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E2IUB0

- CASS_KALDA

UniProt

E2IUB0 - CASS_KALDA

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Protein
Cycloartenol synthase
Gene
N/A
Organism
Kalanchoe daigremontiana (Devil's backbone) (Bryophyllum daigremontianum)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Oxidosqualene cyclase which catalyzes the conversion of oxidosqualene to cycloartenol.1 Publication

Catalytic activityi

(3S)-2,3-epoxy-2,3-dihydrosqualene = cycloartenol.1 Publication

GO - Molecular functioni

  1. cycloartenol synthase activity Source: UniProtKB

GO - Biological processi

  1. metabolic process Source: UniProtKB
  2. steroid biosynthetic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Cycloartenol synthase (EC:5.4.99.8)
Short name:
KdCAS
OrganismiKalanchoe daigremontiana (Devil's backbone) (Bryophyllum daigremontianum)
Taxonomic identifieri23013 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeSaxifragalesCrassulaceaeKalanchoe

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei609 – 62921Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 764764Cycloartenol synthase
PRO_0000418479Add
BLAST

Expressioni

Tissue specificityi

Expressed in all leaf tissues.1 Publication

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati148 – 18942PFTB 1
Add
BLAST
Repeati513 – 55846PFTB 2
Add
BLAST
Repeati590 – 63041PFTB 3
Add
BLAST
Repeati639 – 68042PFTB 4
Add
BLAST
Repeati701 – 74242PFTB 5
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BLAST

Sequence similaritiesi

Contains 5 PFTB repeats.

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.50.10.20. 2 hits.
InterProiIPR001330. Prenyltrans.
IPR018333. Squalene_cyclase.
IPR002365. Terpene_synthase_CS.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
[Graphical view]
PfamiPF00432. Prenyltrans. 3 hits.
[Graphical view]
SUPFAMiSSF48239. SSF48239. 2 hits.
TIGRFAMsiTIGR01787. squalene_cyclas. 1 hit.
PROSITEiPS01074. TERPENE_SYNTHASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E2IUB0-1 [UniParc]FASTAAdd to Basket

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MWKLKIADAG GSQWLRSVNN HIGRQIWDFD PALGSPEELA QIEDARDNFA    50
RHRFDKKHSA DLLMRFQLTK ENPQSDLLPK VNIGKIEDIT EDAVTNTLRR 100
AINFHSTTQA HDGHWPGDYG GPLFLMPGLV ITLSITGALN AVLSKEHKKE 150
MCRYLYNHQN EDGGWGLHIE GPSTMFGSVL NYVTLRLLGE DVNGGDGEIE 200
RARKWILDHG GATAITSWGK MWLSVLGVFE WCGNNPLPPE MWLFPYYLPV 250
HPGRMWCHCR MVYLPMSYLY GKRFVGPITP TVLSLRKELF TVPYHEIDWN 300
EARSLCAKED LYYPHPVVQD ILWATLHKVV EPVLLNWPGK KLREKALCSA 350
IEHIHYEDEN TRYICIGPVN KVLNMLCCWV EDPNSEAFKL HIPRLYDYLW 400
IAEDGMKMQG YNGSQLWDTA FSVQAIVATK LVEEFSSTIS KAHEFMKNSQ 450
VLEDYPGDLS YWYRHISKGA WPFSTADHGW PISDCTAEGL KVVLKLSQFP 500
AELVGAPLSA KLVYNAVNVI LSLQNIDGGF ATYELTRSYS WMELLNPAET 550
FGDIVIDYPY VECTSAALQS LVLFKKLHPE HRKEEVELCI KKAAAFIEKI 600
QESDGSWYGS WAVCFTYGTW FGVLGLVAAG RNYKNSPSIR KACDFLLSKQ 650
LASGGWGESY LSCQNKVYTN IPGGRSHVVN TGWAMLALIG AGQAERDPVP 700
LHRAAKFLIE SQLENGDFPQ QEIMGVFNKN CMISYAAYRN IFPIWALGEY 750
RCKVLNASRG QMKT 764
Length:764
Mass (Da):86,531
Last modified:November 30, 2010 - v1
Checksum:i9A59D94C1072CF6A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
HM623872 mRNA. Translation: ADK35127.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
HM623872 mRNA. Translation: ADK35127.1 .

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 1.50.10.20. 2 hits.
InterProi IPR001330. Prenyltrans.
IPR018333. Squalene_cyclase.
IPR002365. Terpene_synthase_CS.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
[Graphical view ]
Pfami PF00432. Prenyltrans. 3 hits.
[Graphical view ]
SUPFAMi SSF48239. SSF48239. 2 hits.
TIGRFAMsi TIGR01787. squalene_cyclas. 1 hit.
PROSITEi PS01074. TERPENE_SYNTHASES. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and characterization of oxidosqualene cyclases from Kalanchoe daigremontiana: enzymes catalyzing up to 10 rearrangement steps yielding friedelin and other triterpenoids."
    Wang Z., Yeats T., Han H., Jetter R.
    J. Biol. Chem. 285:29703-29712(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, CATALYTIC ACTIVITY, TISSUE SPECIFICITY.

Entry informationi

Entry nameiCASS_KALDA
AccessioniPrimary (citable) accession number: E2IUB0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 5, 2012
Last sequence update: November 30, 2010
Last modified: April 16, 2014
This is version 12 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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