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E2QIY7

- E2QIY7_ECOLX

UniProt

E2QIY7 - E2QIY7_ECOLX

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Protein

Phosphoenolpyruvate carboxylase

Gene

ppc

Organism
Escherichia coli
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.UniRule annotation

Catalytic activityi

Phosphate + oxaloacetate = H2O + phosphoenolpyruvate + HCO3-.UniRule annotation

Cofactori

Magnesium.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei138 – 1381UniRule annotation
Active sitei546 – 5461UniRule annotation

GO - Molecular functioni

  1. magnesium ion binding Source: UniProtKB-HAMAP
  2. phosphoenolpyruvate carboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbon fixation Source: UniProtKB-HAMAP
  2. oxaloacetate metabolic process Source: UniProtKB-HAMAP
  3. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotationImported

Keywords - Biological processi

Carbon dioxide fixationUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, PyruvateImported

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxylaseUniRule annotation (EC:4.1.1.31UniRule annotation)
Short name:
PEPCUniRule annotation
Short name:
PEPCaseUniRule annotation
Gene namesi
Name:ppcUniRule annotationImported
ORF Names:BC97_0205620Imported, BC99_0307475Imported, BN17_39251Imported, BU34_18140Imported, BU65_04945Imported, BU66_07000Imported, BU67_03315Imported, BU69_09450Imported, BU70_24520Imported, CF57_29160Imported, CF61_29855Imported, DA88_29135Imported, DC22_24145Imported, DO98_06020Imported, EH61_21055Imported, EH62_00800Imported, EH64_07840Imported, EH65_20460Imported, EH66_22180Imported, EP08_05610Imported, GR02_13690Imported, GR03_21735Imported, JD73_06060Imported, LF82_1696Imported
OrganismiEscherichia coliImported
Taxonomic identifieri562 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000010085: Chromosome

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the PEPCase type 1 family.UniRule annotation

Phylogenomic databases

KOiK01595.
OMAiELSTISC.

Family and domain databases

HAMAPiMF_00595. PEPcase_type1.
InterProiIPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF00311. PEPcase. 1 hit.
[Graphical view]
PRINTSiPR00150. PEPCARBXLASE.
SUPFAMiSSF51621. SSF51621. 1 hit.
PROSITEiPS00781. PEPCASE_1. 1 hit.
PS00393. PEPCASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E2QIY7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNEQYSALRS NVSMLGKVLG ETIKDALGEH ILERVETIRK LSKSSRAGND
60 70 80 90 100
ANRQELLTTL QNLSNDELLP VARAFSQFLN LANTAEQYHS ISPKGEAASN
110 120 130 140 150
PEVIARTLRK LKNQPELSED TIKKAVESLS LELVLTAHPT EITRRTLIHK
160 170 180 190 200
MVEVNACLKQ LDNKDIADYE HNQLMRRLRQ LIAQSWHTDE IRKLRPSPVD
210 220 230 240 250
EAKWGFAVVE NSLWQGVPNY LRELNEQLEE NLGYKLPVEF VPVRFTSWMG
260 270 280 290 300
GDRDGNPNVT ADITRHVLLL SRWKATDLFL KDIQVLVSEL SMVEATPELL
310 320 330 340 350
ALVGEEGAAE PYRYLMKNLR SRLMATQAWL EARLKGEELP KPEGLLTQNE
360 370 380 390 400
ELWEPLYACY QSLQACGMGI IANGDLLDTL RRVKCFGVPL VRIDIRQEST
410 420 430 440 450
RHTEALGELT RYLGIGDYES WSEADKQAFL IRELNSKRPL LPRNWQPSAE
460 470 480 490 500
TREVLDTCQV IAEAPQGSIA AYVISMAKTP SDVLAVHLLL KEAGIGFAMP
510 520 530 540 550
VAPLFETLDD LNNANDVMTQ LLNIDWYRGL IQGKQMVMIG YSDSAKDAGV
560 570 580 590 600
MAASWAQYQA QDALIKTCEK AGIELTLFHG RGGSIGRGGA PAHAALLSQP
610 620 630 640 650
PGSLKGGLRV TEQGEMIRFK YGLPEITVSS LSLYTGAILE ANLLPPPEPK
660 670 680 690 700
ESWRRIMDEL SVISCDLYRG YVRENKDFVP YFRSATPEQE LGKLPLGSRP
710 720 730 740 750
AKRRPTGGVE SLRAIPWIFA WTQNRLMLPA WLGAGTALQK VVEDGKQSEL
760 770 780 790 800
EAMCRDWPFF STRLGMLEMV FAKADLWLAE YYDQRLVDKA LWPLGKELRN
810 820 830 840 850
LQEEDIKVVL AIANDSHLMA DLPWIAESIQ LRNIYTDPLN VLQAELLHRS
860 870 880
RQAEKEGQEP DPRVEQALMV TIAGIAAGMR NTG
Length:883
Mass (Da):99,077
Last modified:November 30, 2010 - v1
Checksum:iC66E18268EB19EFD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP007265 Genomic DNA. Translation: AHM30566.1.
CP007390 Genomic DNA. Translation: AHM36674.1.
CP007391 Genomic DNA. Translation: AHM41273.1.
CU651637 Genomic DNA. Translation: CAP78417.1.
HE964769 Genomic DNA. Translation: CCJ46600.1.
JFFO01000091 Genomic DNA. Translation: EYB38381.1.
JFFN01000049 Genomic DNA. Translation: EYB46321.1.
JFFJ01000012 Genomic DNA. Translation: EYB54837.1.
JFFK01000028 Genomic DNA. Translation: EYB57972.1.
JFFL01000127 Genomic DNA. Translation: EYB59945.1.
JHEW01000078 Genomic DNA. Translation: KDM69695.1.
JHEX01000050 Genomic DNA. Translation: KDM85044.1.
JJNT01000041 Genomic DNA. Translation: KDO88313.1.
JNBX01000113 Genomic DNA. Translation: KDP16079.1.
JMIZ01000008 Genomic DNA. Translation: KEO95706.1.
JMJA01000002 Genomic DNA. Translation: KEP01453.1.
JMJB01000001 Genomic DNA. Translation: KEP03625.1.
JMJD01000003 Genomic DNA. Translation: KEP08351.1.
JMJE01000007 Genomic DNA. Translation: KEP21613.1.
JPQG01000001 Genomic DNA. Translation: KFD78693.1.
JEND02000001 Genomic DNA. Translation: KFF39197.1.
JENE03000001 Genomic DNA. Translation: KFF54047.1.
JNOF01000080 Genomic DNA. Translation: KFH77277.1.
JNOE01000051 Genomic DNA. Translation: KFH98867.1.
RefSeqiYP_002558806.1. NC_011993.1.

Genome annotation databases

EnsemblBacteriaiCAP78417; CAP78417; LF82_1696.
GeneIDi7393205.
KEGGielf:LF82_1696.
PATRICi48658118. VBIEscCol74806_4046.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP007265 Genomic DNA. Translation: AHM30566.1 .
CP007390 Genomic DNA. Translation: AHM36674.1 .
CP007391 Genomic DNA. Translation: AHM41273.1 .
CU651637 Genomic DNA. Translation: CAP78417.1 .
HE964769 Genomic DNA. Translation: CCJ46600.1 .
JFFO01000091 Genomic DNA. Translation: EYB38381.1 .
JFFN01000049 Genomic DNA. Translation: EYB46321.1 .
JFFJ01000012 Genomic DNA. Translation: EYB54837.1 .
JFFK01000028 Genomic DNA. Translation: EYB57972.1 .
JFFL01000127 Genomic DNA. Translation: EYB59945.1 .
JHEW01000078 Genomic DNA. Translation: KDM69695.1 .
JHEX01000050 Genomic DNA. Translation: KDM85044.1 .
JJNT01000041 Genomic DNA. Translation: KDO88313.1 .
JNBX01000113 Genomic DNA. Translation: KDP16079.1 .
JMIZ01000008 Genomic DNA. Translation: KEO95706.1 .
JMJA01000002 Genomic DNA. Translation: KEP01453.1 .
JMJB01000001 Genomic DNA. Translation: KEP03625.1 .
JMJD01000003 Genomic DNA. Translation: KEP08351.1 .
JMJE01000007 Genomic DNA. Translation: KEP21613.1 .
JPQG01000001 Genomic DNA. Translation: KFD78693.1 .
JEND02000001 Genomic DNA. Translation: KFF39197.1 .
JENE03000001 Genomic DNA. Translation: KFF54047.1 .
JNOF01000080 Genomic DNA. Translation: KFH77277.1 .
JNOE01000051 Genomic DNA. Translation: KFH98867.1 .
RefSeqi YP_002558806.1. NC_011993.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAP78417 ; CAP78417 ; LF82_1696 .
GeneIDi 7393205.
KEGGi elf:LF82_1696.
PATRICi 48658118. VBIEscCol74806_4046.

Phylogenomic databases

KOi K01595.
OMAi ELSTISC.

Family and domain databases

HAMAPi MF_00595. PEPcase_type1.
InterProi IPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view ]
Pfami PF00311. PEPcase. 1 hit.
[Graphical view ]
PRINTSi PR00150. PEPCARBXLASE.
SUPFAMi SSF51621. SSF51621. 1 hit.
PROSITEi PS00781. PEPCASE_1. 1 hit.
PS00393. PEPCASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete genome sequence of adherent invasive Escherichia coli strain LF82 isolated from a patient with Crohn's disease."
    Peyretaillade E., Claret L., Bonnet R., Dossat C., Barbe V., Vacherie B., Segurens B., Peyret P., Darfeuille-Michaud A.
    Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: LF82Imported.
  2. "Complete genome sequence of adherent invasive Escherichia coli strain LF82 isolated from a patient with Crohn's disease."
    Peyretaillade E., Claret L., Bonnet R., Dossat C., Barbe V., Vacherie B., Segurens B., Peyret P., Darfeuille-Michaud A.
    Submitted (NOV-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LF82 / AIECImported.
  3. Genoscope - CEA
    Submitted (NOV-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: LF82Imported.
  4. "Identification of avian pathogenic Escherichia coli serogroup O78 genes associated with pathogenesis in poultry."
    Dziva F., Hauser H., Connor T., Van Diemen P.M., Prescott G., Langridge G.C., Eckert S., Chaudhuri R.R., Ewers C., Mellata M., Curtiss III R., Dougan G., Wieler L., Thomson N.R., Pickard D.J., Stevens M.P.
    Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Aslett M.
    Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: IMT2125Imported.
  6. "Sequencing and functional annotation of avian pathogenic Escherichia coli serogroup O78 strains reveal the evolution of E. coli lineages pathogenic for poultry via distinct mechanisms."
    Dziva F., Hauser H., Connor T.R., van Diemen P.M., Prescott G., Langridge G.C., Eckert S., Chaudhuri R.R., Ewers C., Mellata M., Mukhopadhyay S., Curtiss R., Dougan G., Wieler L.H., Thomson N.R., Pickard D.J., Stevens M.P.
    Infect. Immun. 81:838-849(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: IMT2125Imported.
  7. "Complete Genome Sequences of Nitrofurantoin-Sensitive and -Resistant Escherichia coli ST540 and ST2747 Strains."
    Xavier B.B., Vervoort J., Stewardson A., Adriaenssens N., Coenen S., Harbarth S., Goossens H., Malhotra-Kumar S.
    Genome Announc. 2:e00239-14(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: ST540Imported.
  8. "Draft Genome Sequence of Escherichia coli str UCD_JA03."
    Coil D., Jospin G., Adams J., Eisen J.
    Submitted (FEB-2014) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: UCD_JA03Imported.
  9. "Draft Genome Sequence of Escherichia coli str UCD_JA17."
    Coil D., Jospin G., Adams J., Eisen J.
    Submitted (FEB-2014) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: UCD_JA17Imported.
  10. "Draft Genome Sequence of Escherichia coli str UCD_JA23."
    Coil D., Jospin G., Adams J., Eisen J.
    Submitted (FEB-2014) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: UCD_JA23Imported.
  11. "Draft Genome Sequence of Escherichia coli str UCD_JA65."
    Coil D., Jospin G., Adams J., Eisen J.
    Submitted (FEB-2014) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: UCD_JA65Imported.
  12. "Draft Genome Sequence of Escherichia coli str UCD_JA69."
    Coil D., Jospin G., Adams J., Eisen J.
    Submitted (FEB-2014) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: UCD_JA69Imported.
  13. Lai Y.H.
    Submitted (FEB-2014) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: E455Imported and E455LImported.
  14. Britto Xavier B.
    Submitted (FEB-2014) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: ST540Imported.
  15. "Escherichia coli non-O157 genome sequencing."
    Leonard S.R., Lacher D.W.
    Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 97-3250Imported and PMK-5Imported.
  16. "A draft genome of Escherichia coli 2009-46."
    Darling A.E., Roy Chowdhury P., Santos J., Worden P., Djordjevic S.P.
    Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 2009-46Imported.
  17. "Escherichia coli UCD_JA03_pb."
    Coil D.A., Jospin G., Eisen J.A., Adams J.
    Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: UCD_JA03_pbImported.
  18. "Escherichia coli UCD_JA17_pb."
    Coil D.A., Jospin G., Eisen J.A., Adams J.
    Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: UCD_JA17_pbImported.
  19. "Escherichia coli UCD_JA23_pb."
    Coil D.A., Jospin G., Eisen J.A., Adams J.
    Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: UCD_JA23_pbImported.
  20. "Escherichia coli UCD_JA65_pb."
    Coil D.A., Jospin G., Eisen J.A., Adams J.
    Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: UCD_JA65_pbImported.
  21. "Escherichia coli UCD_JA69_pb."
    Coil D.A., Jospin G., Eisen J.A., Adams J.
    Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: UCD_JA69_pbImported.
  22. "Genome Sequence of Enterotoxigenic Escherichia coli Strain W25K."
    Ren W., Liu G., Chen S., Li T., Kong X., Yin Y., Hardwidge P.R.
    Submitted (MAY-2014) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: W25KImported.
  23. "Draft Genome Sequences of 6 Multi-Drug Resistant Human Commensal Escherichia coli Isolates."
    Garrett M.E., Parker J., Stephens C.
    Submitted (JUN-2014) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: CS01Imported and CS02Imported.
  24. "Escherichia coli E455."
    Lai J.Y.H., Zhang H., Chiang M.H.Y., Yu M., Zhang R., Lau S.C.K.
    Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: E455Imported.
  25. "Escherichia coli E455L."
    Lai J.Y.H., Zhang H., Chiang M.H.Y., Yu M., Zhang R., Lau S.C.K.
    Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: E455LImported.
  26. "Prevalence of subtilase cytotoxin-encoding subAB variants among Shiga toxin-producing Escherichia coli strains isolated from wild ruminants and sheep differs from that of cattle and pigs and is predominated by the new allelic variant subAB2-2."
    Nuesch-Inderbinen M.T., Funk J., Cernela N., Tasara T., Klumpp J., Schmidt H., Stephan R.
    Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 48Imported.

Entry informationi

Entry nameiE2QIY7_ECOLX
AccessioniPrimary (citable) accession number: E2QIY7
Entry historyi
Integrated into UniProtKB/TrEMBL: November 30, 2010
Last sequence update: November 30, 2010
Last modified: October 29, 2014
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3