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E2IUA6

- TARS_KALDA

UniProt

E2IUA6 - TARS_KALDA

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Protein
Taraxerol synthase
Gene
N/A
Organism
Kalanchoe daigremontiana (Devil's backbone) (Bryophyllum daigremontianum)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Oxidosqualene cyclase that generates taraxerol, a triterpenoid product. Taraxerol is probably required to coat the leaf exterior as a defense compound against pathogens or herbivores.1 Publication

Catalytic activityi

(3S)-2,3-epoxy-2,3-dihydrosqualene = taraxerol.1 Publication

GO - Molecular functioni

  1. intramolecular transferase activity Source: UniProtKB

GO - Biological processi

  1. triterpenoid biosynthetic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-17976.

Names & Taxonomyi

Protein namesi
Recommended name:
Taraxerol synthase (EC:5.4.99.35)
Short name:
KdTAS
OrganismiKalanchoe daigremontiana (Devil's backbone) (Bryophyllum daigremontianum)
Taxonomic identifieri23013 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeSaxifragalesCrassulaceaeKalanchoe

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 779779Taraxerol synthase
PRO_0000418480Add
BLAST

Expressioni

Tissue specificityi

Expressed only in the epidermal cells on both sides of the leaf and not in internal leaf tissues.1 Publication

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati167 – 20842PFTB 1
Add
BLAST
Repeati659 – 70042PFTB 2
Add
BLAST

Sequence similaritiesi

Contains 2 PFTB repeats.

Keywords - Domaini

Repeat

Family and domain databases

Gene3Di1.50.10.20. 2 hits.
InterProiIPR001330. Prenyltrans.
IPR018333. Squalene_cyclase.
IPR002365. Terpene_synthase_CS.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
[Graphical view]
PfamiPF00432. Prenyltrans. 1 hit.
[Graphical view]
SUPFAMiSSF48239. SSF48239. 2 hits.
TIGRFAMsiTIGR01787. squalene_cyclas. 1 hit.
PROSITEiPS01074. TERPENE_SYNTHASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E2IUA6-1 [UniParc]FASTAAdd to Basket

« Hide

MSFVWVEESK ECSEQRKGSM WKLKIAQGGK DPYLYSTNNY VGRQTWEFDP    50
EAGTPEERAE VEAARLNFYN NRYRVKPSAD LLYRMQFLKE KNFKQTIPPV 100
KVEDGEEITY ETATTALKRA VHFYSALQAS DGHWPAENSG PLFFLPPLVM 150
CLYITGHLNT VFPAEHQREI LRYIYYHQNE DGGWGLHIEG HSTMFCTALS 200
YICMRILGEG PDGGLDNAVA RGRKWILDHG TVTAMPSWGK TWLSIMGLFD 250
WSGSNPMPPE FWLLPSFLPM YPAKMWCYCR MVYMPMSYLY GKRFVGPITP 300
LILQLREELY DQPYEQVNWK QVRHECAKED IYYPHPKIQD LLWDTLYIAI 350
EPLLTRWPFN KLVRERALQR TMKHIHYEDE NSRYITIGCV EKVLCMLACW 400
VEDPNGDYFK KHLARVPDYI WVAEDGMKMQ SFGSQQWDTG FAIQALLASN 450
MSDEIGETLA KGHDFVKKSQ VKDNPSGDFK SMHRHISKGS WTFSDQDHGW 500
QVSDCTAEGL KCCLLFSLMP PELVGEKMEP ERLYDSVNIL LSLQSKNGGL 550
AAWEPAGAPE WLELLNPTEF FADIVIEHEY VECTASAIQA LVLFKKLYPG 600
HRKKDIETFI KGAAQYIEDR QMPDGSWYGS WGVCFTYGTW FALGGLAAAG 650
KNYDNCAAIR KGTEFLLNTQ CENGGWGESY RSCPEKRYVP LEENKSNLVH 700
TAWALMGLIH SRQAERDITP LHRAAKLLIN SQLENGDFPQ QEITGVFMKN 750
CMQHYAAYRN IYPLWGIAEY RKQIPLPLR 779
Length:779
Mass (Da):89,734
Last modified:November 30, 2010 - v1
Checksum:i54BFFFCCDD7D7BD5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
HM623868 mRNA. Translation: ADK35123.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
HM623868 mRNA. Translation: ADK35123.1 .

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

BioCyci MetaCyc:MONOMER-17976.

Family and domain databases

Gene3Di 1.50.10.20. 2 hits.
InterProi IPR001330. Prenyltrans.
IPR018333. Squalene_cyclase.
IPR002365. Terpene_synthase_CS.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
[Graphical view ]
Pfami PF00432. Prenyltrans. 1 hit.
[Graphical view ]
SUPFAMi SSF48239. SSF48239. 2 hits.
TIGRFAMsi TIGR01787. squalene_cyclas. 1 hit.
PROSITEi PS01074. TERPENE_SYNTHASES. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and characterization of oxidosqualene cyclases from Kalanchoe daigremontiana: enzymes catalyzing up to 10 rearrangement steps yielding friedelin and other triterpenoids."
    Wang Z., Yeats T., Han H., Jetter R.
    J. Biol. Chem. 285:29703-29712(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, CATALYTIC ACTIVITY, TISSUE SPECIFICITY.

Entry informationi

Entry nameiTARS_KALDA
AccessioniPrimary (citable) accession number: E2IUA6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 5, 2012
Last sequence update: November 30, 2010
Last modified: April 16, 2014
This is version 14 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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