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E2R3Q9

- E2R3Q9_CANFA

UniProt

E2R3Q9 - E2R3Q9_CANFA

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Protein
Submitted name:

Uncharacterized protein

Gene

NSD1

Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi

Functioni

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].SAAS annotation

GO - Molecular functioni

  1. chromatin binding Source: Ensembl
  2. histone-lysine N-methyltransferase activity Source: InterPro
  3. transcription cofactor activity Source: Ensembl
  4. zinc ion binding Source: Ensembl

GO - Biological processi

  1. gastrulation with mouth forming second Source: Ensembl
  2. positive regulation of transcription, DNA-templated Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

MethyltransferaseUniRule annotationSAAS annotation, Transferase

Keywords - Ligandi

Metal-binding, S-adenosyl-L-methionineSAAS annotation, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:NSD1Imported
OrganismiCanis familiaris (Dog) (Canis lupus familiaris)Imported
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
ProteomesiUP000002254: Chromosome 4

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

NucleusSAAS annotation

Family & Domainsi

Sequence similaritiesi

Contains 1 SET domain.UniRule annotation
Contains SET domain.SAAS annotation
Contains post-SET domain.SAAS annotation

Keywords - Domaini

Zinc-fingerSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000118855.
InParanoidiE2R3Q9.
KOiK15588.
OMAiECRTGIH.
TreeFamiTF329088.

Family and domain databases

Gene3Di3.30.40.10. 3 hits.
InterProiIPR006560. AWS_dom.
IPR003616. Post-SET_dom.
IPR000313. PWWP_dom.
IPR001214. SET_dom.
IPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF00628. PHD. 1 hit.
PF00855. PWWP. 2 hits.
PF00856. SET. 1 hit.
[Graphical view]
SMARTiSM00570. AWS. 1 hit.
SM00249. PHD. 5 hits.
SM00508. PostSET. 1 hit.
SM00293. PWWP. 2 hits.
SM00184. RING. 1 hit.
SM00317. SET. 1 hit.
[Graphical view]
SUPFAMiSSF57903. SSF57903. 3 hits.
PROSITEiPS51215. AWS. 1 hit.
PS50868. POST_SET. 1 hit.
PS50812. PWWP. 2 hits.
PS50280. SET. 1 hit.
PS01359. ZF_PHD_1. 2 hits.
PS50016. ZF_PHD_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E2R3Q9 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDQTCELPRR NCLLPFSNPV NLDAPEDKDS PFGNGQSNFS EPLNGCTMQL
60 70 80 90 100
STASGTSQNA YGQDSPSCYI PLRRLQDLAS MINVEYLNGS ADGSESFQDP
110 120 130 140 150
EKSDSRAQSP VVCTSLSPGG PTALAMKQEP SCNNSPELQV KVTKTIKNGF
160 170 180 190 200
LHFENFTCVD DADVDSEMDP EQPVTEDESI EEIFEETQTN AICNYEPKSE
210 220 230 240 250
NGVDVAMGNE QDSTPESRHG AVKSPFLPLA PQTETQKNKQ RNEVDGSNEK
260 270 280 290 300
AALLPAPFAL GDTNVTIEEQ LNSINLSFQD DPDSSTSTLG NMLELPGTSS
310 320 330 340 350
SSTSQELPFC QPKKKSTPLK YEVGDLIWAK FKRRPWWPCR ICSDPLINTH
360 370 380 390 400
SKMKVSNRRP YRQYYVEAFG DPSERAWVAG KAIVMFEGRH QFEELPVLRR
410 420 430 440 450
RGKQKEKGYR HKVPQKILSK WEASVGLAEQ YDVPKGSKNR RCVSSSIKLD
460 470 480 490 500
SEEDMPFEDC TNDPESEHDL LLNGCLKSLA FDSEHSADEK EKPCAKSRAR
510 520 530 540 550
KSSDNPKRTS MKKGHMQFEA HKEERRGKIP ENLGLSFISG DVSDKQASNE
560 570 580 590 600
LSRIANSLTG SNTAPGSFLF SSCGKNTAKK EFETSNCDSL LGLSEGALIS
610 620 630 640 650
KHSEEKKKLQ RGLMCSSKVQ LCYIGAGDEE KRSDSISICT TSDDGSSDLD
660 670 680 690 700
PIDNSSESDN SVLEITDAFD RTENMLSVQK NEKVKYTRYP ATNTKVKAKQ
710 720 730 740 750
KSLITNSHTD HLMDCAKTVE PGTETSQVNL SDLKVSAVVR KPQSDFRNDS
760 770 780 790 800
FSPKFNTPSS ISSENSLIKS GATNQALLHA KSKQPKIRSI KCKHKENPVV
810 820 830 840 850
VEPPVTNEDC SLKCCSSDTK GSPLASISKS GKVDGLKLLS NMHEKTRDSN
860 870 880 890 900
DIETAVVKHV LSELKELSYR SLSEDVSDSG TSKPSKPLLF SSASGQNHIP
910 920 930 940 950
IEPDYKFSTL LMMLKDMHDS KTKEQRLMTA QNLVSYRSPG LGDCSSSSPV
960 970 980 990 1000
SASKVLVSGS STHSSEKNGD GTQKSVRPSP SGGDSALSGE LSVPVPGLVS
1010 1020 1030 1040 1050
DRRDVPASSK SHSDCVTRRN CGRSKPSSKL RDSFAAQMGR NTLNRKALKT
1060 1070 1080 1090 1100
ERKRKLSRLP AVTLEAALQG DRVSGDSENG SSRGGLEDSG KEEPLQLMGH
1110 1120 1130 1140 1150
LTSEDSAHFS SVHFDNKVNH PDPDKIPEKG PSFENRKGPE LDNEMNSEND
1160 1170 1180 1190 1200
EPSGVNQAVP KKRWQRLNQR RTKPRKRTNR FREKENSEGA FGVLLPSDPV
1210 1220 1230 1240 1250
KKGDEFPEHR PPTSTNVIED TLADPNHTSC LDSIGPRLNV CDKSSASVEE
1260 1270 1280 1290 1300
MEKEPGIPSL TPQPELPEPA VRSEKKRLRK PSKWLLEYTE EYDQIFAPKK
1310 1320 1330 1340 1350
KQKKVQEQVH KVSSRCEEES LLARCRSSAQ NKQVDENSLI STKEEPPVLE
1360 1370 1380 1390 1400
REAPFLEGPL AQSELGGGHA ELPQLTLSVP VAPEVSPRPI LESEELLVKT
1410 1420 1430 1440 1450
PGNYESKRQR KPTKKLLESN DLDPGFMPKK GDLGLSKKCY EAGHLENDSE
1460 1470 1480 1490 1500
SRAASREYGG GAAKIFDKPR KRKRQRHATA KVHCKKMKND DSSKETPGSE
1510 1520 1530 1540 1550
GELMTHRTAA SPKETVEESV ENDHGMPASK KLQGERGGGA ALKENVCQNC
1560 1570 1580 1590 1600
EKLGELLLCE AQCCGAFHLE CLGLTEMPRG KFICNECRTG IHTCFVCKQS
1610 1620 1630 1640 1650
GEDVKRCLLP LCGKFYHEEC VQKYPPTVMQ NKGFRCSLHI CITCHAANPA
1660 1670 1680 1690 1700
SVSASKGRLM RCVRCPVAYH ANDFCLAAGS KILASNSIIC PNHFTPRRGC
1710 1720 1730 1740 1750
RNHEHVNVSW CFVCSEGGSL LCCDSCPAAF HRECLNIDIP EGNWYCNDCK
1760 1770 1780 1790 1800
AGKKPHYREI VWVKVGRYRW WPAEICHPRA VPSNIDKMRH DVGEFPVLFF
1810 1820 1830 1840 1850
GSNDYLWTHQ ARVFPYMEGD VSSKDKMGKG VDGTYKKALQ EAAARFEELK
1860 1870 1880 1890 1900
AQKELRQLQE DRKNDKKPPP YKHIKVNRPI GRVQIFTADL SEIPRCNCKA
1910 1920 1930 1940 1950
TDDNPCGIDS ECINRMLLYE CHPTVCPAGG RCQNQCFTKR QYPEVEIFRT
1960 1970 1980 1990 2000
LQRGWGLRTK TDIKKGEFVN EYVGELIDEE ECRARIRYAQ EHDITNFYML
2010 2020 2030 2040 2050
TLDKDRIIDA GPKGNYARFM NHCCQPNCET QKWSVNGDTR VGLFALSDIK
2060 2070 2080 2090 2100
AGTELTFNYN LECLGNGKTV CKCGAPNCSG FLGVRPKNQP IATEEKSKKF
2110 2120 2130 2140 2150
KKKQQGKRRT QGEITKERED ECFSCGDAGQ LVSCKKPGCP KVYHADCLNL
2160 2170 2180 2190 2200
TKRPAGKWEC PWHQCDICGK EAASFCEMCP SSFCKQHREG MLFISKLDGR
2210 2220 2230 2240 2250
LSCTEHDPCG PNPLEPGEIR EYVPPPVPLP PGPGTHLAEH SSGVAAQGPK
2260 2270 2280 2290 2300
MLDKLPADTN QTLSLSKKAL AGTCQRPLLP ERPPDRTDSR PQPVDRVRDL
2310 2320 2330 2340 2350
AGSGTKPQSL VSSQKPLDRP PAVAGPRPLL SDKPSPVTGI SSSPSVRSQS
2360 2370 2380 2390 2400
LERPLGTADP RLDKSIGAAS PRPQSLEKTP GPPGLRLPPP DRLLVTSSPK
2410 2420 2430 2440 2450
PQTSDRPPDK SHASLSQRLP PPDKVLSAVV QTLVAKEKAL RPVDQNTQSK
2460 2470 2480 2490 2500
NRAALVMDLI DLTPHQKERA ASPHEVTPQV DEKMPVLESS SWTASKGLGQ
2510 2520 2530 2540 2550
MPRAVERGSM SDPVLQPPGK TAVPSEHPWQ AVKSLTQARL LSQPSAKAFL
2560 2570 2580 2590 2600
YEPTTQASGR APAGVEQIPG PPSQAPGLVK QVKQMTGGQQ LPGLAAKSGQ
2610 2620 2630 2640 2650
SFRPLGKAPS TLCTEEKKLA TAEQSPWALG KSSPGPGLWP MVAGQTISPS
2660 2670 2680 2690
CWSSGNTQTL AQTCWSLGRG QDPKPEQNTL PALNQAPSSH KCAESEQK
Length:2,698
Mass (Da):297,057
Last modified:October 31, 2012 - v2
Checksum:iF16CB5576BEB7440
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAEX03002967 Genomic DNA. No translation available.
AAEX03002968 Genomic DNA. No translation available.
AAEX03002969 Genomic DNA. No translation available.
AAEX03002970 Genomic DNA. No translation available.
RefSeqiXP_005619221.1. XM_005619164.1.
XP_005619222.1. XM_005619165.1.
XP_005619223.1. XM_005619166.1.
XP_005619224.1. XM_005619167.1.
XP_005619225.1. XM_005619168.1.
XP_865778.1. XM_860685.3.

Genome annotation databases

EnsembliENSCAFT00000026110; ENSCAFP00000024244; ENSCAFG00000016473.
GeneIDi489094.
KEGGicfa:489094.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAEX03002967 Genomic DNA. No translation available.
AAEX03002968 Genomic DNA. No translation available.
AAEX03002969 Genomic DNA. No translation available.
AAEX03002970 Genomic DNA. No translation available.
RefSeqi XP_005619221.1. XM_005619164.1.
XP_005619222.1. XM_005619165.1.
XP_005619223.1. XM_005619166.1.
XP_005619224.1. XM_005619167.1.
XP_005619225.1. XM_005619168.1.
XP_865778.1. XM_860685.3.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSCAFT00000026110 ; ENSCAFP00000024244 ; ENSCAFG00000016473 .
GeneIDi 489094.
KEGGi cfa:489094.

Organism-specific databases

CTDi 64324.

Phylogenomic databases

GeneTreei ENSGT00760000118855.
InParanoidi E2R3Q9.
KOi K15588.
OMAi ECRTGIH.
TreeFami TF329088.

Family and domain databases

Gene3Di 3.30.40.10. 3 hits.
InterProi IPR006560. AWS_dom.
IPR003616. Post-SET_dom.
IPR000313. PWWP_dom.
IPR001214. SET_dom.
IPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view ]
Pfami PF00628. PHD. 1 hit.
PF00855. PWWP. 2 hits.
PF00856. SET. 1 hit.
[Graphical view ]
SMARTi SM00570. AWS. 1 hit.
SM00249. PHD. 5 hits.
SM00508. PostSET. 1 hit.
SM00293. PWWP. 2 hits.
SM00184. RING. 1 hit.
SM00317. SET. 1 hit.
[Graphical view ]
SUPFAMi SSF57903. SSF57903. 3 hits.
PROSITEi PS51215. AWS. 1 hit.
PS50868. POST_SET. 1 hit.
PS50812. PWWP. 2 hits.
PS50280. SET. 1 hit.
PS01359. ZF_PHD_1. 2 hits.
PS50016. ZF_PHD_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence, comparative analysis and haplotype structure of the domestic dog."
    Broad Sequencing Platform
    Lindblad-Toh K., Wade C.M., Mikkelsen T.S., Karlsson E.K., Jaffe D.B., Kamal M., Clamp M., Chang J.L., Kulbokas E.J. III, Zody M.C., Mauceli E., Xie X., Breen M., Wayne R.K., Ostrander E.A., Ponting C.P., Galibert F., Smith D.R.
    , deJong P.J., Kirkness E.F., Alvarez P., Biagi T., Brockman W., Butler J., Chin C.-W., Cook A., Cuff J., Daly M.J., DeCaprio D., Gnerre S., Grabherr M., Kellis M., Kleber M., Bardeleben C., Goodstadt L., Heger A., Hitte C., Kim L., Koepfli K.-P., Parker H.G., Pollinger J.P., Searle S.M.J., Sutter N.B., Thomas R., Webber C., Baldwin J., Abebe A., Abouelleil A., Aftuck L., Ait-Zahra M., Aldredge T., Allen N., An P., Anderson S., Antoine C., Arachchi H., Aslam A., Ayotte L., Bachantsang P., Barry A., Bayul T., Benamara M., Berlin A., Bessette D., Blitshteyn B., Bloom T., Blye J., Boguslavskiy L., Bonnet C., Boukhgalter B., Brown A., Cahill P., Calixte N., Camarata J., Cheshatsang Y., Chu J., Citroen M., Collymore A., Cooke P., Dawoe T., Daza R., Decktor K., DeGray S., Dhargay N., Dooley K., Dooley K., Dorje P., Dorjee K., Dorris L., Duffey N., Dupes A., Egbiremolen O., Elong R., Falk J., Farina A., Faro S., Ferguson D., Ferreira P., Fisher S., FitzGerald M., Foley K., Foley C., Franke A., Friedrich D., Gage D., Garber M., Gearin G., Giannoukos G., Goode T., Goyette A., Graham J., Grandbois E., Gyaltsen K., Hafez N., Hagopian D., Hagos B., Hall J., Healy C., Hegarty R., Honan T., Horn A., Houde N., Hughes L., Hunnicutt L., Husby M., Jester B., Jones C., Kamat A., Kanga B., Kells C., Khazanovich D., Kieu A.C., Kisner P., Kumar M., Lance K., Landers T., Lara M., Lee W., Leger J.-P., Lennon N., Leuper L., LeVine S., Liu J., Liu X., Lokyitsang Y., Lokyitsang T., Lui A., Macdonald J., Major J., Marabella R., Maru K., Matthews C., McDonough S., Mehta T., Meldrim J., Melnikov A., Meneus L., Mihalev A., Mihova T., Miller K., Mittelman R., Mlenga V., Mulrain L., Munson G., Navidi A., Naylor J., Nguyen T., Nguyen N., Nguyen C., Nguyen T., Nicol R., Norbu N., Norbu C., Novod N., Nyima T., Olandt P., O'Neill B., O'Neill K., Osman S., Oyono L., Patti C., Perrin D., Phunkhang P., Pierre F., Priest M., Rachupka A., Raghuraman S., Rameau R., Ray V., Raymond C., Rege F., Rise C., Rogers J., Rogov P., Sahalie J., Settipalli S., Sharpe T., Shea T., Sheehan M., Sherpa N., Shi J., Shih D., Sloan J., Smith C., Sparrow T., Stalker J., Stange-Thomann N., Stavropoulos S., Stone C., Stone S., Sykes S., Tchuinga P., Tenzing P., Tesfaye S., Thoulutsang D., Thoulutsang Y., Topham K., Topping I., Tsamla T., Vassiliev H., Venkataraman V., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J., Wilson A., Yadav S., Yang S., Yang X., Young G., Yu Q., Zainoun J., Zembek L., Zimmer A., Lander E.S.
    Nature 438:803-819(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BoxerImported.
  2. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: BoxerImported.

Entry informationi

Entry nameiE2R3Q9_CANFA
AccessioniPrimary (citable) accession number: E2R3Q9
Entry historyi
Integrated into UniProtKB/TrEMBL: November 30, 2010
Last sequence update: October 31, 2012
Last modified: October 29, 2014
This is version 36 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3