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E2R0G7

- E2R0G7_CANFA

UniProt

E2R0G7 - E2R0G7_CANFA

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Protein

DNA ligase

Gene

LIG4

Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Unreviewed - Annotation score: 5 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. DNA binding Source: Ensembl
  3. DNA ligase (ATP) activity Source: UniProtKB-EC

GO - Biological processi

  1. cell proliferation Source: Ensembl
  2. central nervous system development Source: Ensembl
  3. chromosome organization Source: Ensembl
  4. DNA biosynthetic process Source: InterPro
  5. DNA ligation involved in DNA recombination Source: Ensembl
  6. DNA ligation involved in DNA repair Source: Ensembl
  7. DNA replication Source: UniProtKB-KW
  8. double-strand break repair via nonhomologous end joining Source: Ensembl
  9. immunoglobulin V(D)J recombination Source: Ensembl
  10. in utero embryonic development Source: Ensembl
  11. isotype switching Source: Ensembl
  12. negative regulation of neuron apoptotic process Source: Ensembl
  13. neuron apoptotic process Source: Ensembl
  14. nucleotide-excision repair, DNA gap filling Source: Ensembl
  15. positive regulation of fibroblast proliferation Source: Ensembl
  16. positive regulation of neurogenesis Source: Ensembl
  17. pro-B cell differentiation Source: Ensembl
  18. response to gamma radiation Source: Ensembl
  19. response to X-ray Source: Ensembl
  20. single strand break repair Source: Ensembl
  21. somatic stem cell maintenance Source: Ensembl
  22. T cell differentiation in thymus Source: Ensembl
  23. T cell receptor V(D)J recombination Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotation

Keywords - Biological processi

DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Gene namesi
Name:LIG4Imported
OrganismiCanis familiaris (Dog) (Canis lupus familiaris)Imported
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
ProteomesiUP000002254: Chromosome 22

Subcellular locationi

GO - Cellular componenti

  1. condensed chromosome Source: Ensembl
  2. cytoplasm Source: Ensembl
  3. DNA-dependent protein kinase-DNA ligase 4 complex Source: Ensembl
  4. DNA ligase IV complex Source: Ensembl
  5. focal adhesion Source: Ensembl
  6. plasma membrane Source: Ensembl
Complete GO annotation...

Structurei

3D structure databases

ProteinModelPortaliE2R0G7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00750000117695.
InParanoidiE2R0G7.
KOiK10777.
OMAiHMCPSTK.
OrthoDBiEOG7BKCT2.
TreeFamiTF312980.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
3.40.50.10190. 2 hits.
InterProiIPR001357. BRCT_dom.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR021536. DNA_ligase_IV_dom.
IPR029710. LIG4.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PANTHERiPTHR10459:SF7. PTHR10459:SF7. 1 hit.
PfamiPF00533. BRCT. 1 hit.
PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
PF11411. DNA_ligase_IV. 1 hit.
[Graphical view]
SMARTiSM00292. BRCT. 2 hits.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF52113. SSF52113. 2 hits.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS50172. BRCT. 2 hits.
PS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E2R0G7 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAATQTSQTV ASHVPFADLC STLERIQRSK GREEKIRHFR EFLDSWRRFH
60 70 80 90 100
DALHKNQKDV RDSFYPAMRL ILPQLERERM AYGIKETMLA KLYIELLNLP
110 120 130 140 150
KEGKDALKLL NYRTPTGTRG DAGDFATIAY FVLKPRCLQK GSLTIQQVND
160 170 180 190 200
ILDSIASNNS ARKKDLIKKS LLQLITQSSA LEQKWLIRMI VKDLKLGFSE
210 220 230 240 250
QSVFSAFHND AAELHNVTTD LEKVCRQLHD PSIGLSDISI TLFSAFKPML
260 270 280 290 300
AAIADIERIE KDMKHQSFYI ETKLDGERMQ MHKDGDVYQY FSRNGYNYTD
310 320 330 340 350
QFGDSPREGS LTPFIHSAFK TDVQICILDG EMMAFNPNTQ TFMQKGNKFD
360 370 380 390 400
IKRMVEDSDL QTCYCVFDVL MVNNKKLGRE TLKKRYEILT SVFTPIPGRI
410 420 430 440 450
EIVQKTQAHT KKEVIDALNE AIDKREEGIM IKHPLSIYKP DKRGEGWLKI
460 470 480 490 500
KPEYVDGLMD ELDILIVGGY WGKGSRGGMM SHFLCAVAEK PPPGEKPSVF
510 520 530 540 550
HTLCRVGSGY TMKELYDLGL KLAKHWKPFH KKALPSSILC GTEKPEVYIE
560 570 580 590 600
PCNSVIVQVK ATEIVSSDMY KTGCTLRFPR IEKIREDKEW HECTTVDDLE
610 620 630 640 650
QLRGKASGKL ASKHLDIGGD DEPQEKKRKA APKIKKIIGI IEHLKAPNLS
660 670 680 690 700
NINKVSNIFE DVEFCVMSGT DSHPKPDLEN RIAEFGGYIV QNPGPDTYCV
710 720 730 740 750
IAGSENIRVK NIISSNKHDV VKPEWLLECF KTKSCVPWQP RFMIHMCPST
760 770 780 790 800
KEHFAREYDC YGDSYFVDLD LNQLKEVFSG IKNSSKQTPR EMASLIADLE
810 820 830 840 850
YRYSWDRSPL CLFRHCIVYL DLYAVINDLS TKIEGTRLAI TALELRFHGA
860 870 880 890 900
KVVSCLAQGV SHVIIGEDHS RVAVLKSFRR TLKRKFKILQ QDWVTESIDK
910
CELQEENQYL V
Length:911
Mass (Da):104,181
Last modified:November 30, 2010 - v1
Checksum:i648D82719A4A8879
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAEX03013370 Genomic DNA. No translation available.
RefSeqiXP_005634152.1. XM_005634095.1.
XP_542663.2. XM_542663.3.

Genome annotation databases

EnsembliENSCAFT00000009725; ENSCAFP00000009027; ENSCAFG00000006031.
GeneIDi485544.
KEGGicfa:485544.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAEX03013370 Genomic DNA. No translation available.
RefSeqi XP_005634152.1. XM_005634095.1.
XP_542663.2. XM_542663.3.

3D structure databases

ProteinModelPortali E2R0G7.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSCAFT00000009725 ; ENSCAFP00000009027 ; ENSCAFG00000006031 .
GeneIDi 485544.
KEGGi cfa:485544.

Organism-specific databases

CTDi 3981.

Phylogenomic databases

GeneTreei ENSGT00750000117695.
InParanoidi E2R0G7.
KOi K10777.
OMAi HMCPSTK.
OrthoDBi EOG7BKCT2.
TreeFami TF312980.

Miscellaneous databases

NextBioi 20859524.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
3.40.50.10190. 2 hits.
InterProi IPR001357. BRCT_dom.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR021536. DNA_ligase_IV_dom.
IPR029710. LIG4.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
PANTHERi PTHR10459:SF7. PTHR10459:SF7. 1 hit.
Pfami PF00533. BRCT. 1 hit.
PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
PF11411. DNA_ligase_IV. 1 hit.
[Graphical view ]
SMARTi SM00292. BRCT. 2 hits.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF52113. SSF52113. 2 hits.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS50172. BRCT. 2 hits.
PS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence, comparative analysis and haplotype structure of the domestic dog."
    Broad Sequencing Platform
    Lindblad-Toh K., Wade C.M., Mikkelsen T.S., Karlsson E.K., Jaffe D.B., Kamal M., Clamp M., Chang J.L., Kulbokas E.J. III, Zody M.C., Mauceli E., Xie X., Breen M., Wayne R.K., Ostrander E.A., Ponting C.P., Galibert F., Smith D.R.
    , deJong P.J., Kirkness E.F., Alvarez P., Biagi T., Brockman W., Butler J., Chin C.-W., Cook A., Cuff J., Daly M.J., DeCaprio D., Gnerre S., Grabherr M., Kellis M., Kleber M., Bardeleben C., Goodstadt L., Heger A., Hitte C., Kim L., Koepfli K.-P., Parker H.G., Pollinger J.P., Searle S.M.J., Sutter N.B., Thomas R., Webber C., Baldwin J., Abebe A., Abouelleil A., Aftuck L., Ait-Zahra M., Aldredge T., Allen N., An P., Anderson S., Antoine C., Arachchi H., Aslam A., Ayotte L., Bachantsang P., Barry A., Bayul T., Benamara M., Berlin A., Bessette D., Blitshteyn B., Bloom T., Blye J., Boguslavskiy L., Bonnet C., Boukhgalter B., Brown A., Cahill P., Calixte N., Camarata J., Cheshatsang Y., Chu J., Citroen M., Collymore A., Cooke P., Dawoe T., Daza R., Decktor K., DeGray S., Dhargay N., Dooley K., Dooley K., Dorje P., Dorjee K., Dorris L., Duffey N., Dupes A., Egbiremolen O., Elong R., Falk J., Farina A., Faro S., Ferguson D., Ferreira P., Fisher S., FitzGerald M., Foley K., Foley C., Franke A., Friedrich D., Gage D., Garber M., Gearin G., Giannoukos G., Goode T., Goyette A., Graham J., Grandbois E., Gyaltsen K., Hafez N., Hagopian D., Hagos B., Hall J., Healy C., Hegarty R., Honan T., Horn A., Houde N., Hughes L., Hunnicutt L., Husby M., Jester B., Jones C., Kamat A., Kanga B., Kells C., Khazanovich D., Kieu A.C., Kisner P., Kumar M., Lance K., Landers T., Lara M., Lee W., Leger J.-P., Lennon N., Leuper L., LeVine S., Liu J., Liu X., Lokyitsang Y., Lokyitsang T., Lui A., Macdonald J., Major J., Marabella R., Maru K., Matthews C., McDonough S., Mehta T., Meldrim J., Melnikov A., Meneus L., Mihalev A., Mihova T., Miller K., Mittelman R., Mlenga V., Mulrain L., Munson G., Navidi A., Naylor J., Nguyen T., Nguyen N., Nguyen C., Nguyen T., Nicol R., Norbu N., Norbu C., Novod N., Nyima T., Olandt P., O'Neill B., O'Neill K., Osman S., Oyono L., Patti C., Perrin D., Phunkhang P., Pierre F., Priest M., Rachupka A., Raghuraman S., Rameau R., Ray V., Raymond C., Rege F., Rise C., Rogers J., Rogov P., Sahalie J., Settipalli S., Sharpe T., Shea T., Sheehan M., Sherpa N., Shi J., Shih D., Sloan J., Smith C., Sparrow T., Stalker J., Stange-Thomann N., Stavropoulos S., Stone C., Stone S., Sykes S., Tchuinga P., Tenzing P., Tesfaye S., Thoulutsang D., Thoulutsang Y., Topham K., Topping I., Tsamla T., Vassiliev H., Venkataraman V., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J., Wilson A., Yadav S., Yang S., Yang X., Young G., Yu Q., Zainoun J., Zembek L., Zimmer A., Lander E.S.
    Nature 438:803-819(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BoxerImported.
  2. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: BoxerImported.

Entry informationi

Entry nameiE2R0G7_CANFA
AccessioniPrimary (citable) accession number: E2R0G7
Entry historyi
Integrated into UniProtKB/TrEMBL: November 30, 2010
Last sequence update: November 30, 2010
Last modified: October 29, 2014
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3