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E2R3Q9

- E2R3Q9_CANFA

UniProt

E2R3Q9 - E2R3Q9_CANFA

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Protein
Submitted name: Uncharacterized protein
Gene
NSD1
Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein predictedi

Functioni

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].SAAS annotations

GO - Molecular functioni

  1. chromatin binding Source: Ensembl
  2. histone-lysine N-methyltransferase activity Source: InterPro
  3. transcription cofactor activity Source: Ensembl
  4. zinc ion binding Source: Ensembl

GO - Biological processi

  1. gastrulation with mouth forming second Source: Ensembl
  2. positive regulation of transcription, DNA-templated Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

MethyltransferaseUniRule annotation, Transferase

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:NSD1Imported
OrganismiCanis familiaris (Dog) (Canis lupus familiaris)Imported
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
ProteomesiUP000002254: Chromosome 4

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

NucleusSAAS annotations

Family & Domainsi

Sequence similaritiesi

Contains 1 SET domain.UniRule annotation
Contains SET domain.SAAS annotations
Contains post-SET domain.SAAS annotations

Keywords - Domaini

Zinc-fingerSAAS annotations

Phylogenomic databases

GeneTreeiENSGT00740000114921.
KOiK15588.
OMAiECRTGIH.
TreeFamiTF329088.

Family and domain databases

Gene3Di3.30.40.10. 3 hits.
InterProiIPR006560. AWS.
IPR003616. Post-SET_dom.
IPR000313. PWWP_dom.
IPR001214. SET_dom.
IPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF00628. PHD. 1 hit.
PF00855. PWWP. 2 hits.
PF00856. SET. 1 hit.
[Graphical view]
SMARTiSM00570. AWS. 1 hit.
SM00249. PHD. 5 hits.
SM00508. PostSET. 1 hit.
SM00293. PWWP. 2 hits.
SM00184. RING. 1 hit.
SM00317. SET. 1 hit.
[Graphical view]
SUPFAMiSSF57903. SSF57903. 3 hits.
PROSITEiPS51215. AWS. 1 hit.
PS50868. POST_SET. 1 hit.
PS50812. PWWP. 2 hits.
PS50280. SET. 1 hit.
PS01359. ZF_PHD_1. 2 hits.
PS50016. ZF_PHD_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E2R3Q9-1 [UniParc]FASTAAdd to Basket

« Hide

MDQTCELPRR NCLLPFSNPV NLDAPEDKDS PFGNGQSNFS EPLNGCTMQL     50
STASGTSQNA YGQDSPSCYI PLRRLQDLAS MINVEYLNGS ADGSESFQDP 100
EKSDSRAQSP VVCTSLSPGG PTALAMKQEP SCNNSPELQV KVTKTIKNGF 150
LHFENFTCVD DADVDSEMDP EQPVTEDESI EEIFEETQTN AICNYEPKSE 200
NGVDVAMGNE QDSTPESRHG AVKSPFLPLA PQTETQKNKQ RNEVDGSNEK 250
AALLPAPFAL GDTNVTIEEQ LNSINLSFQD DPDSSTSTLG NMLELPGTSS 300
SSTSQELPFC QPKKKSTPLK YEVGDLIWAK FKRRPWWPCR ICSDPLINTH 350
SKMKVSNRRP YRQYYVEAFG DPSERAWVAG KAIVMFEGRH QFEELPVLRR 400
RGKQKEKGYR HKVPQKILSK WEASVGLAEQ YDVPKGSKNR RCVSSSIKLD 450
SEEDMPFEDC TNDPESEHDL LLNGCLKSLA FDSEHSADEK EKPCAKSRAR 500
KSSDNPKRTS MKKGHMQFEA HKEERRGKIP ENLGLSFISG DVSDKQASNE 550
LSRIANSLTG SNTAPGSFLF SSCGKNTAKK EFETSNCDSL LGLSEGALIS 600
KHSEEKKKLQ RGLMCSSKVQ LCYIGAGDEE KRSDSISICT TSDDGSSDLD 650
PIDNSSESDN SVLEITDAFD RTENMLSVQK NEKVKYTRYP ATNTKVKAKQ 700
KSLITNSHTD HLMDCAKTVE PGTETSQVNL SDLKVSAVVR KPQSDFRNDS 750
FSPKFNTPSS ISSENSLIKS GATNQALLHA KSKQPKIRSI KCKHKENPVV 800
VEPPVTNEDC SLKCCSSDTK GSPLASISKS GKVDGLKLLS NMHEKTRDSN 850
DIETAVVKHV LSELKELSYR SLSEDVSDSG TSKPSKPLLF SSASGQNHIP 900
IEPDYKFSTL LMMLKDMHDS KTKEQRLMTA QNLVSYRSPG LGDCSSSSPV 950
SASKVLVSGS STHSSEKNGD GTQKSVRPSP SGGDSALSGE LSVPVPGLVS 1000
DRRDVPASSK SHSDCVTRRN CGRSKPSSKL RDSFAAQMGR NTLNRKALKT 1050
ERKRKLSRLP AVTLEAALQG DRVSGDSENG SSRGGLEDSG KEEPLQLMGH 1100
LTSEDSAHFS SVHFDNKVNH PDPDKIPEKG PSFENRKGPE LDNEMNSEND 1150
EPSGVNQAVP KKRWQRLNQR RTKPRKRTNR FREKENSEGA FGVLLPSDPV 1200
KKGDEFPEHR PPTSTNVIED TLADPNHTSC LDSIGPRLNV CDKSSASVEE 1250
MEKEPGIPSL TPQPELPEPA VRSEKKRLRK PSKWLLEYTE EYDQIFAPKK 1300
KQKKVQEQVH KVSSRCEEES LLARCRSSAQ NKQVDENSLI STKEEPPVLE 1350
REAPFLEGPL AQSELGGGHA ELPQLTLSVP VAPEVSPRPI LESEELLVKT 1400
PGNYESKRQR KPTKKLLESN DLDPGFMPKK GDLGLSKKCY EAGHLENDSE 1450
SRAASREYGG GAAKIFDKPR KRKRQRHATA KVHCKKMKND DSSKETPGSE 1500
GELMTHRTAA SPKETVEESV ENDHGMPASK KLQGERGGGA ALKENVCQNC 1550
EKLGELLLCE AQCCGAFHLE CLGLTEMPRG KFICNECRTG IHTCFVCKQS 1600
GEDVKRCLLP LCGKFYHEEC VQKYPPTVMQ NKGFRCSLHI CITCHAANPA 1650
SVSASKGRLM RCVRCPVAYH ANDFCLAAGS KILASNSIIC PNHFTPRRGC 1700
RNHEHVNVSW CFVCSEGGSL LCCDSCPAAF HRECLNIDIP EGNWYCNDCK 1750
AGKKPHYREI VWVKVGRYRW WPAEICHPRA VPSNIDKMRH DVGEFPVLFF 1800
GSNDYLWTHQ ARVFPYMEGD VSSKDKMGKG VDGTYKKALQ EAAARFEELK 1850
AQKELRQLQE DRKNDKKPPP YKHIKVNRPI GRVQIFTADL SEIPRCNCKA 1900
TDDNPCGIDS ECINRMLLYE CHPTVCPAGG RCQNQCFTKR QYPEVEIFRT 1950
LQRGWGLRTK TDIKKGEFVN EYVGELIDEE ECRARIRYAQ EHDITNFYML 2000
TLDKDRIIDA GPKGNYARFM NHCCQPNCET QKWSVNGDTR VGLFALSDIK 2050
AGTELTFNYN LECLGNGKTV CKCGAPNCSG FLGVRPKNQP IATEEKSKKF 2100
KKKQQGKRRT QGEITKERED ECFSCGDAGQ LVSCKKPGCP KVYHADCLNL 2150
TKRPAGKWEC PWHQCDICGK EAASFCEMCP SSFCKQHREG MLFISKLDGR 2200
LSCTEHDPCG PNPLEPGEIR EYVPPPVPLP PGPGTHLAEH SSGVAAQGPK 2250
MLDKLPADTN QTLSLSKKAL AGTCQRPLLP ERPPDRTDSR PQPVDRVRDL 2300
AGSGTKPQSL VSSQKPLDRP PAVAGPRPLL SDKPSPVTGI SSSPSVRSQS 2350
LERPLGTADP RLDKSIGAAS PRPQSLEKTP GPPGLRLPPP DRLLVTSSPK 2400
PQTSDRPPDK SHASLSQRLP PPDKVLSAVV QTLVAKEKAL RPVDQNTQSK 2450
NRAALVMDLI DLTPHQKERA ASPHEVTPQV DEKMPVLESS SWTASKGLGQ 2500
MPRAVERGSM SDPVLQPPGK TAVPSEHPWQ AVKSLTQARL LSQPSAKAFL 2550
YEPTTQASGR APAGVEQIPG PPSQAPGLVK QVKQMTGGQQ LPGLAAKSGQ 2600
SFRPLGKAPS TLCTEEKKLA TAEQSPWALG KSSPGPGLWP MVAGQTISPS 2650
CWSSGNTQTL AQTCWSLGRG QDPKPEQNTL PALNQAPSSH KCAESEQK 2698
Length:2,698
Mass (Da):297,057
Last modified:October 31, 2012 - v2
Checksum:iF16CB5576BEB7440
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAEX03002967 Genomic DNA. No translation available.
AAEX03002968 Genomic DNA. No translation available.
AAEX03002969 Genomic DNA. No translation available.
AAEX03002970 Genomic DNA. No translation available.
RefSeqiXP_005619221.1. XM_005619164.1.
XP_005619222.1. XM_005619165.1.
XP_005619223.1. XM_005619166.1.
XP_005619224.1. XM_005619167.1.
XP_005619225.1. XM_005619168.1.
XP_865778.1. XM_860685.3.

Genome annotation databases

EnsembliENSCAFT00000026110; ENSCAFP00000024244; ENSCAFG00000016473.
GeneIDi489094.
KEGGicfa:489094.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAEX03002967 Genomic DNA. No translation available.
AAEX03002968 Genomic DNA. No translation available.
AAEX03002969 Genomic DNA. No translation available.
AAEX03002970 Genomic DNA. No translation available.
RefSeqi XP_005619221.1. XM_005619164.1.
XP_005619222.1. XM_005619165.1.
XP_005619223.1. XM_005619166.1.
XP_005619224.1. XM_005619167.1.
XP_005619225.1. XM_005619168.1.
XP_865778.1. XM_860685.3.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSCAFT00000026110 ; ENSCAFP00000024244 ; ENSCAFG00000016473 .
GeneIDi 489094.
KEGGi cfa:489094.

Organism-specific databases

CTDi 64324.

Phylogenomic databases

GeneTreei ENSGT00740000114921.
KOi K15588.
OMAi ECRTGIH.
TreeFami TF329088.

Family and domain databases

Gene3Di 3.30.40.10. 3 hits.
InterProi IPR006560. AWS.
IPR003616. Post-SET_dom.
IPR000313. PWWP_dom.
IPR001214. SET_dom.
IPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view ]
Pfami PF00628. PHD. 1 hit.
PF00855. PWWP. 2 hits.
PF00856. SET. 1 hit.
[Graphical view ]
SMARTi SM00570. AWS. 1 hit.
SM00249. PHD. 5 hits.
SM00508. PostSET. 1 hit.
SM00293. PWWP. 2 hits.
SM00184. RING. 1 hit.
SM00317. SET. 1 hit.
[Graphical view ]
SUPFAMi SSF57903. SSF57903. 3 hits.
PROSITEi PS51215. AWS. 1 hit.
PS50868. POST_SET. 1 hit.
PS50812. PWWP. 2 hits.
PS50280. SET. 1 hit.
PS01359. ZF_PHD_1. 2 hits.
PS50016. ZF_PHD_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence, comparative analysis and haplotype structure of the domestic dog."
    Broad Sequencing Platform
    Lindblad-Toh K., Wade C.M., Mikkelsen T.S., Karlsson E.K., Jaffe D.B., Kamal M., Clamp M., Chang J.L., Kulbokas E.J. III, Zody M.C., Mauceli E., Xie X., Breen M., Wayne R.K., Ostrander E.A., Ponting C.P., Galibert F., Smith D.R.
    , deJong P.J., Kirkness E.F., Alvarez P., Biagi T., Brockman W., Butler J., Chin C.-W., Cook A., Cuff J., Daly M.J., DeCaprio D., Gnerre S., Grabherr M., Kellis M., Kleber M., Bardeleben C., Goodstadt L., Heger A., Hitte C., Kim L., Koepfli K.-P., Parker H.G., Pollinger J.P., Searle S.M.J., Sutter N.B., Thomas R., Webber C., Baldwin J., Abebe A., Abouelleil A., Aftuck L., Ait-Zahra M., Aldredge T., Allen N., An P., Anderson S., Antoine C., Arachchi H., Aslam A., Ayotte L., Bachantsang P., Barry A., Bayul T., Benamara M., Berlin A., Bessette D., Blitshteyn B., Bloom T., Blye J., Boguslavskiy L., Bonnet C., Boukhgalter B., Brown A., Cahill P., Calixte N., Camarata J., Cheshatsang Y., Chu J., Citroen M., Collymore A., Cooke P., Dawoe T., Daza R., Decktor K., DeGray S., Dhargay N., Dooley K., Dooley K., Dorje P., Dorjee K., Dorris L., Duffey N., Dupes A., Egbiremolen O., Elong R., Falk J., Farina A., Faro S., Ferguson D., Ferreira P., Fisher S., FitzGerald M., Foley K., Foley C., Franke A., Friedrich D., Gage D., Garber M., Gearin G., Giannoukos G., Goode T., Goyette A., Graham J., Grandbois E., Gyaltsen K., Hafez N., Hagopian D., Hagos B., Hall J., Healy C., Hegarty R., Honan T., Horn A., Houde N., Hughes L., Hunnicutt L., Husby M., Jester B., Jones C., Kamat A., Kanga B., Kells C., Khazanovich D., Kieu A.C., Kisner P., Kumar M., Lance K., Landers T., Lara M., Lee W., Leger J.-P., Lennon N., Leuper L., LeVine S., Liu J., Liu X., Lokyitsang Y., Lokyitsang T., Lui A., Macdonald J., Major J., Marabella R., Maru K., Matthews C., McDonough S., Mehta T., Meldrim J., Melnikov A., Meneus L., Mihalev A., Mihova T., Miller K., Mittelman R., Mlenga V., Mulrain L., Munson G., Navidi A., Naylor J., Nguyen T., Nguyen N., Nguyen C., Nguyen T., Nicol R., Norbu N., Norbu C., Novod N., Nyima T., Olandt P., O'Neill B., O'Neill K., Osman S., Oyono L., Patti C., Perrin D., Phunkhang P., Pierre F., Priest M., Rachupka A., Raghuraman S., Rameau R., Ray V., Raymond C., Rege F., Rise C., Rogers J., Rogov P., Sahalie J., Settipalli S., Sharpe T., Shea T., Sheehan M., Sherpa N., Shi J., Shih D., Sloan J., Smith C., Sparrow T., Stalker J., Stange-Thomann N., Stavropoulos S., Stone C., Stone S., Sykes S., Tchuinga P., Tenzing P., Tesfaye S., Thoulutsang D., Thoulutsang Y., Topham K., Topping I., Tsamla T., Vassiliev H., Venkataraman V., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J., Wilson A., Yadav S., Yang S., Yang X., Young G., Yu Q., Zainoun J., Zembek L., Zimmer A., Lander E.S.
    Nature 438:803-819(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BoxerImported.
  2. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: BoxerImported.

Entry informationi

Entry nameiE2R3Q9_CANFA
AccessioniPrimary (citable) accession number: E2R3Q9
Entry historyi
Integrated into UniProtKB/TrEMBL: November 30, 2010
Last sequence update: October 31, 2012
Last modified: July 9, 2014
This is version 34 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3