    Entry informationi

    Entry nameiE2RHY7_CANFA
    AccessioniPrimary (citable) accession number: E2RHY7
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 30, 2010
    Last sequence update: November 30, 2010
    Last modified: October 1, 2014
    This is version 32 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    3D-structureImported, Complete proteome, Reference proteomeImported

    External Data

    Dasty 3