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Protein

Voltage-dependent L-type calcium channel subunit alpha

Gene

EAG_10276

Organism
Camponotus floridanus (Florida carpenter ant)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein inferred from homologyi

Functioni

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1C gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing the alpha-1C subunit play an important role in excitation-contraction coupling in the heart. Binding of calmodulin or CABP1 at the same regulatory sites results in an opposit effects on the channel function.UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionCalcium channelUniRule annotation, Ion channel, Voltage-gated channelUniRule annotation
Biological processCalcium transport, Ion transport, Transport
LigandCalcium

Names & Taxonomyi

Protein namesi
Recommended name:
Voltage-dependent L-type calcium channel subunit alphaUniRule annotation
Gene namesi
ORF Names:EAG_10276Imported
OrganismiCamponotus floridanus (Florida carpenter ant)Imported
Taxonomic identifieri104421 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaHymenopteraApocritaAculeataVespoideaFormicidaeFormicinaeCamponotus
Proteomesi
  • UP000000311 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei7 – 25HelicalSequence analysisAdd BLAST19
Transmembranei45 – 66HelicalSequence analysisAdd BLAST22
Transmembranei78 – 97HelicalSequence analysisAdd BLAST20
Transmembranei138 – 160HelicalSequence analysisAdd BLAST23
Transmembranei217 – 238HelicalSequence analysisAdd BLAST22
Transmembranei250 – 272HelicalSequence analysisAdd BLAST23
Transmembranei379 – 400HelicalSequence analysisAdd BLAST22
Transmembranei412 – 430HelicalSequence analysisAdd BLAST19
Transmembranei494 – 527HelicalSequence analysisAdd BLAST34
Transmembranei581 – 608HelicalSequence analysisAdd BLAST28
Transmembranei810 – 831HelicalSequence analysisAdd BLAST22
Transmembranei843 – 869HelicalSequence analysisAdd BLAST27
Transmembranei890 – 923HelicalSequence analysisAdd BLAST34

Keywords - Cellular componenti

Membrane

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 283Ion_transInterPro annotationAdd BLAST279
Domaini378 – 616Ion_transInterPro annotationAdd BLAST239
Domaini771 – 924Ion_transInterPro annotationAdd BLAST154

Sequence similaritiesi

Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

InParanoidiE2ARS8.
OMAiHNITDEI.

Family and domain databases

InterProiView protein in InterPro
IPR005821. Ion_trans_dom.
IPR005446. VDCC_L_a1su.
IPR002077. VDCCAlpha1.
PfamiView protein in Pfam
PF00520. Ion_trans. 3 hits.
PRINTSiPR00167. CACHANNEL.
PR01630. LVDCCALPHA1.

Sequencei

Sequence statusi: Complete.

E2ARS8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLRRPFEWL ILMTIFANCV ALAVYTPYPF GDSNLTNQYL EKIEYVFLVI
60 70 80 90 100
FTVECVMKII AYGFVAHPGA YLRNGWNLLD FTIVVIGMIS TVLMMLMKEG
110 120 130 140 150
FDVKALRAFR VLRPLRLVSG VPSLQVVLNS ILRAMVPLLH IALLVLFVII
160 170 180 190 200
IYAIIGLELF SGKLHKTCRH NITDEIMDNP VPCGEMGYQC SNIGPEYYCS
210 220 230 240 250
KQFWEGPNYG ITNFDNFGLA MLTVFQCVTL EGWTDVLYNI EDAMGSSWQW
260 270 280 290 300
IYFISMVILG AFFVMNLILG VLSGEFSKER EKAKARGDFH KLREKQQIED
310 320 330 340 350
DLRGYLDWIT QAEDIEPEID ESKQDGKTKQ QNEIESTDQL EGDEEGIQQE
360 370 380 390 400
SVWKKKKRDL ERVNRRMRRA CRKAVKSQVF YWLIIVLVFL NTGVLATEHY
410 420 430 440 450
DQPHWLDEFQ EITNMFFIVL FSMEMMLKMY SLGFQGYFVS LFNRFDCFVV
460 470 480 490 500
IGSITEMILT NTRVMPPLGI SVLRCVRLLR VFKVTKYWRS LSNLVASLLN
510 520 530 540 550
SIQSIASLLL LLFLFIVIFA LLGMQVFGGK FNFSESEEKT RHNFDSFWQS
560 570 580 590 600
LLTVFQILTG EDWNVVMYVG IQAYGGVASI GVLACVYFII LFICGNYILL
610 620 630 640 650
NVFLAIAVDN LADAESLTAI EKEAEEEAEK NKSRSGSPAR DEVSGEAGDD
660 670 680 690 700
GGEGTGGEDE GAGTDLEQDP NETMEDYEAA LDTETSEKSD DMNTHKVRLN
710 720 730 740 750
IESDEEMEED EEKEGDDQDM QDDGQEISAR PRRMSEYNMA TKKEPIPAGS
760 770 780 790 800
AFFIFSSTNR FRIFCHWFCN HSYFSNVILV CIMISSAMLA AEDPLSASAE
810 820 830 840 850
RNRILNYFDY FFTTVFTIEI CLKMISYGFI IHEGAFCRSA FNLLDLLVVC
860 870 880 890 900
ASLVSMSVST GAFSFIKVLR VLRVLRPLRA INRAKGLKHV VQCVIVAVKT
910 920 930 940
IGNIVLVTSL LQFVFAVIGV QLFKVGLSGP DTPTRPQKSS PPNLL
Length:945
Mass (Da):107,168
Last modified:November 30, 2010 - v1
Checksum:i61190F2BA6042BA0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GL442170 Genomic DNA. Translation: EFN63846.1.

Similar proteinsi

Entry informationi

Entry nameiE2ARS8_CAMFO
AccessioniPrimary (citable) accession number: E2ARS8
Entry historyiIntegrated into UniProtKB/TrEMBL: November 30, 2010
Last sequence update: November 30, 2010
Last modified: September 27, 2017
This is version 29 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported