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E2IUB0

- CASS_KALDA

UniProt

E2IUB0 - CASS_KALDA

Protein

Cycloartenol synthase

Gene
N/A
Organism
Kalanchoe daigremontiana (Devil's backbone) (Bryophyllum daigremontianum)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 13 (01 Oct 2014)
      Sequence version 1 (30 Nov 2010)
      Previous versions | rss
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    Functioni

    Oxidosqualene cyclase which catalyzes the conversion of oxidosqualene to cycloartenol.1 Publication

    Catalytic activityi

    (3S)-2,3-epoxy-2,3-dihydrosqualene = cycloartenol.1 Publication

    GO - Molecular functioni

    1. cycloartenol synthase activity Source: UniProtKB

    GO - Biological processi

    1. metabolic process Source: UniProtKB
    2. steroid biosynthetic process Source: UniProtKB

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cycloartenol synthase (EC:5.4.99.8)
    Short name:
    KdCAS
    OrganismiKalanchoe daigremontiana (Devil's backbone) (Bryophyllum daigremontianum)
    Taxonomic identifieri23013 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeSaxifragalesCrassulaceaeKalanchoe

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 764764Cycloartenol synthasePRO_0000418479Add
    BLAST

    Expressioni

    Tissue specificityi

    Expressed in all leaf tissues.1 Publication

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei609 – 62921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati148 – 18942PFTB 1Add
    BLAST
    Repeati513 – 55846PFTB 2Add
    BLAST
    Repeati590 – 63041PFTB 3Add
    BLAST
    Repeati639 – 68042PFTB 4Add
    BLAST
    Repeati701 – 74242PFTB 5Add
    BLAST

    Sequence similaritiesi

    Belongs to the terpene cyclase/mutase family.Curated
    Contains 5 PFTB repeats.Curated

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Family and domain databases

    Gene3Di1.50.10.20. 2 hits.
    InterProiIPR001330. Prenyltrans.
    IPR018333. Squalene_cyclase.
    IPR002365. Terpene_synthase_CS.
    IPR008930. Terpenoid_cyclase/PrenylTrfase.
    [Graphical view]
    PfamiPF00432. Prenyltrans. 3 hits.
    [Graphical view]
    SUPFAMiSSF48239. SSF48239. 2 hits.
    TIGRFAMsiTIGR01787. squalene_cyclas. 1 hit.
    PROSITEiPS01074. TERPENE_SYNTHASES. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    E2IUB0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MWKLKIADAG GSQWLRSVNN HIGRQIWDFD PALGSPEELA QIEDARDNFA    50
    RHRFDKKHSA DLLMRFQLTK ENPQSDLLPK VNIGKIEDIT EDAVTNTLRR 100
    AINFHSTTQA HDGHWPGDYG GPLFLMPGLV ITLSITGALN AVLSKEHKKE 150
    MCRYLYNHQN EDGGWGLHIE GPSTMFGSVL NYVTLRLLGE DVNGGDGEIE 200
    RARKWILDHG GATAITSWGK MWLSVLGVFE WCGNNPLPPE MWLFPYYLPV 250
    HPGRMWCHCR MVYLPMSYLY GKRFVGPITP TVLSLRKELF TVPYHEIDWN 300
    EARSLCAKED LYYPHPVVQD ILWATLHKVV EPVLLNWPGK KLREKALCSA 350
    IEHIHYEDEN TRYICIGPVN KVLNMLCCWV EDPNSEAFKL HIPRLYDYLW 400
    IAEDGMKMQG YNGSQLWDTA FSVQAIVATK LVEEFSSTIS KAHEFMKNSQ 450
    VLEDYPGDLS YWYRHISKGA WPFSTADHGW PISDCTAEGL KVVLKLSQFP 500
    AELVGAPLSA KLVYNAVNVI LSLQNIDGGF ATYELTRSYS WMELLNPAET 550
    FGDIVIDYPY VECTSAALQS LVLFKKLHPE HRKEEVELCI KKAAAFIEKI 600
    QESDGSWYGS WAVCFTYGTW FGVLGLVAAG RNYKNSPSIR KACDFLLSKQ 650
    LASGGWGESY LSCQNKVYTN IPGGRSHVVN TGWAMLALIG AGQAERDPVP 700
    LHRAAKFLIE SQLENGDFPQ QEIMGVFNKN CMISYAAYRN IFPIWALGEY 750
    RCKVLNASRG QMKT 764
    Length:764
    Mass (Da):86,531
    Last modified:November 30, 2010 - v1
    Checksum:i9A59D94C1072CF6A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    HM623872 mRNA. Translation: ADK35127.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    HM623872 mRNA. Translation: ADK35127.1 .

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 1.50.10.20. 2 hits.
    InterProi IPR001330. Prenyltrans.
    IPR018333. Squalene_cyclase.
    IPR002365. Terpene_synthase_CS.
    IPR008930. Terpenoid_cyclase/PrenylTrfase.
    [Graphical view ]
    Pfami PF00432. Prenyltrans. 3 hits.
    [Graphical view ]
    SUPFAMi SSF48239. SSF48239. 2 hits.
    TIGRFAMsi TIGR01787. squalene_cyclas. 1 hit.
    PROSITEi PS01074. TERPENE_SYNTHASES. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of oxidosqualene cyclases from Kalanchoe daigremontiana: enzymes catalyzing up to 10 rearrangement steps yielding friedelin and other triterpenoids."
      Wang Z., Yeats T., Han H., Jetter R.
      J. Biol. Chem. 285:29703-29712(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, CATALYTIC ACTIVITY, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiCASS_KALDA
    AccessioniPrimary (citable) accession number: E2IUB0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 5, 2012
    Last sequence update: November 30, 2010
    Last modified: October 1, 2014
    This is version 13 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3