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Protein

Thymidine kinase

Gene

TK1

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseUniRule annotation, Transferase
Biological processDNA synthesisUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-CFA-73614. Pyrimidine salvage.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:TK1Imported
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)Imported
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Chromosome 9

Organism-specific databases

VGNCiVGNC:47389. TK1.

PTM / Processingi

Proteomic databases

PaxDbiE2QXP4.

Expressioni

Gene expression databases

BgeeiENSCAFG00000005294.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000007911.

Structurei

3D structure databases

ProteinModelPortaliE2QXP4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG3125. Eukaryota.
COG1435. LUCA.
GeneTreeiENSGT00390000011309.
InParanoidiE2QXP4.
KOiK00857.
OMAiCAGLDQD.
OrthoDBiEOG091G0HZR.
TreeFamiTF314839.

Family and domain databases

InterProiView protein in InterPro
IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiView protein in Pfam
PF00265. TK. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiView protein in PROSITE
PS00603. TK_CELLULAR_TYPE. 1 hit.

Sequencei

Sequence statusi: Complete.

E2QXP4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSCINLPTVL PGSPSKTRGQ IQVILGPMFS GKSTELMRRV RRFQIAQYKC
60 70 80 90 100
LVIKYAKDTR YSNSFSTHDR NTMEALPACL LRDVAQEALG VAVIGIDEGQ
110 120 130 140 150
FFPDIVEFSE TMANAGKTVI VAALDGTFQR KAFGTILNLV PLAESVVKLT
160 170 180 190 200
AVCMECFREA AYTKRLGSEK EVEVIGGADK YHSVCRLCYF KKASGPPMGL
210 220 230 240
DSRENKENVL VLVPGKPGEG KEATGVRKLF APQHVLQCSP AN
Length:242
Mass (Da):26,451
Last modified:November 30, 2010 - v1
Checksum:i8E32F5DCD095EC40
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAEX03006245 Genomic DNA. No translation available.
RefSeqiXP_003639284.1. XM_003639236.2.

Genome annotation databases

EnsembliENSCAFT00000008537; ENSCAFP00000007911; ENSCAFG00000005294.
GeneIDi100855947.
KEGGicfa:100855947.

Entry informationi

Entry nameiE2QXP4_CANLF
AccessioniPrimary (citable) accession number: E2QXP4
Entry historyiIntegrated into UniProtKB/TrEMBL: November 30, 2010
Last sequence update: November 30, 2010
Last modified: March 28, 2018
This is version 49 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported