E2R3Q9 (E2R3Q9_CANFA) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Uncharacterized protein Ensembl ENSCAFP00000024244

Gene names

Name:

NSD1 Ensembl ENSCAFP00000024244

Organism

Canis familiaris (Dog) (Canis lupus familiaris) [Reference proteome] Ensembl ENSCAFP00000024244

Taxonomic identifier

9615 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Carnivora › Caniformia › Canidae › Canis › Canis lupus

Protein attributes

Sequence length	2698 AA.
Sequence status	Complete.
Protein existence	Predicted

General annotation (Comments)

Catalytic activity	S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone]. SAAS SAAS001214
Sequence similarities	Contains 1 SET domain. RuleBase RU004538 SAAS SAAS001214 Contains 1 post-SET domain. RuleBase RU004541 SAAS SAAS001214
Caution	The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. Ensembl ENSCAFP00000024244

Ontologies

Keywords
Cellular component	Nucleus SAAS SAAS001214
Domain	Zinc-finger SAAS SAAS019787
Ligand	Metal-binding Zinc
Molecular function	Methyltransferase RuleBase RU004541 SAAS SAAS001214 Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	histone lysine methylation Inferred from electronic annotation. Source: GOC
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	histone-lysine N-methyltransferase activity Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	E2R3Q9 [UniParc]. Last modified October 31, 2012. Version 2. Checksum: F16CB5576BEB7440	FASTA	2,698	297,057
	10 20 30 40 50 60 MDQTCELPRR NCLLPFSNPV NLDAPEDKDS PFGNGQSNFS EPLNGCTMQL STASGTSQNA 70 80 90 100 110 120 YGQDSPSCYI PLRRLQDLAS MINVEYLNGS ADGSESFQDP EKSDSRAQSP VVCTSLSPGG 130 140 150 160 170 180 PTALAMKQEP SCNNSPELQV KVTKTIKNGF LHFENFTCVD DADVDSEMDP EQPVTEDESI 190 200 210 220 230 240 EEIFEETQTN AICNYEPKSE NGVDVAMGNE QDSTPESRHG AVKSPFLPLA PQTETQKNKQ 250 260 270 280 290 300 RNEVDGSNEK AALLPAPFAL GDTNVTIEEQ LNSINLSFQD DPDSSTSTLG NMLELPGTSS 310 320 330 340 350 360 SSTSQELPFC QPKKKSTPLK YEVGDLIWAK FKRRPWWPCR ICSDPLINTH SKMKVSNRRP 370 380 390 400 410 420 YRQYYVEAFG DPSERAWVAG KAIVMFEGRH QFEELPVLRR RGKQKEKGYR HKVPQKILSK 430 440 450 460 470 480 WEASVGLAEQ YDVPKGSKNR RCVSSSIKLD SEEDMPFEDC TNDPESEHDL LLNGCLKSLA 490 500 510 520 530 540 FDSEHSADEK EKPCAKSRAR KSSDNPKRTS MKKGHMQFEA HKEERRGKIP ENLGLSFISG 550 560 570 580 590 600 DVSDKQASNE LSRIANSLTG SNTAPGSFLF SSCGKNTAKK EFETSNCDSL LGLSEGALIS 610 620 630 640 650 660 KHSEEKKKLQ RGLMCSSKVQ LCYIGAGDEE KRSDSISICT TSDDGSSDLD PIDNSSESDN 670 680 690 700 710 720 SVLEITDAFD RTENMLSVQK NEKVKYTRYP ATNTKVKAKQ KSLITNSHTD HLMDCAKTVE 730 740 750 760 770 780 PGTETSQVNL SDLKVSAVVR KPQSDFRNDS FSPKFNTPSS ISSENSLIKS GATNQALLHA 790 800 810 820 830 840 KSKQPKIRSI KCKHKENPVV VEPPVTNEDC SLKCCSSDTK GSPLASISKS GKVDGLKLLS 850 860 870 880 890 900 NMHEKTRDSN DIETAVVKHV LSELKELSYR SLSEDVSDSG TSKPSKPLLF SSASGQNHIP 910 920 930 940 950 960 IEPDYKFSTL LMMLKDMHDS KTKEQRLMTA QNLVSYRSPG LGDCSSSSPV SASKVLVSGS 970 980 990 1000 1010 1020 STHSSEKNGD GTQKSVRPSP SGGDSALSGE LSVPVPGLVS DRRDVPASSK SHSDCVTRRN 1030 1040 1050 1060 1070 1080 CGRSKPSSKL RDSFAAQMGR NTLNRKALKT ERKRKLSRLP AVTLEAALQG DRVSGDSENG 1090 1100 1110 1120 1130 1140 SSRGGLEDSG KEEPLQLMGH LTSEDSAHFS SVHFDNKVNH PDPDKIPEKG PSFENRKGPE 1150 1160 1170 1180 1190 1200 LDNEMNSEND EPSGVNQAVP KKRWQRLNQR RTKPRKRTNR FREKENSEGA FGVLLPSDPV 1210 1220 1230 1240 1250 1260 KKGDEFPEHR PPTSTNVIED TLADPNHTSC LDSIGPRLNV CDKSSASVEE MEKEPGIPSL 1270 1280 1290 1300 1310 1320 TPQPELPEPA VRSEKKRLRK PSKWLLEYTE EYDQIFAPKK KQKKVQEQVH KVSSRCEEES 1330 1340 1350 1360 1370 1380 LLARCRSSAQ NKQVDENSLI STKEEPPVLE REAPFLEGPL AQSELGGGHA ELPQLTLSVP 1390 1400 1410 1420 1430 1440 VAPEVSPRPI LESEELLVKT PGNYESKRQR KPTKKLLESN DLDPGFMPKK GDLGLSKKCY 1450 1460 1470 1480 1490 1500 EAGHLENDSE SRAASREYGG GAAKIFDKPR KRKRQRHATA KVHCKKMKND DSSKETPGSE 1510 1520 1530 1540 1550 1560 GELMTHRTAA SPKETVEESV ENDHGMPASK KLQGERGGGA ALKENVCQNC EKLGELLLCE 1570 1580 1590 1600 1610 1620 AQCCGAFHLE CLGLTEMPRG KFICNECRTG IHTCFVCKQS GEDVKRCLLP LCGKFYHEEC 1630 1640 1650 1660 1670 1680 VQKYPPTVMQ NKGFRCSLHI CITCHAANPA SVSASKGRLM RCVRCPVAYH ANDFCLAAGS 1690 1700 1710 1720 1730 1740 KILASNSIIC PNHFTPRRGC RNHEHVNVSW CFVCSEGGSL LCCDSCPAAF HRECLNIDIP 1750 1760 1770 1780 1790 1800 EGNWYCNDCK AGKKPHYREI VWVKVGRYRW WPAEICHPRA VPSNIDKMRH DVGEFPVLFF 1810 1820 1830 1840 1850 1860 GSNDYLWTHQ ARVFPYMEGD VSSKDKMGKG VDGTYKKALQ EAAARFEELK AQKELRQLQE 1870 1880 1890 1900 1910 1920 DRKNDKKPPP YKHIKVNRPI GRVQIFTADL SEIPRCNCKA TDDNPCGIDS ECINRMLLYE 1930 1940 1950 1960 1970 1980 CHPTVCPAGG RCQNQCFTKR QYPEVEIFRT LQRGWGLRTK TDIKKGEFVN EYVGELIDEE 1990 2000 2010 2020 2030 2040 ECRARIRYAQ EHDITNFYML TLDKDRIIDA GPKGNYARFM NHCCQPNCET QKWSVNGDTR 2050 2060 2070 2080 2090 2100 VGLFALSDIK AGTELTFNYN LECLGNGKTV CKCGAPNCSG FLGVRPKNQP IATEEKSKKF 2110 2120 2130 2140 2150 2160 KKKQQGKRRT QGEITKERED ECFSCGDAGQ LVSCKKPGCP KVYHADCLNL TKRPAGKWEC 2170 2180 2190 2200 2210 2220 PWHQCDICGK EAASFCEMCP SSFCKQHREG MLFISKLDGR LSCTEHDPCG PNPLEPGEIR 2230 2240 2250 2260 2270 2280 EYVPPPVPLP PGPGTHLAEH SSGVAAQGPK MLDKLPADTN QTLSLSKKAL AGTCQRPLLP 2290 2300 2310 2320 2330 2340 ERPPDRTDSR PQPVDRVRDL AGSGTKPQSL VSSQKPLDRP PAVAGPRPLL SDKPSPVTGI 2350 2360 2370 2380 2390 2400 SSSPSVRSQS LERPLGTADP RLDKSIGAAS PRPQSLEKTP GPPGLRLPPP DRLLVTSSPK 2410 2420 2430 2440 2450 2460 PQTSDRPPDK SHASLSQRLP PPDKVLSAVV QTLVAKEKAL RPVDQNTQSK NRAALVMDLI 2470 2480 2490 2500 2510 2520 DLTPHQKERA ASPHEVTPQV DEKMPVLESS SWTASKGLGQ MPRAVERGSM SDPVLQPPGK 2530 2540 2550 2560 2570 2580 TAVPSEHPWQ AVKSLTQARL LSQPSAKAFL YEPTTQASGR APAGVEQIPG PPSQAPGLVK 2590 2600 2610 2620 2630 2640 QVKQMTGGQQ LPGLAAKSGQ SFRPLGKAPS TLCTEEKKLA TAEQSPWALG KSSPGPGLWP 2650 2660 2670 2680 2690 MVAGQTISPS CWSSGNTQTL AQTCWSLGRG QDPKPEQNTL PALNQAPSSH KCAESEQK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genome sequence, comparative analysis and haplotype structure of the domestic dog." Broad Sequencing Platform Lindblad-Toh K., Wade C.M., Mikkelsen T.S., Karlsson E.K., Jaffe D.B., Kamal M., Clamp M., Chang J.L., Kulbokas E.J. III, Zody M.C., Mauceli E., Xie X., Breen M., Wayne R.K., Ostrander E.A., Ponting C.P., Galibert F., Smith D.R. , deJong P.J., Kirkness E.F., Alvarez P., Biagi T., Brockman W., Butler J., Chin C.-W., Cook A., Cuff J., Daly M.J., DeCaprio D., Gnerre S., Grabherr M., Kellis M., Kleber M., Bardeleben C., Goodstadt L., Heger A., Hitte C., Kim L., Koepfli K.-P., Parker H.G., Pollinger J.P., Searle S.M.J., Sutter N.B., Thomas R., Webber C., Baldwin J., Abebe A., Abouelleil A., Aftuck L., Ait-Zahra M., Aldredge T., Allen N., An P., Anderson S., Antoine C., Arachchi H., Aslam A., Ayotte L., Bachantsang P., Barry A., Bayul T., Benamara M., Berlin A., Bessette D., Blitshteyn B., Bloom T., Blye J., Boguslavskiy L., Bonnet C., Boukhgalter B., Brown A., Cahill P., Calixte N., Camarata J., Cheshatsang Y., Chu J., Citroen M., Collymore A., Cooke P., Dawoe T., Daza R., Decktor K., DeGray S., Dhargay N., Dooley K., Dooley K., Dorje P., Dorjee K., Dorris L., Duffey N., Dupes A., Egbiremolen O., Elong R., Falk J., Farina A., Faro S., Ferguson D., Ferreira P., Fisher S., FitzGerald M., Foley K., Foley C., Franke A., Friedrich D., Gage D., Garber M., Gearin G., Giannoukos G., Goode T., Goyette A., Graham J., Grandbois E., Gyaltsen K., Hafez N., Hagopian D., Hagos B., Hall J., Healy C., Hegarty R., Honan T., Horn A., Houde N., Hughes L., Hunnicutt L., Husby M., Jester B., Jones C., Kamat A., Kanga B., Kells C., Khazanovich D., Kieu A.C., Kisner P., Kumar M., Lance K., Landers T., Lara M., Lee W., Leger J.-P., Lennon N., Leuper L., LeVine S., Liu J., Liu X., Lokyitsang Y., Lokyitsang T., Lui A., Macdonald J., Major J., Marabella R., Maru K., Matthews C., McDonough S., Mehta T., Meldrim J., Melnikov A., Meneus L., Mihalev A., Mihova T., Miller K., Mittelman R., Mlenga V., Mulrain L., Munson G., Navidi A., Naylor J., Nguyen T., Nguyen N., Nguyen C., Nguyen T., Nicol R., Norbu N., Norbu C., Novod N., Nyima T., Olandt P., O'Neill B., O'Neill K., Osman S., Oyono L., Patti C., Perrin D., Phunkhang P., Pierre F., Priest M., Rachupka A., Raghuraman S., Rameau R., Ray V., Raymond C., Rege F., Rise C., Rogers J., Rogov P., Sahalie J., Settipalli S., Sharpe T., Shea T., Sheehan M., Sherpa N., Shi J., Shih D., Sloan J., Smith C., Sparrow T., Stalker J., Stange-Thomann N., Stavropoulos S., Stone C., Stone S., Sykes S., Tchuinga P., Tenzing P., Tesfaye S., Thoulutsang D., Thoulutsang Y., Topham K., Topping I., Tsamla T., Vassiliev H., Venkataraman V., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J., Wilson A., Yadav S., Yang S., Yang X., Young G., Yu Q., Zainoun J., Zembek L., Zimmer A., Lander E.S. Nature 438:803-819(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Boxer Ensembl ENSCAFP00000024244.
[2]	Ensembl Submitted (JUL-2011) to UniProtKB Cited for: IDENTIFICATION. Strain: Boxer Ensembl ENSCAFP00000024244.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AAEX03002967 Genomic DNA. No translation available. AAEX03002968 Genomic DNA. No translation available. AAEX03002969 Genomic DNA. No translation available. AAEX03002970 Genomic DNA. No translation available.
RefSeq	XP_865778.1. XM_860685.2.
UniGene	Cfa.35831.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSCAFT00000026110; ENSCAFP00000024244; ENSCAFG00000016473.
GeneID	489094.
KEGG	cfa:489094.
Organism-specific databases
CTD	64324.
Phylogenomic databases
GeneTree	ENSGT00700000104009.
KO	K15588.
OMA	NIDKMRH.
Family and domain databases
Gene3D	3.30.40.10. 3 hits.
InterPro	IPR006560. AWS. IPR003616. Post-SET_dom. IPR000313. PWWP. IPR001214. SET_dom. IPR019786. Zinc_finger_PHD-type_CS. IPR011011. Znf_FYVE_PHD. IPR001965. Znf_PHD. IPR019787. Znf_PHD-finger. IPR001841. Znf_RING. IPR013083. Znf_RING/FYVE/PHD. [Graphical view]
Pfam	PF00628. PHD. 1 hit. PF00855. PWWP. 2 hits. PF00856. SET. 1 hit. [Graphical view]
SMART	SM00570. AWS. 1 hit. SM00249. PHD. 5 hits. SM00508. PostSET. 1 hit. SM00293. PWWP. 2 hits. SM00184. RING. 1 hit. SM00317. SET. 1 hit. [Graphical view]
SUPFAM	SSF57903. FYVE_PHD_ZnF. 3 hits.
PROSITE	PS51215. AWS. 1 hit. PS50868. POST_SET. 1 hit. PS50812. PWWP. 2 hits. PS50280. SET. 1 hit. PS01359. ZF_PHD_1. 2 hits. PS50016. ZF_PHD_2. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

E2R3Q9_CANFA

Accession

Primary (citable) accession number: E2R3Q9

Entry history

Integrated into UniProtKB/TrEMBL:	November 30, 2010
Last sequence update:	October 31, 2012
Last modified:	May 29, 2013
This is version 24 of the entry and version 2 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)