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Protein
Submitted name:

Thioredoxin reductase 1, cytoplasmic

Gene

TXNRD1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
LigandFADUniRule annotation, Flavoprotein

Names & Taxonomyi

Protein namesi
Submitted name:
Thioredoxin reductase 1, cytoplasmicImported
Gene namesi
Name:TXNRD1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000198431.15
HGNCiHGNC:12437 TXNRD1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000198431

PTM / Processingi

Proteomic databases

EPDiE2QRB9
PeptideAtlasiE2QRB9
PRIDEiE2QRB9

Expressioni

Gene expression databases

BgeeiENSG00000198431
ExpressionAtlasiE2QRB9 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliE2QRB9
SMRiE2QRB9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini17 – 312FAD/NAD-binding_domInterPro annotationAdd BLAST296
Domaini332 – 443Pyr_redox_dimInterPro annotationAdd BLAST112

Sequence similaritiesi

Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.UniRule annotation

Keywords - Domaini

Redox-active centerUniRule annotation

Phylogenomic databases

eggNOGiKOG1752 Eukaryota
KOG4716 Eukaryota
COG1249 LUCA
GeneTreeiENSGT00390000007578

Family and domain databases

Gene3Di3.30.390.30, 1 hit
3.50.50.60, 3 hits
InterProiView protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR023753 FAD/NAD-binding_dom
IPR016156 FAD/NAD-linked_Rdtase_dimer_sf
IPR001100 Pyr_nuc-diS_OxRdtase
IPR004099 Pyr_nucl-diS_OxRdtase_dimer
IPR012999 Pyr_OxRdtase_I_AS
IPR006338 Thioredoxin/glutathione_Rdtase
PfamiView protein in Pfam
PF07992 Pyr_redox_2, 1 hit
PF02852 Pyr_redox_dim, 1 hit
PIRSFiPIRSF000350 Mercury_reductase_MerA, 1 hit
SUPFAMiSSF51905 SSF51905, 1 hit
SSF55424 SSF55424, 1 hit
TIGRFAMsiTIGR01438 TGR, 1 hit
PROSITEiView protein in PROSITE
PS00076 PYRIDINE_REDOX_1, 1 hit

Sequencei

Sequence statusi: Complete.

E2QRB9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLDFVTPTP LGTRWGLGGT CVNVGCIPKK LMHQAALLGQ ALQDSRNYGW
60 70 80 90 100
KVEETVKHDW DRMIEAVQNH IGSLNWGYRV ALREKKVVYE NAYGQFIGPH
110 120 130 140 150
RIKATNNKGK EKIYSAERFL IATGERPRYL GIPGDKEYCI SSDDLFSLPY
160 170 180 190 200
CPGKTLVVGA SYVALECAGF LAGIGLDVTV MVRSILLRGF DQDMANKIGE
210 220 230 240 250
HMEEHGIKFI RQFVPIKVEQ IEAGTPGRLR VVAQSTNSEE IIEGEYNTVM
260 270 280 290 300
LAIGRDACTR KIGLETVGVK INEKTGKIPV TDEEQTNVPY IYAIGDILED
310 320 330 340 350
KVELTPVAIQ AGRLLAQRLY AGSTVKCDYE NVPTTVFTPL EYGACGLSEE
360 370 380 390 400
KAVEKFGEEN IEVYHSYFWP LEWTIPSRDN NKCYAKIICN TKDNERVVGF
410 420 430 440 450
HVLGPNAGEV TQGFAAALKC GLTKKQLDST IGIHPVCAEV FTTLSVTKRS
460
GASILQAGCG
Length:460
Mass (Da):50,723
Last modified:October 29, 2014 - v2
Checksum:iBBC620A6BD82EA42
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC089983 Genomic DNA No translation available.
AC090107 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000397736; ENSP00000380844; ENSG00000198431
UCSCiuc058soa.1 human

Similar proteinsi

Entry informationi

Entry nameiE2QRB9_HUMAN
AccessioniPrimary (citable) accession number: E2QRB9
Entry historyiIntegrated into UniProtKB/TrEMBL: November 30, 2010
Last sequence update: October 29, 2014
Last modified: March 28, 2018
This is version 59 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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