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Protein
Submitted name:

T-cell factor-4 variant L

Gene

TCF7L2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi355 – 423HMG boxPROSITE-ProRule annotationAdd BLAST69

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingPROSITE-ProRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
T-cell factor-4 variant LImported
Submitted name:
Transcription factor 7-like 2Imported
Gene namesi
Name:TCF7L2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000148737.15
HGNCiHGNC:11641 TCF7L2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusPROSITE-ProRule annotation

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000148737

PTM / Processingi

Proteomic databases

PeptideAtlasiE2GH26

Expressioni

Gene expression databases

BgeeiENSG00000148737
ExpressionAtlasiE2GH26 baseline and differential

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

SMRiE2GH26
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini355 – 423HMG boxInterPro annotationAdd BLAST69

Phylogenomic databases

eggNOGiKOG3248 Eukaryota
ENOG41109RU LUCA
GeneTreeiENSGT00390000009964

Family and domain databases

Gene3Di1.10.30.10, 1 hit
4.10.900.10, 1 hit
InterProiView protein in InterPro
IPR027397 Catenin_binding_dom_sf
IPR013558 CTNNB1-bd_N
IPR009071 HMG_box_dom
IPR036910 HMG_box_dom_sf
IPR024940 TCF/LEF
IPR028773 TCF7L
PANTHERiPTHR10373 PTHR10373, 1 hit
PTHR10373:SF25 PTHR10373:SF25, 1 hit
PfamiView protein in Pfam
PF08347 CTNNB1_binding, 1 hit
PF00505 HMG_box, 1 hit
SMARTiView protein in SMART
SM00398 HMG, 1 hit
SUPFAMiSSF47095 SSF47095, 1 hit
PROSITEiView protein in PROSITE
PS50118 HMG_BOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

E2GH26-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPQLNGGGGD DLGANDELIS FKDEGEQEEK SSENSSAERD LADVKSSLVN
60 70 80 90 100
ESETNQNSSS DSEAERRPPP RSESFRDKSR ESLEEAAKRQ DGGLFKGPPY
110 120 130 140 150
PGYPFIMIPD LTSPYLPNGS LSPTARTLHF QSGSTHYSAY KTIEHQIAVQ
160 170 180 190 200
YLQMKWPLLD VQAGSLQSRQ ALKDARSPSP AHIVSNKVPV VQHPHHVHPL
210 220 230 240 250
TPLITYSNEH FTPGNPPPHL PADVDPKTGI PRPPHPPDIS PYYPLSPGTV
260 270 280 290 300
GQIPHPLGWL VPQQGQPVYP ITTGGFRHPY PTALTVNASM SSFLSSRFPP
310 320 330 340 350
HMVPPHHTLH TTGIPHPAIV TPTVKQESSQ SDVGSLHSSK HQDSKKEEEK
360 370 380 390 400
KKPHIKKPLN AFMLYMKEMR AKVVAECTLK ESAAINQILG RRWHALSREE
410 420 430 440 450
QAKYYELARK ERQLHMQLYP GWSARDNYGK KKKRKRDKQP GETNDANTPK
460 470 480 490 500
KCRALFGLDR QTLWCKPCRR KKKCVRYIQG EGSCLSPPSS DGSLLDSPPP
510 520 530 540 550
SPNLLGSPPR DAKSQTEQTQ PLSLSLKPDP LAHLSMMPPP PALLLAEATH
560 570 580 590 600
KASALCPNGA LDLPPAALQP AAPSSSIAQP STSSLHSHSS LAGTQPQPLS

LVTKSLE
Length:607
Mass (Da):66,615
Last modified:November 30, 2010 - v1
Checksum:iBB9849F75D6A9FAC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL135792 Genomic DNA No translation available.
AL158212 Genomic DNA No translation available.
AL445486 Genomic DNA No translation available.
AL451084 Genomic DNA No translation available.
HM352851 mRNA Translation: ADK35186.1
RefSeqiXP_005270142.1, XM_005270085.1
UniGeneiHs.593995

Genome annotation databases

EnsembliENST00000543371; ENSP00000444972; ENSG00000148737
GeneIDi6934
UCSCiuc021pyn.2 human

Similar proteinsi

Entry informationi

Entry nameiE2GH26_HUMAN
AccessioniPrimary (citable) accession number: E2GH26
Entry historyiIntegrated into UniProtKB/TrEMBL: November 30, 2010
Last sequence update: November 30, 2010
Last modified: May 23, 2018
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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