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E2IUA6

- TARS_KALDA

UniProt

E2IUA6 - TARS_KALDA

Protein

Taraxerol synthase

Gene
N/A
Organism
Kalanchoe daigremontiana (Devil's backbone) (Bryophyllum daigremontianum)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 15 (01 Oct 2014)
      Sequence version 1 (30 Nov 2010)
      Previous versions | rss
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    Functioni

    Oxidosqualene cyclase that generates taraxerol, a triterpenoid product. Taraxerol is probably required to coat the leaf exterior as a defense compound against pathogens or herbivores.1 Publication

    Catalytic activityi

    (3S)-2,3-epoxy-2,3-dihydrosqualene = taraxerol.1 Publication

    GO - Molecular functioni

    1. intramolecular transferase activity Source: UniProtKB

    GO - Biological processi

    1. triterpenoid biosynthetic process Source: UniProtKB

    Keywords - Molecular functioni

    Isomerase

    Enzyme and pathway databases

    BioCyciMetaCyc:MONOMER-17976.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Taraxerol synthase (EC:5.4.99.35)
    Short name:
    KdTAS
    OrganismiKalanchoe daigremontiana (Devil's backbone) (Bryophyllum daigremontianum)
    Taxonomic identifieri23013 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeSaxifragalesCrassulaceaeKalanchoe

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 779779Taraxerol synthasePRO_0000418480Add
    BLAST

    Expressioni

    Tissue specificityi

    Expressed only in the epidermal cells on both sides of the leaf and not in internal leaf tissues.1 Publication

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati167 – 20842PFTB 1Add
    BLAST
    Repeati659 – 70042PFTB 2Add
    BLAST

    Sequence similaritiesi

    Belongs to the terpene cyclase/mutase family.Curated
    Contains 2 PFTB repeats.Curated

    Keywords - Domaini

    Repeat

    Family and domain databases

    Gene3Di1.50.10.20. 2 hits.
    InterProiIPR001330. Prenyltrans.
    IPR018333. Squalene_cyclase.
    IPR002365. Terpene_synthase_CS.
    IPR008930. Terpenoid_cyclase/PrenylTrfase.
    [Graphical view]
    PfamiPF00432. Prenyltrans. 1 hit.
    [Graphical view]
    SUPFAMiSSF48239. SSF48239. 2 hits.
    TIGRFAMsiTIGR01787. squalene_cyclas. 1 hit.
    PROSITEiPS01074. TERPENE_SYNTHASES. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    E2IUA6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSFVWVEESK ECSEQRKGSM WKLKIAQGGK DPYLYSTNNY VGRQTWEFDP    50
    EAGTPEERAE VEAARLNFYN NRYRVKPSAD LLYRMQFLKE KNFKQTIPPV 100
    KVEDGEEITY ETATTALKRA VHFYSALQAS DGHWPAENSG PLFFLPPLVM 150
    CLYITGHLNT VFPAEHQREI LRYIYYHQNE DGGWGLHIEG HSTMFCTALS 200
    YICMRILGEG PDGGLDNAVA RGRKWILDHG TVTAMPSWGK TWLSIMGLFD 250
    WSGSNPMPPE FWLLPSFLPM YPAKMWCYCR MVYMPMSYLY GKRFVGPITP 300
    LILQLREELY DQPYEQVNWK QVRHECAKED IYYPHPKIQD LLWDTLYIAI 350
    EPLLTRWPFN KLVRERALQR TMKHIHYEDE NSRYITIGCV EKVLCMLACW 400
    VEDPNGDYFK KHLARVPDYI WVAEDGMKMQ SFGSQQWDTG FAIQALLASN 450
    MSDEIGETLA KGHDFVKKSQ VKDNPSGDFK SMHRHISKGS WTFSDQDHGW 500
    QVSDCTAEGL KCCLLFSLMP PELVGEKMEP ERLYDSVNIL LSLQSKNGGL 550
    AAWEPAGAPE WLELLNPTEF FADIVIEHEY VECTASAIQA LVLFKKLYPG 600
    HRKKDIETFI KGAAQYIEDR QMPDGSWYGS WGVCFTYGTW FALGGLAAAG 650
    KNYDNCAAIR KGTEFLLNTQ CENGGWGESY RSCPEKRYVP LEENKSNLVH 700
    TAWALMGLIH SRQAERDITP LHRAAKLLIN SQLENGDFPQ QEITGVFMKN 750
    CMQHYAAYRN IYPLWGIAEY RKQIPLPLR 779
    Length:779
    Mass (Da):89,734
    Last modified:November 30, 2010 - v1
    Checksum:i54BFFFCCDD7D7BD5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    HM623868 mRNA. Translation: ADK35123.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    HM623868 mRNA. Translation: ADK35123.1 .

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    BioCyci MetaCyc:MONOMER-17976.

    Family and domain databases

    Gene3Di 1.50.10.20. 2 hits.
    InterProi IPR001330. Prenyltrans.
    IPR018333. Squalene_cyclase.
    IPR002365. Terpene_synthase_CS.
    IPR008930. Terpenoid_cyclase/PrenylTrfase.
    [Graphical view ]
    Pfami PF00432. Prenyltrans. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48239. SSF48239. 2 hits.
    TIGRFAMsi TIGR01787. squalene_cyclas. 1 hit.
    PROSITEi PS01074. TERPENE_SYNTHASES. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of oxidosqualene cyclases from Kalanchoe daigremontiana: enzymes catalyzing up to 10 rearrangement steps yielding friedelin and other triterpenoids."
      Wang Z., Yeats T., Han H., Jetter R.
      J. Biol. Chem. 285:29703-29712(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, CATALYTIC ACTIVITY, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiTARS_KALDA
    AccessioniPrimary (citable) accession number: E2IUA6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 5, 2012
    Last sequence update: November 30, 2010
    Last modified: October 1, 2014
    This is version 15 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3