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Protein

Phosphoenolpyruvate carboxylase

Gene

ppc

Organism
Escherichia coli
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.UniRule annotationSAAS annotation

Catalytic activityi

Phosphate + oxaloacetate = H2O + phosphoenolpyruvate + HCO3-.UniRule annotationSAAS annotation

Cofactori

Mg2+UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei138UniRule annotation1
Active sitei546UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseImported, LyaseUniRule annotationSAAS annotationImported, Transferase
Biological processCarbon dioxide fixationUniRule annotationSAAS annotation
LigandMagnesiumUniRule annotationSAAS annotation, PyruvateImported

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxylaseUniRule annotationSAAS annotation (EC:4.1.1.31UniRule annotationSAAS annotation)
Short name:
PEPCUniRule annotation
Short name:
PEPCaseUniRule annotation
Gene namesi
Name:ppcUniRule annotationImported
ORF Names:A9819_22580Imported, A9R57_01340Imported, AA102_12115Imported, AC789_1c43500Imported, ACN002_4049Imported, ACN81_01785Imported, ACU90_16625Imported, AL530_000955Imported, AM270_21675Imported, AMK83_18650Imported, AML07_17720Imported, AML35_25185Imported, APT94_04385Imported, APU18_06430Imported, APZ14_16065Imported, AUS26_09575Imported, AW059_17395Imported, AW106_23910Imported, AZZ83_004704Imported, B1K96_05115Imported, BB545_13650Imported, BHF46_24910Imported, BHS81_23640Imported, BHS87_22125Imported, BJJ90_25280Imported, BK248_25805Imported, BK292_26680Imported, BK400_24190Imported, BMT53_13815Imported, BMT91_08040Imported, BN17_39251Imported, BTQ06_03940Imported, BZL31_11110Imported, BZL69_14295Imported, CIJ94_09635Imported, COD30_25765Imported, COD46_21395Imported, CR534_25795Imported, CR538_24400Imported, CR539_01495Imported, CRM83_18820Imported, CT143_19915Imported, CU078_14695Imported, CWS33_22670Imported, EC1094V2_4306Imported, ERS085365_01466Imported, ERS085374_04342Imported, ERS085379_02839Imported, ERS085386_04012Imported, ERS085416_02135Imported, ERS139211_02505Imported, ERS150873_02890Imported, ERS150876_04531Imported, FORC28_5800Imported, HMPREF3040_04369Imported, HW43_01420Imported, JD73_06060Imported, PU06_06535Imported, RG28_25185Imported, RX35_03722Imported, UN86_23480Imported, UN91_00375Imported, WM48_21875Imported, WQ89_06110Imported
OrganismiEscherichia coliImported
Taxonomic identifieri562 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000233549 Componenti: Unassembled WGS sequence
  • UP000044893 Componenti: Unassembled WGS sequence
  • UP000230908 Componenti: Chromosome
  • UP000078545 Componenti: Chromosome
  • UP000194954 Componenti: Unassembled WGS sequence
  • UP000217968 Componenti: Unassembled WGS sequence
  • UP000193530 Componenti: Unassembled WGS sequence
  • UP000194908 Componenti: Unassembled WGS sequence
  • UP000231393 Componenti: Unassembled WGS sequence
  • UP000194247 Componenti: Unassembled WGS sequence
  • UP000053450 Componenti: Unassembled WGS sequence
  • UP000038112 Componenti: Unassembled WGS sequence
  • UP000234324 Componenti: Chromosome
  • UP000184379 Componenti: Chromosome
  • UP000051846 Componenti: Unassembled WGS sequence
  • UP000194285 Componenti: Unassembled WGS sequence
  • UP000040934 Componenti: Unassembled WGS sequence
  • UP000193168 Componenti: Unassembled WGS sequence
  • UP000070450 Componenti: Unassembled WGS sequence
  • UP000234238 Componenti: Chromosome
  • UP000185422 Componenti: Chromosome
  • UP000185961 Componenti: Unassembled WGS sequence
  • UP000218543 Componenti: Unassembled WGS sequence
  • UP000044469 Componenti: Unassembled WGS sequence
  • UP000076106 Componenti: Unassembled WGS sequence
  • UP000195177 Componenti: Unassembled WGS sequence
  • UP000028651 Componenti: Unassembled WGS sequence
  • UP000033371 Componenti: Unassembled WGS sequence
  • UP000188855 Componenti: Unassembled WGS sequence
  • UP000233768 Componenti: Chromosome iv
  • UP000031522 Componenti: Chromosome
  • UP000030783 Componenti: Chromosome
  • UP000054864 Componenti: Unassembled WGS sequence
  • UP000036812 Componenti: Unassembled WGS sequence
  • UP000186275 Componenti: Unassembled WGS sequence
  • UP000030834 Componenti: Unassembled WGS sequence
  • UP000095493 Componenti: Unassembled WGS sequence
  • UP000184168 Componenti: Unassembled WGS sequence
  • UP000218721 Componenti: Unassembled WGS sequence
  • UP000054277 Componenti: Unassembled WGS sequence
  • UP000215493 Componenti: Unassembled WGS sequence
  • UP000184369 Componenti: Unassembled WGS sequence
  • UP000066343 Componenti: Chromosome
  • UP000194319 Componenti: Unassembled WGS sequence
  • UP000076262 Componenti: Unassembled WGS sequence
  • UP000040589 Componenti: Unassembled WGS sequence
  • UP000050307 Componenti: Unassembled WGS sequence
  • UP000033592 Componenti: Unassembled WGS sequence
  • UP000234543 Componenti: Chromosome
  • UP000094022 Componenti: Unassembled WGS sequence
  • UP000042305 Componenti: Unassembled WGS sequence
  • UP000094451 Componenti: Chromosome
  • UP000184336 Componenti: Unassembled WGS sequence
  • UP000218701 Componenti: Unassembled WGS sequence
  • UP000034530 Componenti: Chromosome
  • UP000053643 Componenti: Unassembled WGS sequence
  • UP000042887 Componenti: Unassembled WGS sequence
  • UP000218167 Componenti: Unassembled WGS sequence
  • UP000220282 Componenti: Unassembled WGS sequence
  • UP000076304 Componenti: Unassembled WGS sequence
  • UP000095183 Componenti: Unassembled WGS sequence
  • UP000041959 Componenti: Unassembled WGS sequence
  • UP000070338 Componenti: Unassembled WGS sequence
  • UP000216687 Componenti: Unassembled WGS sequence

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi469008.ECD_03841

Family & Domainsi

Sequence similaritiesi

Belongs to the PEPCase type 1 family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105CCA Bacteria
COG2352 LUCA
OMAiPWVFGWT

Family and domain databases

HAMAPiMF_00595 PEPcase_type1, 1 hit
InterProiView protein in InterPro
IPR021135 PEP_COase
IPR022805 PEP_COase_bac/pln-type
IPR018129 PEP_COase_Lys_AS
IPR033129 PEPCASE_His_AS
IPR015813 Pyrv/PenolPyrv_Kinase-like_dom
PANTHERiPTHR30523 PTHR30523, 1 hit
PfamiView protein in Pfam
PF00311 PEPcase, 1 hit
PRINTSiPR00150 PEPCARBXLASE
SUPFAMiSSF51621 SSF51621, 1 hit
PROSITEiView protein in PROSITE
PS00781 PEPCASE_1, 1 hit
PS00393 PEPCASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

E2QIY7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNEQYSALRS NVSMLGKVLG ETIKDALGEH ILERVETIRK LSKSSRAGND
60 70 80 90 100
ANRQELLTTL QNLSNDELLP VARAFSQFLN LANTAEQYHS ISPKGEAASN
110 120 130 140 150
PEVIARTLRK LKNQPELSED TIKKAVESLS LELVLTAHPT EITRRTLIHK
160 170 180 190 200
MVEVNACLKQ LDNKDIADYE HNQLMRRLRQ LIAQSWHTDE IRKLRPSPVD
210 220 230 240 250
EAKWGFAVVE NSLWQGVPNY LRELNEQLEE NLGYKLPVEF VPVRFTSWMG
260 270 280 290 300
GDRDGNPNVT ADITRHVLLL SRWKATDLFL KDIQVLVSEL SMVEATPELL
310 320 330 340 350
ALVGEEGAAE PYRYLMKNLR SRLMATQAWL EARLKGEELP KPEGLLTQNE
360 370 380 390 400
ELWEPLYACY QSLQACGMGI IANGDLLDTL RRVKCFGVPL VRIDIRQEST
410 420 430 440 450
RHTEALGELT RYLGIGDYES WSEADKQAFL IRELNSKRPL LPRNWQPSAE
460 470 480 490 500
TREVLDTCQV IAEAPQGSIA AYVISMAKTP SDVLAVHLLL KEAGIGFAMP
510 520 530 540 550
VAPLFETLDD LNNANDVMTQ LLNIDWYRGL IQGKQMVMIG YSDSAKDAGV
560 570 580 590 600
MAASWAQYQA QDALIKTCEK AGIELTLFHG RGGSIGRGGA PAHAALLSQP
610 620 630 640 650
PGSLKGGLRV TEQGEMIRFK YGLPEITVSS LSLYTGAILE ANLLPPPEPK
660 670 680 690 700
ESWRRIMDEL SVISCDLYRG YVRENKDFVP YFRSATPEQE LGKLPLGSRP
710 720 730 740 750
AKRRPTGGVE SLRAIPWIFA WTQNRLMLPA WLGAGTALQK VVEDGKQSEL
760 770 780 790 800
EAMCRDWPFF STRLGMLEMV FAKADLWLAE YYDQRLVDKA LWPLGKELRN
810 820 830 840 850
LQEEDIKVVL AIANDSHLMA DLPWIAESIQ LRNIYTDPLN VLQAELLHRS
860 870 880
RQAEKEGQEP DPRVEQALMV TIAGIAAGMR NTG
Length:883
Mass (Da):99,077
Last modified:November 30, 2010 - v1
Checksum:iC66E18268EB19EFD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP009106 Genomic DNA Translation: AIZ85153.1
CP010315 Genomic DNA Translation: AJE58518.1
CP011416 Genomic DNA Translation: AKH24622.1
CP007491 Genomic DNA Translation: ALY15507.1
CP014667 Genomic DNA Translation: ANK34784.1
CP012693 Genomic DNA Translation: AOM48774.1
CP010122 Genomic DNA Translation: APJ79356.1
CP017631 Genomic DNA Translation: APT05062.1
CP024821 Genomic DNA Translation: ATX09846.1
CP024147 Genomic DNA Translation: AUJ94236.1
CP024141 Genomic DNA Translation: AUK03285.1
CP024127 Genomic DNA Translation: AUK24140.1
HE964769 Genomic DNA Translation: CCJ46600.1
CYAQ01000009 Genomic DNA Translation: CTS32688.1
CXZU01000040 Genomic DNA Translation: CTS38322.1
CYBF01000019 Genomic DNA Translation: CTT76047.1
CYBM01000026 Genomic DNA Translation: CTU09550.1
CYCX01000015 Genomic DNA Translation: CTV87326.1
CYDH01000024 Genomic DNA Translation: CTW14419.1
CYFX01000018 Genomic DNA Translation: CTZ55244.1
CYGC01000041 Genomic DNA Translation: CTZ95415.1
JPQG01000001 Genomic DNA Translation: KFD78693.1
JUDN01000035 Genomic DNA Translation: KHJ20479.1
JZDU01000119 Genomic DNA Translation: KJW25933.1
JZDZ01000016 Genomic DNA Translation: KJW54553.1
LGZP01000007 Genomic DNA Translation: KNF81384.1
LECN01000116 Genomic DNA Translation: KPO51433.1
LIVI01000035 Genomic DNA Translation: KQJ37849.1
LMBK01000541 Genomic DNA Translation: KST28200.1
LNHR01000121 Genomic DNA Translation: KSX91894.1
LNIP01000005 Genomic DNA Translation: KSZ22526.1
LSNZ01000174 Genomic DNA Translation: KXG92831.1
LPXZ01000167 Genomic DNA Translation: KXL63369.1
LOFS01000166 Genomic DNA Translation: KYR49916.1
LOGT01000171 Genomic DNA Translation: KYS87185.1
LOCS01000151 Genomic DNA Translation: KYV68032.1
LZEH01000212 Genomic DNA Translation: OEI63355.1
MIWY01000035 Genomic DNA Translation: OEN31950.1
MOFD01000073 Genomic DNA Translation: OJK70979.1
MOGU01000073 Genomic DNA Translation: OJM84596.1
MOKZ01000038 Genomic DNA Translation: OJS86973.1
MPGT01000001 Genomic DNA Translation: OKB90496.1
LGMY01000034 Genomic DNA Translation: OKU30152.1
MPAF01000012 Genomic DNA Translation: OOK29234.1
NAHY01000335 Genomic DNA Translation: ORJ73518.1
NAFT01000080 Genomic DNA Translation: ORS98755.1
NEME01000011 Genomic DNA Translation: OTB38204.1
NENZ01000066 Genomic DNA Translation: OTD94714.1
NBCM01000005 Genomic DNA Translation: OTE94075.1
NGSK01000011 Genomic DNA Translation: OUG21577.1
MUAB01000018 Genomic DNA Translation: OUK51715.1
MUBQ01000018 Genomic DNA Translation: OUK94974.1
LEOO01000019 Genomic DNA Translation: OYC67178.1
NQIT01000023 Genomic DNA Translation: OZX95611.1
MRVZ01000008 Genomic DNA Translation: PAU26196.1
NWBE01000052 Genomic DNA Translation: PBR07033.1
NWAO01000040 Genomic DNA Translation: PBR50385.1
NTDZ01000055 Genomic DNA Translation: PBT38140.1
NTEV01000121 Genomic DNA Translation: PBU44058.1
PDEE01000004 Genomic DNA Translation: PEH99907.1
PENR01000013 Genomic DNA Translation: PIM26972.1
PITP01000030 Genomic DNA Translation: PKD86823.1
LORS02000001 Genomic DNA Translation: PNP61871.1
LT883142 Genomic DNA Translation: SMZ47399.1
RefSeqiWP_001005579.1, NZ_PUDZ01000028.1

Genome annotation databases

EnsemblBacteriaiAIZ80600; AIZ80600; HW42_01315
AJE58518; AJE58518; AC789_1c43500
AKH24622; AKH24622; AA102_12115
ALY15507; ALY15507; ACN002_4049
ALZ69232; ALZ69232; AWH59_25230
ANK34784; ANK34784; WM48_21875
ANM84771; ANM84771; A8V37_20600
ANP20803; ANP20803; GJ12_24340
AOM48774; AOM48774; FORC28_5800
CTS32688; CTS32688; ERS085365_01466
CTS38322; CTS38322; ERS085374_04342
CTT76047; CTT76047; ERS085379_02839
CTU09550; CTU09550; ERS085386_04012
CTV87326; CTV87326; ERS085416_02135
CTW14419; CTW14419; ERS139211_02505
CTY13507; CTY13507; ERS139235_04345
CTY64980; CTY64980; ERS139266_04318
CTY96197; CTY96197; ERS139269_04188
CTZ55244; CTZ55244; ERS150873_02890
CTZ95415; CTZ95415; ERS150876_04531
KFD78693; KFD78693; JD73_06060
KHI36097; KHI36097; PU33_05885
KHJ20479; KHJ20479; PU06_06535
KIG77690; KIG77690; PU38_20930
KIH03375; KIH03375; PU21_16325
KIQ44902; KIQ44902; IY32_18940
KJW25933; KJW25933; UN86_23480
KJW54553; KJW54553; UN91_00375
KNF81384; KNF81384; WQ89_06110
KPO51433; KPO51433; ACU90_16625
KQJ37849; KQJ37849; AM270_21675
KST28200; KST28200; APZ14_16065
KSX91894; KSX91894; APT94_04385
KSZ22526; KSZ22526; APU18_06430
KUU44303; KUU44303; AWF22_20255
KXG92831; KXG92831; HMPREF3040_04369
KXG97229; KXG97229; HMPREF3041_01652
KXL63369; KXL63369; AUS26_09575
KYR49916; KYR49916; AML07_17720
KYS87185; KYS87185; AML35_25185
KYV68032; KYV68032; AMK83_18650
KZJ53327; KZJ53327; AWG90_23065
OAF38034; OAF38034; AXK33_03235
OAJ86803; OAJ86803; A5958_09010
OAO70846; OAO70846; OO96_03820
OAS95868; OAS95868; A6I92_22285
OCS74281; OCS74281; BBZ52_20990
ODA86196; ODA86196; A9D65_22905
OEI63355; OEI63355; A9R57_01340
OEN31950; OEN31950; BHF46_24910
PATRICifig|562.10476.peg.2960

Similar proteinsi

Entry informationi

Entry nameiE2QIY7_ECOLX
AccessioniPrimary (citable) accession number: E2QIY7
Entry historyiIntegrated into UniProtKB/TrEMBL: November 30, 2010
Last sequence update: November 30, 2010
Last modified: May 23, 2018
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
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Main funding by: National Institutes of Health