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Protein
Submitted name:

Neurolysin

Gene

NLN

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, MetalloproteaseUniRule annotationSAAS annotation, Protease
LigandMetal-bindingUniRule annotationSAAS annotation, ZincUniRule annotationSAAS annotation

Enzyme and pathway databases

ReactomeiR-CFA-375276. Peptide ligand-binding receptors.

Names & Taxonomyi

Protein namesi
Submitted name:
NeurolysinImported
Gene namesi
Name:NLNImported
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)Imported
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Chromosome 2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

PaxDbiE2QXQ8.

Expressioni

Gene expression databases

BgeeiENSCAFG00000007515.

Interactioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000011157.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini406 – 855Peptidase_M3InterPro annotationAdd BLAST450

Sequence similaritiesi

Belongs to the peptidase M3 family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG2089. Eukaryota.
COG0339. LUCA.
GeneTreeiENSGT00550000074738.
InParanoidiE2QXQ8.
OMAiLRHKFAR.
OrthoDBiEOG091G0325.
TreeFamiTF300459.

Family and domain databases

Gene3Di1.20.1050.40. 1 hit.
InterProiView protein in InterPro
IPR024080. Neurolysin/TOP_N.
IPR001567. Pept_M3A_M3B.
PfamiView protein in Pfam
PF01432. Peptidase_M3. 1 hit.

Sequencei

Sequence statusi: Complete.

E2QXQ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGRGRGGADE GASVGLPHVR GRRSDRRRRR LPRGAAGSRL PGTPPPLPAP
60 70 80 90 100
EDDAPPPLTP PAARSARDPG LSRELAPGRC QARGAGPEWA GRCAEVGGAR
110 120 130 140 150
GGAEVGAGVG LPHVGGRGPG RRRLPPGAAS RLPGAPPPAS PPPASPPPPP
160 170 180 190 200
PPLGRPMIAR CLPAVRGLHR VGGSKILFMT LGREVRSPLQ AMSSYTVAGR
210 220 230 240 250
NVLRWDLSPE QIKTRTEELI VQTKQVYDAI GMLDIEEVTY ENCLQALADV
260 270 280 290 300
EVKYIVERTM LDFPQHVSSD KEVRAASTEA DKRLSRFDIE MSMREDIFLR
310 320 330 340 350
IVHLQETSDL SKIKPEARRY LEKSIKMGKR NGLHLPEQVQ NEIKAMKKRV
360 370 380 390 400
SELCIDFNKN LNEDDTFLVF SKAELGALPD DFIDSLEKTD DDKYKITLKY
410 420 430 440 450
PHYFPVMKKC CIPETRRKME MAFNTRCKEE NTVILQQLLP LRARVAKLLG
460 470 480 490 500
YSTHADFVLE MNTAKSTSHV TAFLDDLSQK LKPLGEAERE FILNLKKKEC
510 520 530 540 550
EERGFEYDGK INAWDLHYYM TQTEELKYSI DQESLKEYFP IEVVTEGLLN
560 570 580 590 600
IYQELLGLSF EQVADAHVWH KSVTLYTVKD KATGEVLGQF YLDLYPREGK
610 620 630 640 650
YNHAACFGLQ PGCLLPDGSR MMSVAALVVN FSQPTAARPS LLRHDEVRTY
660 670 680 690 700
FHEFGHVMHQ ICAQTDFARF SGTNVETDFV EVPSQMLENW VWDMDSLRRL
710 720 730 740 750
SKHYKDGSPI MDDLLEKLVD SRLVNTGLLT LRQIVLSKVD QSLHTNASLD
760 770 780 790 800
AASEYAKYCT EVLGVAATPG TNMPATFGHL AGGYDGQYYG YLWSEVFSMD
810 820 830 840 850
MFYSCFKKKG IMNPEVGMKY RNLILKPGGS LDGMDMLQNF LKREPNQKAF

LMSRGLHAP
Length:859
Mass (Da):96,059
Last modified:October 31, 2012 - v2
Checksum:i6535E666CB77ED6D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAEX03001473 Genomic DNA. No translation available.
AAEX03001474 Genomic DNA. No translation available.
AAEX03001475 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSCAFT00000012032; ENSCAFP00000011157; ENSCAFG00000007515.

Similar proteinsi

Entry informationi

Entry nameiE2QXQ8_CANLF
AccessioniPrimary (citable) accession number: E2QXQ8
Entry historyiIntegrated into UniProtKB/TrEMBL: November 30, 2010
Last sequence update: October 31, 2012
Last modified: August 30, 2017
This is version 45 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported