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E2R3Q9

- E2R3Q9_CANFA

UniProt

E2R3Q9 - E2R3Q9_CANFA

Protein
Submitted name:

Uncharacterized protein

Gene

NSD1

Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi
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    • History
      Entry version 35 (01 Oct 2014)
      Sequence version 2 (31 Oct 2012)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].SAAS annotation

    GO - Molecular functioni

    1. chromatin binding Source: Ensembl
    2. histone-lysine N-methyltransferase activity Source: InterPro
    3. transcription cofactor activity Source: Ensembl
    4. zinc ion binding Source: Ensembl

    GO - Biological processi

    1. gastrulation with mouth forming second Source: Ensembl
    2. positive regulation of transcription, DNA-templated Source: Ensembl

    Keywords - Molecular functioni

    MethyltransferaseUniRule annotation, Transferase

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Uncharacterized proteinImported
    Gene namesi
    Name:NSD1Imported
    OrganismiCanis familiaris (Dog) (Canis lupus familiaris)Imported
    Taxonomic identifieri9615 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
    ProteomesiUP000002254: Chromosome 4

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-KW

    Keywords - Cellular componenti

    NucleusSAAS annotation

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 SET domain.UniRule annotation
    Contains SET domain.SAAS annotation
    Contains post-SET domain.SAAS annotation

    Keywords - Domaini

    Zinc-fingerSAAS annotation

    Phylogenomic databases

    GeneTreeiENSGT00740000114921.
    KOiK15588.
    OMAiECRTGIH.
    TreeFamiTF329088.

    Family and domain databases

    Gene3Di3.30.40.10. 3 hits.
    InterProiIPR006560. AWS.
    IPR003616. Post-SET_dom.
    IPR000313. PWWP_dom.
    IPR001214. SET_dom.
    IPR019786. Zinc_finger_PHD-type_CS.
    IPR011011. Znf_FYVE_PHD.
    IPR001965. Znf_PHD.
    IPR019787. Znf_PHD-finger.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view]
    PfamiPF00628. PHD. 1 hit.
    PF00855. PWWP. 2 hits.
    PF00856. SET. 1 hit.
    [Graphical view]
    SMARTiSM00570. AWS. 1 hit.
    SM00249. PHD. 5 hits.
    SM00508. PostSET. 1 hit.
    SM00293. PWWP. 2 hits.
    SM00184. RING. 1 hit.
    SM00317. SET. 1 hit.
    [Graphical view]
    SUPFAMiSSF57903. SSF57903. 3 hits.
    PROSITEiPS51215. AWS. 1 hit.
    PS50868. POST_SET. 1 hit.
    PS50812. PWWP. 2 hits.
    PS50280. SET. 1 hit.
    PS01359. ZF_PHD_1. 2 hits.
    PS50016. ZF_PHD_2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    E2R3Q9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDQTCELPRR NCLLPFSNPV NLDAPEDKDS PFGNGQSNFS EPLNGCTMQL     50
    STASGTSQNA YGQDSPSCYI PLRRLQDLAS MINVEYLNGS ADGSESFQDP 100
    EKSDSRAQSP VVCTSLSPGG PTALAMKQEP SCNNSPELQV KVTKTIKNGF 150
    LHFENFTCVD DADVDSEMDP EQPVTEDESI EEIFEETQTN AICNYEPKSE 200
    NGVDVAMGNE QDSTPESRHG AVKSPFLPLA PQTETQKNKQ RNEVDGSNEK 250
    AALLPAPFAL GDTNVTIEEQ LNSINLSFQD DPDSSTSTLG NMLELPGTSS 300
    SSTSQELPFC QPKKKSTPLK YEVGDLIWAK FKRRPWWPCR ICSDPLINTH 350
    SKMKVSNRRP YRQYYVEAFG DPSERAWVAG KAIVMFEGRH QFEELPVLRR 400
    RGKQKEKGYR HKVPQKILSK WEASVGLAEQ YDVPKGSKNR RCVSSSIKLD 450
    SEEDMPFEDC TNDPESEHDL LLNGCLKSLA FDSEHSADEK EKPCAKSRAR 500
    KSSDNPKRTS MKKGHMQFEA HKEERRGKIP ENLGLSFISG DVSDKQASNE 550
    LSRIANSLTG SNTAPGSFLF SSCGKNTAKK EFETSNCDSL LGLSEGALIS 600
    KHSEEKKKLQ RGLMCSSKVQ LCYIGAGDEE KRSDSISICT TSDDGSSDLD 650
    PIDNSSESDN SVLEITDAFD RTENMLSVQK NEKVKYTRYP ATNTKVKAKQ 700
    KSLITNSHTD HLMDCAKTVE PGTETSQVNL SDLKVSAVVR KPQSDFRNDS 750
    FSPKFNTPSS ISSENSLIKS GATNQALLHA KSKQPKIRSI KCKHKENPVV 800
    VEPPVTNEDC SLKCCSSDTK GSPLASISKS GKVDGLKLLS NMHEKTRDSN 850
    DIETAVVKHV LSELKELSYR SLSEDVSDSG TSKPSKPLLF SSASGQNHIP 900
    IEPDYKFSTL LMMLKDMHDS KTKEQRLMTA QNLVSYRSPG LGDCSSSSPV 950
    SASKVLVSGS STHSSEKNGD GTQKSVRPSP SGGDSALSGE LSVPVPGLVS 1000
    DRRDVPASSK SHSDCVTRRN CGRSKPSSKL RDSFAAQMGR NTLNRKALKT 1050
    ERKRKLSRLP AVTLEAALQG DRVSGDSENG SSRGGLEDSG KEEPLQLMGH 1100
    LTSEDSAHFS SVHFDNKVNH PDPDKIPEKG PSFENRKGPE LDNEMNSEND 1150
    EPSGVNQAVP KKRWQRLNQR RTKPRKRTNR FREKENSEGA FGVLLPSDPV 1200
    KKGDEFPEHR PPTSTNVIED TLADPNHTSC LDSIGPRLNV CDKSSASVEE 1250
    MEKEPGIPSL TPQPELPEPA VRSEKKRLRK PSKWLLEYTE EYDQIFAPKK 1300
    KQKKVQEQVH KVSSRCEEES LLARCRSSAQ NKQVDENSLI STKEEPPVLE 1350
    REAPFLEGPL AQSELGGGHA ELPQLTLSVP VAPEVSPRPI LESEELLVKT 1400
    PGNYESKRQR KPTKKLLESN DLDPGFMPKK GDLGLSKKCY EAGHLENDSE 1450
    SRAASREYGG GAAKIFDKPR KRKRQRHATA KVHCKKMKND DSSKETPGSE 1500
    GELMTHRTAA SPKETVEESV ENDHGMPASK KLQGERGGGA ALKENVCQNC 1550
    EKLGELLLCE AQCCGAFHLE CLGLTEMPRG KFICNECRTG IHTCFVCKQS 1600
    GEDVKRCLLP LCGKFYHEEC VQKYPPTVMQ NKGFRCSLHI CITCHAANPA 1650
    SVSASKGRLM RCVRCPVAYH ANDFCLAAGS KILASNSIIC PNHFTPRRGC 1700
    RNHEHVNVSW CFVCSEGGSL LCCDSCPAAF HRECLNIDIP EGNWYCNDCK 1750
    AGKKPHYREI VWVKVGRYRW WPAEICHPRA VPSNIDKMRH DVGEFPVLFF 1800
    GSNDYLWTHQ ARVFPYMEGD VSSKDKMGKG VDGTYKKALQ EAAARFEELK 1850
    AQKELRQLQE DRKNDKKPPP YKHIKVNRPI GRVQIFTADL SEIPRCNCKA 1900
    TDDNPCGIDS ECINRMLLYE CHPTVCPAGG RCQNQCFTKR QYPEVEIFRT 1950
    LQRGWGLRTK TDIKKGEFVN EYVGELIDEE ECRARIRYAQ EHDITNFYML 2000
    TLDKDRIIDA GPKGNYARFM NHCCQPNCET QKWSVNGDTR VGLFALSDIK 2050
    AGTELTFNYN LECLGNGKTV CKCGAPNCSG FLGVRPKNQP IATEEKSKKF 2100
    KKKQQGKRRT QGEITKERED ECFSCGDAGQ LVSCKKPGCP KVYHADCLNL 2150
    TKRPAGKWEC PWHQCDICGK EAASFCEMCP SSFCKQHREG MLFISKLDGR 2200
    LSCTEHDPCG PNPLEPGEIR EYVPPPVPLP PGPGTHLAEH SSGVAAQGPK 2250
    MLDKLPADTN QTLSLSKKAL AGTCQRPLLP ERPPDRTDSR PQPVDRVRDL 2300
    AGSGTKPQSL VSSQKPLDRP PAVAGPRPLL SDKPSPVTGI SSSPSVRSQS 2350
    LERPLGTADP RLDKSIGAAS PRPQSLEKTP GPPGLRLPPP DRLLVTSSPK 2400
    PQTSDRPPDK SHASLSQRLP PPDKVLSAVV QTLVAKEKAL RPVDQNTQSK 2450
    NRAALVMDLI DLTPHQKERA ASPHEVTPQV DEKMPVLESS SWTASKGLGQ 2500
    MPRAVERGSM SDPVLQPPGK TAVPSEHPWQ AVKSLTQARL LSQPSAKAFL 2550
    YEPTTQASGR APAGVEQIPG PPSQAPGLVK QVKQMTGGQQ LPGLAAKSGQ 2600
    SFRPLGKAPS TLCTEEKKLA TAEQSPWALG KSSPGPGLWP MVAGQTISPS 2650
    CWSSGNTQTL AQTCWSLGRG QDPKPEQNTL PALNQAPSSH KCAESEQK 2698
    Length:2,698
    Mass (Da):297,057
    Last modified:October 31, 2012 - v2
    Checksum:iF16CB5576BEB7440
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAEX03002967 Genomic DNA. No translation available.
    AAEX03002968 Genomic DNA. No translation available.
    AAEX03002969 Genomic DNA. No translation available.
    AAEX03002970 Genomic DNA. No translation available.
    RefSeqiXP_005619221.1. XM_005619164.1.
    XP_005619222.1. XM_005619165.1.
    XP_005619223.1. XM_005619166.1.
    XP_005619224.1. XM_005619167.1.
    XP_005619225.1. XM_005619168.1.
    XP_865778.1. XM_860685.3.

    Genome annotation databases

    EnsembliENSCAFT00000026110; ENSCAFP00000024244; ENSCAFG00000016473.
    GeneIDi489094.
    KEGGicfa:489094.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAEX03002967 Genomic DNA. No translation available.
    AAEX03002968 Genomic DNA. No translation available.
    AAEX03002969 Genomic DNA. No translation available.
    AAEX03002970 Genomic DNA. No translation available.
    RefSeqi XP_005619221.1. XM_005619164.1.
    XP_005619222.1. XM_005619165.1.
    XP_005619223.1. XM_005619166.1.
    XP_005619224.1. XM_005619167.1.
    XP_005619225.1. XM_005619168.1.
    XP_865778.1. XM_860685.3.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSCAFT00000026110 ; ENSCAFP00000024244 ; ENSCAFG00000016473 .
    GeneIDi 489094.
    KEGGi cfa:489094.

    Organism-specific databases

    CTDi 64324.

    Phylogenomic databases

    GeneTreei ENSGT00740000114921.
    KOi K15588.
    OMAi ECRTGIH.
    TreeFami TF329088.

    Family and domain databases

    Gene3Di 3.30.40.10. 3 hits.
    InterProi IPR006560. AWS.
    IPR003616. Post-SET_dom.
    IPR000313. PWWP_dom.
    IPR001214. SET_dom.
    IPR019786. Zinc_finger_PHD-type_CS.
    IPR011011. Znf_FYVE_PHD.
    IPR001965. Znf_PHD.
    IPR019787. Znf_PHD-finger.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view ]
    Pfami PF00628. PHD. 1 hit.
    PF00855. PWWP. 2 hits.
    PF00856. SET. 1 hit.
    [Graphical view ]
    SMARTi SM00570. AWS. 1 hit.
    SM00249. PHD. 5 hits.
    SM00508. PostSET. 1 hit.
    SM00293. PWWP. 2 hits.
    SM00184. RING. 1 hit.
    SM00317. SET. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57903. SSF57903. 3 hits.
    PROSITEi PS51215. AWS. 1 hit.
    PS50868. POST_SET. 1 hit.
    PS50812. PWWP. 2 hits.
    PS50280. SET. 1 hit.
    PS01359. ZF_PHD_1. 2 hits.
    PS50016. ZF_PHD_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence, comparative analysis and haplotype structure of the domestic dog."
      Broad Sequencing Platform
      Lindblad-Toh K., Wade C.M., Mikkelsen T.S., Karlsson E.K., Jaffe D.B., Kamal M., Clamp M., Chang J.L., Kulbokas E.J. III, Zody M.C., Mauceli E., Xie X., Breen M., Wayne R.K., Ostrander E.A., Ponting C.P., Galibert F., Smith D.R.
      , deJong P.J., Kirkness E.F., Alvarez P., Biagi T., Brockman W., Butler J., Chin C.-W., Cook A., Cuff J., Daly M.J., DeCaprio D., Gnerre S., Grabherr M., Kellis M., Kleber M., Bardeleben C., Goodstadt L., Heger A., Hitte C., Kim L., Koepfli K.-P., Parker H.G., Pollinger J.P., Searle S.M.J., Sutter N.B., Thomas R., Webber C., Baldwin J., Abebe A., Abouelleil A., Aftuck L., Ait-Zahra M., Aldredge T., Allen N., An P., Anderson S., Antoine C., Arachchi H., Aslam A., Ayotte L., Bachantsang P., Barry A., Bayul T., Benamara M., Berlin A., Bessette D., Blitshteyn B., Bloom T., Blye J., Boguslavskiy L., Bonnet C., Boukhgalter B., Brown A., Cahill P., Calixte N., Camarata J., Cheshatsang Y., Chu J., Citroen M., Collymore A., Cooke P., Dawoe T., Daza R., Decktor K., DeGray S., Dhargay N., Dooley K., Dooley K., Dorje P., Dorjee K., Dorris L., Duffey N., Dupes A., Egbiremolen O., Elong R., Falk J., Farina A., Faro S., Ferguson D., Ferreira P., Fisher S., FitzGerald M., Foley K., Foley C., Franke A., Friedrich D., Gage D., Garber M., Gearin G., Giannoukos G., Goode T., Goyette A., Graham J., Grandbois E., Gyaltsen K., Hafez N., Hagopian D., Hagos B., Hall J., Healy C., Hegarty R., Honan T., Horn A., Houde N., Hughes L., Hunnicutt L., Husby M., Jester B., Jones C., Kamat A., Kanga B., Kells C., Khazanovich D., Kieu A.C., Kisner P., Kumar M., Lance K., Landers T., Lara M., Lee W., Leger J.-P., Lennon N., Leuper L., LeVine S., Liu J., Liu X., Lokyitsang Y., Lokyitsang T., Lui A., Macdonald J., Major J., Marabella R., Maru K., Matthews C., McDonough S., Mehta T., Meldrim J., Melnikov A., Meneus L., Mihalev A., Mihova T., Miller K., Mittelman R., Mlenga V., Mulrain L., Munson G., Navidi A., Naylor J., Nguyen T., Nguyen N., Nguyen C., Nguyen T., Nicol R., Norbu N., Norbu C., Novod N., Nyima T., Olandt P., O'Neill B., O'Neill K., Osman S., Oyono L., Patti C., Perrin D., Phunkhang P., Pierre F., Priest M., Rachupka A., Raghuraman S., Rameau R., Ray V., Raymond C., Rege F., Rise C., Rogers J., Rogov P., Sahalie J., Settipalli S., Sharpe T., Shea T., Sheehan M., Sherpa N., Shi J., Shih D., Sloan J., Smith C., Sparrow T., Stalker J., Stange-Thomann N., Stavropoulos S., Stone C., Stone S., Sykes S., Tchuinga P., Tenzing P., Tesfaye S., Thoulutsang D., Thoulutsang Y., Topham K., Topping I., Tsamla T., Vassiliev H., Venkataraman V., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J., Wilson A., Yadav S., Yang S., Yang X., Young G., Yu Q., Zainoun J., Zembek L., Zimmer A., Lander E.S.
      Nature 438:803-819(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BoxerImported.
    2. Ensembl
      Submitted (JUL-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: BoxerImported.

    Entry informationi

    Entry nameiE2R3Q9_CANFA
    AccessioniPrimary (citable) accession number: E2R3Q9
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 30, 2010
    Last sequence update: October 31, 2012
    Last modified: October 1, 2014
    This is version 35 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3