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Protein
Submitted name:

Sialidase B (Neuraminidase B)

Gene

nanB

Organism
Streptococcus pneumoniae serotype 1 (strain INV104)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

  1. exo-alpha-(2->3)-sialidase activity Source: UniProtKB-EC
  2. exo-alpha-(2->6)-sialidase activity Source: UniProtKB-EC
  3. exo-alpha-(2->8)-sialidase activity Source: UniProtKB-EC

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

GlycosidaseImported, Hydrolase

Enzyme and pathway databases

BioCyciSPNE869269:GLL8-1444-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Sialidase B (Neuraminidase B)Imported (EC:3.2.1.18Imported)
Gene namesi
Name:nanBImported
Ordered Locus Names:INV104_14370Imported
OrganismiStreptococcus pneumoniae serotype 1 (strain INV104)Imported
Taxonomic identifieri869269 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000008966: Chromosome

Structurei

3D structure databases

ProteinModelPortaliE1XSK8.
SMRiE1XSK8. Positions 39-696.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

KOiK01186.
OMAiWRYHYDI.

Family and domain databases

Gene3Di2.120.10.10. 2 hits.
2.40.220.10. 1 hit.
2.60.120.200. 1 hit.
InterProiIPR002860. BNR_rpt.
IPR013320. ConA-like_dom.
IPR004124. Glyco_hydro_33_N.
IPR011040. Sialidases.
IPR023364. Trans_sialidase_dom3.
[Graphical view]
PfamiPF02012. BNR. 1 hit.
PF02973. Sialidase. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
SSF50939. SSF50939. 2 hits.

Sequencei

Sequence statusi: Complete.

E1XSK8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNKRGLYSKL GISVVGISLL MGVPTLIHAN ELNYGQLSIS PIFQGGSYQL
60 70 80 90 100
NNKSIDISSL LLDKLSGESQ TVVMKFKADK PNSLQALFGL SNSKAGFKNN
110 120 130 140 150
YFSIFMRDSG EIGVEIRDAQ KGINYLFSRP ASLWGKHKGQ AVENTLVFVS
160 170 180 190 200
DSKDKTYTMY VNGIEVFSET VDTFLPISNI NGIDKATLGA VNREGKEHYL
210 220 230 240 250
AKGSIDEISL FNKAISDQEV STIPLSNPFQ LIFQSGDSTQ ANYFRIPTLY
260 270 280 290 300
TLSSGRVLSS IDARYGGTHD SKSKINIATS YSDDNGKTWS EPIFAMKFND
310 320 330 340 350
YEEQLVYWPR DNKLKNSQIS GSASFIDSSI VEDKKSGKTI LLADVMPAGI
360 370 380 390 400
GNNNANKADS GFKEINGHYY LKLKKNGDND FRYTVRENGV VYNETTNKPT
410 420 430 440 450
NYTINDKYEV LEGGKSLTVE QYSVDFDSGS LRERHNGKQV PMNVFYKDSL
460 470 480 490 500
FKVTPTNYIA MTTSQNRGES WEQFKLLPPF LGEKHNGTYL CPGQGLALKS
510 520 530 540 550
SNRLIFATYT SGELTYLISD DSGQTWKKSS ASIPFKNATA EAQMVELRDG
560 570 580 590 600
VIRTFFRTTT GKIAYMTSRD SGETWSKVSY IDGIQQTSYG TQVSAIKYSQ
610 620 630 640 650
LIDGKEAVIL STPNSRSGRK GGQLVVGLVN KEDDSIDWKY HYDIDLPSYG
660 670 680 690
YAYSAITELP NHHIGVLFEK YDSWSRNELH LSNVVQYIDL EINDLTK
Length:697
Mass (Da):77,695
Last modified:November 30, 2010 - v1
Checksum:iA0D9F9AFDE46AFD7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FQ312030 Genomic DNA. Translation: CBW37118.1.
RefSeqiYP_006063057.1. NC_017591.1.

Genome annotation databases

EnsemblBacteriaiCBW37118; CBW37118; INV104_14370.
GeneIDi12889709.
KEGGisni:INV104_14370.
PATRICi43222891. VBIStrPne166045_1797.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FQ312030 Genomic DNA. Translation: CBW37118.1.
RefSeqiYP_006063057.1. NC_017591.1.

3D structure databases

ProteinModelPortaliE1XSK8.
SMRiE1XSK8. Positions 39-696.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCBW37118; CBW37118; INV104_14370.
GeneIDi12889709.
KEGGisni:INV104_14370.
PATRICi43222891. VBIStrPne166045_1797.

Phylogenomic databases

KOiK01186.
OMAiWRYHYDI.

Enzyme and pathway databases

BioCyciSPNE869269:GLL8-1444-MONOMER.

Family and domain databases

Gene3Di2.120.10.10. 2 hits.
2.40.220.10. 1 hit.
2.60.120.200. 1 hit.
InterProiIPR002860. BNR_rpt.
IPR013320. ConA-like_dom.
IPR004124. Glyco_hydro_33_N.
IPR011040. Sialidases.
IPR023364. Trans_sialidase_dom3.
[Graphical view]
PfamiPF02012. BNR. 1 hit.
PF02973. Sialidase. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
SSF50939. SSF50939. 2 hits.
ProtoNetiSearch...

Publicationsi

  1. "Comparative genomic analyses of seventeen Streptococcus pneumoniae strains: insights into the pneumococcal supragenome."
    Hiller N.L., Janto B., Hogg J.S., Boissy R., Yu S., Powell E., Keefe R., Ehrlich N.E., Shen K., Hayes J., Barbadora K., Klimke W., Dernovoy D., Tatusova T., Parkhill J., Bentley S.D., Post J.C., Ehrlich G.D., Hu F.Z.
    J. Bacteriol. 189:8186-8195(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: INV104Imported.

Entry informationi

Entry nameiE1XSK8_STRZI
AccessioniPrimary (citable) accession number: E1XSK8
Entry historyi
Integrated into UniProtKB/TrEMBL: November 30, 2010
Last sequence update: November 30, 2010
Last modified: January 7, 2015
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.