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E2R0G7

- E2R0G7_CANFA

UniProt

E2R0G7 - E2R0G7_CANFA

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Protein

DNA ligase

Gene
LIG4
Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Unreviewed - Annotation score: 5 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. DNA binding Source: Ensembl
  3. DNA ligase (ATP) activity Source: UniProtKB-EC

GO - Biological processi

  1. cell proliferation Source: Ensembl
  2. central nervous system development Source: Ensembl
  3. chromosome organization Source: Ensembl
  4. DNA ligation involved in DNA recombination Source: Ensembl
  5. DNA ligation involved in DNA repair Source: Ensembl
  6. DNA replication Source: UniProtKB-KW
  7. double-strand break repair via nonhomologous end joining Source: Ensembl
  8. immunoglobulin V(D)J recombination Source: Ensembl
  9. in utero embryonic development Source: Ensembl
  10. isotype switching Source: Ensembl
  11. negative regulation of neuron apoptotic process Source: Ensembl
  12. neuron apoptotic process Source: Ensembl
  13. nucleotide-excision repair, DNA gap filling Source: Ensembl
  14. positive regulation of fibroblast proliferation Source: Ensembl
  15. positive regulation of neurogenesis Source: Ensembl
  16. pro-B cell differentiation Source: Ensembl
  17. response to gamma radiation Source: Ensembl
  18. response to X-ray Source: Ensembl
  19. single strand break repair Source: Ensembl
  20. somatic stem cell maintenance Source: Ensembl
  21. T cell differentiation in thymus Source: Ensembl
  22. T cell receptor V(D)J recombination Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotation

Keywords - Biological processi

DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Gene namesi
Name:LIG4Imported
OrganismiCanis familiaris (Dog) (Canis lupus familiaris)Imported
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
ProteomesiUP000002254: Chromosome 22

Subcellular locationi

GO - Cellular componenti

  1. condensed chromosome Source: Ensembl
  2. cytoplasm Source: Ensembl
  3. DNA-dependent protein kinase-DNA ligase 4 complex Source: Ensembl
  4. DNA ligase IV complex Source: Ensembl
  5. focal adhesion Source: Ensembl
  6. plasma membrane Source: Ensembl
Complete GO annotation...

Structurei

3D structure databases

ProteinModelPortaliE2R0G7.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00750000117695.
KOiK10777.
OMAiHMCPSTK.
OrthoDBiEOG7BKCT2.
TreeFamiTF312980.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
3.40.50.10190. 2 hits.
InterProiIPR001357. BRCT_dom.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR021536. DNA_ligase_IV_dom.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF00533. BRCT. 1 hit.
PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
PF11411. DNA_ligase_IV. 1 hit.
[Graphical view]
SMARTiSM00292. BRCT. 2 hits.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF52113. SSF52113. 2 hits.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS50172. BRCT. 2 hits.
PS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E2R0G7-1 [UniParc]FASTAAdd to Basket

« Hide

MAATQTSQTV ASHVPFADLC STLERIQRSK GREEKIRHFR EFLDSWRRFH    50
DALHKNQKDV RDSFYPAMRL ILPQLERERM AYGIKETMLA KLYIELLNLP 100
KEGKDALKLL NYRTPTGTRG DAGDFATIAY FVLKPRCLQK GSLTIQQVND 150
ILDSIASNNS ARKKDLIKKS LLQLITQSSA LEQKWLIRMI VKDLKLGFSE 200
QSVFSAFHND AAELHNVTTD LEKVCRQLHD PSIGLSDISI TLFSAFKPML 250
AAIADIERIE KDMKHQSFYI ETKLDGERMQ MHKDGDVYQY FSRNGYNYTD 300
QFGDSPREGS LTPFIHSAFK TDVQICILDG EMMAFNPNTQ TFMQKGNKFD 350
IKRMVEDSDL QTCYCVFDVL MVNNKKLGRE TLKKRYEILT SVFTPIPGRI 400
EIVQKTQAHT KKEVIDALNE AIDKREEGIM IKHPLSIYKP DKRGEGWLKI 450
KPEYVDGLMD ELDILIVGGY WGKGSRGGMM SHFLCAVAEK PPPGEKPSVF 500
HTLCRVGSGY TMKELYDLGL KLAKHWKPFH KKALPSSILC GTEKPEVYIE 550
PCNSVIVQVK ATEIVSSDMY KTGCTLRFPR IEKIREDKEW HECTTVDDLE 600
QLRGKASGKL ASKHLDIGGD DEPQEKKRKA APKIKKIIGI IEHLKAPNLS 650
NINKVSNIFE DVEFCVMSGT DSHPKPDLEN RIAEFGGYIV QNPGPDTYCV 700
IAGSENIRVK NIISSNKHDV VKPEWLLECF KTKSCVPWQP RFMIHMCPST 750
KEHFAREYDC YGDSYFVDLD LNQLKEVFSG IKNSSKQTPR EMASLIADLE 800
YRYSWDRSPL CLFRHCIVYL DLYAVINDLS TKIEGTRLAI TALELRFHGA 850
KVVSCLAQGV SHVIIGEDHS RVAVLKSFRR TLKRKFKILQ QDWVTESIDK 900
CELQEENQYL V 911
Length:911
Mass (Da):104,181
Last modified:November 30, 2010 - v1
Checksum:i648D82719A4A8879
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAEX03013370 Genomic DNA. No translation available.
RefSeqiXP_005634152.1. XM_005634095.1.
XP_542663.2. XM_542663.3.

Genome annotation databases

EnsembliENSCAFT00000009725; ENSCAFP00000009027; ENSCAFG00000006031.
GeneIDi485544.
KEGGicfa:485544.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAEX03013370 Genomic DNA. No translation available.
RefSeqi XP_005634152.1. XM_005634095.1.
XP_542663.2. XM_542663.3.

3D structure databases

ProteinModelPortali E2R0G7.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSCAFT00000009725 ; ENSCAFP00000009027 ; ENSCAFG00000006031 .
GeneIDi 485544.
KEGGi cfa:485544.

Organism-specific databases

CTDi 3981.

Phylogenomic databases

GeneTreei ENSGT00750000117695.
KOi K10777.
OMAi HMCPSTK.
OrthoDBi EOG7BKCT2.
TreeFami TF312980.

Miscellaneous databases

NextBioi 20859524.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
3.40.50.10190. 2 hits.
InterProi IPR001357. BRCT_dom.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR021536. DNA_ligase_IV_dom.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF00533. BRCT. 1 hit.
PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
PF11411. DNA_ligase_IV. 1 hit.
[Graphical view ]
SMARTi SM00292. BRCT. 2 hits.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF52113. SSF52113. 2 hits.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS50172. BRCT. 2 hits.
PS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence, comparative analysis and haplotype structure of the domestic dog."
    Broad Sequencing Platform
    Lindblad-Toh K., Wade C.M., Mikkelsen T.S., Karlsson E.K., Jaffe D.B., Kamal M., Clamp M., Chang J.L., Kulbokas E.J. III, Zody M.C., Mauceli E., Xie X., Breen M., Wayne R.K., Ostrander E.A., Ponting C.P., Galibert F., Smith D.R.
    , deJong P.J., Kirkness E.F., Alvarez P., Biagi T., Brockman W., Butler J., Chin C.-W., Cook A., Cuff J., Daly M.J., DeCaprio D., Gnerre S., Grabherr M., Kellis M., Kleber M., Bardeleben C., Goodstadt L., Heger A., Hitte C., Kim L., Koepfli K.-P., Parker H.G., Pollinger J.P., Searle S.M.J., Sutter N.B., Thomas R., Webber C., Baldwin J., Abebe A., Abouelleil A., Aftuck L., Ait-Zahra M., Aldredge T., Allen N., An P., Anderson S., Antoine C., Arachchi H., Aslam A., Ayotte L., Bachantsang P., Barry A., Bayul T., Benamara M., Berlin A., Bessette D., Blitshteyn B., Bloom T., Blye J., Boguslavskiy L., Bonnet C., Boukhgalter B., Brown A., Cahill P., Calixte N., Camarata J., Cheshatsang Y., Chu J., Citroen M., Collymore A., Cooke P., Dawoe T., Daza R., Decktor K., DeGray S., Dhargay N., Dooley K., Dooley K., Dorje P., Dorjee K., Dorris L., Duffey N., Dupes A., Egbiremolen O., Elong R., Falk J., Farina A., Faro S., Ferguson D., Ferreira P., Fisher S., FitzGerald M., Foley K., Foley C., Franke A., Friedrich D., Gage D., Garber M., Gearin G., Giannoukos G., Goode T., Goyette A., Graham J., Grandbois E., Gyaltsen K., Hafez N., Hagopian D., Hagos B., Hall J., Healy C., Hegarty R., Honan T., Horn A., Houde N., Hughes L., Hunnicutt L., Husby M., Jester B., Jones C., Kamat A., Kanga B., Kells C., Khazanovich D., Kieu A.C., Kisner P., Kumar M., Lance K., Landers T., Lara M., Lee W., Leger J.-P., Lennon N., Leuper L., LeVine S., Liu J., Liu X., Lokyitsang Y., Lokyitsang T., Lui A., Macdonald J., Major J., Marabella R., Maru K., Matthews C., McDonough S., Mehta T., Meldrim J., Melnikov A., Meneus L., Mihalev A., Mihova T., Miller K., Mittelman R., Mlenga V., Mulrain L., Munson G., Navidi A., Naylor J., Nguyen T., Nguyen N., Nguyen C., Nguyen T., Nicol R., Norbu N., Norbu C., Novod N., Nyima T., Olandt P., O'Neill B., O'Neill K., Osman S., Oyono L., Patti C., Perrin D., Phunkhang P., Pierre F., Priest M., Rachupka A., Raghuraman S., Rameau R., Ray V., Raymond C., Rege F., Rise C., Rogers J., Rogov P., Sahalie J., Settipalli S., Sharpe T., Shea T., Sheehan M., Sherpa N., Shi J., Shih D., Sloan J., Smith C., Sparrow T., Stalker J., Stange-Thomann N., Stavropoulos S., Stone C., Stone S., Sykes S., Tchuinga P., Tenzing P., Tesfaye S., Thoulutsang D., Thoulutsang Y., Topham K., Topping I., Tsamla T., Vassiliev H., Venkataraman V., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J., Wilson A., Yadav S., Yang S., Yang X., Young G., Yu Q., Zainoun J., Zembek L., Zimmer A., Lander E.S.
    Nature 438:803-819(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BoxerImported.
  2. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: BoxerImported.

Entry informationi

Entry nameiE2R0G7_CANFA
AccessioniPrimary (citable) accession number: E2R0G7
Entry historyi
Integrated into UniProtKB/TrEMBL: November 30, 2010
Last sequence update: November 30, 2010
Last modified: September 3, 2014
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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