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Protein

Conotoxin Vc1.3

Gene
N/A
Organism
Conus victoriae (Queen Victoria cone)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May act as a toxin.By similarity

Miscellaneous

Does not show activity on alpha-3/beta-2 (CHRNA3/CHRNB2), alpha-7 (CHRNA7), alpha-9/alpha-10 (CHRNA9/CHRNA10), alpha-3/beta-4 (CHRNA3/CHRNB4), alpha-4/beta-2 (CHRNA4/CHRNB2) and alpha-4/beta-4 (CHRNA4/CHRNB4) acetylcholine receptors. Does not show inhibition on high-voltage activated (HVA) calcium channels currents that are mediated by GABA-B receptors.1 Publication

GO - Molecular functioni

Keywordsi

Molecular functionToxin

Names & Taxonomyi

Protein namesi
Recommended name:
Conotoxin Vc1.3
OrganismiConus victoriae (Queen Victoria cone)
Taxonomic identifieri319920 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaHypsogastropodaNeogastropodaConoideaConidaeConus

Organism-specific databases

ConoServeri4201. Vc1.3 precursor.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
PropeptideiPRO_000042516122 – 43By similarityAdd BLAST22
PeptideiPRO_000042516245 – 60Conotoxin Vc1.3Add BLAST16

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi46 ↔ 52By similarity
Disulfide bondi47 ↔ 60By similarity
Modified residuei60Cysteine amideBy similarity1

Keywords - PTMi

Amidation, Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom duct.

Developmental stagei

Mostly expressed in embryos. Also slightly expressed in adults, but the toxin is not found in adult venom.1 Publication

Family & Domainsi

Domaini

The cysteine framework is I (CC-C-C). Alpha4/7 pattern.

Sequence similaritiesi

Belongs to the conotoxin A superfamily.Curated

Keywords - Domaini

Signal

Family and domain databases

InterProiView protein in InterPro
IPR009958. Conotoxin_a-typ.
PfamiView protein in Pfam
PF07365. Toxin_8. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

E2DIH6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGMRMMFTVF LLVVLATTVV SFTSDRASDG RKAAASDLIT LTIKGCCSDP
60
PCIANNPDLC GRRR
Length:64
Mass (Da):6,896
Last modified:November 30, 2010 - v1
Checksum:iF633B76797CF432E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GU046309 mRNA. Translation: ADC80510.1.

Similar proteinsi

Entry informationi

Entry nameiCA13_CONVC
AccessioniPrimary (citable) accession number: E2DIH6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 22, 2014
Last sequence update: November 30, 2010
Last modified: November 22, 2017
This is version 19 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families