E2RGT8 (E2RGT8_CANFA) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Uncharacterized protein Ensembl ENSCAFP00000027443

Gene names

Name:

VAV1 Ensembl ENSCAFP00000027443

Organism

Canis familiaris (Dog) (Canis lupus familiaris) [Reference proteome] Ensembl ENSCAFP00000027443

Taxonomic identifier

9615 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Carnivora › Caniformia › Canidae › Canis › Canis lupus

Protein attributes

Sequence length	845 AA.
Sequence status	Complete.
Protein existence	Predicted

General annotation (Comments)

Sequence similarities	Contains 1 DH (DBL-homology) domain. SAAS SAAS001331 Contains 1 PH domain. RuleBase RU003350 Contains 2 SH3 domains. RuleBase RU003338
Caution	The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. Ensembl ENSCAFP00000027443

Ontologies

Keywords
Domain	SH3 domain RuleBase RU003338 SAAS SAAS000980
Ligand	Metal-binding SAAS SAAS002219 Zinc SAAS SAAS002219
PTM	Phosphoprotein SAAS SAAS000980
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	T cell activation Inferred from electronic annotation. Source: Compara immune response Inferred from electronic annotation. Source: Compara integrin-mediated signaling pathway Inferred from electronic annotation. Source: Compara intracellular signal transduction Inferred from electronic annotation. Source: Compara phagocytosis Inferred from electronic annotation. Source: Compara positive regulation of cell adhesion Inferred from electronic annotation. Source: Compara regulation of GTPase activity Inferred from electronic annotation. Source: Compara regulation of Rho protein signal transduction Inferred from electronic annotation. Source: InterPro
Cellular_component	intracellular Inferred from electronic annotation. Source: InterPro
Molecular_function	Rac guanyl-nucleotide exchange factor activity Inferred from electronic annotation. Source: Compara metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW phospholipid binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	E2RGT8 [UniParc]. Last modified November 30, 2010. Version 1. Checksum: 7DBBAD169B1D7D7E	FASTA	845	98,431
	10 20 30 40 50 60 MELWRQCTHW LIQCRVLPPS HRVTWDGAQV CELAQALRDG VLLCQLLNNL LPHAINLREV 70 80 90 100 110 120 NLRPQMSQFL CLKNIRTFLS TCCEKFGLKR SELFEAFDLF DVQDFGKVIY TLSALSWTPI 130 140 150 160 170 180 AQNKGIMPFP TEEESVGDED IYSGLSDQID DTVEEDEDLY DCVENEEAEG DEIYEDLMRT 190 200 210 220 230 240 EPMPMPPKMT EYDKRCCCLR EIQQTEEKYT DTLGSIQQHF MKPLQRFLKP QDIEIIFINI 250 260 270 280 290 300 EDLLRVHTHF LKEMKEALAA PTAPTLYQVF IKYKERFLVY GRYCSQVESA SKHLDRVATA 310 320 330 340 350 360 REDVQMKLEE CSQRANNGRF TLRDLLMVPM QRVLKYHLLL QELVKHTQDA VEKENLRLAL 370 380 390 400 410 420 DAMRDLAQCV NEVKRDNETL RQITNFQLSI ENLDQSLAHY GRPKIDGELK ITSVERRSKM 430 440 450 460 470 480 DRYAFLLDKA LLICKRRGDS YDLKDFVNLH SFQVRDDSSG ERENKKWTHM FLLIEDQGVQ 490 500 510 520 530 540 GYELFFKTRE LKKKWMEQFE MAISNIYPEN ATANGHDFQM FSFEETTSCK ACQMLLRGTF 550 560 570 580 590 600 YQGYRCHRCR APAHKECLGR VPPCGRHGQD FSGTMKKDKP HRRAQDKKRN ELGLPKMEVC 610 620 630 640 650 660 QEYYGLPPPP GAFGPFLRLN PGDIVELTKA EAEQNWWEGR NTATNEVGWF PCNRVKPYVH 670 680 690 700 710 720 GPPQDLSVHL WYAGPMERSG AESILTNRSD GTFLVRQRVK DTAEFAISIK YNVEVKHIKI 730 740 750 760 770 780 MTAEGLYRIT EKKAFRGLTE LVEFYQQNSL KDCFKSLDTT LQFPFKEPEK RAISKPPAGS 790 800 810 820 830 840 TKYFGTAKAR YDFCARDRSE LSLKEGDIIK ILNKKGQQGW WRGEIYGRVG WFPSNYVEED YSEYC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genome sequence, comparative analysis and haplotype structure of the domestic dog." Broad Sequencing Platform Lindblad-Toh K., Wade C.M., Mikkelsen T.S., Karlsson E.K., Jaffe D.B., Kamal M., Clamp M., Chang J.L., Kulbokas E.J. III, Zody M.C., Mauceli E., Xie X., Breen M., Wayne R.K., Ostrander E.A., Ponting C.P., Galibert F., Smith D.R. , deJong P.J., Kirkness E.F., Alvarez P., Biagi T., Brockman W., Butler J., Chin C.-W., Cook A., Cuff J., Daly M.J., DeCaprio D., Gnerre S., Grabherr M., Kellis M., Kleber M., Bardeleben C., Goodstadt L., Heger A., Hitte C., Kim L., Koepfli K.-P., Parker H.G., Pollinger J.P., Searle S.M.J., Sutter N.B., Thomas R., Webber C., Baldwin J., Abebe A., Abouelleil A., Aftuck L., Ait-Zahra M., Aldredge T., Allen N., An P., Anderson S., Antoine C., Arachchi H., Aslam A., Ayotte L., Bachantsang P., Barry A., Bayul T., Benamara M., Berlin A., Bessette D., Blitshteyn B., Bloom T., Blye J., Boguslavskiy L., Bonnet C., Boukhgalter B., Brown A., Cahill P., Calixte N., Camarata J., Cheshatsang Y., Chu J., Citroen M., Collymore A., Cooke P., Dawoe T., Daza R., Decktor K., DeGray S., Dhargay N., Dooley K., Dooley K., Dorje P., Dorjee K., Dorris L., Duffey N., Dupes A., Egbiremolen O., Elong R., Falk J., Farina A., Faro S., Ferguson D., Ferreira P., Fisher S., FitzGerald M., Foley K., Foley C., Franke A., Friedrich D., Gage D., Garber M., Gearin G., Giannoukos G., Goode T., Goyette A., Graham J., Grandbois E., Gyaltsen K., Hafez N., Hagopian D., Hagos B., Hall J., Healy C., Hegarty R., Honan T., Horn A., Houde N., Hughes L., Hunnicutt L., Husby M., Jester B., Jones C., Kamat A., Kanga B., Kells C., Khazanovich D., Kieu A.C., Kisner P., Kumar M., Lance K., Landers T., Lara M., Lee W., Leger J.-P., Lennon N., Leuper L., LeVine S., Liu J., Liu X., Lokyitsang Y., Lokyitsang T., Lui A., Macdonald J., Major J., Marabella R., Maru K., Matthews C., McDonough S., Mehta T., Meldrim J., Melnikov A., Meneus L., Mihalev A., Mihova T., Miller K., Mittelman R., Mlenga V., Mulrain L., Munson G., Navidi A., Naylor J., Nguyen T., Nguyen N., Nguyen C., Nguyen T., Nicol R., Norbu N., Norbu C., Novod N., Nyima T., Olandt P., O'Neill B., O'Neill K., Osman S., Oyono L., Patti C., Perrin D., Phunkhang P., Pierre F., Priest M., Rachupka A., Raghuraman S., Rameau R., Ray V., Raymond C., Rege F., Rise C., Rogers J., Rogov P., Sahalie J., Settipalli S., Sharpe T., Shea T., Sheehan M., Sherpa N., Shi J., Shih D., Sloan J., Smith C., Sparrow T., Stalker J., Stange-Thomann N., Stavropoulos S., Stone C., Stone S., Sykes S., Tchuinga P., Tenzing P., Tesfaye S., Thoulutsang D., Thoulutsang Y., Topham K., Topping I., Tsamla T., Vassiliev H., Venkataraman V., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J., Wilson A., Yadav S., Yang S., Yang X., Young G., Yu Q., Zainoun J., Zembek L., Zimmer A., Lander E.S. Nature 438:803-819(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Boxer Ensembl ENSCAFP00000027443.
[2]	Ensembl Submitted (JUL-2011) to UniProtKB Cited for: IDENTIFICATION. Strain: Boxer Ensembl ENSCAFP00000027443.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AAEX03012484 Genomic DNA. No translation available. AAEX03012485 Genomic DNA. No translation available. AAEX03012486 Genomic DNA. No translation available. AAEX03012487 Genomic DNA. No translation available. AAEX03012488 Genomic DNA. No translation available.
RefSeq	XP_542134.2. XM_542134.3.
3D structure databases
ProteinModelPortal	E2RGT8.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSCAFT00000029523; ENSCAFP00000027443; ENSCAFG00000018590.
GeneID	485016.
KEGG	cfa:485016.
Organism-specific databases
CTD	7409.
Phylogenomic databases
GeneTree	ENSGT00700000104383.
KO	K05730.
OMA	HRVTWDG.
Family and domain databases
Gene3D	1.10.418.10. 1 hit. 1.20.900.10. 1 hit. 2.30.29.30. 1 hit. 3.30.505.10. 1 hit.
InterPro	IPR022613. CAMSAP_CH. IPR001715. CH-domain. IPR000219. DH-domain. IPR001331. GDS_CDC24_CS. IPR011993. PH_like_dom. IPR001849. Pleckstrin_homology. IPR002219. Prot_Kinase_C-like_PE/DAG-bd. IPR000980. SH2. IPR011511. SH3_2. IPR001452. SH3_domain. IPR003096. SM22_calponin. [Graphical view]
Pfam	PF00130. C1_1. 1 hit. PF11971. CAMSAP_CH. 1 hit. PF00169. PH. 1 hit. PF00621. RhoGEF. 1 hit. PF00017. SH2. 1 hit. PF00018. SH3_1. 1 hit. PF07653. SH3_2. 1 hit. [Graphical view]
PRINTS	PR00401. SH2DOMAIN. PR00452. SH3DOMAIN. PR00888. SM22CALPONIN.
SMART	SM00109. C1. 1 hit. SM00033. CH. 1 hit. SM00233. PH. 1 hit. SM00325. RhoGEF. 1 hit. SM00252. SH2. 1 hit. SM00326. SH3. 2 hits. [Graphical view]
SUPFAM	SSF47576. Calponin-homology. 1 hit. SSF48065. DH-domain. 1 hit. SSF50044. SH3. 2 hits.
PROSITE	PS50021. CH. 1 hit. PS00741. DH_1. 1 hit. PS50010. DH_2. 1 hit. PS50003. PH_DOMAIN. 1 hit. PS50001. SH2. 1 hit. PS50002. SH3. 2 hits. PS00479. ZF_DAG_PE_1. 1 hit. PS50081. ZF_DAG_PE_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20859080.

Entry information

Entry name

E2RGT8_CANFA

Accession

Primary (citable) accession number: E2RGT8

Entry history

Integrated into UniProtKB/TrEMBL:	November 30, 2010
Last sequence update:	November 30, 2010
Last modified:	April 3, 2013
This is version 23 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)