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Protein

Tyrosine-protein kinase

Gene

LCK

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase, Tyrosine-protein kinaseUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-CFA-114604. GPVI-mediated activation cascade.
R-CFA-1257604. PIP3 activates AKT signaling.
R-CFA-1266695. Interleukin-7 signaling.
R-CFA-1433557. Signaling by SCF-KIT.
R-CFA-1433559. Regulation of KIT signaling.
R-CFA-2424491. DAP12 signaling.
R-CFA-389356. CD28 co-stimulation.
R-CFA-389357. CD28 dependent PI3K/Akt signaling.
R-CFA-389359. CD28 dependent Vav1 pathway.
R-CFA-389513. CTLA4 inhibitory signaling.
R-CFA-389948. PD-1 signaling.
R-CFA-451927. Interleukin-2 family signaling.
R-CFA-6811558. PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinaseUniRule annotation (EC:2.7.10.2UniRule annotation)
Gene namesi
Name:LCKImported
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)Imported
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Chromosome 2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

PaxDbiE2R589.

Expressioni

Gene expression databases

BgeeiENSCAFG00000010625.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000015667.

Structurei

3D structure databases

ProteinModelPortaliE2R589.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini61 – 121SH3InterPro annotationAdd BLAST61
Domaini127 – 224SH2InterPro annotationAdd BLAST98
Domaini245 – 528Protein kinaseInterPro annotationAdd BLAST284

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family.UniRule annotationSAAS annotation

Keywords - Domaini

SH2 domainPROSITE-ProRule annotation, SH3 domainPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG0197. Eukaryota.
COG0515. LUCA.
GeneTreeiENSGT00760000118938.
InParanoidiE2R589.
OMAiNPEDDWM.
OrthoDBiEOG091G0D46.
TreeFamiTF351634.

Family and domain databases

CDDicd10362. SH2_Src_Lck. 1 hit.
cd12005. SH3_Lck. 1 hit.
Gene3Di3.30.505.10. 1 hit.
InterProiView protein in InterPro
IPR011009. Kinase-like_dom_sf.
IPR035850. Lck_SH2.
IPR035749. Lck_SH3.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR036860. SH2_dom_sf.
IPR036028. SH3-like_dom_sf.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
PfamiView protein in Pfam
PF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
PRINTSiPR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
PR00109. TYRKINASE.
SMARTiView protein in SMART
SM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 2 hits.
PROSITEiView protein in PROSITE
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.

Sequencei

Sequence statusi: Complete.

E2R589-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGCSCSSNPE DDWMENIDVC ENCHYPIVPL DGKATLPMRN GSDVRDPLVI
60 70 80 90 100
YEGSNPPASP LQDNLVIALH SYEPSHDGDL GFEKGEQLRI LERNGEWWKA
110 120 130 140 150
QSLTTGQEGF IPFNFVAKAN SLEPEPWFFK NLSRKDAERQ LLAPGNTHGS
160 170 180 190 200
FLIRESESTA GSFSLSVRDF DQNQGEVVKH YKIRNLDKGG FYISPRITFP
210 220 230 240 250
GLHELVRHYT NSSDGLCTRL SRPCQTQKPQ KPWWEDEWEV PRETLKLVER
260 270 280 290 300
LGAGQFGEVW MGYYNGHTKV AVKSLKQGSM SPDAFLAEAN LMKQLQHQRL
310 320 330 340 350
VRLYAVVTQE PIYIITEYME NGELLDSQLG EEGLRASAKG SLSQQLLLSL
360 370 380 390 400
AGSLVDFLKT PPGIKLTINK LLDMAAQIAE GMAFIEERNY IHRDLRAANI
410 420 430 440 450
LVSDTLSCKI ADFGLARLIE DNEYTAREGA KFPIKWTAPE AINYGTFTIK
460 470 480 490 500
SDVWSFGILL TEIVTHGRIP YPGMTNPEVI QNLERGYRMV RPDNCPEELY
510 520 530
QLMMLCWKER PEDRPTFDYL RSVLEDFFTA TEGQYQPQP
Length:539
Mass (Da):61,158
Last modified:October 31, 2012 - v2
Checksum:i26AFE7D4BC89B693
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAEX03001657 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSCAFT00000016931; ENSCAFP00000015667; ENSCAFG00000010625.

Similar proteinsi

Entry informationi

Entry nameiE2R589_CANLF
AccessioniPrimary (citable) accession number: E2R589
Entry historyiIntegrated into UniProtKB/TrEMBL: November 30, 2010
Last sequence update: October 31, 2012
Last modified: November 22, 2017
This is version 61 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported