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E2QIY7

- E2QIY7_ECOLX

UniProt

E2QIY7 - E2QIY7_ECOLX

Protein

Phosphoenolpyruvate carboxylase

Gene

ppc

Organism
Escherichia coli
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 27 (01 Oct 2014)
      Sequence version 1 (30 Nov 2010)
      Previous versions | rss
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    Functioni

    Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.UniRule annotationSAAS annotation

    Catalytic activityi

    Phosphate + oxaloacetate = H2O + phosphoenolpyruvate + HCO3-.UniRule annotationSAAS annotation

    Cofactori

    Magnesium.UniRule annotationSAAS annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei138 – 1381UniRule annotation
    Active sitei546 – 5461UniRule annotation

    GO - Molecular functioni

    1. magnesium ion binding Source: UniProtKB-HAMAP
    2. phosphoenolpyruvate carboxylase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. carbon fixation Source: UniProtKB-HAMAP
    2. oxaloacetate metabolic process Source: UniProtKB-HAMAP
    3. tricarboxylic acid cycle Source: InterPro

    Keywords - Molecular functioni

    LyaseUniRule annotationSAAS annotationImported

    Keywords - Biological processi

    Carbon dioxide fixationUniRule annotationSAAS annotation

    Keywords - Ligandi

    MagnesiumUniRule annotationSAAS annotation, PyruvateImported

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoenolpyruvate carboxylaseUniRule annotation (EC:4.1.1.31UniRule annotation)
    Short name:
    PEPCUniRule annotation
    Short name:
    PEPCaseUniRule annotation
    Gene namesi
    Name:ppcUniRule annotationImported
    ORF Names:BC97_15605Imported, BC99_0203685Imported, BN17_39251Imported, BU34_18140Imported, BU65_04945Imported, BU66_07000Imported, BU67_03315Imported, BU69_09450Imported, BU70_24520Imported, CF57_29160Imported, CF61_29855Imported, DA88_29135Imported, DC22_24145Imported, DO98_06020Imported, EH61_21055Imported, EH62_00800Imported, EH64_07840Imported, EH65_20460Imported, EH66_22180Imported, EP08_05610Imported, LF82_1696Imported
    OrganismiEscherichia coliImported
    Taxonomic identifieri562 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000010085: Chromosome

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PEPCase type 1 family.UniRule annotation

    Phylogenomic databases

    KOiK01595.
    OMAiELSTISC.

    Family and domain databases

    HAMAPiMF_00595. PEPcase_type1.
    InterProiIPR021135. PEP_COase.
    IPR018129. PEP_COase_AS.
    IPR022805. PEP_COase_bac/pln-type.
    IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
    [Graphical view]
    PfamiPF00311. PEPcase. 1 hit.
    [Graphical view]
    PRINTSiPR00150. PEPCARBXLASE.
    SUPFAMiSSF51621. SSF51621. 1 hit.
    PROSITEiPS00781. PEPCASE_1. 1 hit.
    PS00393. PEPCASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    E2QIY7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNEQYSALRS NVSMLGKVLG ETIKDALGEH ILERVETIRK LSKSSRAGND    50
    ANRQELLTTL QNLSNDELLP VARAFSQFLN LANTAEQYHS ISPKGEAASN 100
    PEVIARTLRK LKNQPELSED TIKKAVESLS LELVLTAHPT EITRRTLIHK 150
    MVEVNACLKQ LDNKDIADYE HNQLMRRLRQ LIAQSWHTDE IRKLRPSPVD 200
    EAKWGFAVVE NSLWQGVPNY LRELNEQLEE NLGYKLPVEF VPVRFTSWMG 250
    GDRDGNPNVT ADITRHVLLL SRWKATDLFL KDIQVLVSEL SMVEATPELL 300
    ALVGEEGAAE PYRYLMKNLR SRLMATQAWL EARLKGEELP KPEGLLTQNE 350
    ELWEPLYACY QSLQACGMGI IANGDLLDTL RRVKCFGVPL VRIDIRQEST 400
    RHTEALGELT RYLGIGDYES WSEADKQAFL IRELNSKRPL LPRNWQPSAE 450
    TREVLDTCQV IAEAPQGSIA AYVISMAKTP SDVLAVHLLL KEAGIGFAMP 500
    VAPLFETLDD LNNANDVMTQ LLNIDWYRGL IQGKQMVMIG YSDSAKDAGV 550
    MAASWAQYQA QDALIKTCEK AGIELTLFHG RGGSIGRGGA PAHAALLSQP 600
    PGSLKGGLRV TEQGEMIRFK YGLPEITVSS LSLYTGAILE ANLLPPPEPK 650
    ESWRRIMDEL SVISCDLYRG YVRENKDFVP YFRSATPEQE LGKLPLGSRP 700
    AKRRPTGGVE SLRAIPWIFA WTQNRLMLPA WLGAGTALQK VVEDGKQSEL 750
    EAMCRDWPFF STRLGMLEMV FAKADLWLAE YYDQRLVDKA LWPLGKELRN 800
    LQEEDIKVVL AIANDSHLMA DLPWIAESIQ LRNIYTDPLN VLQAELLHRS 850
    RQAEKEGQEP DPRVEQALMV TIAGIAAGMR NTG 883
    Length:883
    Mass (Da):99,077
    Last modified:November 30, 2010 - v1
    Checksum:iC66E18268EB19EFD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP007265 Genomic DNA. Translation: AHM30566.1.
    CP007390 Genomic DNA. Translation: AHM36674.1.
    CP007391 Genomic DNA. Translation: AHM41273.1.
    CU651637 Genomic DNA. Translation: CAP78417.1.
    HE964769 Genomic DNA. Translation: CCJ46600.1.
    JFFO01000091 Genomic DNA. Translation: EYB38381.1.
    JFFN01000049 Genomic DNA. Translation: EYB46321.1.
    JFFJ01000012 Genomic DNA. Translation: EYB54837.1.
    JFFK01000028 Genomic DNA. Translation: EYB57972.1.
    JFFL01000127 Genomic DNA. Translation: EYB59945.1.
    JEND01000006 Genomic DNA. Translation: KAJ45254.1.
    JHEW01000078 Genomic DNA. Translation: KDM69695.1.
    JHEX01000050 Genomic DNA. Translation: KDM85044.1.
    JJNT01000041 Genomic DNA. Translation: KDO88313.1.
    JNBX01000113 Genomic DNA. Translation: KDP16079.1.
    JMIZ01000008 Genomic DNA. Translation: KEO95706.1.
    JMJA01000002 Genomic DNA. Translation: KEP01453.1.
    JMJB01000001 Genomic DNA. Translation: KEP03625.1.
    JMJD01000003 Genomic DNA. Translation: KEP08351.1.
    JMJE01000007 Genomic DNA. Translation: KEP21613.1.
    JENE02000001 Genomic DNA. Translation: KEP81266.1.
    RefSeqiYP_002558806.1. NC_011993.1.

    Genome annotation databases

    EnsemblBacteriaiCAP78417; CAP78417; LF82_1696.
    GeneIDi7393205.
    KEGGielf:LF82_1696.
    PATRICi48658118. VBIEscCol74806_4046.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP007265 Genomic DNA. Translation: AHM30566.1 .
    CP007390 Genomic DNA. Translation: AHM36674.1 .
    CP007391 Genomic DNA. Translation: AHM41273.1 .
    CU651637 Genomic DNA. Translation: CAP78417.1 .
    HE964769 Genomic DNA. Translation: CCJ46600.1 .
    JFFO01000091 Genomic DNA. Translation: EYB38381.1 .
    JFFN01000049 Genomic DNA. Translation: EYB46321.1 .
    JFFJ01000012 Genomic DNA. Translation: EYB54837.1 .
    JFFK01000028 Genomic DNA. Translation: EYB57972.1 .
    JFFL01000127 Genomic DNA. Translation: EYB59945.1 .
    JEND01000006 Genomic DNA. Translation: KAJ45254.1 .
    JHEW01000078 Genomic DNA. Translation: KDM69695.1 .
    JHEX01000050 Genomic DNA. Translation: KDM85044.1 .
    JJNT01000041 Genomic DNA. Translation: KDO88313.1 .
    JNBX01000113 Genomic DNA. Translation: KDP16079.1 .
    JMIZ01000008 Genomic DNA. Translation: KEO95706.1 .
    JMJA01000002 Genomic DNA. Translation: KEP01453.1 .
    JMJB01000001 Genomic DNA. Translation: KEP03625.1 .
    JMJD01000003 Genomic DNA. Translation: KEP08351.1 .
    JMJE01000007 Genomic DNA. Translation: KEP21613.1 .
    JENE02000001 Genomic DNA. Translation: KEP81266.1 .
    RefSeqi YP_002558806.1. NC_011993.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAP78417 ; CAP78417 ; LF82_1696 .
    GeneIDi 7393205.
    KEGGi elf:LF82_1696.
    PATRICi 48658118. VBIEscCol74806_4046.

    Phylogenomic databases

    KOi K01595.
    OMAi ELSTISC.

    Family and domain databases

    HAMAPi MF_00595. PEPcase_type1.
    InterProi IPR021135. PEP_COase.
    IPR018129. PEP_COase_AS.
    IPR022805. PEP_COase_bac/pln-type.
    IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
    [Graphical view ]
    Pfami PF00311. PEPcase. 1 hit.
    [Graphical view ]
    PRINTSi PR00150. PEPCARBXLASE.
    SUPFAMi SSF51621. SSF51621. 1 hit.
    PROSITEi PS00781. PEPCASE_1. 1 hit.
    PS00393. PEPCASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of adherent invasive Escherichia coli strain LF82 isolated from a patient with Crohn's disease."
      Peyretaillade E., Claret L., Bonnet R., Dossat C., Barbe V., Vacherie B., Segurens B., Peyret P., Darfeuille-Michaud A.
      Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: LF82Imported.
    2. "Complete genome sequence of adherent invasive Escherichia coli strain LF82 isolated from a patient with Crohn's disease."
      Peyretaillade E., Claret L., Bonnet R., Dossat C., Barbe V., Vacherie B., Segurens B., Peyret P., Darfeuille-Michaud A.
      Submitted (NOV-2010) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: LF82 / AIECImported.
    3. Genoscope - CEA
      Submitted (NOV-2010) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: LF82Imported.
    4. "Identification of avian pathogenic Escherichia coli serogroup O78 genes associated with pathogenesis in poultry."
      Dziva F., Hauser H., Connor T., Van Diemen P.M., Prescott G., Langridge G.C., Eckert S., Chaudhuri R.R., Ewers C., Mellata M., Curtiss III R., Dougan G., Wieler L., Thomson N.R., Pickard D.J., Stevens M.P.
      Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Aslett M.
      Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: IMT2125Imported.
    6. "Sequencing and functional annotation of avian pathogenic Escherichia coli serogroup O78 strains reveal the evolution of E. coli lineages pathogenic for poultry via distinct mechanisms."
      Dziva F., Hauser H., Connor T.R., van Diemen P.M., Prescott G., Langridge G.C., Eckert S., Chaudhuri R.R., Ewers C., Mellata M., Mukhopadhyay S., Curtiss R., Dougan G., Wieler L.H., Thomson N.R., Pickard D.J., Stevens M.P.
      Infect. Immun. 81:838-849(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: IMT2125Imported.
    7. "Complete Genome Sequences of Nitrofurantoin-Sensitive and -Resistant Escherichia coli ST540 and ST2747 Strains."
      Xavier B.B., Vervoort J., Stewardson A., Adriaenssens N., Coenen S., Harbarth S., Goossens H., Malhotra-Kumar S.
      Genome Announc. 2:e00239-14(2014) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: ST540Imported.
    8. "Draft Genome Sequence of Escherichia coli str UCD_JA03."
      Coil D., Jospin G., Adams J., Eisen J.
      Submitted (FEB-2014) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: UCD_JA03Imported.
    9. "Draft Genome Sequence of Escherichia coli str UCD_JA17."
      Coil D., Jospin G., Adams J., Eisen J.
      Submitted (FEB-2014) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: UCD_JA17Imported.
    10. "Draft Genome Sequence of Escherichia coli str UCD_JA23."
      Coil D., Jospin G., Adams J., Eisen J.
      Submitted (FEB-2014) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: UCD_JA23Imported.
    11. "Draft Genome Sequence of Escherichia coli str UCD_JA65."
      Coil D., Jospin G., Adams J., Eisen J.
      Submitted (FEB-2014) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: UCD_JA65Imported.
    12. "Draft Genome Sequence of Escherichia coli str UCD_JA69."
      Coil D., Jospin G., Adams J., Eisen J.
      Submitted (FEB-2014) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: UCD_JA69Imported.
    13. Lai Y.H.
      Submitted (FEB-2014) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: 455Imported.
    14. Britto Xavier B.
      Submitted (FEB-2014) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: ST540Imported.
    15. "Escherichia coli non-O157 genome sequencing."
      Leonard S.R., Lacher D.W.
      Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: 97-3250Imported and PMK-5Imported.
    16. "A draft genome of Escherichia coli 2009-46."
      Darling A.E., Roy Chowdhury P., Santos J., Worden P., Djordjevic S.P.
      Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: 2009-46Imported.
    17. "Escherichia coli UCD_JA03_pb."
      Coil D.A., Jospin G., Eisen J.A., Adams J.
      Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: UCD_JA03_pbImported.
    18. "Escherichia coli UCD_JA17_pb."
      Coil D.A., Jospin G., Eisen J.A., Adams J.
      Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: UCD_JA17_pbImported.
    19. "Escherichia coli UCD_JA23_pb."
      Coil D.A., Jospin G., Eisen J.A., Adams J.
      Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: UCD_JA23_pbImported.
    20. "Escherichia coli UCD_JA65_pb."
      Coil D.A., Jospin G., Eisen J.A., Adams J.
      Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: UCD_JA65_pbImported.
    21. "Escherichia coli UCD_JA69_pb."
      Coil D.A., Jospin G., Eisen J.A., Adams J.
      Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: UCD_JA69_pbImported.
    22. "Genome Sequence of Enterotoxigenic Escherichia coli Strain W25K."
      Ren W., Liu G., Chen S., Li T., Kong X., Yin Y., Hardwidge P.R.
      Submitted (MAY-2014) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: W25KImported.
    23. Lai Y.H.
      Submitted (JUN-2014) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: 455LImported.

    Entry informationi

    Entry nameiE2QIY7_ECOLX
    AccessioniPrimary (citable) accession number: E2QIY7
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 30, 2010
    Last sequence update: November 30, 2010
    Last modified: October 1, 2014
    This is version 27 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3