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Protein

Odorant receptor coreceptor

Gene

Orco

Organism
Harpegnathos saltator (Jerdon's jumping ant)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Odorant coreceptor which complexes with conventional odorant receptors (ORs) to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability (By similarity). Obligate coreceptor of all odorant receptors (By similarity). Orco is a universal and integral part of the functional odorant receptor, involved in the dendritic localization of other olfactory receptors. Can form functional ion channels in the absence of an odor-binding odorant receptor (By similarity). Plays a central role in the perception of olfactory stimuli in ants and is essential for ant social organization (PubMed:28802043). Required for pheromone sensing and mating behavior (PubMed:28802043). Also required for the development and maintenance of odorant receptor neurons (ORNs) and of antennal lobe glomeruli (PubMed:28802043).By similarity1 Publication

Miscellaneous

In contrast to most eusocial ant species, where only the queen can transmit genetic information, workers in H.saltator ants can be converted into gamergates (pseudoqueens) that can found entire colonies, facilitating genetic studies (PubMed:28802043).1 Publication

GO - Molecular functioni

  • odorant binding Source: InterPro
  • olfactory receptor activity Source: UniProtKB

GO - Biological processi

  • antennal development Source: UniProtKB
  • detection of chemical stimulus involved in sensory perception of smell Source: UniProtKB
  • detection of pheromone Source: UniProtKB
  • mating behavior Source: UniProtKB
  • olfactory behavior Source: UniProtKB
  • response to pheromone Source: UniProtKB
  • social behavior Source: UniProtKB

Keywordsi

Molecular functionReceptor, Transducer
Biological processBehavior, Olfaction, Sensory transduction

Names & Taxonomyi

Protein namesi
Recommended name:
Odorant receptor coreceptor1 Publication
Gene namesi
Name:Orco1 Publication
ORF Names:EAI_09968Imported
OrganismiHarpegnathos saltator (Jerdon's jumping ant)
Taxonomic identifieri610380 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaHymenopteraApocritaAculeataVespoideaFormicidaePonerinaePoneriniHarpegnathos
Proteomesi
  • UP000008237 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 43Cytoplasmic1 PublicationAdd BLAST43
Transmembranei44 – 64Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini65 – 73Extracellular1 Publication9
Transmembranei74 – 94Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini95 – 133Cytoplasmic1 PublicationAdd BLAST39
Transmembranei134 – 154Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini155 – 190ExtracellularCuratedAdd BLAST36
Transmembranei191 – 211Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini212 – 350Cytoplasmic1 PublicationAdd BLAST139
Transmembranei351 – 371Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini372 – 383ExtracellularCuratedAdd BLAST12
Transmembranei384 – 404Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini405 – 455Cytoplasmic1 PublicationAdd BLAST51
Transmembranei456 – 476Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini477 – 479Extracellular1 Publication3

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Impaired behavior and decreased reproductive performance, probably due to loss of pheromone sensing. Ants show strongly decreased sensitivity to various pure semiochemicals delivered in puffs of air, and display increased levels of wandering outside of the nest. In a solitary environment, homozygous mutants also display an abnormal antennal twitching behavior: they quickly move their antennae, similar to the quick antennal movement observed during dueling among workers in the transition to gamergates. Mating and reproduction are impaired: worker dueling and the transition to gamergates in the absence of a reproductive queen or gamergates. Ants also display gross neuroanatomical defects in the antennal lobe, with a dramatic decrease in the number of odorant receptor neurons and antennal lobe glomeruli.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004420021 – 479Odorant receptor coreceptorAdd BLAST479

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi167N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1

Keywords - PTMi

Glycoprotein

Interactioni

Subunit structurei

Heterodimer with conventional odorant receptors (ORs).By similarity

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiE2BJ30.
KOiK08471.
OMAiQIYYVLF.

Family and domain databases

InterProiView protein in InterPro
IPR004117. 7tm6_olfct_rcpt.
PANTHERiPTHR21137. PTHR21137. 1 hit.
PfamiView protein in Pfam
PF02949. 7tm_6. 1 hit.

Sequencei

Sequence statusi: Complete.

E2BJ30-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMKMKQQGLV ADLLPNIRVM KFFGHFVFNY YDDNSSKYLH KIFCCVNLFL
60 70 80 90 100
LLLQFALCAV NLIIESADVD DLTANTITLL FFTHSIVKII YFAVRSKYFY
110 120 130 140 150
RTWAIWNNPN SHPLFAESNA RYHAIALKKM RLLLFLVGAT TVLSAIAWTV
160 170 180 190 200
LTFFEHPIRK LVDPVTNETT IIELPQLLLR SYYPFDASKG IMHVIVLIYQ
210 220 230 240 250
FYWVLFMLID ANSLDVLFCS WLLFACEQLQ HLKQIMKPLM ELSATLDTVV
260 270 280 290 300
PNSSELFKAG SAEHLRESEN QPPPPVPPQG DSMLDLDLRN IYSNRQDFTA
310 320 330 340 350
TFRPTAGMTF NGGVGPNGLT KKQEMLVRSA IKYWVERHKH IVRLVTAVGD
360 370 380 390 400
AYGFALLLHM LTTTITLTLL AYQATKVNGV NVYAASTIGY IIYTFGQVFL
410 420 430 440 450
FCIFGNRLIE ESTSVMEAAY SCHWYDGSEE AKTFVQIVCQ QCQKAMSISG
460 470
AKFFTVSLDL FASVLGAVVT YFMVLVQLK
Length:479
Mass (Da):54,426
Last modified:November 30, 2010 - v1
Checksum:i8964D26B6FE1DB5A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GL448558 Genomic DNA. Translation: EFN84180.1.
RefSeqiXP_011139767.1. XM_011141465.2.

Genome annotation databases

GeneIDi105183395.
KEGGihst:105183395.

Similar proteinsi

Entry informationi

Entry nameiORCO_HARSA
AccessioniPrimary (citable) accession number: E2BJ30
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2017
Last sequence update: November 30, 2010
Last modified: October 25, 2017
This is version 29 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families