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Protein
Submitted name:

T-cell factor-4 variant L

Gene

TCF7L2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi355 – 423HMG boxPROSITE-ProRule annotationAdd BLAST69

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingPROSITE-ProRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
T-cell factor-4 variant LImported
Submitted name:
Transcription factor 7-like 2Imported
Gene namesi
Name:TCF7L2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:11641. TCF7L2.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

NucleusPROSITE-ProRule annotation

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000148737.

Expressioni

Gene expression databases

BgeeiENSG00000148737.
ExpressionAtlasiE2GH26. baseline and differential.

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

SMRiE2GH26.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini355 – 423HMG box DNA-bindingInterPro annotationAdd BLAST69

Phylogenomic databases

eggNOGiKOG3248. Eukaryota.
ENOG41109RU. LUCA.
GeneTreeiENSGT00390000009964.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
4.10.900.10. 1 hit.
InterProiView protein in InterPro
IPR027397. Catenin_binding_dom.
IPR013558. CTNNB1-bd_N.
IPR009071. HMG_box_dom.
IPR024940. TCF/LEF.
IPR028773. TCF7L2.
PANTHERiPTHR10373. PTHR10373. 1 hit.
PTHR10373:SF44. PTHR10373:SF44. 1 hit.
PfamiView protein in Pfam
PF08347. CTNNB1_binding. 1 hit.
PF00505. HMG_box. 1 hit.
SMARTiView protein in SMART
SM00398. HMG. 1 hit.
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiView protein in PROSITE
PS50118. HMG_BOX_2. 1 hit.

Sequencei

Sequence statusi: Complete.

E2GH26-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPQLNGGGGD DLGANDELIS FKDEGEQEEK SSENSSAERD LADVKSSLVN
60 70 80 90 100
ESETNQNSSS DSEAERRPPP RSESFRDKSR ESLEEAAKRQ DGGLFKGPPY
110 120 130 140 150
PGYPFIMIPD LTSPYLPNGS LSPTARTLHF QSGSTHYSAY KTIEHQIAVQ
160 170 180 190 200
YLQMKWPLLD VQAGSLQSRQ ALKDARSPSP AHIVSNKVPV VQHPHHVHPL
210 220 230 240 250
TPLITYSNEH FTPGNPPPHL PADVDPKTGI PRPPHPPDIS PYYPLSPGTV
260 270 280 290 300
GQIPHPLGWL VPQQGQPVYP ITTGGFRHPY PTALTVNASM SSFLSSRFPP
310 320 330 340 350
HMVPPHHTLH TTGIPHPAIV TPTVKQESSQ SDVGSLHSSK HQDSKKEEEK
360 370 380 390 400
KKPHIKKPLN AFMLYMKEMR AKVVAECTLK ESAAINQILG RRWHALSREE
410 420 430 440 450
QAKYYELARK ERQLHMQLYP GWSARDNYGK KKKRKRDKQP GETNDANTPK
460 470 480 490 500
KCRALFGLDR QTLWCKPCRR KKKCVRYIQG EGSCLSPPSS DGSLLDSPPP
510 520 530 540 550
SPNLLGSPPR DAKSQTEQTQ PLSLSLKPDP LAHLSMMPPP PALLLAEATH
560 570 580 590 600
KASALCPNGA LDLPPAALQP AAPSSSIAQP STSSLHSHSS LAGTQPQPLS

LVTKSLE
Length:607
Mass (Da):66,615
Last modified:November 30, 2010 - v1
Checksum:iBB9849F75D6A9FAC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL135792 Genomic DNA. No translation available.
AL158212 Genomic DNA. No translation available.
AL445486 Genomic DNA. No translation available.
AL451084 Genomic DNA. No translation available.
HM352851 mRNA. Translation: ADK35186.1.
RefSeqiXP_005270142.1. XM_005270085.1.
UniGeneiHs.593995.

Genome annotation databases

EnsembliENST00000543371; ENSP00000444972; ENSG00000148737.
GeneIDi6934.
UCSCiuc021pyn.2. human.

Similar proteinsi

Entry informationi

Entry nameiE2GH26_HUMAN
AccessioniPrimary (citable) accession number: E2GH26
Entry historyiIntegrated into UniProtKB/TrEMBL: November 30, 2010
Last sequence update: November 30, 2010
Last modified: July 5, 2017
This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported