Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

E2R0G7 (E2R0G7_CANFA) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 29. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order

Protein attributes

Sequence length911 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m). RuleBase RU000617

Sequence similarities

Belongs to the ATP-dependent DNA ligase family.

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. Ensembl ENSCAFP00000009027

Ontologies

Keywords
   Biological processDNA damage
DNA recombination RuleBase RU000617
DNA repair RuleBase RU000617
DNA replication RuleBase RU000617
   LigandATP-binding RuleBase RU000617
Nucleotide-binding
   Molecular functionLigase RuleBase RU000617
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processDNA ligation involved in DNA recombination

Inferred from electronic annotation. Source: Ensembl

DNA ligation involved in DNA repair

Inferred from electronic annotation. Source: Ensembl

DNA replication

Inferred from electronic annotation. Source: UniProtKB-KW

T cell differentiation in thymus

Inferred from electronic annotation. Source: Ensembl

T cell receptor V(D)J recombination

Inferred from electronic annotation. Source: Ensembl

cell proliferation

Inferred from electronic annotation. Source: Ensembl

central nervous system development

Inferred from electronic annotation. Source: Ensembl

chromosome organization

Inferred from electronic annotation. Source: Ensembl

double-strand break repair via nonhomologous end joining

Inferred from electronic annotation. Source: Ensembl

immunoglobulin V(D)J recombination

Inferred from electronic annotation. Source: Ensembl

in utero embryonic development

Inferred from electronic annotation. Source: Ensembl

isotype switching

Inferred from electronic annotation. Source: Ensembl

negative regulation of neuron apoptotic process

Inferred from electronic annotation. Source: Ensembl

neuron apoptotic process

Inferred from electronic annotation. Source: Ensembl

nucleotide-excision repair, DNA gap filling

Inferred from electronic annotation. Source: Ensembl

positive regulation of fibroblast proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of neurogenesis

Inferred from electronic annotation. Source: Ensembl

pro-B cell differentiation

Inferred from electronic annotation. Source: Ensembl

response to X-ray

Inferred from electronic annotation. Source: Ensembl

response to gamma radiation

Inferred from electronic annotation. Source: Ensembl

single strand break repair

Inferred from electronic annotation. Source: Ensembl

somatic stem cell maintenance

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentDNA ligase IV complex

Inferred from electronic annotation. Source: Ensembl

DNA-dependent protein kinase-DNA ligase 4 complex

Inferred from electronic annotation. Source: Ensembl

condensed chromosome

Inferred from electronic annotation. Source: Ensembl

cytoplasm

Inferred from electronic annotation. Source: Ensembl

focal adhesion

Inferred from electronic annotation. Source: Ensembl

plasma membrane

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

DNA binding

Inferred from electronic annotation. Source: Ensembl

DNA ligase (ATP) activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
E2R0G7 [UniParc].

Last modified November 30, 2010. Version 1.
Checksum: 648D82719A4A8879

FASTA911104,181
        10         20         30         40         50         60 
MAATQTSQTV ASHVPFADLC STLERIQRSK GREEKIRHFR EFLDSWRRFH DALHKNQKDV 

        70         80         90        100        110        120 
RDSFYPAMRL ILPQLERERM AYGIKETMLA KLYIELLNLP KEGKDALKLL NYRTPTGTRG 

       130        140        150        160        170        180 
DAGDFATIAY FVLKPRCLQK GSLTIQQVND ILDSIASNNS ARKKDLIKKS LLQLITQSSA 

       190        200        210        220        230        240 
LEQKWLIRMI VKDLKLGFSE QSVFSAFHND AAELHNVTTD LEKVCRQLHD PSIGLSDISI 

       250        260        270        280        290        300 
TLFSAFKPML AAIADIERIE KDMKHQSFYI ETKLDGERMQ MHKDGDVYQY FSRNGYNYTD 

       310        320        330        340        350        360 
QFGDSPREGS LTPFIHSAFK TDVQICILDG EMMAFNPNTQ TFMQKGNKFD IKRMVEDSDL 

       370        380        390        400        410        420 
QTCYCVFDVL MVNNKKLGRE TLKKRYEILT SVFTPIPGRI EIVQKTQAHT KKEVIDALNE 

       430        440        450        460        470        480 
AIDKREEGIM IKHPLSIYKP DKRGEGWLKI KPEYVDGLMD ELDILIVGGY WGKGSRGGMM 

       490        500        510        520        530        540 
SHFLCAVAEK PPPGEKPSVF HTLCRVGSGY TMKELYDLGL KLAKHWKPFH KKALPSSILC 

       550        560        570        580        590        600 
GTEKPEVYIE PCNSVIVQVK ATEIVSSDMY KTGCTLRFPR IEKIREDKEW HECTTVDDLE 

       610        620        630        640        650        660 
QLRGKASGKL ASKHLDIGGD DEPQEKKRKA APKIKKIIGI IEHLKAPNLS NINKVSNIFE 

       670        680        690        700        710        720 
DVEFCVMSGT DSHPKPDLEN RIAEFGGYIV QNPGPDTYCV IAGSENIRVK NIISSNKHDV 

       730        740        750        760        770        780 
VKPEWLLECF KTKSCVPWQP RFMIHMCPST KEHFAREYDC YGDSYFVDLD LNQLKEVFSG 

       790        800        810        820        830        840 
IKNSSKQTPR EMASLIADLE YRYSWDRSPL CLFRHCIVYL DLYAVINDLS TKIEGTRLAI 

       850        860        870        880        890        900 
TALELRFHGA KVVSCLAQGV SHVIIGEDHS RVAVLKSFRR TLKRKFKILQ QDWVTESIDK 

       910 
CELQEENQYL V 

« Hide

References

« Hide 'large scale' references
[1]"Genome sequence, comparative analysis and haplotype structure of the domestic dog."
Broad Sequencing Platform
Lindblad-Toh K., Wade C.M., Mikkelsen T.S., Karlsson E.K., Jaffe D.B., Kamal M., Clamp M., Chang J.L., Kulbokas E.J. III, Zody M.C., Mauceli E., Xie X., Breen M., Wayne R.K., Ostrander E.A., Ponting C.P., Galibert F., Smith D.R. expand/collapse author list , deJong P.J., Kirkness E.F., Alvarez P., Biagi T., Brockman W., Butler J., Chin C.-W., Cook A., Cuff J., Daly M.J., DeCaprio D., Gnerre S., Grabherr M., Kellis M., Kleber M., Bardeleben C., Goodstadt L., Heger A., Hitte C., Kim L., Koepfli K.-P., Parker H.G., Pollinger J.P., Searle S.M.J., Sutter N.B., Thomas R., Webber C., Baldwin J., Abebe A., Abouelleil A., Aftuck L., Ait-Zahra M., Aldredge T., Allen N., An P., Anderson S., Antoine C., Arachchi H., Aslam A., Ayotte L., Bachantsang P., Barry A., Bayul T., Benamara M., Berlin A., Bessette D., Blitshteyn B., Bloom T., Blye J., Boguslavskiy L., Bonnet C., Boukhgalter B., Brown A., Cahill P., Calixte N., Camarata J., Cheshatsang Y., Chu J., Citroen M., Collymore A., Cooke P., Dawoe T., Daza R., Decktor K., DeGray S., Dhargay N., Dooley K., Dooley K., Dorje P., Dorjee K., Dorris L., Duffey N., Dupes A., Egbiremolen O., Elong R., Falk J., Farina A., Faro S., Ferguson D., Ferreira P., Fisher S., FitzGerald M., Foley K., Foley C., Franke A., Friedrich D., Gage D., Garber M., Gearin G., Giannoukos G., Goode T., Goyette A., Graham J., Grandbois E., Gyaltsen K., Hafez N., Hagopian D., Hagos B., Hall J., Healy C., Hegarty R., Honan T., Horn A., Houde N., Hughes L., Hunnicutt L., Husby M., Jester B., Jones C., Kamat A., Kanga B., Kells C., Khazanovich D., Kieu A.C., Kisner P., Kumar M., Lance K., Landers T., Lara M., Lee W., Leger J.-P., Lennon N., Leuper L., LeVine S., Liu J., Liu X., Lokyitsang Y., Lokyitsang T., Lui A., Macdonald J., Major J., Marabella R., Maru K., Matthews C., McDonough S., Mehta T., Meldrim J., Melnikov A., Meneus L., Mihalev A., Mihova T., Miller K., Mittelman R., Mlenga V., Mulrain L., Munson G., Navidi A., Naylor J., Nguyen T., Nguyen N., Nguyen C., Nguyen T., Nicol R., Norbu N., Norbu C., Novod N., Nyima T., Olandt P., O'Neill B., O'Neill K., Osman S., Oyono L., Patti C., Perrin D., Phunkhang P., Pierre F., Priest M., Rachupka A., Raghuraman S., Rameau R., Ray V., Raymond C., Rege F., Rise C., Rogers J., Rogov P., Sahalie J., Settipalli S., Sharpe T., Shea T., Sheehan M., Sherpa N., Shi J., Shih D., Sloan J., Smith C., Sparrow T., Stalker J., Stange-Thomann N., Stavropoulos S., Stone C., Stone S., Sykes S., Tchuinga P., Tenzing P., Tesfaye S., Thoulutsang D., Thoulutsang Y., Topham K., Topping I., Tsamla T., Vassiliev H., Venkataraman V., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J., Wilson A., Yadav S., Yang S., Yang X., Young G., Yu Q., Zainoun J., Zembek L., Zimmer A., Lander E.S.
Nature 438:803-819(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Boxer Ensembl ENSCAFP00000009027.
[2]Ensembl
Submitted (JUL-2011) to UniProtKB
Cited for: IDENTIFICATION.
Strain: Boxer Ensembl ENSCAFP00000009027.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AAEX03013370 Genomic DNA. No translation available.
RefSeqXP_005634152.1. XM_005634095.1.
XP_542663.2. XM_542663.3.

3D structure databases

ProteinModelPortalE2R0G7.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSCAFT00000009725; ENSCAFP00000009027; ENSCAFG00000006031.
GeneID485544.
KEGGcfa:485544.

Organism-specific databases

CTD3981.

Phylogenomic databases

GeneTreeENSGT00750000117695.
KOK10777.
OMAHMCPSTK.
OrthoDBEOG7BKCT2.
TreeFamTF312980.

Family and domain databases

Gene3D1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
3.40.50.10190. 2 hits.
InterProIPR001357. BRCT_dom.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR021536. DNA_ligase_IV.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamPF00533. BRCT. 1 hit.
PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
PF11411. DNA_ligase_IV. 1 hit.
[Graphical view]
SMARTSM00292. BRCT. 2 hits.
[Graphical view]
SUPFAMSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF52113. SSF52113. 2 hits.
TIGRFAMsTIGR00574. dnl1. 1 hit.
PROSITEPS50172. BRCT. 2 hits.
PS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20859524.

Entry information

Entry nameE2R0G7_CANFA
AccessionPrimary (citable) accession number: E2R0G7
Entry history
Integrated into UniProtKB/TrEMBL: November 30, 2010
Last sequence update: November 30, 2010
Last modified: April 16, 2014
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)