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E2IUB0

- CASS_KALDA

UniProt

E2IUB0 - CASS_KALDA

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Protein

Cycloartenol synthase

Gene
N/A
Organism
Kalanchoe daigremontiana (Devil's backbone) (Bryophyllum daigremontianum)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Oxidosqualene cyclase which catalyzes the conversion of oxidosqualene to cycloartenol.1 Publication

Catalytic activityi

(3S)-2,3-epoxy-2,3-dihydrosqualene = cycloartenol.1 Publication

GO - Molecular functioni

  1. cycloartenol synthase activity Source: UniProtKB

GO - Biological processi

  1. metabolic process Source: UniProtKB
  2. steroid biosynthetic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Cycloartenol synthase (EC:5.4.99.8)
Short name:
KdCAS
OrganismiKalanchoe daigremontiana (Devil's backbone) (Bryophyllum daigremontianum)
Taxonomic identifieri23013 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeSaxifragalesCrassulaceaeKalanchoe

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei609 – 62921HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 764764Cycloartenol synthasePRO_0000418479Add
BLAST

Expressioni

Tissue specificityi

Expressed in all leaf tissues.1 Publication

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati148 – 18942PFTB 1Add
BLAST
Repeati513 – 55846PFTB 2Add
BLAST
Repeati590 – 63041PFTB 3Add
BLAST
Repeati639 – 68042PFTB 4Add
BLAST
Repeati701 – 74242PFTB 5Add
BLAST

Sequence similaritiesi

Belongs to the terpene cyclase/mutase family.Curated
Contains 5 PFTB repeats.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.50.10.20. 2 hits.
InterProiIPR001330. Prenyltrans.
IPR018333. Squalene_cyclase.
IPR002365. Terpene_synthase_CS.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
[Graphical view]
PfamiPF00432. Prenyltrans. 3 hits.
[Graphical view]
SUPFAMiSSF48239. SSF48239. 2 hits.
TIGRFAMsiTIGR01787. squalene_cyclas. 1 hit.
PROSITEiPS01074. TERPENE_SYNTHASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E2IUB0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MWKLKIADAG GSQWLRSVNN HIGRQIWDFD PALGSPEELA QIEDARDNFA
60 70 80 90 100
RHRFDKKHSA DLLMRFQLTK ENPQSDLLPK VNIGKIEDIT EDAVTNTLRR
110 120 130 140 150
AINFHSTTQA HDGHWPGDYG GPLFLMPGLV ITLSITGALN AVLSKEHKKE
160 170 180 190 200
MCRYLYNHQN EDGGWGLHIE GPSTMFGSVL NYVTLRLLGE DVNGGDGEIE
210 220 230 240 250
RARKWILDHG GATAITSWGK MWLSVLGVFE WCGNNPLPPE MWLFPYYLPV
260 270 280 290 300
HPGRMWCHCR MVYLPMSYLY GKRFVGPITP TVLSLRKELF TVPYHEIDWN
310 320 330 340 350
EARSLCAKED LYYPHPVVQD ILWATLHKVV EPVLLNWPGK KLREKALCSA
360 370 380 390 400
IEHIHYEDEN TRYICIGPVN KVLNMLCCWV EDPNSEAFKL HIPRLYDYLW
410 420 430 440 450
IAEDGMKMQG YNGSQLWDTA FSVQAIVATK LVEEFSSTIS KAHEFMKNSQ
460 470 480 490 500
VLEDYPGDLS YWYRHISKGA WPFSTADHGW PISDCTAEGL KVVLKLSQFP
510 520 530 540 550
AELVGAPLSA KLVYNAVNVI LSLQNIDGGF ATYELTRSYS WMELLNPAET
560 570 580 590 600
FGDIVIDYPY VECTSAALQS LVLFKKLHPE HRKEEVELCI KKAAAFIEKI
610 620 630 640 650
QESDGSWYGS WAVCFTYGTW FGVLGLVAAG RNYKNSPSIR KACDFLLSKQ
660 670 680 690 700
LASGGWGESY LSCQNKVYTN IPGGRSHVVN TGWAMLALIG AGQAERDPVP
710 720 730 740 750
LHRAAKFLIE SQLENGDFPQ QEIMGVFNKN CMISYAAYRN IFPIWALGEY
760
RCKVLNASRG QMKT
Length:764
Mass (Da):86,531
Last modified:November 30, 2010 - v1
Checksum:i9A59D94C1072CF6A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HM623872 mRNA. Translation: ADK35127.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HM623872 mRNA. Translation: ADK35127.1 .

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 1.50.10.20. 2 hits.
InterProi IPR001330. Prenyltrans.
IPR018333. Squalene_cyclase.
IPR002365. Terpene_synthase_CS.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
[Graphical view ]
Pfami PF00432. Prenyltrans. 3 hits.
[Graphical view ]
SUPFAMi SSF48239. SSF48239. 2 hits.
TIGRFAMsi TIGR01787. squalene_cyclas. 1 hit.
PROSITEi PS01074. TERPENE_SYNTHASES. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and characterization of oxidosqualene cyclases from Kalanchoe daigremontiana: enzymes catalyzing up to 10 rearrangement steps yielding friedelin and other triterpenoids."
    Wang Z., Yeats T., Han H., Jetter R.
    J. Biol. Chem. 285:29703-29712(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, CATALYTIC ACTIVITY, TISSUE SPECIFICITY.

Entry informationi

Entry nameiCASS_KALDA
AccessioniPrimary (citable) accession number: E2IUB0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 5, 2012
Last sequence update: November 30, 2010
Last modified: October 1, 2014
This is version 13 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3