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Protein
Submitted name:

Thioredoxin reductase 1, cytoplasmic

Gene

TXNRD1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Ligandi

FADUniRule annotation, Flavoprotein

Names & Taxonomyi

Protein namesi
Submitted name:
Thioredoxin reductase 1, cytoplasmicImported
Gene namesi
Name:TXNRD1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:12437. TXNRD1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000198431.

PTM / Processingi

Proteomic databases

PaxDbiE2QRB9.
PeptideAtlasiE2QRB9.
PRIDEiE2QRB9.

Expressioni

Gene expression databases

BgeeiENSG00000198431.
ExpressionAtlasiE2QRB9. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000434516.

Structurei

3D structure databases

ProteinModelPortaliE2QRB9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini17 – 312FAD/NAD-binding_domInterPro annotationAdd BLAST296
Domaini332 – 443Pyr_redox_dimInterPro annotationAdd BLAST112

Sequence similaritiesi

Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.UniRule annotation

Keywords - Domaini

Redox-active centerUniRule annotation

Phylogenomic databases

eggNOGiKOG1752. Eukaryota.
KOG4716. Eukaryota.
COG1249. LUCA.
GeneTreeiENSGT00390000007578.

Family and domain databases

Gene3Di3.30.390.30. 1 hit.
3.50.50.60. 2 hits.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR016156. FAD/NAD-linked_Rdtase_dimer.
IPR004099. Pyr_nucl-diS_OxRdtase_dimer.
IPR012999. Pyr_OxRdtase_I_AS.
IPR006338. Thioredoxin/glutathione_Rdtase.
[Graphical view]
PfamiPF07992. Pyr_redox_2. 1 hit.
PF02852. Pyr_redox_dim. 1 hit.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 1 hit.
SSF55424. SSF55424. 1 hit.
TIGRFAMsiTIGR01438. TGR. 1 hit.
PROSITEiPS00076. PYRIDINE_REDOX_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E2QRB9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLDFVTPTP LGTRWGLGGT CVNVGCIPKK LMHQAALLGQ ALQDSRNYGW
60 70 80 90 100
KVEETVKHDW DRMIEAVQNH IGSLNWGYRV ALREKKVVYE NAYGQFIGPH
110 120 130 140 150
RIKATNNKGK EKIYSAERFL IATGERPRYL GIPGDKEYCI SSDDLFSLPY
160 170 180 190 200
CPGKTLVVGA SYVALECAGF LAGIGLDVTV MVRSILLRGF DQDMANKIGE
210 220 230 240 250
HMEEHGIKFI RQFVPIKVEQ IEAGTPGRLR VVAQSTNSEE IIEGEYNTVM
260 270 280 290 300
LAIGRDACTR KIGLETVGVK INEKTGKIPV TDEEQTNVPY IYAIGDILED
310 320 330 340 350
KVELTPVAIQ AGRLLAQRLY AGSTVKCDYE NVPTTVFTPL EYGACGLSEE
360 370 380 390 400
KAVEKFGEEN IEVYHSYFWP LEWTIPSRDN NKCYAKIICN TKDNERVVGF
410 420 430 440 450
HVLGPNAGEV TQGFAAALKC GLTKKQLDST IGIHPVCAEV FTTLSVTKRS
460
GASILQAGCG
Length:460
Mass (Da):50,723
Last modified:October 29, 2014 - v2
Checksum:iBBC620A6BD82EA42
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC089983 Genomic DNA. No translation available.
AC090107 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000397736; ENSP00000380844; ENSG00000198431.
UCSCiuc058soa.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC089983 Genomic DNA. No translation available.
AC090107 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortaliE2QRB9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000434516.

Proteomic databases

PaxDbiE2QRB9.
PeptideAtlasiE2QRB9.
PRIDEiE2QRB9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000397736; ENSP00000380844; ENSG00000198431.
UCSCiuc058soa.1. human.

Organism-specific databases

HGNCiHGNC:12437. TXNRD1.
OpenTargetsiENSG00000198431.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1752. Eukaryota.
KOG4716. Eukaryota.
COG1249. LUCA.
GeneTreeiENSGT00390000007578.

Miscellaneous databases

ChiTaRSiTXNRD1. human.

Gene expression databases

BgeeiENSG00000198431.
ExpressionAtlasiE2QRB9. baseline and differential.

Family and domain databases

Gene3Di3.30.390.30. 1 hit.
3.50.50.60. 2 hits.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR016156. FAD/NAD-linked_Rdtase_dimer.
IPR004099. Pyr_nucl-diS_OxRdtase_dimer.
IPR012999. Pyr_OxRdtase_I_AS.
IPR006338. Thioredoxin/glutathione_Rdtase.
[Graphical view]
PfamiPF07992. Pyr_redox_2. 1 hit.
PF02852. Pyr_redox_dim. 1 hit.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 1 hit.
SSF55424. SSF55424. 1 hit.
TIGRFAMsiTIGR01438. TGR. 1 hit.
PROSITEiPS00076. PYRIDINE_REDOX_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiE2QRB9_HUMAN
AccessioniPrimary (citable) accession number: E2QRB9
Entry historyi
Integrated into UniProtKB/TrEMBL: November 30, 2010
Last sequence update: October 29, 2014
Last modified: November 2, 2016
This is version 49 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.